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LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease.
- Published in:
- NPJ Parkinson's Disease, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41531-022-00354-3
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- Publication type:
- Article
Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.
- Published in:
- NPJ Parkinson's Disease, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41531-018-0049-1
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- Publication type:
- Article
Age-modulated association between prefrontal NAA and the BDNF gene.
- Published in:
- International Journal of Neuropsychopharmacology, 2013, v. 16, n. 6, p. 1185, doi. 10.1017/S1461145712001204
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- Article
Role of LRRK2 kinase dysfunction in Parkinson disease.
- Published in:
- Expert Reviews in Molecular Medicine, 2011, v. 13, p. 1, doi. 10.1017/S146239941100192X
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- Publication type:
- Article
Role of LRRK2 kinase dysfunction in Parkinson disease.
- Published in:
- Expert Reviews in Molecular Medicine, 2011, v. 13, p. N.PAG, doi. 10.1017/S146239941100192X
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- Publication type:
- Article
CoExp: A Web Tool for the Exploitation of Co-expression Networks.
- Published in:
- Frontiers in Genetics, 2021, v. 11, p. N.PAG, doi. 10.3389/fgene.2021.630187
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- Article
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.
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- Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00417
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- Article
Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.
- Published in:
- 2022
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- Publication type:
- journal article
An ANXA11 P93S variant dysregulates TDP‐43 and causes corticobasal syndrome.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 8, p. 5220, doi. 10.1002/alz.13915
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- Article
Multi‐omic characterization of a novel FTD/ALS‐associated variant in ANXA11.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078408
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- Publication type:
- Article
Signatures of disrupted synaptic maintenance in the entorhinal cortex of both pathology‐free APOE4 carriers and aged APOE4 mice: Molecular and cell biology/synaptic disruption.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.046192
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- Article
The LRRK2 signalling system.
- Published in:
- Cell & Tissue Research, 2018, v. 373, n. 1, p. 39, doi. 10.1007/s00441-017-2759-9
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- Publication type:
- Article
The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.
- Published in:
- Biochemical Journal, 2017, v. 474, n. 9, p. 1547, doi. 10.1042/BCJ20160909
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- Article
The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.
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- Biochemical Journal, 2016, v. 473, n. 3, p. 221, doi. 10.1042/BJ20150985
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- Publication type:
- Article
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
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- Biochemical Journal, 2013, v. 456, n. 1, p. 119, doi. 10.1042/BJ20121772
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- Publication type:
- Article
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson’s disease is a partial loss-of-function mutation.
- Published in:
- Biochemical Journal, 2012, v. 446, n. 1, p. 99, doi. 10.1042/BJ20120637
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- Publication type:
- Article
Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies.
- Published in:
- Nucleic Acids Research, 2013, v. 41, n. 7, p. e88, doi. 10.1093/nar/gkt069
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- Publication type:
- Article
High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22744-6
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- Publication type:
- Article
The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo.
- Published in:
- Frontiers in Neuroscience, 2017, p. 1, doi. 10.3389/fnins.2017.00702
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- Article
Neurons inflict self-harm.
- Published in:
- Nature Medicine, 2005, v. 11, n. 11, p. 1159, doi. 10.1038/nm1105-1159
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- Publication type:
- Article
PARKINSON’S DISEASE-ASSOCIATED MUTATIONS IN LRRK2 CAUSE CENTROSOMAL DEFECTS VIA RAB8A PHOSPHORYLATION.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1501, doi. 10.1016/j.jalz.2017.07.604
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- Article
P3-423: LRRK2 regulates the stress response in C. elegans and mammalian cells
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- 2008
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- Publication type:
- Abstract
P3-403: Parkin ubiquitylates phospholipase C-γ1 and protects against dopamine induced cell death
- Published in:
- 2008
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- Publication type:
- Abstract
P3-374: PINK1 transfected cell lines exhibit mitochondrial protection in vitro when exposed to mitochondrial toxins
- Published in:
- 2006
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- Publication type:
- Abstract
P3-374: PINK1 transfected cell lines exhibit mitochondrial protection in vitro when exposed to mitochondrial toxins
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- 2006
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- Publication type:
- Abstract
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
- Published in:
- Scientific Reports, 2016, p. 35106, doi. 10.1038/srep35106
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- Publication type:
- Article
Structure and regulation of full-length human leucine-rich repeat kinase 1.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40532-2
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- Publication type:
- Article
Aging-RNA in development and disease.
