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Cytotoxic activity of chalcones isolated from lonchocarpus sericeus (pocr.) kunth.
Published in:
2003
By:
- Cunha, Geanne M. de Andrade;
- Fontenele, Juvenia Bezerra;
- Nobre Júnior, Hélio V.;
- de Sousa, Francisco C. M.;
- Silveira, Edilberto R.;
- Nogueira, Nádia A. P.;
- de Moraes, Manoel Odorico;
- Viana, Glauce S. B.;
- Costa-Lotufo, Letícia V.;
- Nobre Júnior, Hélio V;
- Nogueira, Nádia A P;
- Costa-Lotufo, Letícia V
Publication type:
journal article
Enriching cancer pharmacology with drugs of marine origin.
Published in:
2020
By:
- Jimenez, Paula C.;
- Wilke, Diego V.;
- Branco, Paola C.;
- Bauermeister, Anelize;
- Rezende‐Teixeira, Paula;
- Gaudêncio, Susana P.;
- Costa‐Lotufo, Leticia V.;
- Rezende-Teixeira, Paula;
- Costa-Lotufo, Leticia V
Publication type:
journal article
Thermosensitive Polymeric Nanoparticles for Drug Co-Encapsulation and Breast Cancer Treatment.
Published in:
Pharmaceutics, 2024, v. 16, n. 2, p. 231, doi. 10.3390/pharmaceutics16020231
By:
- Dartora, Vanessa Franco Carvalho;
- Passos, Julia S.;
- Costa-Lotufo, Leticia V.;
- Lopes, Luciana B.;
- Panitch, Alyssa
Publication type:
Article
Beyond Formulation: Contributions of Nanotechnology for Translation of Anticancer Natural Products into New Drugs.
Published in:
Pharmaceutics, 2022, v. 14, n. 8, p. 1722, doi. 10.3390/pharmaceutics14081722
By:
- Miguel, Rodrigo dos A.;
- Hirata, Amanda S.;
- Jimenez, Paula C.;
- Lopes, Luciana B.;
- Costa-Lotufo, Leticia V.
Publication type:
Article
Synthesis of Cytotoxic Benzofurans and Ethers Derivatives of Paeonol.
Published in:
Chemistry & Biodiversity, 2024, v. 21, n. 10, p. 1, doi. 10.1002/cbdv.202400943
By:
- Figueroa, Laura P. R.;
- Domingos, Helori V.;
- Pardo, Jennifer B.;
- Santiago, Pedro H. O.;
- Ellena, Javier;
- Lacerda Junior, Valdemar;
- Costa‐Lotufo, Letícia V.;
- Borges, Warley de S.
Publication type:
Article
Cytotoxicity of actinomycetes associated with the ascidian Eudistoma vannamei (Millar, 1977), endemic of northeastern coast of Brazil.
Published in:
Latin American Journal of Aquatic Research, 2013, v. 41, n. S2, p. 335, doi. 10.3856/vol41-issue2-fulltext-12
By:
- Jimenez, Paula C.;
- Ferreira, Elthon G.;
- Araújo, Luana A.;
- Guimarães, Larissa A.;
- Sousa, Thiciana S.;
- Pessoa, Otília Deusdenia L.;
- Lotufo, Tito M. C.;
- Costa-Lotufo, Letícia V.
Publication type:
Article
Caffeoylquinic Acids: Separation Method, Antiradical Properties and Cytotoxicity.
Published in:
Chemistry & Biodiversity, 2019, v. 16, n. 7, p. N.PAG, doi. 10.1002/cbdv.201900093
By:
- Indy Tamayose, Cinthia;
- dos Santos, Evelyne A.;
- Roque, Nádia;
- Costa‐Lotufo, Letícia V.;
- Pena Ferreira, Marcelo J.
Publication type:
Article
Prospecting Anticancer Compounds in Actinomycetes Recovered from the Sediments of Saint Peter and Saint Paul's Archipelago, Brazil.
