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Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism.
Published in:
2013
By:
- Dwyer, Andrew A;
- Sykiotis, Gerasimos P;
- Hayes, Frances J;
- Boepple, Paul A;
- Lee, Hang;
- Loughlin, Kevin R;
- Dym, Martin;
- Sluss, Patrick M;
- Crowley Jr, William F;
- Pitteloud, Nelly;
- Crowley, William F Jr
Publication type:
journal article
Prioritizing genetic testing in patients with Kallmann syndrome using clinical phenotypes.
Published in:
2013
By:
- Costa-Barbosa, Flavia Amanda;
- Balasubramanian, Ravikumar;
- Keefe, Kimberly W;
- Shaw, Natalie D;
- Al-Tassan, Nada;
- Plummer, Lacey;
- Dwyer, Andrew A;
- Buck, Cassandra L;
- Choi, Jin-Ho;
- Seminara, Stephanie B;
- Quinton, Richard;
- Monies, Dorota;
- Meyer, Brian;
- Hall, Janet E;
- Pitteloud, Nelly;
- Crowley Jr, William F;
- Crowley, William F Jr
Publication type:
journal article
Clinical Research in the United States at a Crossroads: Proposal for a Novel Public-Private Partnership to Establish a National Clinical Research Enterprise.
Published in:
JAMA: Journal of the American Medical Association, 2004, v. 291, n. 9, p. 1120, doi. 10.1001/jama.291.9.1120
By:
- Crowley, Jr, William F.;
- Sherwood, Louis;
- Salber, Patricia;
- Scheinberg, David;
- Slavkin, Hal;
- Tilson, Hugh;
- Reece, E. Albert;
- Catanese, Veronica;
- Johnson, Stephen B.;
- Dobs, Adrian;
- Genel, Myron;
- Korn, Allan;
- Reame, Nancy;
- Bonow, Robert;
- Grebb, Jack;
- Rimoin, David
Publication type:
Article
Central Challenges Facing the National Clinical Research Enterprise.
Published in:
JAMA: Journal of the American Medical Association, 2003, v. 289, n. 10, p. 1278, doi. 10.1001/jama.289.10.1278
By:
- Sung, Nancy S.;
- Crowley, Jr, William F.;
- Genel, Myron;
- Salber, Patricia;
- Sandy, Lewis;
- Sherwood, Louis M.;
- Johnson, Stephen B.;
- Catanese, Veronica;
- Tilson, Hugh;
- Getz, Kenneth;
- Larson, Elaine L.;
- Scheinberg, David;
- Reece, E. Albert;
- Slavkin, Harold;
- Dobs, Adrian;
- Grebb, Jack;
- Martinez, Rick A.;
- Korn, Allan;
- Rimoin, David
Publication type:
Article
Activin: an endocrine or paracrine agent?
Published in:
European Journal of Endocrinology, 1998, v. 139, n. 5, p. 469, doi. 10.1530/eje.0.1390469
By:
- Welt, Corrine K.;
- Crowley Jr., William F.
Publication type:
Article
Human GnRH Deficiency: A Unique Disease Model to Unravel the Ontogeny of GnRH Neurons.
Published in:
Neuroendocrinology, 2010, v. 92, n. 2, p. 81, doi. 10.1159/000314193
By:
- Balasubramanian, Ravikumar;
- Dwyer, Andrew;
- Seminara, Stephanie B.;
- Pitteloud, Nelly;
- Kaiser, Ursula B.;
- Crowley Jr., William F.
Publication type:
Article
Role of Seminiferous Tubular Development in Determining the FSH versus LH Responsiveness to GnRH in Early Sexual Maturation.
Published in:
Neuroendocrinology, 2009, v. 90, n. 3, p. 260, doi. 10.1159/000245383
By:
- Pitteloud, Nelly;
- Thambundit, Apisadaporn;
- Dwyer, Andrew A.;
- Falardeau, John L.;
- Plummer, Lacey;
- Caronia, Lisa M.;
- Hayes, Frances J.;
- Hang Lee;
- Boepple, Paul A.;
- Crowley Jr., William F.
Publication type:
Article
Expanding the Spectrum of Founder Mutations Causing Isolated Gonadotropin-Releasing Hormone Deficiency.
