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Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.
- Published in:
- 2016
- By:
- Publication type:
- journal article
Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line.
- Published in:
- 2015
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- Publication type:
- journal article
Carrier-Mediated Cocaine Transport at the Blood-Brain Barrier as a Putative Mechanism in Addiction Liability.
- Published in:
- International Journal of Neuropsychopharmacology, 2015, v. 18, n. 1, p. 1, doi. 10.1093/ijnp/pyu001
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- Publication type:
- Article
Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab.
- Published in:
- Pharmaceutics, 2023, v. 15, n. 8, p. 2129, doi. 10.3390/pharmaceutics15082129
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- Publication type:
- Article
Phenotyping Indices of CYP450 and P-Glycoprotein in Human Volunteers and in Patients Treated with Painkillers or Psychotropic Drugs.
- Published in:
- Pharmaceutics, 2023, v. 15, n. 3, p. 979, doi. 10.3390/pharmaceutics15030979
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- Publication type:
- Article
Exposure–Response Analysis of Osimertinib in Patients with Advanced Non-Small-Cell Lung Cancer.
- Published in:
- Pharmaceutics, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/pharmaceutics14091844
- By:
- Publication type:
- Article
Pharmacophore-Based Discovery of Substrates of a Novel Drug/Proton-Antiporter in the Human Brain Endothelial hCMEC/D3 Cell Line.
- Published in:
- Pharmaceutics, 2022, v. 14, n. 2, p. 255, doi. 10.3390/pharmaceutics14020255
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- Publication type:
- Article
A Review of Mathematics Determining Solute Uptake at the Blood–Brain Barrier in Normal and Pathological Conditions.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 5, p. 756, doi. 10.3390/pharmaceutics13050756
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- Publication type:
- Article
Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 3, p. 369, doi. 10.3390/pharmaceutics13030369
- By:
- Publication type:
- Article
Transient Receptor Potential Vanilloid in the Brain Gliovascular Unit: Prospective Targets in Therapy.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 3, p. 334, doi. 10.3390/pharmaceutics13030334
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- Publication type:
- Article
Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 3, p. 331, doi. 10.3390/pharmaceutics13030331
- By:
- Publication type:
- Article
A Physiologically-Based Pharmacokinetic Framework for Prediction of Drug Exposure in Malnourished Children.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 2, p. 204, doi. 10.3390/pharmaceutics13020204
- By:
- Publication type:
- Article
Non-Invasive Low Pulsed Electrical Fields for Inducing BBB Disruption in Mice—Feasibility Demonstration.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 2, p. 169, doi. 10.3390/pharmaceutics13020169
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- Publication type:
- Article
Characterization of the Blood–Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma.
- Published in:
- Pharmaceutics, 2020, v. 12, n. 5, p. 399, doi. 10.3390/pharmaceutics12050399
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- Publication type:
- Article
An Interspecies Molecular and Functional Study of Organic Cation Transporters at the Blood-Brain Barrier: From Rodents to Humans.
- Published in:
- Pharmaceutics, 2020, v. 12, n. 4, p. 308, doi. 10.3390/pharmaceutics12040308
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- Publication type:
- Article
Mechanisms of respiratory insufficiency induced by methadone overdose in rats.
- Published in:
- Addiction Biology, 2010, v. 15, n. 1, p. 62, doi. 10.1111/j.1369-1600.2009.00184.x
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- Publication type:
- Article
Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report.
- Published in:
- Neonatology (16617800), 2021, v. 118, n. 5, p. 624, doi. 10.1159/000518657
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- Publication type:
- Article
The Use of Levothyroxine Absorption Tests in Clinical Practice.
- Published in:
- Journal of Clinical Endocrinology & Metabolism, 2023, v. 108, n. 8, p. 1875, doi. 10.1210/clinem/dgad132
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- Publication type:
- Article
Review of the Existing Translational Pharmacokinetics Modeling Approaches Specific to Monoclonal Antibodies (mAbs) to Support the First-In-Human (FIH) Dose Selection.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 12754, doi. 10.3390/ijms232112754
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- Publication type:
- Article
TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12476, doi. 10.3390/ijms232012476
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- Publication type:
- Article
Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses.
- Published in:
- Fluids & Barriers of the CNS, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12987-022-00344-w
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- Publication type:
- Article
How to obtain DNA from injection drug users?
- Published in:
- Clinical Chemistry & Laboratory Medicine, 2011, v. 49, n. 8, p. 1391, doi. 10.1515/CCLM.2011.614
- By:
- Publication type:
- Article
A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations.
- Published in:
- Pharmaceutical Research, 2023, v. 40, n. 11, p. 2687, doi. 10.1007/s11095-023-03614-w
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- Publication type:
- Article
Double or Simple Emulsion Process to Encapsulate Hydrophilic Oxytocin Peptide in PLA-PEG Nanoparticles.
- Published in:
- Pharmaceutical Research, 2018, v. 35, n. 4, p. N.PAG, doi. 10.1007/s11095-018-2358-9
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- Publication type:
- Article
Améliorer le ciblage tissulaire des anticorps thérapeutiques par de nouveaux formats: L'exemple de la barrière hémato-encéphalique.
- Published in:
- Médecine Sciences, 2019, v. 35, n. 12, p. 1106, doi. 10.1051/medsci/2019223
- By:
- Publication type:
- Article
Comparing translational population-PBPK modelling of brain microdialysis with bottom-up prediction of brain-to-plasma distribution in rat and human.
- Published in:
- Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 8, p. 485, doi. 10.1002/bdd.1908
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- Publication type:
- Article
Relevance of red blood cell Lithium concentration in the management of Lithium-treated bipolar and unipolar disorders: a systematic narrative review.