Published in:
Chemistry & Biodiversity, 2016, v. 13, n. 9, p. 1149, doi. 10.1002/cbdv.201500514
By:
- Ferreira, Elthon G.;
- Torres, Maria da Conceição M.;
- Silva, Alison B.;
- Colares, Larissa L. F.;
- Pires, Karine;
- Lotufo, Tito M. C.;
- Silveira, Edilberto R.;
- Pessoa, Otília D. L.;
- Costa‐Lotufo, Leticia V.;
- Jimenez, Paula C.
Publication type:
Article
Structure Elucidation, Antimicrobial and Cytotoxic Activities of a Halimane Isolated from Vellozia kolbekii Alves (Velloziaceae).
Published in:
Chemistry & Biodiversity, 2015, v. 12, n. 12, p. 1891, doi. 10.1002/cbdv.201500071
By:
- Silva, Carmelita G.;
- Santos Júnior, Helvécio M.;
- Barbosa, Jussara P.;
- Costa, Gisela L.;
- Rodrigues, Felipe A. R.;
- Oliveira, Denilson F.;
- Costa-Lotufo, Letícia V.;
- Alves, Ruy J. V.;
- Eleutherio, Elis C. A.;
- Rezende, Claudia M.
Publication type:
Article
Bioprospection of Cytotoxic Compounds in Fungal Strains Recovered from Sediments of the Brazilian Coast.
Published in:
Chemistry & Biodiversity, 2015, v. 12, n. 3, p. 432, doi. 10.1002/cbdv.201400193
By:
- Rodrigues, Bárbara S. F.;
- Sahm, Bianca D. B.;
- Jimenez, Paula C.;
- Pinto, Francisco C. L.;
- Mafezoli, Jair;
- Mattos, Marcos C.;
- Rodrigues-Filho, Edson;
- Pfenning, Ludwig H.;
- Abreu, Lucas M.;
- Costa-Lotufo, Letícia V.;
- Oliveira, Maria C. F.
Publication type:
Article
Cytotoxic Activity of Fungal Strains Isolated from the Ascidian Eudistoma vannamei.
Published in:
Chemistry & Biodiversity, 2012, v. 9, n. 10, p. 2203, doi. 10.1002/cbdv.201100366
By:
- Montenegro, Tasso G. C.;
- Rodrigues, Felipe A. R.;
- Jimenez, Paula C.;
- Angelim, Alysson L.;
- Melo, Vânia M. M.;
- Rodrigues Filho, Edson;
- de Oliveira, Maria da Conceição F.;
- Costa-Lotufo, Letícia V.
Publication type:
Article
Studies on the Secondary Metabolites of a Pseudoalteromonas sp. Isolated from Sediments Collected at the Northeastern Coast of Brazil.
Published in:
Chemistry & Biodiversity, 2012, v. 9, n. 2, p. 418, doi. 10.1002/cbdv.201100092
By:
- Arthaud, Isabelle D. B.;
- Rodrigues, Felipe A. R.;
- Jimenez, Paula C.;
- Montenegro, Raquel C.;
- Angelim, Alysson L.;
- Maciel, Vânia M. M.;
- Silveira, Edilberto R.;
- Freitas, Hozana P. S.;
- Sousa, Thiciana S.;
- Pessoa, Otília D. L.;
- Lotufo, Tito M. C.;
- Costa-Lotufo, Letícia V.
Publication type:
Article
Antitumor Activity of the Essential Oil from the Leaves of Croton regelianus and Its Component Ascaridole.
Published in:
Chemistry & Biodiversity, 2009, v. 6, n. 8, p. 1224, doi. 10.1002/cbdv.200800253
By:
- Bezerra, Daniel P.;
- Filho, José D. B. Marinho;
- Alves, Ana Paula N. N.;
- Pessoa, Cláudia;
- de Moraes, Manoel O.;
- Pessoa, Otília Deusdênia L.;
- Torres, Maria Conceição M.;
- Silveira, Edilberto R.;
- Viana, Francisco A.;
- Costa-Lotufo, Letícia V.
Publication type:
Article
Larvicidal and Nematicidal Activities of the Leaf Essential Oil of Croton regelianus.
