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Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL‐286, a novel retinoic acid receptor‐β agonist for treatment of spinal cord injury, in male healthy participants.
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- British Journal of Clinical Pharmacology, 2023, v. 89, n. 12, p. 3573, doi. 10.1111/bcp.15854
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- Article
The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling.
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- FASEB Journal, 2019, v. 33, n. 6, p. 7225, doi. 10.1096/fj.201802097R
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- Article
Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist.
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- European Journal of Neuroscience, 2013, v. 37, n. 7, p. 1182, doi. 10.1111/ejn.12142
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- Article
Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain.
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- European Journal of Neuroscience, 2004, v. 20, n. 4, p. 896, doi. 10.1111/j.1460-9568.2004.03563.x
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- Article
C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair.
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- Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2024.1411384
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- Article
Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells.
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- Journal of Neuroscience, 2019, v. 39, n. 16, p. 3013, doi. 10.1523/JNEUROSCI.2922-18.2019
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- Article
Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration.
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- Journal of Neuroscience, 2015, v. 35, n. 47, p. 15731, doi. 10.1523/JNEUROSCI.1339-15.2015
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- Article