- Published in:
- International Journal of Bipolar Disorders, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40345-024-00356-5
- By:
- Publication type:
- Article
Physiologically Based Pharmacokinetic Modelling of Drug Penetration Across the Blood-Brain Barrier-Towards a Mechanistic IVIVE-Based Approach.
- Published in:
- AAPS Journal, 2013, v. 15, n. 4, p. 913, doi. 10.1208/s12248-013-9496-0
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- Publication type:
- Article
Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit.
- Published in:
- eLife, 2021, p. 1, doi. 10.7554/eLife.71379
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- Publication type:
- Article
Population pharmacokinetics and dosing optimization of teicoplanin in children with malignant haematological disease.
- Published in:
- British Journal of Clinical Pharmacology, 2015, v. 80, n. 5, p. 1197, doi. 10.1111/bcp.12710
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- Publication type:
- Article
Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity.
- Published in:
- British Journal of Clinical Pharmacology, 2015, v. 79, n. 6, p. 967, doi. 10.1111/bcp.12576
- By:
- Publication type:
- Article
Diphenhydramine as a selective probe to study H<sup>+</sup>-antiporter function at the blood-brain barrier: Application to [<sup>11</sup>C]diphenhydramine positron emission tomography imaging.
- Published in:
- Journal of Cerebral Blood Flow & Metabolism, 2017, v. 37, n. 6, p. 2185, doi. 10.1177/0271678X16662042
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- Publication type:
- Article
Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography.
- Published in:
- EJNMMI Research, 2019, v. 9, n. 1, p. 1, doi. 10.1186/s13550-019-0581-y
- By:
- Publication type:
- Article
Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus -- Lessons from Three Unsuccessful Approaches.
- Published in:
- European Journal of Microbiology & Immunology, 2018, v. 8, n. 3, p. 78, doi. 10.1556/1886.2018.00008
- By:
- Publication type:
- Article
Blood–Brain Barrier Dynamic Device with Uniform Shear Stress Distribution for Microscopy and Permeability Measurements.
- Published in:
- Applied Sciences (2076-3417), 2021, v. 11, n. 12, p. 5584, doi. 10.3390/app11125584
- By:
- Publication type:
- Article
Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines.
- Published in:
- International Journal of Cancer, 2002, v. 98, n. 2, p. 173, doi. 10.1002/ijc.10135
- By:
- Publication type:
- Article
Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells.
- Published in:
- Journal of Neurochemistry, 2015, v. 132, n. 4, p. 373, doi. 10.1111/jnc.12972
- By:
- Publication type:
- Article
Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/ COX-2 activation.
- Published in:
- Journal of Neurochemistry, 2012, v. 123, n. 4, p. 491, doi. 10.1111/j.1471-4159.2012.07890.x
- By:
- Publication type:
- Article
Liquid chromatography high resolution mass spectrometry for the determination of baclofen and its metabolites in plasma: Application to therapeutic drug monitoring.
- Published in:
- Biomedical Chromatography, 2017, v. 31, n. 8, p. n/a, doi. 10.1002/bmc.3936
- By:
- Publication type:
- Article
Effect of a Roux-en-Y Gastric Bypass on the Pharmacokinetics of Oral Morphine Using a Population Approach.
- Published in:
- Clinical Pharmacokinetics, 2014, v. 53, n. 10, p. 919, doi. 10.1007/s40262-014-0163-0
- By:
- Publication type:
- Article
Pharmacology of morphine in obese patients: clinical implications.
- Published in:
- 2009
- By:
- Publication type:
- journal article
Pharmacology of Morphine in Obese Patients.
- Published in:
- 2009
- By:
- Publication type:
- Abstract
Influence of Development, HIV Infection, and Antiretroviral Therapies on the Gene Expression Profiles of ABC Transporters in Human Lymphocytes.
- Published in:
- Journal of Clinical Pharmacology, 2010, v. 50, n. 2, p. 226, doi. 10.1177/0091270009343696
- By:
- Publication type:
- Article
Extending the dosing intervals of nivolumab: model-based simulations in unselected cancer patients.
- Published in:
- British Journal of Cancer, 2024, v. 130, n. 11, p. 1866, doi. 10.1038/s41416-024-02659-x
- By:
- Publication type:
- Article
Accelerating robust plausible virtual patient cohort generation by substituting ODE simulations with parameter space mapping.
- Published in:
- Journal of Pharmacokinetics & Pharmacodynamics, 2022, v. 49, n. 6, p. 625, doi. 10.1007/s10928-022-09826-8
- By:
- Publication type:
- Article
Astroglial Connexin 43 Deficiency Protects against LPS-Induced Neuroinflammation: A TSPO Brain µPET Study with [18F]FEPPA.
- Published in:
- Cells (2073-4409), 2020, v. 9, n. 2, p. 389, doi. 10.3390/cells9020389
- By:
- Publication type:
- Article
A polyspecific drug/proton antiporter mediates diphenhydramine and clonidine transport at the mouse blood-retinal barrier.
- Published in:
- 2015
- By:
- Publication type:
- journal article
A polyspecific drug/proton antiporter mediates diphenhydramine and clonidine transport at the mouse blood-retinal barrier.
- Published in:
- British Journal of Pharmacology, 2015, v. 172, n. 19, p. 4714, doi. 10.1111/bph.13246
- By:
- Publication type:
- Article
Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation.
- Published in:
- Fluids & Barriers of the CNS, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12987-024-00526-8
- By:
- Publication type:
- Article
[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model.
- Published in:
- Molecules, 2018, v. 23, n. 6, p. 1375, doi. 10.3390/molecules23061375
- By:
- Publication type:
- Article