Works by Döhner, Konstanze

Results: 64

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis.

Published in:

2007

By:

Scholl, Claudia;
Bansal, Dimple;
Döhner, Konstanze;
Eiwen, Karina;
Huntly, Brian J. P.;
Lee, Benjamin H.;
Rücker, Frank G.;
Schlenk, Richard F.;
Bullinger, Lars;
Döhner, Hartmut;
Gilliland, D. Gary;
Fröhling, Stefan;
Döhner, Konstanze;
Rücker, Frank G;
Döhner, Hartmut;
Fröhling, Stefan

Publication type:

journal article

Evaluating the impact of genetic and epigenetic aberrations on survival and response in acute myeloid leukemia patients receiving epigenetic therapy.

Published in:

2017

By:

Hiller, Jan;
Schmoor, Claudia;
Gaidzik, Verena;
Schmidt-Salzmann, Charlotte;
Yalcin, Arzu;
Abdelkarim, Mahmoud;
Blagitko-Dorfs, Nadja;
Döhner, Konstanze;
Bullinger, Lars;
Duyster, Justus;
Lübbert, Michael;
Hackanson, Björn;
Hiller, Jan K;
Gaidzik, Verena I;
Döhner, Konstanze;
Lübbert, Michael;
Hackanson, Björn

Publication type:

journal article

Measurable residual disease monitoring in patients with acute myeloid leukemia treated with lower‐intensity therapy: Roadmap from an ELN‐DAVID expert panel.

Published in:

American Journal of Hematology, 2023, v. 98, n. 12, p. 1847, doi. 10.1002/ajh.27087

By:

Ravandi, Farhad;
Cloos, Jacqueline;
Buccisano, Francesco;
Dillon, Richard;
Döhner, Konstanze;
Freeman, Sylvie D.;
Hourigan, Christopher S.;
Ossenkoppele, Gerrit J.;
Roboz, Gail J.;
Subklewe, Marion;
Thiede, Christian;
Arnhardt, Isabell;
Valk, Peter J. M.;
Venditti, Adriano;
Wei, Andrew H.;
Walter, Roland B.;
Heuser, Michael

Publication type:

Article

Prognostic Impact of COVID-19 Inflammation Score Response: A Sub-Group Analysis on Critically Ill Patients of the RuxCoFlam Trial.

Published in:

Life (2075-1729), 2025, v. 15, n. 5, p. 781, doi. 10.3390/life15050781

By:

Weiss, Manfred;
Hammersen, Jakob;
Rudolphi, Sebastian;
Formann, Isabell;
Träger, Karl;
Rücker, Frank G.;
Grüner, Beate;
Allgöwer, Andreas;
Birndt, Sebastian;
Fabisch, Christian;
Hochhaus, Andreas;
Döhner, Konstanze;
Rosée, Paul La;
Stegelmann, Frank

Publication type:

Article

TET2 deficiency cooperates with CBFB‐MYH11 to induce acute myeloid leukaemia and represents an early leukaemogenic event.

Published in:

British Journal of Haematology, 2022, v. 197, n. 2, p. 201, doi. 10.1111/bjh.18027

By:

Reckzeh, Kristian;
Estruch, Montserrat;
Ali, Mina;
Søgaard Helbo, Alexandra;
Mosbech, Anna;
Jae Won, Kyoung;
Rücker, Frank;
Döhner, Konstanze;
Theilgaard‐Mönch, Kim

Publication type:

Article

Phase I/II study on cytarabine and idarubicin combined with escalating doses of clofarabine in newly diagnosed patients with acute myeloid leukaemia and high risk for induction failure (AMLSG 17‐10 CIARA trial).

Published in:

British Journal of Haematology, 2018, v. 183, n. 2, p. 235, doi. 10.1111/bjh.15546

By:

Krauter, Jürgen;
Fiedler, Walter;
Schlenk, Richard F.;
Paschka, Peter;
Thol, Felicitas;
Lübbert, Michael;
Wattad, Mohammed;
Verbeek, Mareike;
Könecke, Christian;
Neuhaus, Barbara;
Papkalla, Armin;
Kebenko, Maxim;
Janning, Melanie;
Döhner, Konstanze;
Gaidzik, Verena I.;
Becker, Heiko;
Greil, Christine;
Reimer, Peter;
Götze, Katharina S.;
Döhner, Hartmut

Publication type:

Article

A phase I/II study of sunitinib and intensive chemotherapy in patients over 60 years of age with acute myeloid leukaemia and activating FLT3 mutations.