Published in:
2015
By:
- Choi, Jin-Ho;
- Balasubramanian, Ravikumar;
- Lee, Phil H;
- Shaw, Natalie D;
- Hall, Janet E;
- Plummer, Lacey;
- Buck, Cassandra L;
- Kottler, Marie-Laure;
- Jarzabek, Katarzyna;
- Wołczynski, Sławomir;
- Quinton, Richard;
- Latronico, Ana Claudia;
- Dode, Catherine;
- Ogata, Tsutomu;
- Kim, Hyung-Goo;
- Layman, Lawrence C;
- Gusella, James F;
- Crowley, William F Jr
Publication type:
journal article
Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications.
Published in:
2012
By:
- Lewkowitz-Shpuntoff HM;
- Hughes VA;
- Plummer L;
- Au MG;
- Doty RL;
- Seminara SB;
- Chan YM;
- Pitteloud N;
- Crowley WF Jr;
- Balasubramanian R;
- Lewkowitz-Shpuntoff, Hilana M;
- Hughes, Virginia A;
- Plummer, Lacey;
- Au, Margaret G;
- Doty, Richard L;
- Seminara, Stephanie B;
- Chan, Yee-Ming;
- Pitteloud, Nelly;
- Crowley, William F Jr;
- Balasubramanian, Ravikumar
Publication type:
journal article
Kisspeptin resets the hypothalamic GnRH clock in men.
Published in:
2011
By:
- Chan, Yee-Ming;
- Butler, James P;
- Pinnell, Nancy E;
- Pralong, François P;
- Crowley, William F Jr;
- Ren, Chen;
- Chan, Kenneth K;
- Seminara, Stephanie B
Publication type:
journal article
Expanding the phenotype and genotype of female GnRH deficiency.
Published in:
2011
By:
- Shaw, Natalie D;
- Seminara, Stephanie B;
- Welt, Corrine K;
- Au, Margaret G;
- Plummer, Lacey;
- Hughes, Virginia A;
- Dwyer, Andrew A;
- Martin, Kathryn A;
- Quinton, Richard;
- Mericq, Veronica;
- Merino, Paulina M;
- Gusella, James F;
- Crowley, William F Jr;
- Pitteloud, Nelly;
- Hall, Janet E
Publication type:
journal article
Signaling Role of Prokineticin 2 on the Estrous Cycle of Female Mice.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090860
By:
- Xiao, Ling;
- Zhang, Chengkang;
- Li, Xiaohan;
- Gong, Shiaoching;
- Hu, Renming;
- Balasubramanian, Ravikumar;
- Crowley W. Jr., William F.;
- Hastings, Michael H.;
- Zhou, Qun-Yong
Publication type:
Article
The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism.
Published in:
2010
By:
- Dwyer, Andrew A;
- Hayes, Frances J;
- Plummer, Lacey;
- Pitteloud, Nelly;
- Crowley, William F Jr
Publication type:
journal article
Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes.
Published in:
2010
By:
- Sykiotis, Gerasimos P;
- Hoang, Xuan-Huong;
- Avbelj, Magdalena;
- Hayes, Frances J;
- Thambundit, Apisadaporn;
- Dwyer, Andrew;
- Au, Margaret;
- Plummer, Lacey;
- Crowley, William F Jr;
- Pitteloud, Nelly
Publication type:
journal article
Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.
Published in:
2008
By:
- Cole, Lindsay W;
- Sidis, Yisrael;
- Zhang, ChengKang;
- Quinton, Richard;
- Plummer, Lacey;
- Pignatelli, Duarte;
- Hughes, Virginia A;
- Dwyer, Andrew A;
- Raivio, Taneli;
- Hayes, Frances J;
- Seminara, Stephanie B;
- Huot, Celine;
- Alos, Nathalie;
- Speiser, Phyllis;
- Takeshita, Akira;
- Van Vliet, Guy;
- Pearce, Simon;
- Crowley, William F Jr;
- Zhou, Qun-Yong;
- Pitteloud, Nelly
Publication type:
journal article
The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men.