Published in:
Chemistry & Biodiversity, 2008, v. 5, n. 12, p. 2724, doi. 10.1002/cbdv.200890227
By:
- Torres, Maria Conceição M.;
- Assunção, João Carlos;
- Santiago, Gilvandete Maria P.;
- Andrade-Neto, Manoel;
- Silveira, Edilberto R.;
- Costa-Lotufo, Leticia V.;
- Bezerra, Daniel P.;
- Filho, José Delano B. Marinho;
- Viana, Francisco Arnaldo;
- Pessoa, Otília Deusdênia L.
Publication type:
Article
Studies on the Cytotoxicity of Miscellaneous Compounds from Eupatorium betonicaeforme (D.C.) Baker (Asteraceae).
Published in:
Chemistry & Biodiversity, 2007, v. 4, n. 12, p. 2835, doi. 10.1002/cbdv.200790233
By:
- Rocha, Danilo D.;
- Dantas, Ivana N. F.;
- Albuquerque, Maria Rose Jane R.;
- Montenegro, Raquel C.;
- Pessoa, Cláudia;
- de Moraes, Manoel Odorico;
- Pessoa, Otília Deusdênia L.;
- Silveira, Edilberto R.;
- Costa-Lotufo, Letícia V.
Publication type:
Article
Metabolomic study of marine Streptomyces sp.: Secondary metabolites and the production of potential anticancer compounds.
Published in:
PLoS ONE, 2020, v. 15, n. 12, p. 1, doi. 10.1371/journal.pone.0244385
By:
- Tangerina, Marcelo M. P.;
- Furtado, Luciana Costa;
- Leite, Vida M. B.;
- Bauermeister, Anelize;
- Velasco-Alzate, Karen;
- Jimenez, Paula C.;
- Garrido, Leandro M.;
- Padilla, Gabriel;
- Lopes, Norberto P.;
- Costa-Lotufo, Leticia V.;
- Pena Ferreira, Marcelo J.
Publication type:
Article
Marine Bacteria from Rocas Atoll as a Rich Source of Pharmacologically Active Compounds.
Published in:
Marine Drugs, 2019, v. 17, n. 12, p. 671, doi. 10.3390/md17120671
By:
- Velasco-Alzate, Karen Y.;
- Bauermeister, Anelize;
- Tangerina, Marcelo M. P.;
- Lotufo, Tito M. C.;
- Ferreira, Marcelo J. P.;
- Jimenez, Paula C.;
- Padilla, Gabriel;
- Lopes, Norberto P.;
- Costa-Lotufo, Letícia V.
Publication type:
Article
Potent Cytotoxic Analogs of Amphidinolides from the Atlantic Octocoral Stragulum bicolor.
Published in:
Marine Drugs, 2019, v. 17, n. 1, p. 58, doi. 10.3390/md17010058
By:
- Nuzzo, Genoveffa;
- Gomes, Bruno de Araújo;
- Gallo, Carmela;
- Amodeo, Pietro;
- Sansone, Clementina;
- Pessoa, Otília D. L.;
- Manzo, Emiliano;
- Vitale, Rosa Maria;
- Ianora, Adrianna;
- Santos, Evelyne A.;
- Costa-Lotufo, Leticia V.;
- Fontana, Angelo
Publication type:
Article
Palyosulfonoceramides A and B: Unique Sulfonylated Ceramides from the Brazilian Zoanthids Palythoa caribaeorum and Protopalyhtoa variabilis.
Published in:
Marine Drugs, 2012, v. 10, n. 12, p. 2846, doi. 10.3390/md10122846
By:
- Almeida, Jose Gustavo L.;
- Maia, Ana Isabel V.;
- Wilke, Diego V.;
- Silveira, Edilberto R.;
- Braz-Filho, Raimundo;
- La Clair, James J.;
- Costa-Lotufo, Leticia V.;
- Pessoa, Otília Deusdenia L.
Publication type:
Article
Ritterostatin G<sub>N</sub>1<sub>N</sub>, a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78.