Published in:

British Journal of Haematology, 2015, v. 169, n. 5, p. 694, doi. 10.1111/bjh.13353

By:

Fiedler, Walter;
Kayser, Sabine;
Kebenko, Maxim;
Janning, Melanie;
Krauter, Jürgen;
Schittenhelm, Marcus;
Götze, Katharina;
Weber, Daniela;
Göhring, Gudrun;
Teleanu, Veronica;
Thol, Felicitas;
Heuser, Michael;
Döhner, Konstanze;
Ganser, Arnold;
Döhner, Hartmut;
Schlenk, Richard F.

Publication type:

Article

Mitigation of atrial fibrillation‐related complications with antithrombotic and cytoreductive therapy in patients with Myeloproliferative Neoplasms: Implications from the GSG‐MPN bioregistry.

Published in:

HemaSphere, 2025, v. 9, n. 3, p. 1, doi. 10.1002/hem3.70090

By:

Cho, Hyunyee Rosa;
Isfort, Susanne;
Kricheldorf, Kim;
Stegelmann, Frank;
Klausmann, Martine;
Heidel, Florian H.;
Griesshammer, Martin;
Schulz, Holger;
Hochhaus, Andreas;
Göthert, Joachim;
Schlag, Rudolf;
Hollburg, Wiebke;
Teichmann, Lino;
Sockel, Katja;
Wilop, Stefan;
Gezer, Deniz;
Kirschner, Martin;
Döhner, Konstanze;
Brümmendorf, Tim H.;
Koschmieder, Steffen

Publication type:

Article

Disease characteristics and outcomes of acute myeloid leukemia in germline RUNX1 deficiency (Familial Platelet Disorder with associated Myeloid Malignancy).

Published in:

HemaSphere, 2025, v. 9, n. 1, p. 1, doi. 10.1002/hem3.70057

By:

Ernst, Martijn P. T.;
Versluis, Jurjen;
Valk, Peter J. M.;
Bierings, Marc;
Tamminga, Rienk Y. J.;
Hooimeijer, Louise H.;
Döhner, Konstanze;
Gresele, Paolo;
Tawana, Kiran;
Langemeijer, Saskia M. C.;
Van der Reijden, Bert A.;
Podgornik, Helena;
Sever, Matjaz;
Tvedt, Tor H. A.;
Vulliamy, Tom;
Fitzgibbon, Jude;
Dokal, Inderjeet;
Baliakas, Panagiotis;
Bastida, José M.;
Pohlkamp, Christian

Publication type:

Article

Precision hematology: Navigating the evolution of diagnostic classifications in the era of globalized medicine.

Published in:

HemaSphere, 2024, v. 8, n. 4, p. 1, doi. 10.1002/hem3.65

By:

Macintyre, Elizabeth;
Döhner, Konstanze;
Grønbæk, Kirsten;
Dreyling, Martin;
Huntly, Brian;
Almeida, Antonio;
Gribben, John

Publication type:

Article

P1542: RUXOLITINIB IN COVID‐19 PATIENTS WITH DEFINED HYPERINFLAMMATION: THE RUXCOFLAM TRIAL.

Published in:

HemaSphere, 2023, v. 7, p. 1, doi. 10.1097/01.HS9.0000973044.21308.32

By:

Birndt, Sebastian;
Hammersen, Jakob;
Döhner, Konstanze;
Reuken, Philipp;
Sauerbrey, Paul;
Rosée, Felicitas La;
Pfirrmann, Markus;
Fabisch, Christian;
Illerhaus, Gerald;
Weiß, Manfred;
Träger, Karl;
Bremer, Hinrich;
Drömann, Daniel;
Schneider, Sylke;
Rosee, Paul La;
Hochhaus, Andreas

Publication type:

Article

P453: NOVEL INSIGHTS INTO MINIMAL RESIDUAL DISEASE OF ACUTE MYELOID LEUKEMIA USING PRIMARY SAMPLES AND A CLINICALLY RELEVANT PDX MODEL.

