Found: 24

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  • Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation.

    Published in:
    Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01079-1
    By:
    • Wojtas, Aleksandra M.;
    • Carlomagno, Yari;
    • Sens, Jonathon P.;
    • Kang, Silvia S.;
    • Jensen, Tanner D.;
    • Kurti, Aishe;
    • Baker, Kelsey E.;
    • Berry, Taylor J.;
    • Phillips, Virginia R.;
    • Castanedes, Monica Casey;
    • Awan, Ayesha;
    • DeTure, Michael;
    • De Castro, Cristhoper H. Fernandez;
    • Librero, Ariston L.;
    • Yue, Mei;
    • Daughrity, Lillian;
    • Jansen-West, Karen R.;
    • Cook, Casey N.;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard
    Publication type:
    Article

  • Generation and characterization of monoclonal antibodies against pathologically phosphorylated TDP-43.

    Published in:
    PLoS ONE, 2024, v. 19, n. 4, p. 1, doi. 10.1371/journal.pone.0298080
    By:
    • Castellanos Otero, Paula;
    • Todd, Tiffany W.;
    • Shao, Wei;
    • Jones, Caroline J.;
    • Huang, Kexin;
    • Daughrity, Lillian M.;
    • Yue, Mei;
    • Sheth, Udit;
    • Gendron, Tania F.;
    • Prudencio, Mercedes;
    • Oskarsson, Björn;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard;
    • Zhang, Yong-Jie
    Publication type:
    Article

  • Tau exhibits unique seeding properties in globular glial tauopathy.

    Published in:
    Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0691-9
    By:
    • Chung, Dah-eun Chloe;
    • Carlomagno, Yari;
    • Cook, Casey N.;
    • Jansen-West, Karen;
    • Daughrity, Lillian;
    • Lewis-Tuffin, Laura J.;
    • Castanedes-Casey, Monica;
    • DeTure, Michael;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard
    Publication type:
    Article

  • Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant.

    Published in:
    Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0661-2
    By:
    • Carlomagno, Yari;
    • Chung, Dah-eun Chloe;
    • Yue, Mei;
    • Kurti, Aishe;
    • Avendano, Nicole M.;
    • Castanedes-Casey, Monica;
    • Hinkle, Kelly M.;
    • Jansen-West, Karen;
    • Daughrity, Lillian M.;
    • Tong, Jimei;
    • Phillips, Virginia;
    • Rademakers, Rosa;
    • DeTure, Michael;
    • Fryer, John D.;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard;
    • Cook, Casey
    Publication type:
    Article

  • Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of <italic>C9ORF72</italic>-repeat induced toxicity.

    Published in:
    Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0545-x
    By:
    • Nicholson, Alexandra M.;
    • Zhou, Xiaolai;
    • Perkerson, Ralph B.;
    • Parsons, Tammee M.;
    • Chew, Jeannie;
    • Brooks, Mieu;
    • DeJesus-Hernandez, Mariely;
    • Finch, NiCole A.;
    • Matchett, Billie J.;
    • Kurti, Aishe;
    • Jansen-West, Karen R.;
    • Perkerson, Emilie;
    • Daughrity, Lillian;
    • Castanedes-Casey, Monica;
    • Rousseau, Linda;
    • Phillips, Virginia;
    • Hu, Fenghua;
    • Gendron, Tania F.;
    • Murray, Melissa E.;
    • Dickson, Dennis W.
    Publication type:
    Article

  • Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.

    Published in:
    2020
    By:
    • Prudencio, Mercedes;
    • Humphrey, Jack;
    • Pickles, Sarah;
    • Brown, Anna-Leigh;
    • Hill, Sarah E.;
    • Kachergus, Jennifer M.;
    • Shi, J.;
    • Heckman, Michael G.;
    • Spiegel, Matthew R.;
    • Cook, Casey;
    • Yuping Song;
    • Mei Yue;
    • Daughrity, Lillian M.;
    • Carlomagno, Yari;
    • Jansen-West, Karen;
    • de Castro, Cristhoper Fernandez;
    • DeTure, Michael;
    • Koga, Shunsuke;
    • Ying-Chih Wang;
    • Sivakumar, Prasanth
    Publication type:
    journal article

  • Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.