Published in:
ChemBioChem, 2017, v. 18, n. 6, p. 506, doi. 10.1002/cbic.201600669
By:
- Ambrose, Andrew J.;
- Santos, Evelyne A.;
- Jimenez, Paula C.;
- Rocha, Danilo D.;
- Wilke, Diego V.;
- Beuzer, Paolo;
- Axelrod, Josh;
- Kumar Kanduluru, Ananda;
- Fuchs, Philip L.;
- Cang, Hu;
- Costa‐Lotufo, Letícia V.;
- Chapman, Eli;
- La Clair, James J.
Publication type:
Article
The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (−)-Chlorizidine A Targets Proteins within the Glycolytic Pathway.
Published in:
ChemBioChem, 2015, v. 16, n. 14, p. 2002, doi. 10.1002/cbic.201500229
By:
- Álvarez‐Micó, Xavier;
- Rocha, Danilo D.;
- Guimarães, Larissa A.;
- Ambrose, Andrew;
- Chapman, Eli;
- Costa‐Lotufo, Leticia V.;
- La Clair, James J.;
- Fenical, William
Publication type:
Article
Identification of Pyrroloformamide as a Cytokinesis Modulator.
Published in:
ChemBioChem, 2014, v. 15, n. 4, p. 501, doi. 10.1002/cbic.201300717
By:
- Abreu, Paula A.;
- Sousa, Thiciana S.;
- Jimenez, Paula C.;
- Wilke, Diego V.;
- Rocha, Danilo D.;
- Freitas, Hozana P. S.;
- Pessoa, Otília D. L.;
- La Clair, James J.;
- Costa‐Lotufo, Letícia V.
Publication type:
Article
Uncovering Metabolic Alterations in HCT-116 Colon Cancer Cells upon Exposure to Bamboo Leaf Extract Obtained from Guadua incana Londoño.
Published in:
Molecules, 2024, v. 29, n. 13, p. 1, doi. 10.3390/molecules29132985
By:
- Carlos Chitiva, Luis;
- Andrea Santamaría-Torres, Mary;
- Rezende-Teixeira, Paula;
- Pereira de Oliveira Borlot, Jessica Rodrigues;
- de Almeida Romagna, Rodrigo;
- Londoño, Ximena;
- Rezende Kitagawa, Rodrigo;
- Costa-Lotufo, Leticia V.;
- Prieto-Rodríguez, Juliet A.;
- Castro-Gamboa, Ian;
- Modesti Costa, Geison
Publication type:
Article
Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas.
Published in:
Molecules, 2021, v. 26, n. 23, p. 7362, doi. 10.3390/molecules26237362
By:
- Hirata, Amanda S.;
- Rezende-Teixeira, Paula;
- Machado-Neto, João Agostinho;
- Jimenez, Paula C.;
- Clair, James J. La;
- Fenical, William;
- Costa-Lotufo, Leticia V.
Publication type:
Article
OSMAC Strategy Integrated with Molecular Networking for Accessing Griseofulvin Derivatives from Endophytic Fungi of Moquiniastrum polymorphum (Asteraceae).
Published in:
Molecules, 2021, v. 26, n. 23, p. 7316, doi. 10.3390/molecules26237316
By:
- Farinella, Victor F.;
- Kawafune, Eunizinis S.;
- Tangerina, Marcelo M. P.;
- Domingos, Helori V.;
- Costa-Lotufo, Leticia V.;
- Ferreira, Marcelo J. P.
Publication type:
Article
Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis - Falkenbergia stage.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-48655-7
By:
- Medina, Rebeca P.;
- Araujo, Angela R.;
- Batista, João M.;
- Cardoso, Carmen L.;
- Seidl, Cláudia;
- Vilela, Adriana F. L.;
- Domingos, Helori V.;
- Costa-Lotufo, Leticia V.;
- Andersen, Raymond J.;
- Silva, Dulce H. S.
Publication type:
Article
Microorganisms: the secret agents of the biosphere, and their key roles in biotechnology.