Published in:

HemaSphere, 2023, v. 7, p. 1, doi. 10.1097/01.HS9.0000968720.73631.e7

By:

Aroua, Nesrine;
Karpova, Darja;
Leppä, Aino‐Maija;
Donato, Elisa;
Przybylla, Adriana;
Sohn, Markus;
Zeisberger, Petra;
Klein, Corinna;
Döhner, Konstanze;
Trumpp, Andreas

Publication type:

Article

P440: ENHANCER HIJACKING IN COMPLEX‐KARYOTYPE AML.

Published in:

HemaSphere, 2023, v. 7, p. 1, doi. 10.1097/01.HS9.0000968668.46493.04

By:

Sollier, Etienne;
Riedel, Anna;
Kelly, Katherine;
Weichenhan, Dieter;
Jahn, Ekaterina;
Döhner, Konstanze;
Döhner, Hartmut;
Ernst, Aurélie;
Lutsik, Pavlo;
Plass, Christoph

Publication type:

Article

S136: ANALYSIS OF FACTORS ASSOCIATED WITH LONG‐TERM SURVIVAL IN A LARGE ACUTE PROMYELOCYTIC LEUKEMIA (APL) PATIENT COHORT: A HARMONY ALLIANCE STUDY.

Published in:

HemaSphere, 2023, v. 7, p. 1, doi. 10.1097/01.HS9.0000967456.53745.c4

By:

Guarnera, Luca;
Lehmann, Soren;
Döhner, Konstanze;
Döhner, Hartmut;
Ossenkoppele, Gert;
Russell, Nigel;
Dillon, Richard;
Platzbecker, Uwe;
Vignetti, Marco;
la Sala, Edoardo;
Villaverde, Angela;
Tur, Laura;
Hernández Rivas, Jesus;
Teresa Voso, Maria

Publication type:

Article

P416: DNA METHYLATION-BASED CHARACTERIZATION OF ACUTE MYELOID LEUKEMIA POINTS TOWARDS KDM3B AS A 5Q HAPLOINSUFFICIENCY CANDIDATE.

Published in:

2023

By:

Kelly, Katherine;
Sollier, Etienne;
Riedel, Anna;
Welte, Linda;
Jahn, Ekaterina;
Döhner, Hartmut;
Döhner, Konstanze;
Lutsik, Pavlo;
Plass, Christoph

Publication type:

Abstract

P417: GENOMIC LANDSCAPE AND PROGNOSIS IN OLDER ACUTE MYELOID LEUKEMIA PATIENTS NOT ELIGIBLE FOR INTENSIVE CHEMOTHERAPY.

Published in:

2023

By:

Jahn, Ekaterina;
Saadati, Maral;
Fenaux, Pierre;
Gobbi, Marco;
Roboz, Gail;
Bullinger, Lars;
Lutsik, Pavlo;
Riedel, Anna;
Plass, Christoph;
Jahn, Nikolaus;
Walter, Claudia;
Holzmann, Karlheinz;
Hao, Yong;
Naim, Sue;
Schreck, Nicholas;
Krzykalla, Julia;
Benner, Axel;
Keer, Harold;
Azab, Mohammad;
Döhner, Konstanze

Publication type:

Abstract

Palbociclib in Acute Leukemias With KMT2A‐rearrangement: Results of AMLSG 23‐14 Trial.

Published in:

HemaSphere, 2023, v. 7, n. 5, p. e877, doi. 10.1097/HS9.0000000000000877

By:

Gaidzik, Verena I.;
Paschka, Peter;
Schlenk, Richard F.;
Weber, Daniela;
Fröhling, Stefan;
Krämer, Alwin;
Wäsch, Ralph;
Westermann, Jörg;
Mayer, Karin;
de Wit, Maike;
Fiedler, Walter;
Benner, Axel;
Heuser, Michael;
Thol, Felicitas;
Döhner, Konstanze;
Ganser, Arnold;
Döhner, Hartmut

Publication type:

Article

Outcome of 129 Pregnancies in Polycythemia Vera Patients: A Report of the European LeukemiaNET.