Published in:
2008
By:
- Pitteloud, Nelly;
- Dwyer, Andrew A;
- DeCruz, Suzzunne;
- Lee, Hang;
- Boepple, Paul A;
- Crowley, William F Jr;
- Hayes, Frances J
Publication type:
journal article
Relative roles of inhibin B and sex steroids in the negative feedback regulation of follicle-stimulating hormone in men across the full spectrum of seminiferous epithelium function.
Published in:
2008
By:
- Boepple, Paul A;
- Hayes, Frances J;
- Dwyer, Andrew A;
- Raivio, Taneli;
- Lee, Hang;
- Crowley, William F Jr;
- Pitteloud, Nelly
Publication type:
journal article
Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men.
Published in:
2008
By:
- Pitteloud, Nelly;
- Dwyer, Andrew A;
- DeCruz, Suzzunne;
- Lee, Hang;
- Boepple, Paul A;
- Crowley, William F Jr;
- Hayes, Frances J
Publication type:
journal article
Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene.
Published in:
2005
By:
- Pitteloud, Nelly;
- Acierno Jr., James S.;
- Meysing, Astrid U.;
- Dwyer, Andrew A.;
- Hayes, Frances J.;
- Crowley Jr., William F.
Publication type:
journal article
Polycystic Ovarian Morphology with Regular Ovulatory Cycles: Insights into the Pathophysiology of Polycystic Ovarian Syndrome.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2004, v. 89, n. 9, p. 4343, doi. 10.1210/jc.2003-031600
By:
- ADAMS, JUDITH M.;
- TAYLOR, ANN E.;
- CROWLEY, JR., WILLIAM F.;
- HALL, JANET E.
Publication type:
Article
GNRHR Mutations in a Woman with Idiopathic Hypogonadotropic Hypogonadism Highlight the Differential Sensitivity of Luteinizing Hormone and Follicle-Stimulating Hormone to Gonadotropin-Releasing Hormone.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2004, v. 89, n. 7, p. 3189, doi. 10.1210/jc.2003-031808
By:
- MEYSING, ASTRID U.;
- KANASAKI, HARUHIKO;
- BEDECARRATS, GREGOY Y.;
- ACIERNO JR., JAMES S.;
- CONN, P. MICHAEL;
- MARTIN, KATHRYN A.;
- SEMINARA, STEPHANIE B.;
- HALL, JANET E.;
- CROWLEY JR., WILLIAM F.;
- KAISER, URSULA B.
Publication type:
Article
GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone.
Published in:
2004
By:
- Meysing, Astrid U;
- Kanasaki, Haruhiko;
- Bedecarrats, Gregoy Y;
- Acierno, James S Jr;
- Conn, P Michael;
- Martin, Kathryn A;
- Seminara, Stephanie B;
- Hall, Janet E;
- Crowley, William F Jr;
- Kaiser, Ursula B
Publication type:
journal article
Acute stress masking the biochemical phenotype of partial androgen insensitivity syndrome in a patient with a novel mutation in the androgen receptor.
Published in:
2004
By:
- Pitteloud, Nelly;
- Villegas, Jacob;
- Dwyer, Andrew A;
- Crowley, William F Jr;
- McPhaul, Michael J;
- Hayes, Frances J
Publication type:
journal article
A Locus for Autosomal Recessive Idiopathic Hypogonadotropic Hypogonadism on Chromosome 19p13.3
Published in:
Journal of Clinical Endocrinology & Metabolism, 2003, v. 88, n. 6, p. 2947, doi. 10.1210/jc.2003-030423
By:
- Acierno Jr., James S.;
- Shagoury, Jenna K.;
- Bo-Abbas, Yøusef;
- Crowley Jr., William F.;
- Seminara, Stephanie B.
Publication type:
Article
Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism.
Published in:
2002
By:
- Pitteloud, Nelly;
- Hayes, Frances J;
- Dwyer, Andrew;
- Boepple, Paul A;
- Lee, Hang;
- Crowley, William F Jr
Publication type:
journal article
Hypogonadotropic hypogonadism and cerebellar ataxia: detailed phenotypic characterization of a large, extended kindred.
Published in:
2002
By:
- Seminara, Stephanie B.;
- Acierno, James S. Jr.;
- Abdulwahid, Najim A.;
- Crowley, William F. Jr.;
- Margolin, David H.
