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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.
Published in:
2022
By:
- Soutar, Marc P M;
- Melandri, Daniela;
- O'Callaghan, Benjamin;
- Annuario, Emily;
- Monaghan, Amy E;
- Welsh, Natalie J;
- D'Sa, Karishma;
- Guelfi, Sebastian;
- Zhang, David;
- Pittman, Alan;
- Trabzuni, Daniah;
- Verboven, Anouk H A;
- Pan, Kylie S;
- Kia, Demis A;
- Bictash, Magda;
- Gandhi, Sonia;
- Houlden, Henry;
- Cookson, Mark R;
- Kasri, Nael Nadif;
- Wood, Nicholas W
Publication type:
journal article
Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22262-5
By:
- Chen, Zhongbo;
- Zhang, David;
- Reynolds, Regina H.;
- Gustavsson, Emil K.;
- García-Ruiz, Sonia;
- D'Sa, Karishma;
- Fairbrother-Browne, Aine;
- Vandrovcova, Jana;
- International Parkinson's Disease Genomics Consortium (IPDGC);
- Noyce, Alastair J.;
- Kaiyrzhanov, Rauan;
- Middlehurst, Ben;
- Kia, Demis A.;
- Tan, Manuela;
- Morris, Huw R.;
- Plun-Favreau, Helene;
- Holmans, Peter;
- Trabzuni, Daniah;
- Bras, Jose;
- Quinn, John
Publication type:
Article
An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks.
Published in:
BMC Systems Biology, 2017, v. 11, p. 1, doi. 10.1186/s12918-017-0420-6
By:
- Botía, Juan A.;
- Vandrovcova, Jana;
- Forabosco, Paola;
- Guelfi, Sebastian;
- D'Sa, Karishma;
- Hardy, John;
- Lewis, Cathryn M.;
- Ryten, Mina;
- Weale, Michael E.
Publication type:
Article
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.
Published in:
Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01424-6
By:
- Toomey, Christina E.;
- Heywood, Wendy E.;
- Evans, James R.;
- Lachica, Joanne;
- Pressey, Sarah N.;
- Foti, Sandrine C.;
- Al Shahrani, Mesfer;
- D'Sa, Karishma;
- Hargreaves, Iain P.;
- Heales, Simon;
- Orford, Michael;
- Troakes, Claire;
- Attems, Johannes;
- Gelpi, Ellen;
- Palkovits, Miklos;
- Lashley, Tammaryn;
- Gentleman, Steve M.;
- Revesz, Tamas;
- Mills, Kevin;
- Gandhi, Sonia
Publication type:
Article
Analysis of subcellular RNA fractions demonstrates significant genetic regulation of gene expression in human brain post-transcriptionally.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-40324-0
By:
- D'Sa, Karishma;
- Guelfi, Sebastian;
- Vandrovcova, Jana;
- Reynolds, Regina H.;
- Zhang, David;
- Hardy, John;
- Botía, Juan A.;
- Weale, Michael E.;
- Taliun, Sarah A. Gagliano;
- Small, Kerrin S.;
- Ryten, Mina
Publication type:
Article
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14483-x
By:
- Guelfi, Sebastian;
- D'Sa, Karishma;
- Botía, Juan A.;
- Vandrovcova, Jana;
- Reynolds, Regina H.;
- Zhang, David;
- Trabzuni, Daniah;
- Collado-Torres, Leonardo;
- Thomason, Andrew;
- Quijada Leyton, Pedro;
- Gagliano Taliun, Sarah A.;
- Nalls, Mike A.;
- International Parkinson's Disease Genomics Consortium (IPDGC);
- Noyce, Alastair J.;
- Nicolas, Aude;
- Cookson, Mark R.;
- Bandres-Ciga, Sara;
- Gibbs, J. Raphael;
- Hernandez, Dena G.;
- Singleton, Andrew B.
Publication type:
Article

Found: 6

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.

Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.

An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks.

Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.

Analysis of subcellular RNA fractions demonstrates significant genetic regulation of gene expression in human brain post-transcriptionally.

Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information.