Published in:

HemaSphere, 2023, v. 7, n. 5, p. e882, doi. 10.1097/HS9.0000000000000882

By:

Wille, Kai;
Brouka, Maja;
Bernhardt, Johannes;
Rüfer, Axel;
Niculescu‐Mizil, Emilia;
Gotic, Mirjana;
Isfort, Susanne;
Koschmieder, Steffen;
Barbui, Tiziano;
Sadjadian, Parvis;
Becker, Tatjana;
Kolatzki, Vera;
Meixner, Raphael;
Marchi, Hannah;
Fuchs, Christiane;
Stegelmann, Frank;
Döhner, Konstanze;
Kiladjian, Jean‐Jacques;
Griesshammer, Martin

Publication type:

Article

Experience With IVDR Implementation in Three Diagnostic Laboratories: Messages to EU Health Institutions, Diagnostic Healthcare Payers, and Authorities.

Published in:

HemaSphere, 2023, v. 7, n. 4, p. e865, doi. 10.1097/HS9.0000000000000865

By:

Lubbers, Bart R.;
Dombrink, Isabel;
Kalina, Tomas;
Hofmans, Mattias;
Bruun, Morten S.;
Stanworth, Simon J.;
Béné, Marie C.;
Döhner, Konstanze;
Brüggemann, Monika;
Macintyre, Elizabeth;
van Dongen, Jacques J.M.

Publication type:

Article

A Lack of Diversity, Equity, and Inclusion in Clinical Research Has Direct Impact on Patient Care.

Published in:

HemaSphere, 2023, v. 7, n. 3, p. e842, doi. 10.1097/HS9.0000000000000842

By:

El‐Galaly, Tarec Christoffer;
Gaidzik, Verena I.;
Gaman, Mihnea‐Alexandru;
Antic, Darko;
Okosun, Jessica;
Copland, Mhairi;
Sexl, Veronika;
Fielding, Adele K.;
Doeswijk, Robin;
Parker, Helen;
Dreyling, Martin;
Döhner, Konstanze;
Almeida, António Medina;
Macintyre, Elizabeth;
Gribben, John G.;
Grønbæk, Kirsten

Publication type:

Article

The Renovated Face of EHA Classical Master Class: A Survey-based Evaluation on Behalf of the EHA Campus Working Group.

Published in:

HemaSphere, 2022, v. 6, n. 10, p. 1, doi. 10.1097/HS9.0000000000000777

By:

Gurnari, Carmelo;
Bouaziz, Malik;
Marinova, Joana;
van Havre, Nathalie;
Döhner, Konstanze;
Ar, Muhlis Cem

Publication type:

Article

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.

Published in:

Molecular Cancer, 2022, v. 21, n. 1, p. 1, doi. 10.1186/s12943-022-01635-4

By:

Zhai, Yanan;
Singh, Prashant;
Dolnik, Anna;
Brazda, Peter;
Atlasy, Nader;
del Gaudio, Nunzio;
Döhner, Konstanze;
Döhner, Hartmut;
Minucci, Saverio;
Martens, Joost;
Altucci, Lucia;
Megchelenbrink, Wout;
Bullinger, Lars;
Stunnenberg, Hendrik G.

Publication type:

Article

Inactivating CUX1 mutations promote tumorigenesis.

Published in:

Nature Genetics, 2014, v. 46, n. 1, p. 33, doi. 10.1038/ng.2846

By:

Wong, Chi C;
Martincorena, Inigo;
Rust, Alistair G;
Rashid, Mamunur;
Alifrangis, Constantine;
Alexandrov, Ludmil B;
Tiffen, Jessamy C;
Kober, Christina;
Green, Anthony R;
Massie, Charles E;
Nangalia, Jyoti;
Lempidaki, Stella;
Döhner, Hartmut;
Döhner, Konstanze;
Bray, Sarah J;
McDermott, Ultan;
Papaemmanuil, Elli;
Campbell, Peter J;
Adams, David J

Publication type:

Article

DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy.

Published in:

2015

By:

Grishina, Olga;
Schmoor, Claudia;
Döhner, Konstanze;
Hackanson, Björn;
Lubrich, Beate;
May, Annette M;
Cieslik, Caroline;
Müller, Michael J;
Lübbert, Michael

Publication type:

journal article

Expressed sequences as candidates for a novel tumor suppressor gene at band 13q14 in B-cell chronic lymphocytic leukemia and mantle cell lymphoma.

Published in:

Oncogene, 1998, v. 16, n. 14, p. 1891, doi. 10.1038/sj.onc.1201764

By:

Stilgenbauer, Stephan;
Nickolenko, Jeremy;
Wilhelm, Jens;
Wolf, Stephan;
Weitz, Sandra;
Döhner, Konstanze;
Boehm, Thomas;
Döhner, Hartmut;
Lichter, Peter

Publication type:

Article

Leukemic progenitor cells are susceptible to targeting by stimulated cytotoxic T cells against immunogenic leukemia-associated antigens.