Publication type:
journal article
The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism.
Published in:
2002
By:
- Pitteloud, Nelly;
- Hayes, Frances J;
- Boepple, Paul A;
- DeCruz, Suzzunne;
- Seminara, Stephanie B;
- MacLaughlin, David T;
- Crowley, William F Jr
Publication type:
journal article
Importance of inhibin B in the regulation of FSH secretion in the human male.
Published in:
2001
By:
- HAYES, FRANCES J.;
- PITTELOUD, NELLY;
- DECRUZ, SUZZUNNE;
- CROWLEY JR., WILLIAM F.;
- BOEPPLE, PAUL A.
Publication type:
journal article
The Fertile Eunuch Variant of Idiopathic Hypogonadotropic Hypogonadism: Spontaneous Reversal Associated with a Homozygous Mutation in the Gonadotropin-Releasing Hormone Receptor.
Published in:
2001
By:
- PITTELOUD, NELLY;
- BOEPPLE, PAUL A.;
- DECRUZ, SUZZUNNE;
- VALKENBURGH, SARAH B.;
- CROWLEY JR., WILLIAM F.;
- HAYES, FRANCES J.
Publication type:
journal article
The Importance of Autosomal Genes in Kallmann Syndrome: Genotype-Phenotype Correlations and Neuroendocrine Characteristics.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2001, v. 86, n. 4, p. 1532, doi. 10.1210/jcem.86.4.7420
By:
- OLIVEIRA, LUCIANA M. B.;
- SEMINARA, STEPHANIE B.;
- BERANOVA, MILENA;
- HAYES, FRANCES J.;
- VALKENBURGH, SARAH B.;
- SCHIPANI, ERNESTINA;
- COSTA, ELAINE MARIA F.;
- LATRONICO, ANA CLAUDIA;
- CROWLEY JR., WILLIAM F.;
- VALLEJO, MARIO
Publication type:
Article
Differential Regulation of Gonadotropin Secretion by Testosterone in the Human Male: Absence of a Negative Feedback Effect of Testosterone on Follicle-Stimulating Hormone Secretion.
Published in:
2001
By:
- HAYES, FRANCES J.;
- DECRUZ, SUZZUNNE;
- SEMINARA, STEPHANIE B.;
- BOEPPLE, PAUL A.;
- CROWLEY, JR., WILLIAM F.
Publication type:
journal article
Is Obesity an Outcome of Gonadotropin-Releasing Hormone Agonist Administration? Analysis of Growth and Body Composition in 110 Patients with Central Precocious Puberty.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1999, v. 84, n. 12, p. 4480, doi. 10.1210/jcem.84.12.6204
By:
- PALMERT, MARK R.;
- MANSFIELD, M. JOAN;
- CROWLEY, JR., WILLIAM F.;
- CRIGLER, JR., JOHN F.;
- CRAWFORD, JOHN D.;
- BOEPPLE, PAUL A.
Publication type:
Article
X-Linked Adrenal Hypoplasia Congenita: A Mutation in DAX1 Expands the Phenotypic Spectrum in Males and Females.
Published in:
1999
By:
- SEMINARA, STEPHANIE B.;
- ACHERMANN, JOHN C.;
- GENEL, MYRON;
- JAMESON, J. LARRY;
- CROWLEY, JR., WILLIAM F.
Publication type:
journal article
Mutational Analysis of DAX1 in Patients with Hypogonadotropic Hypogonadism or Pubertal Delay.