    Published in:
    Science Translational Medicine, 2017, v. 9, n. 383, p. 1, doi. 10.1126/scitranslmed.aai7866
    By:
    • Gendron, Tania F.;
    • Chew, Jeannie;
    • Stankowski, Jeannette N.;
    • Hayes, Lindsey R.;
    • Yong-Jie Zhang;
    • Prudencio, Mercedes;
    • Carlomagno, Yari;
    • Daughrity, Lillian M.;
    • Jansen-West, Karen;
    • Perkerson, Emilie A.;
    • O'Raw, Aliesha;
    • Cook, Casey;
    • Pregent, Luc;
    • Belzil, Veronique;
    • van Blitterswijk, Marka;
    • Tabassian, Lilia J.;
    • Lee, Chris W.;
    • Mei Yue;
    • Jimei Tong;
    • Yuping Song
    Publication type:
    Article

  • Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis.

    Published in:
    2017
    By:
    • Gendron, Tania F.;
    • Daughrity, Lillian M.;
    • Heckman, Michael G.;
    • Diehl, Nancy N.;
    • Wuu, Joanne;
    • Miller, Timothy M.;
    • Pastor, Pau;
    • Trojanowski, John Q.;
    • Grossman, Murray;
    • Berry, James D.;
    • Hu, William T.;
    • Ratti, Antonia;
    • Benatar, Michael;
    • Silani, Vincenzo;
    • Glass, Jonathan D.;
    • Floeter, Mary Kay;
    • Jeromin, Andreas;
    • Boylan, Kevin B.;
    • Petrucelli, Leonard
    Publication type:
    journal article

  • Correction: TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A.

    Published in:
    2023
    By:
    • Koike, Yuka;
    • Pickles, Sarah;
    • Ayuso, Virginia Estades;
    • Jansen-West, Karen;
    • Qi, Yue A.;
    • Li, Ziyi;
    • Daughrity, Lillian M.;
    • Yue, Mei;
    • Zhang, Yong-Jie;
    • Cook, Casey N.;
    • Dickson, Dennis W.;
    • Ward, Michael;
    • Petrucelli, Leonard;
    • Prudencio, Mercedes
    Publication type:
    Correction Notice

  • TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A.

    Published in:
    PLoS Biology, 2023, v. 21, n. 3, p. 1, doi. 10.1371/journal.pbio.3002028
    By:
    • Koike, Yuka;
    • Pickles, Sarah;
    • Estades Ayuso, Virginia;
    • Jansen-West, Karen;
    • Qi, Yue A.;
    • Li, Ziyi;
    • Daughrity, Lillian M.;
    • Yue, Mei;
    • Zhang, Yong-Jie;
    • Cook, Casey N.;
    • Dickson, Dennis W.;
    • Ward, Michael;
    • Petrucelli, Leonard;
    • Prudencio, Mercedes
    Publication type:
    Article

  • Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.

    Published in:
    Human Molecular Genetics, 2017, v. 26, n. 17, p. 3421, doi. 10.1093/hmg/ddx233
    By:
    • Prudencio, Mercedes;
    • Gonzales, Patrick K.;
    • Cook, Casey N.;
    • Gendron, Tania F.;
    • Daughrity, Lillian M.;
    • Song, Yuping;
    • Ebbert, Mark T. W.;
    • van Blitterswijk, Marka;
    • Zhang, Yong-Jie;
    • Jansen-West, Karen;
    • Baker, Matthew C.;
    • DeTure, Michael;
    • Rademakers, Rosa;
    • Boylan, Kevin B.;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard;
    • Link, Christopher D.
    Publication type:
    Article

  • Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72.

    Published in:
    Acta Neuropathologica, 2015, v. 130, n. 6, p. 863, doi. 10.1007/s00401-015-1480-6
    By:
    • van Blitterswijk, Marka;
    • Gendron, Tania;
    • Baker, Matthew;
    • DeJesus-Hernandez, Mariely;
    • Finch, NiCole;
    • Brown, Patricia;
    • Daughrity, Lillian;
    • Murray, Melissa;
    • Heckman, Michael;
    • Jiang, Jie;
    • Lagier-Tourenne, Clotilde;
    • Edbauer, Dieter;
    • Cleveland, Don;
    • Josephs, Keith;
    • Parisi, Joseph;
    • Knopman, David;
    • Petersen, Ronald;
    • Petrucelli, Leonard;
    • Boeve, Bradley;
    • Graff-Radford, Neill
    Publication type:
    Article

  • Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers.

    Published in:
    Acta Neuropathologica, 2015, v. 130, n. 4, p. 559, doi. 10.1007/s00401-015-1474-4
    By:
    • Bieniek, Kevin;
    • Lagier-Tourenne, Clotilde;
    • Edbauer, Dieter;
    • Cleveland, Don;
    • Gendron, Tania;
    • van Blitterswijk, Marka;
    • Daughrity, Lillian;
    • Murray, Melissa;
    • Castanedes-Casey, Monica;
    • Rousseau, Linda;
    • Rademakers, Rosa;
    • Dickson, Dennis;
    • Petrucelli, Leonard;
    • Jiang, Jie;
    • Rush, Beth;
    • Pedraza, Otto;
    • Lucas, John;
    • Desaro, Pamela;
    • Robertson, Amelia;
    • Overstreet, Karen
    Publication type:
    Article

  • Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.