Published in:

International Journal of Cancer, 2015, v. 137, n. 9, p. 2083, doi. 10.1002/ijc.29583

By:

Schneider, Vanessa;
Zhang, Lu;
Rojewski, Markus;
Fekete, Natalie;
Schrezenmeier, Hubert;
Erle, Alexander;
Bullinger, Lars;
Hofmann, Susanne;
Götz, Marlies;
Döhner, Konstanze;
Ihme, Susann;
Döhner, Hartmut;
Buske, Christian;
Feuring‐Buske, Michaela;
Greiner, Jochen

Publication type:

Article

Gene expression analysis of decitabine treated AML: high impact of tumor suppressor gene expression changes.

Published in:

2017

By:

Bohl, Stephan R.;
Dolnik, Anna;
Jensen, Thomas;
Lang, Katharina M.;
Hackanson, Björn;
Gaidzik, Verena I.;
Paschka, Peter;
Knudsen, Steen;
Döhner, Konstanze;
Döhner, Hartmut;
Claus, Rainer;
Lübbert, Michael;
Bullinger, Lars

Publication type:

Letter to the Editor

Functional Classification of TP53 Mutations in Acute Myeloid Leukemia.

Published in:

Cancers, 2020, v. 12, n. 3, p. 637, doi. 10.3390/cancers12030637

By:

Dutta, Sayantanee;
Pregartner, Gudrun;
Rücker, Frank G.;
Heitzer, Ellen;
Zebisch, Armin;
Bullinger, Lars;
Berghold, Andrea;
Döhner, Konstanze;
Sill, Heinz

Publication type:

Article

SEURAT: Visual analytics for the integrated analysis of microarray data.

Published in:

2010

By:

Gribov, Alexander;
Sill, Martin;
Lück, Sonja;
Rücker, Frank;
Döhner, Konstanze;
Bullinger, Lars;
Benner, Axel;
Unwin, Antony

Publication type:

Product Review

A review of hydroxyurea-related cutaneous adverse events.

Published in:

Expert Opinion on Drug Safety, 2021, v. 20, n. 12, p. 1515, doi. 10.1080/14740338.2021.1945032

By:

Griesshammer, Martin;
Wille, Kai;
Sadjadian, Parvis;
Stegelmann, Frank;
Döhner, Konstanze

Publication type:

Article

Defining disease modification in myelofibrosis in the era of targeted therapy.

Published in:

Cancer (0008543X), 2022, v. 128, n. 13, p. 2420, doi. 10.1002/cncr.34205

By:

Pemmaraju, Naveen;
Verstovsek, Srdan;
Mesa, Ruben;
Gupta, Vikas;
Garcia, Jacqueline S.;
Scandura, Joseph M.;
Oh, Stephen T.;
Passamonti, Francesco;
Döhner, Konstanze;
Mead, Adam J.

Publication type:

Article

First-in-human study of WT1 recombinant protein vaccination in elderly patients with AML in remission: a single-center experience.

Published in:

Cancer Immunology, Immunotherapy, 2022, v. 71, n. 12, p. 2913, doi. 10.1007/s00262-022-03202-8

By:

Kreutmair, Stefanie;
Pfeifer, Dietmar;
Waterhouse, Miguel;
Takács, Ferenc;
Graessel, Linda;
Döhner, Konstanze;
Duyster, Justus;
Illert, Anna Lena;
Frey, Anna-Verena;
Schmitt, Michael;
Lübbert, Michael

Publication type:

Article

Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia.

Published in:

Molecular Cancer, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-4598-12-46

By:

Kampa-Schittenhelm, Kerstin Maria;
Heinrich, Michael Charles;
Akmut, Figen;
Rasp, Katharina Henriette;
Illing, Barbara;
Döhner, Hartmut;
Döhner, Konstanze;
Schittenhelm, Marcus Matthias

Publication type:

Article

Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms.

Published in:

Molecular Cancer, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-4598-12-19

By:

Kampa-Schittenhelm, Kerstin Maria;
Heinrich, Michael Charles;
Akmut, Figen;
Döhner, Hartmut;
Döhner, Konstanze;
Schittenhelm, Marcus Matthias

Publication type:

Article

Molecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML.

