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Human iPSC co-culture model to investigate the interaction between microglia and motor neurons.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-16896-8
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- Publication type:
- Article
A causal role for TRESK loss of function in migraine mechanisms.
- Published in:
- 2019
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- Publication type:
- journal article
Human microglia, microglial LRRK2, and tau pathogenesis: a complex relationship.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082811
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- Publication type:
- Article
Role of peripheral inflammation in driving central nervous system inflammatory signature in pathogenesis of Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080179
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- Publication type:
- Article
Genome‐wide CRISPR knockout screening to identify key regulators of phagocytosis in induced pluripotent stem cell derived microglia.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074152
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- Publication type:
- Article
The role of human microglia and microglial LRRK2 in tau pathogenesis.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069393
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- Publication type:
- Article
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to TREM2 knockout in human IPSC‐derived macrophages: Developing topics.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047388
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- Publication type:
- Article
Investigating amyloid beta‐induced toxicity in tau‐deficient human neurons: Developing topics.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047060
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- Publication type:
- Article
Targeting SHIP1 for therapeutic intervention in Alzheimer's disease: Nonhuman/Target identification and validation studies: Inflammation and innate immunity.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045839
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- Publication type:
- Article
Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 13, p. 4808, doi. 10.3390/ijms21134808
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- Publication type:
- Article
Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation.
- Published in:
- Biotechnology Progress, 2010, v. 26, n. 3, p. 781, doi. 10.1002/btpr.368
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- Publication type:
- Article
The roles of apoptotic pathways in the low recovery rate after cryopreservation of dissociated human embryonic stem cells.
- Published in:
- Biotechnology Progress, 2010, v. 26, n. 3, p. 827, doi. 10.1002/btpr.368
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- Publication type:
- Article
A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.
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- Cerebellum, 2018, v. 17, n. 4, p. 419, doi. 10.1007/s12311-017-0913-2
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- Publication type:
- Article
Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-23477-2
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- Publication type:
- Article
Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia.
- Published in:
- Frontiers in Immunology, 2022, v. 13, p. 01, doi. 10.3389/fimmu.2022.1035532
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- Publication type:
- Article
Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.
- Published in:
- Nucleic Acids Research, 2016, v. 44, n. 22, p. 10960, doi. 10.1093/nar/gkw711
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- Publication type:
- Article
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
- Published in:
- Alzheimer's Research & Therapy, 2020, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13195-020-00709-z
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- Publication type:
- Article
The Current State of Naïve Human Pluripotency.
- Published in:
- Stem Cells, 2015, v. 33, n. 11, p. 3181, doi. 10.1002/stem.2085
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- Publication type:
- Article
Derivation and Functional Analysis of Patient-Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease.
- Published in:
- Stem Cells, 2012, v. 30, n. 4, p. 599, doi. 10.1002/stem.1053
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- Publication type:
- Article
ADAM17‐triggered TNF signalling protects the ageing Drosophila retina from lipid droplet‐mediated degeneration.
- Published in:
- EMBO Journal, 2020, v. 39, n. 17, p. 1, doi. 10.15252/embj.2020104415
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- Publication type:
- Article
MAPT GENETIC VARIATION AND NEURONAL MATURITY ALTER ISOFORM EXPRESSION AFFECTING AXONAL TRANSPORT IN IPSC-DERIVED NEURONS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P556, doi. 10.1016/j.jalz.2017.07.158
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- Publication type:
- Article
MODELLING MICROGLIA WITH HUMAN PLURIPOTENT STEM CELLS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P268, doi. 10.1016/j.jalz.2016.06.486
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- Publication type:
- Article
Integration of 3D-printed cerebral cortical tissue into an ex vivo lesioned brain slice.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41356-w
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- Publication type:
- Article
Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons.
- Published in:
- PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0087388
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- Publication type:
- Article
The Productive Entry Pathway of HIV-1 in Macrophages Is Dependent on Endocytosis through Lipid Rafts Containing CD4.