Published in:
1999
By:
- ACHERMANN, JOHN C.;
- WEN-XIA GU;
- KOTLAR, TOM J.;
- MEEKS, JOSHUA J.;
- SABACAN, LEAH P.;
- SEMINARA, STEPHANIE B.;
- HABIBY, REEMA L.;
- HINDMARSH, PETER C.;
- BICK, DAVID P.;
- SHERINS, RICHARD J.;
- CROWLEY, JR., WILLIAM F.;
- LAYMAN, LAWRENCE C.;
- JAMESON, J. LARRY
Publication type:
journal article
A Two-Site Chemiluminescent Assay for Activin-Free Follistatin Reveals That Most Follistatin Circulating in Men and Normal Cycling Women Is in an Activin-Bound State.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1998, v. 83, n. 3, p. 851, doi. 10.1210/jcem.83.3.4651
By:
- MCCONNELL, DANIEL S.;
- QIFA WANG;
- SLUSS, PATRICK M.;
- BOLF, NICOLA;
- KHOURY, RITA H.;
- SCHNEYER, ALAN L.;
- MIDGLEY JR, A. REES;
- REAME, NANCY E.;
- CROWLEY JR, WILLIAM F.;
- PADMANABHAN, VASANTHA
Publication type:
Article
Genetic heterogeneity evidenced by low incidence of KAL-1 gene mutations in sporadic cases of gonadotropin-releasing hormone deficiency.
Published in:
1997
By:
- GEORGOPOULOS, NEOKLIS A.;
- PRALONG, FRANÇOIS P.;
- SEIDMAN, CHRISTINE E.;
- SEIDMAN, J. G.;
- CROWLEY JR., WILLIAM F.;
- VALLEJO, MARIO
Publication type:
journal article
A randomized, controlled trial of estradiol replacement therapy in women with hypergonadotropic amenorrhe
Published in:
Journal of Clinical Endocrinology & Metabolism, 1996, v. 81, n. 10, p. 3615, doi. 10.1210/jc.81.10.3615
By:
- TAYLOR, ANN E.;
- ADAMS, JUDITH M.;
- MULDER, JEAN E.;
- MARTIN, KATHRYN A.;
- SLUSS, PATRICK M.;
- CROWLEY, JR., WILLIAM F.
Publication type:
Article
Deciphering Genetic Disease in the Genomic Era: The Model of GnRH Deficiency.
Published in:
Science Translational Medicine, 2010, v. 2, n. 32, p. 1, doi. 10.1126/scitranslmed.3000288
By:
- Sykiotis, Gerasimos P.;
- Pitteloud, Nelly;
- Seminara, Stephanie B.;
- Kaiser, Ursula B.;
- Crowley Jr., William F.
Publication type:
Article
Changing Models of Biomedical Research.
Published in:
Science Translational Medicine, 2009, v. 1, n. 1, p. 1, doi. 10.1126/scitranslmed.3000124
By:
- Crowley Jr., William F.;
- Gusella, James F.
Publication type:
Article
Interplay between Dose and Frequency of GnRH Administration in Determining Pituitary Gonadotropin Responsiveness.
Published in:
Neuroendocrinology, 2008, v. 87, n. 3, p. 142, doi. 10.1159/000112421
By:
- Hughes, Virginia A.;
- Boepple, Paul A.;
- Crowley Jr., William F.;
- Seminara, Stephanie B.
Publication type:
Article
Is GnRH Reduced at the Midcycle Surge in the Human?
Published in:
Neuroendocrinology, 1998, v. 67, n. 6, p. 363, doi. 10.1159/000054334
By:
- Martin, Kathryn A.;
- Welt, Corrine K.;
- Taylor, Ann E.;
- Smith, Julie A.;
- Crowley Jr., William F.;
- Hall, Janet E.
Publication type:
Article
Contour of the GnRH Pulse Independently Modulates Gonadotropin Secretion in the Human Male.
Published in:
Neuroendocrinology, 1996, v. 64, n. 3, p. 247, doi. 10.1159/000127125
By:
- Pralong, François P.;
- Boepple, Paul A.;
- Conn, Michael;
- Whitcomb, Randall W.;
- Butler, James P.;
- Schoenfeld, D.;
- Crowley, Jr., William F.
Publication type:
Article
Functional Hypogonadotropic Hypogonadism in Men: Underlying Neuroendocrine Mechanisms and Natural History.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2019, v. 104, n. 8, p. 3403, doi. 10.1210/jc.2018-02697
By:
- Dwyer, Andrew A.;
- Chavan, Niraj R.;
- Lewkowitz-Shpuntoff, Hilana;
- Plummer, Lacey;
- Hayes, Frances J.;
- Seminara, Stephanie B.;
- Crowley Jr, William F.;
- Pitteloud, Nelly;
- Balasubramanian, Ravikumar
Publication type:
Article

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