Published in:

Genes, Chromosomes & Cancer, 2011, v. 50, n. 1, p. 51, doi. 10.1002/gcc.20830

By:

Rücker, Frank G.;
Bullinger, Lars;
Gribov, Alexander;
Sill, Martin;
Schlenk, Richard F.;
Lichter, Peter;
Döhner, Hartmut;
Döhner, Konstanze

Publication type:

Article

Caspase-8L expression protects CD34+hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis.

Published in:

Oncogene, 2005, v. 24, n. 14, p. 2421, doi. 10.1038/sj.onc.1208432

By:

Mohr, Andrea;
Zwacka, Ralf Michael;
Jarmy, Gergely;
Büneker, Chirlei;
Schrezenmeier, Hubert;
Döhner, Konstanze;
Beltinger, Christian;
Wiesneth, Markus;
Debatin, Klaus-Michael;
Stahnke, Karsten

Publication type:

Article

Quantitative analyses of DAPK1 methylation in AML and MDS.

Published in:

International Journal of Cancer, 2012, v. 131, n. 2, p. E138, doi. 10.1002/ijc.26429

By:

Claus, Rainer;
Hackanson, Björn;
Poetsch, Anna R.;
Zucknick, Manuela;
Sonnet, Miriam;
Blagitko-Dorfs, Nadja;
Hiller, Jan;
Wilop, Stefan;
Brümmendorf, Tim H.;
Galm, Oliver;
Platzbecker, Uwe;
Byrd, John C.;
Döhner, Konstanze;
Döhner, Hartmut;
Lübbert, Michael;
Plass, Christoph

Publication type:

Article

MPN-038: PACIFICA: A Randomized, Controlled Phase 3 Study of Pacritinib Versus Physician's Choice in Patients with Primary or Secondary Myelofibrosis and Severe Thrombocytopenia.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S352, doi. 10.1016/S2152-2650(21)01815-2

By:

Mascarenhas, John;
Gerds, Aaron;
Kiladjian, Jean-Jacques;
Döhner, Konstanze;
Buckley, Sarah;
Smith, Jennifer;
Craig, Adam;
Singh, Simran;
Verstovsek, Srdan;
Harrison, Claire

Publication type:

Article

Poster: MPN-038: PACIFICA: A Randomized, Controlled Phase 3 Study of Pacritinib Versus Physician's Choice in Patients with Primary or Secondary Myelofibrosis and Severe Thrombocytopenia.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S235, doi. 10.1016/S2152-2650(21)01480-4

By:

Mascarenhas, John;
Gerds, Aaron;
Kiladjian, Jean-Jacques;
Döhner, Konstanze;
Buckley, Sarah;
Smith, Jennifer;
Craig, Adam;
Singh, Simran;
Verstovsek, Srdan;
Harrison, Claire

Publication type:

Article

Continued decitabine/all-trans retinoic acid treatment: extended complete remission in an elderly AML patient with multi-hit TP53 lesions and complex-monosomal karyotype.

Published in:

Clinical Epigenetics, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13148-024-01737-4

By:

Thomas, Johanna;
Rehman, Usama-Ur;
Bresser, Helena;
Grishina, Olga;
Pfeifer, Dietmar;
Sollier, Etienne;
Döhner, Konstanze;
Plass, Christoph;
Becker, Heiko;
Schmoor, Claudia;
de Wit, Maike;
Lübbert, Michael

Publication type:

Article

Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen.

Published in:

Clinical Epigenetics, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13148-023-01580-z

By:

Schmutz, Maximilian;
Zucknick, Manuela;
Schlenk, Richard F.;
Mertens, Daniel;
Benner, Axel;
Weichenhan, Dieter;
Mücke, Oliver;
Döhner, Konstanze;
Plass, Christoph;
Bullinger, Lars;
Claus, Rainer

Publication type:

Article

Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype.