Published in:
Biota Neotropica (Edicao em Iingles), 2022, v. 22, p. 1, doi. 10.1590/1676-0611-BN-2022-1343
By:
- Maia Oliveira, Valeria;
- Dini Andreote, Fernando;
- Cardoso Cortelo, Patricia;
- Castro-Gamboa, Ian;
- Costa-Lotufo, Leticia V.;
- Polizeli, Maria de Lourdes T. M.;
- Thiemann, Otávio H.;
- Setubal, João Carlos
Publication type:
Article
The Cloning and Characterization of a Three-Finger Toxin Homolog (NXH8) from the Coralsnake Micrurus corallinus That Interacts with Skeletal Muscle Nicotinic Acetylcholine Receptors.
Published in:
Toxins, 2024, v. 16, n. 4, p. 164, doi. 10.3390/toxins16040164
By:
- Roman-Ramos, Henrique;
- Prieto-da-Silva, Álvaro R. B.;
- Dellê, Humberto;
- Floriano, Rafael S.;
- Dias, Lourdes;
- Hyslop, Stephen;
- Schezaro-Ramos, Raphael;
- Servent, Denis;
- Mourier, Gilles;
- de Oliveira, Jéssica Lopes;
- Lemes, Douglas Edgard;
- Costa-Lotufo, Letícia V.;
- Oliveira, Jane S.;
- Menezes, Milene Cristina;
- Markus, Regina P.;
- Ho, Paulo Lee
Publication type:
Article
Endophytic fungi found in association with Smallanthus sonchifolius (Asteraceae) as resourceful producers of cytotoxic bioactive natural products.
Published in:
Journal of Basic Microbiology, 2009, v. 49, n. 2, p. 142, doi. 10.1002/jobm.200800093
By:
- GaIIo, Margareth B. C.;
- Chagas, Fernanda O.;
- Almeida, Marilia O.;
- Macedo, Claudia C.;
- Cavalcanti, Bruno C.;
- Barros, Francisco W. A.;
- de Moraes, Manoel O.;
- Costa-Lotufo, LetIcia V.;
- Pessoa, Claudia;
- Bastos, Jairo K.;
- Pupo, Monica T.
Publication type:
Article
Development of a method for quantitative determination of the cytotoxic agent piplartine (piperlongumine) in multiple skin layers.
Published in:
Biomedical Chromatography, 2019, v. 33, n. 2, p. N.PAG, doi. 10.1002/bmc.4386
By:
- Carvalho, Vanessa F. M.;
- Giacone, Daniela V.;
- Costa‐Lotufo, Leticia V.;
- Silveira, Edilberto Rocha;
- Lopes, Luciana B.
Publication type:
Article
ANKHD1 contributes to the malignant phenotype of triple‐negative breast cancer cells.
Published in:
Cell Biology International, 2022, v. 46, n. 9, p. 1433, doi. 10.1002/cbin.11844
By:
- de Almeida, Bruna O.;
- de Almeida, Larissa C.;
- Costa‐Lotufo, Leticia V.;
- Machado‐Neto, João A.
Publication type:
Article
Metabolomic fingerprinting of Brazilian marine sponges: a case study of Plakinidae species from Fernando de Noronha Archipelago.
Published in:
Analytical & Bioanalytical Chemistry, 2021, v. 413, n. 16, p. 4301, doi. 10.1007/s00216-021-03385-6
By:
- Fagundes, Thayssa da Silva F.;
- da Silva, Larissa Ramos G.;
- Brito, Mateus de Freitas;
- Schmitz, Letícia S. S.;
- Rigato, Dhiego B.;
- Jimenez, Paula Christine;
- Soares, Angélica Ribeiro;
- Costa-Lotufo, Letícia V.;
- Muricy, Guilherme;
- Vasconcelos, Thatyana Rocha A.;
- Cass, Quezia Bezerra;
- Valverde, Alessandra Leda
Publication type:
Article
Molecular Mechanism of Action of 2-Ferrocenyl-1,1-diphenylbut-1-ene on HL-60 Leukemia Cells.