    Published in:
    Acta Neuropathologica, 2014, v. 128, n. 4, p. 505, doi. 10.1007/s00401-014-1336-5
    By:
    • Zhang, Yong-Jie;
    • Jansen-West, Karen;
    • Xu, Ya-Fei;
    • Gendron, Tania;
    • Bieniek, Kevin;
    • Lin, Wen-Lang;
    • Sasaguri, Hiroki;
    • Caulfield, Thomas;
    • Hubbard, Jaime;
    • Daughrity, Lillian;
    • Chew, Jeannie;
    • Belzil, Veronique;
    • Prudencio, Mercedes;
    • Stankowski, Jeannette;
    • Castanedes-Casey, Monica;
    • Whitelaw, Ena;
    • Ash, Peter;
    • DeTure, Michael;
    • Rademakers, Rosa;
    • Boylan, Kevin
    Publication type:
    Article

  • Antisense transcripts of the expanded <i>C9ORF72</i> hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS.

    Published in:
    Acta Neuropathologica, 2013, v. 126, n. 6, p. 829, doi. 10.1007/s00401-013-1192-8
    By:
    • Gendron, Tania F.;
    • Bieniek, Kevin F.;
    • Zhang, Yong-Jie;
    • Jansen-West, Karen;
    • Ash, Peter E. A.;
    • Caulfield, Thomas;
    • Daughrity, Lillian;
    • Dunmore, Judith H.;
    • Castanedes-Casey, Monica;
    • Chew, Jeannie;
    • Cosio, Danielle M.;
    • van Blitterswijk, Marka;
    • Lee, Wing C.;
    • Rademakers, Rosa;
    • Boylan, Kevin B.;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard
    Publication type:
    Article

  • Reduced <i>C9orf72</i> gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood.

    Published in:
    Acta Neuropathologica, 2013, v. 126, n. 6, p. 895, doi. 10.1007/s00401-013-1199-1
    By:
    • Belzil, Veronique V.;
    • Bauer, Peter O.;
    • Prudencio, Mercedes;
    • Gendron, Tania F.;
    • Stetler, Caroline T.;
    • Yan, Irene K.;
    • Pregent, Luc;
    • Daughrity, Lillian;
    • Baker, Matthew C.;
    • Rademakers, Rosa;
    • Boylan, Kevin;
    • Patel, Tushar C.;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard
    Publication type:
    Article

  • TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.

    Published in:
    Science Translational Medicine, 2024, v. 16, n. 730, p. 1, doi. 10.1126/scitranslmed.adf9735
    By:
    • Marks, Jordan D.;
    • Ayuso, Virginia Estades;
    • Carlomagno, Yari;
    • Yue, Mei;
    • Todd, Tiffany W.;
    • Hao, Ying;
    • Li, Ziyi;
    • McEachin, Zachary T.;
    • Shantaraman, Anantharaman;
    • Duong, Duc M.;
    • Daughrity, Lillian M.;
    • Jansen-West, Karen;
    • Shao, Wei;
    • Calliari, Anna;
    • Bejarano, Jesus Gonzalez;
    • DeTure, Michael;
    • Rawlinson, Bailey;
    • Casey, Monica Castanedes;
    • Lilley, Meredith T.;
    • Donahue, Megan H.
    Publication type:
    Article

  • Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3.

    Published in:
    Science Translational Medicine, 2020, v. 12, n. 566, p. 1, doi. 10.1126/scitranslmed.abb7086
    By:
    • Prudencio, Mercedes;
    • Garcia-Moreno, Hector;
    • Jansen-West, Karen R.;
    • AL-Shaikh, Rana Hanna;
    • Gendron, Tania F.;
    • Heckman, Michael G.;
    • Spiegel, Matthew R.;
    • Carlomagno, Yari;
    • Daughrity, Lillian M.;
    • Song, Yuping;
    • Dunmore, Judith A.;
    • Byron, Natalie;
    • Oskarsson, Björn;
    • Nicholson, Katharine A.;
    • Staff, Nathan P.;
    • Gorcenco, Sorina;
    • Puschmann, Andreas;
    • Lemos, João;
    • Januário, Cristina;
    • LeDoux, Mark S.
    Publication type:
    Article

  • C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy.