Published in:

BMC Genomics, 2014, v. 15, n. 1, p. 784, doi. 10.1186/1471-2164-15-784

By:

Feurstein, Simone;
Rücker, Frank G;
Bullinger, Lars;
Hofmann, Winfried;
Manukjan, Georgi;
Göhring, Gudrun;
Lehmann, Ulrich;
Heuser, Michael;
Ganser, Arnold;
Döhner, Konstanze;
Schlegelberger, Brigitte;
Steinemann, Doris

Publication type:

Article

CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPAR? signaling.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 1, p. 299, doi. 10.1172/JCI64745

By:

Faber, Katrin;
Bullinger, Lars;
Ragu, Christine;
Garding, Angela;
Mertens, Daniel;
Miller, Christina;
Martin, Daniela;
Walcher, Daniel;
Döhner, Konstanze;
Döhner, Hartmut;
Claus, Rainer;
Plass, Christoph;
Sykes, Stephen M.;
Lane, Steven W.;
Scholl, Claudia;
Fröhling, Stefan

Publication type:

Article

Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations.

Published in:

Genes, Chromosomes & Cancer, 2005, v. 42, n. 4, p. 427, doi. 10.1002/gcc.20152

By:

Fröhling, Stefan;
Schlenk, Richard F.;
Krauter, Jürgen;
Thiede, Christian;
Ehninger, Gerhard;
Haase, Detlef;
Harder, Lana;
Kreitmeier, Sylvia;
Scholl, Claudia;
Caligiuri, Michael A.;
Bloomfield, Clara D.;
Döhner, Hartmut;
Döhner, Konstanze

Publication type:

Article

Development of a real-time RT-PCR assay for the quantification of the most frequent MLL/AF9 fusion types resulting from translocation t(9;11)(p22;q23) in acute myeloid leukemia.

Published in:

Genes, Chromosomes & Cancer, 2003, v. 38, n. 3, p. 274, doi. 10.1002/gcc.10284

By:

Claudia Scholl;
Heike Breitinger;
Richard F. Schlenk;
Hartmut Döhner;
Stefan Fröhling;
Konstanze Döhner

Publication type:

Article

Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22.

Published in:

Human Genetics, 2001, v. 108, n. 4, p. 304, doi. 10.1007/s004390100498

By:

Fröhling, Stefan;
Nakabayashi, Kazuhiko;
Scherer, Stephen W.;
Döhner, Hartmut;
Döhner, Konstanze

Publication type:

Article

Unified classification and risk-stratification in Acute Myeloid Leukemia.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32103-8

By:

Tazi, Yanis;
Arango-Ossa, Juan E.;
Zhou, Yangyu;
Bernard, Elsa;
Thomas, Ian;
Gilkes, Amanda;
Freeman, Sylvie;
Pradat, Yoann;
Johnson, Sean J.;
Hills, Robert;
Dillon, Richard;
Levine, Max F.;
Leongamornlert, Daniel;
Butler, Adam;
Ganser, Arnold;
Bullinger, Lars;
Döhner, Konstanze;
Ottmann, Oliver;
Adams, Richard;
Döhner, Hartmut

Publication type:

Article

Phase I study evaluating the Fc-optimized FLT3 antibody FLYSYN in AML patients with measurable residual disease.

Published in:

Journal of Hematology & Oncology, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s13045-023-01490-w

By:

Heitmann, Jonas S.;
Schlenk, Richard F.;
Dörfel, Daniela;
Kayser, Sabine;
Döhner, Konstanze;
Heuser, Michael;
Thol, Felicitas;
Kapp-Schwoerer, Silke;
Labrenz, Jannik;
Edelmann, Dominic;
Märklin, Melanie;
Vogel, Wichard;
Bethge, Wolfgang;
Walz, Juliane S.;
Große-Hovest, Ludger;
Steiner, Martin;
Jung, Gundram;
Salih, Helmut R.

Publication type:

Article

Inactivating I kappa B epsilon mutations in Hodgkin/ReedSternberg cells.

Published in:

Journal of Pathology, 2003, v. 201, n. 3, p. 413, doi. 10.1002/path.1454

By:

Florian Emmerich;
Sebastian Theurich;
Michael Hummel;
Antje Haeffker;
Magnus S Vry;
Konstanze Döhner;
Kurt Bommert;
Harald Stein

Publication type:

Article

The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression.

Published in:

Cell Death & Disease, 2021, v. 12, n. 7, p. 1, doi. 10.1038/s41419-021-03948-6

By:

Gentle, Ian Edward;
Moelter, Isabel;
Badr, Mohamed Tarek;
Döhner, Konstanze;
Lübbert, Michael;
Häcker, Georg

Publication type:

Article