Published in:
ChemMedChem, 2014, v. 9, n. 11, p. 2580, doi. 10.1002/cmdc.201402219
By:
- de Oliveira, Alane Cabral;
- da Silva, Emanuella Gomes;
- Rocha, Danilo Damasceno;
- Hillard, Elizabeth A.;
- Pigeon, Pascal;
- Jaouen, Gérard;
- Rodrigues, Felipe A. R.;
- de Abreu, Fabiane C.;
- da Rocha Ferreira, Fabrícia;
- Goulart, Marilia O. F.;
- Costa‐Lotufo, Letícia V.
Publication type:
Article
Inhibitory effect of pisosterol on human glioblastoma cell lines with C-MYC amplification.
Published in:
Journal of Applied Toxicology, 2011, v. 31, n. 6, p. 554, doi. 10.1002/jat.1596
By:
- Pereira, Edmundo L. R.;
- Lima, Patrícia D. L.;
- Khayat, André S.;
- Bahia, Marcelo O.;
- Bezerra, Franciglauber S.;
- Andrade-Neto, Manoel;
- Montenegro, Raquel C.;
- Pessoa, Cláudia;
- Costa-Lotufo, Letícia V.;
- Moraes, Manoel O.;
- Yoshioka, France K. N.;
- Pinto, Giovanny R.;
- Burbano, Rommel R.
Publication type:
Article
Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells.
Published in:
2009
By:
- Cavalcanti, Bruno C.;
- Bezerra, Daniel P.;
- Magalhaes, Hemerson I. F.;
- Moraes, Manoel O.;
- Lima, Mary Anne S.;
- Silveira, Edilberto R.;
- Câmara, Cláudio A. G.;
- Rao, Vietla S.;
- Pessoa, Claudia;
- Costa-Lotufo, LetIcia V.
Publication type:
Case Study
Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz-Pifferer).
Published in:
Journal of Applied Toxicology, 2009, v. 29, n. 1, p. 20, doi. 10.1002/jat.1374
By:
- Lins, Kézia O. A. L.;
- Bezerra, Daniel P.;
- Alves, Ana Paula N. N.;
- Alencar, Nylane M. N.;
- Lima, Michael W.;
- Torres, Valeska M.;
- Farias, Wiadimir R. L.;
- Pessoa, Claudia;
- de Moraesa, Manoel O.;
- Costa-Lotufo, Letícia V.
Publication type:
Article
In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species.
Published in:
Journal of Applied Toxicology, 2008, v. 28, n. 5, p. 599, doi. 10.1002/jat.1311
By:
- Bezerra, Daniel P.;
- Pessoa, Cláudia;
- de Moraes, Manoel Odorico;
- de Alencar, Nylane M. N.;
- Mesquita, Rodney O.;
- Lima, Michael W.;
- Alves, Ana Paula N. N.;
- Pessoa, Otília Deusdênia L.;
- Chaves, João Henrique;
- Silveira, Edilberto R.;
- Costa-Lotufo, Letícia V.
Publication type:
Article
In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine.
Published in:
Journal of Applied Toxicology, 2008, v. 28, n. 2, p. 156, doi. 10.1002/jat.1261
By:
- Bezerra, Daniel P.;
- De Castro, Fernanda O.;
- Alves, Ana Paula N. N.;
- Pessoa, Claudia;
- Odorico De Moraes, Manoel;
- Silveira, Edilberto R.;
- Lima, Mary Anne S.;
- Elmiro, Francisca Juliana M.;
- De Alencar, Nylane M. N.;
- Mesquita, Rodney O.;
- Lima, Michael W.;
- Costa-Lotufo, Leticia V.
Publication type:
Article
Genome mining of Streptomyces sp. BRB081 reveals the production of the antitumor pyrrolobenzodiazepine sibiromycin.
Published in:
3 Biotech, 2022, v. 12, n. 10, p. 1, doi. 10.1007/s13205-022-03305-0
By:
- Leite, Vida M. B.;
- Garrido, Leandro M.;
- Tangerina, Marcelo M. P.;
- Costa-Lotufo, Leticia V.;
- Ferreira, Marcelo J. P.;
- Padilla, Gabriel
Publication type:
Article

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