    Published in:
    Science Translational Medicine, 2020, v. 12, n. 559, p. 1, doi. 10.1126/scitranslmed.abb3774
    By:
    • Cook, Casey N.;
    • Wu, Yanwei;
    • Odeh, Hana M.;
    • Gendron, Tania F.;
    • Jansen-West, Karen;
    • del Rosso, Giulia;
    • Yue, Mei;
    • Jiang, Peizhou;
    • Gomes, Edward;
    • Tong, Jimei;
    • Daughrity, Lillian M.;
    • Avendano, Nicole M.;
    • Castanedes-Casey, Monica;
    • Shao, Wei;
    • Oskarsson, Björn;
    • Tomassy, Giulio S.;
    • McCampbell, Alexander;
    • Rigo, Frank;
    • Dickson, Dennis W.;
    • Shorter, James
    Publication type:
    Article

  • Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases.

    Published in:
    2024
    By:
    • Calliari, Anna;
    • Daughrity, Lillian M.;
    • Albagli, Ellen A.;
    • Castellanos Otero, Paula;
    • Yue, Mei;
    • Jansen-West, Karen;
    • Islam, Naeyma N.;
    • Caulfield, Thomas;
    • Rawlinson, Bailey;
    • DeTure, Michael;
    • Cook, Casey;
    • Graff-Radford, Neill R.;
    • Day, Gregory S.;
    • Boeve, Bradley F.;
    • Knopman, David S.;
    • Petersen, Ronald C.;
    • Josephs, Keith A.;
    • Oskarsson, Björn;
    • Gitler, Aaron D.;
    • Dickson, Dennis W.
    Publication type:
    Correction Notice

  • HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases.

    Published in:
    Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-024-00718-8
    By:
    • Calliari, Anna;
    • Daughrity, Lillian M.;
    • Albagli, Ellen A.;
    • Castellanos Otero, Paula;
    • Yue, Mei;
    • Jansen-West, Karen;
    • Islam, Naeyma N.;
    • Caulfield, Thomas;
    • Rawlinson, Bailey;
    • DeTure, Michael;
    • Cook, Casey;
    • Graff-Radford, Neill R.;
    • Day, Gregory S.;
    • Boeve, Bradley F.;
    • Knopman, David S.;
    • Petersen, Ronald C.;
    • Josephs, Keith A.;
    • Oskarsson, Björn;
    • Gitler, Aaron D.;
    • Dickson, Dennis W.
    Publication type:
    Article

  • HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases.

    Published in:
    Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-024-00718-8
    By:
    • Calliari, Anna;
    • Daughrity, Lillian M.;
    • Albagli, Ellen A.;
    • Castellanos Otero, Paula;
    • Yue, Mei;
    • Jansen-West, Karen;
    • Islam, Naeyma N.;
    • Caulfield, Thomas;
    • Rawlinson, Bailey;
    • DeTure, Michael;
    • Cook, Casey;
    • Graff-Radford, Neill R.;
    • Day, Gregory S.;
    • Boeve, Bradley F.;
    • Knopman, David S.;
    • Petersen, Ronald C.;
    • Josephs, Keith A.;
    • Oskarsson, Björn;
    • Gitler, Aaron D.;
    • Dickson, Dennis W.
    Publication type:
    Article

  • Astrocyte-derived clusterin suppresses amyloid formation in vivo.

    Published in:
    Molecular Neurodegeneration, 2020, v. 15, n. 1, p. N.PAG, doi. 10.1186/s13024-020-00416-1
    By:
    • Wojtas, Aleksandra M.;
    • Sens, Jonathon P.;
    • Kang, Silvia S.;
    • Baker, Kelsey E.;
    • Berry, Taylor J.;
    • Kurti, Aishe;
    • Daughrity, Lillian;
    • Jansen-West, Karen R.;
    • Dickson, Dennis W.;
    • Petrucelli, Leonard;
    • Bu, Guojun;
    • Liu, Chia-Chen;
    • Fryer, John D.
    Publication type:
    Article

  • Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy.

    Published in:
    Molecular Neurodegeneration, 2019, v. 14, n. 1, p. N.PAG, doi. 10.1186/s13024-019-0310-z
    By:
    • Chew, Jeannie;
    • Cook, Casey;
    • Gendron, Tania F.;
    • Jansen-West, Karen;
    • del Rosso, Giulia;
    • Daughrity, Lillian M.;
    • Castanedes-Casey, Monica;
    • Kurti, Aishe;
    • Stankowski, Jeannette N.;
    • Disney, Matthew D.;
    • Rothstein, Jeffrey D.;
    • Dickson, Dennis W.;
    • Fryer, John D.;
    • Zhang, Yong-Jie;
    • Petrucelli, Leonard
    Publication type:
    Article