- Published in:
- Wiley Interdisciplinary Reviews: RNA, 2012, v. 3, n. 1, p. 133, doi. 10.1002/wrna.109
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- Publication type:
- Article
Post-Translational Decrease in Respiratory Chain Proteins in the Polg Mutator Mouse Brain.
- Published in:
- PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094646
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- Publication type:
- Article
Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies.
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- PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0046817
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- Publication type:
- Article
Sequences Located within the N-Terminus of the PD-Linked LRRK2 Lead to Increased Aggregation and Attenuation of 6-Hydroxydopamine-Induced Cell Death.
- Published in:
- PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045149
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- Article
Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043472
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- Publication type:
- Article
The Role of the Subthalamic Nucleus in L-DOPA Induced Dyskinesia in 6- Hydroxydopamine Lesioned Rats.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042652
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- Publication type:
- Article
Identification of Stk25 as a Genetic Modifier of Tau Phosphorylation in Dab1-Mutant Mice.
- Published in:
- PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0031152
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- Publication type:
- Article
LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding.
- Published in:
- PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0023207
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- Article
Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue.
- Published in:
- PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0022489
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- Publication type:
- Article
The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation.
- Published in:
- PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008730
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- Publication type:
- Article
Mitochondrial Alterations in PINK1 Deficient Cells Are Influenced by Calcineurin-Dependent Dephosphorylation of Dynamin-Related Protein 1.
- Published in:
- PLoS ONE, 2009, v. 4, n. 5, p. 1, doi. 10.1371/journal.pone.0005701
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- Article
DJ‐1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons.
- Published in:
- Journal of Neurochemistry, 2022, v. 162, n. 3, p. 245, doi. 10.1111/jnc.15656
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- Article
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
- Published in:
- BMC Neurology, 2006, v. 6, p. 1, doi. 10.1186/1471-2377-6-44
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- Article
The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2.
- Published in:
- Journal of Neuroscience, 2008, v. 28, n. 13, p. 3384, doi. 10.1523/JNEUROSCI.0185-08.2008
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- Publication type:
- Article
The Roles of Kinases in Familial Parkinson's Disease.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 44, p. 11865, doi. 10.1523/JNEUROSCI.3695-07.2007
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- Publication type:
- Article
The Metalloprotease Inhibitor TIMP-3 Regulates Amyloid Precursor Protein and Apolipoprotein E Receptor Proteolysis.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 40, p. 10895, doi. 10.1523/JNEUROSCI.3135-07.2007
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- Publication type:
- Article
Amyotrophic Lateral Sclerosis 2-Deficiency Leads to Neuronal Degeneration in Amyotrophic Lateral Sclerosis through Altered AMPA Receptor Trafficking.
- Published in:
- Journal of Neuroscience, 2006, v. 26, n. 45, p. 29, doi. 10.1523/JNEUROSCI.2084-06.2006
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- Publication type:
- Article
Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells.
- Published in:
- 2010
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- Publication type:
- journal article
α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells.
- Published in:
- BMC Neuroscience, 2010, v. 11, p. 41, doi. 10.1186/1471-2202-11-41
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- Publication type:
- Article
LRRK2 recruitment, activity, and function in organelles.
- Published in:
- FEBS Journal, 2022, v. 289, n. 22, p. 6871, doi. 10.1111/febs.16099
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- Publication type:
- Article
DNAJC proteins and pathways to parkinsonism.
- Published in:
- FEBS Journal, 2019, v. 286, n. 16, p. 3080, doi. 10.1111/febs.14936
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- Publication type:
- Article
Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis.
- Published in:
- JAMA Neurology, 2021, v. 78, n. 10, p. 1236, doi. 10.1001/jamaneurol.2021.2598
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- Publication type:
- Article
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-61142-8
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- Publication type:
- Article