- Published in:
- PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0086071
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- Publication type:
- Article
Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions.
- Published in:
- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071098
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- Publication type:
- Article
Derivation and characterisation of the human embryonic stem cell line, OxF1.
- Published in:
- 2010
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- Publication type:
- Report
Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.
- Published in:
- Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0600-7
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- Publication type:
- Article
Molecular and electrophysiological features of spinocerebellar ataxia type seven in induced pluripotent stem cells.
- Published in:
- PLoS ONE, 2021, v. 16, n. 2, p. 1, doi. 10.1371/journal.pone.0247434
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- Publication type:
- Article
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
- Published in:
- Stem Cells, 2016, v. 34, n. 8, p. 2063, doi. 10.1002/stem.2388
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- Publication type:
- Article
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
- Published in:
- EMBO Journal, 2018, v. 37, n. 12, p. 1, doi. 10.15252/embj.201798694
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- Publication type:
- Article
Optical genome mapping of structural variants in Parkinson's disease-related induced pluripotent stem cells.
- Published in:
- BMC Genomics, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s12864-024-10902-1
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- Publication type:
- Article
Systematic identification of structure-specific protein–protein interactions.
- Published in:
- Molecular Systems Biology, 2024, v. 20, n. 6, p. 651, doi. 10.1038/s44320-024-00037-6
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- Publication type:
- Article
Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.
- Published in:
- Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.617860
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- Publication type:
- Article
Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models.
- Published in:
- Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.614972
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- Publication type:
- Article
Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1.
- Published in:
- 2018
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- Publication type:
- journal article
Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration.
- Published in:
- PLoS Pathogens, 2011, v. 7, n. 8, p. 1, doi. 10.1371/journal.ppat.1002194
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- Publication type:
- Article
Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-82137-z
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- Publication type:
- Article
Profiling of naïve and primed human pluripotent stem cells reveals state-associated miRNAs.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-67376-w
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- Publication type:
- Article
Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets.
- Published in:
- 2019
- By:
- Publication type:
- journal article
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair.
- Published in:
- Human Molecular Genetics, 2020, v. 29, n. 13, p. 2200, doi. 10.1093/hmg/ddaa106
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- Publication type:
- Article
Cellular α -synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.
- Published in:
- Human Molecular Genetics, 2019, v. 28, n. 12, p. 2001, doi. 10.1093/hmg/ddz038
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- Publication type:
- Article
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.
- Published in:
- Human Molecular Genetics, 2017, v. 26, n. 22, p. 4441, doi. 10.1093/hmg/ddx331
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- Publication type:
- Article
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.
- Published in:
- Human Molecular Genetics, 2017, v. 26, n. 3, p. 552, doi. 10.1093/hmg/ddw412
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- Publication type:
- Article
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics.
- Published in:
- Human Molecular Genetics, 2016, v. 25, n. 5, p. 989, doi. 10.1093/hmg/ddv637
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- Publication type:
- Article
Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells.
- Published in:
- Human Molecular Genetics, 2011, v. 20, n. 15, p. 2905, doi. 10.1093/hmg/ddr144
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- Publication type:
- Article
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.
- Published in:
- Cell Death & Disease, 2018, v. 9, n. 10, p. 1, doi. 10.1038/s41419-018-1053-4
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- Publication type:
- Article
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.
- Published in:
- Biochemical Society Transactions, 2017, v. 45, n. 1, p. 131, doi. 10.1042/BST20160262
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- Publication type:
- Article
Cellular reprogramming: a new approach to modelling Parkinson's disease.
- Published in:
- Biochemical Society Transactions, 2012, v. 40, n. 5, p. 1152, doi. 10.1042/BST20120159
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- Publication type:
- Article
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.
- Published in:
- Glia, 2022, v. 70, n. 7, p. 1267, doi. 10.1002/glia.24167
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- Publication type:
- Article