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The hydrology of glacier‐bed overdeepenings: Sediment transport mechanics, drainage system morphology, and geomorphological implications.
Published in:
Earth Surface Processes & Landforms, 2021, v. 46, n. 11, p. 2264, doi. 10.1002/esp.5173
By:
- Swift, Darrel A.;
- Tallentire, Guy D.;
- Farinotti, Daniel;
- Cook, Simon J.;
- Higson, William J.;
- Bryant, Robert G.
Publication type:
Article
Accelerated mass loss of Himalayan glaciers since the Little Ice Age.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-03805-8
By:
- Lee, Ethan;
- Carrivick, Jonathan L.;
- Quincey, Duncan J.;
- Cook, Simon J.;
- James, William H. M.;
- Brown, Lee E.
Publication type:
Article
Heterogeneity in Karakoram glacier surges.
Published in:
Journal of Geophysical Research. Earth Surface, 2015, v. 120, n. 7, p. 1288, doi. 10.1002/2015JF003515
By:
- Quincey, Duncan J.;
- Glasser, Neil F.;
- Cook, Simon J.;
- Luckman, Adrian
Publication type:
Article
Copy number variation and susceptibility to complex traits.
Published in:
EMBO Molecular Medicine, 2010, v. 2, n. 11, p. 458, doi. 10.1002/emmm.201000099
By:
- Carragher, Linda A. S.;
- Snell, Kimberley R.;
- Giblett, Susan M.;
- Aldridge, Victoria S. S.;
- Patel, Bipin;
- Cook, Simon J.;
- Winton, Doug J.;
- Marais, Richard;
- Pritchard, Catrin A.
Publication type:
Article
IKKα plays a major role in canonical NF-κB signalling in colorectal cells.
Published in:
Biochemical Journal, 2022, v. 479, n. 3, p. 305, doi. 10.1042/BCJ20210783
By:
- Prescott, Jack A.;
- Balmanno, Kathryn;
- Mitchell, Jennifer P.;
- Okkenhaug, Hanneke;
- Cook, Simon J.
Publication type:
Article
Inhibitory feedback control of NF-κB signalling in health and disease.
Published in:
Biochemical Journal, 2021, v. 478, n. 13, p. 2619, doi. 10.1042/BCJ20210139
By:
- Prescott, Jack A.;
- Mitchell, Jennifer P.;
- Cook, Simon J.
Publication type:
Article
The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G1 cell-cycle arrest and not a direct effect on BIK protein stability.
Published in:
Biochemical Journal, 2014, v. 459, n. 3, p. 513, doi. 10.1042/BJ20131346
By:
- SALE, Matthew J.;
- COOK, Simon J.
Publication type:
Article
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288.
Published in:
Biochemical Journal, 2014, v. 457, n. 1, p. 43, doi. 10.1042/BJ20130461
By:
- ASHFORD, Anne L.;
- OXLEY, David;
- KETTLE, Jason;
- HUDSON, Kevin;
- GUICHARD, Sylvie;
- COOK, Simon J.;
- LOCHHEAD, Pamela A.
Publication type:
Article
The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance.
Published in:
Biochemical Journal, 2013, v. 450, n. 2, p. 285, doi. 10.1042/BJ20121212
By:
- SALE, Matthew J.;
- COOK, Simon J.
Publication type:
Article
Thrust faulting in glaciers? Re‐examination of debris bands near the margin of Storglaciären, Sweden.
Published in:
Boreas, 2022, v. 51, n. 1, p. 78, doi. 10.1111/bor.12549
By:
- Monz, Morgan E.;
- Hudleston, Peter J.;
- Cook, Simon J.;
- Zimmerman, Troy;
- Leng, Melanie J.
Publication type:
Article
Role of glaciohydraulic supercooling in the formation of stratified facies basal ice: Svínafellsjökull and Skaftafellsjökull, southeast Iceland.
Published in:
Boreas, 2010, v. 39, n. 1, p. 24, doi. 10.1111/j.1502-3885.2009.00112.x
By:
- COOK, SIMON J.;
- ROBINSON, ZOE P.;
- FAIRCHILD, IAN J.;
- KNIGHT, PETER G.;
- WALLER, RICHARD I.;
- BOOMER, IAN
Publication type:
Article
War of the Ghosts: Marshall, Veblen, and Bartlett.
Published in:
History of Political Economy, 2016, v. 48, n. 5, p. 44, doi. 10.1215/00182702-3619238
By:
- Cook, Simon J.;
- Foresti, Tiziana
Publication type:
Article
From Ancients and Moderns to Geography and Anthropology: The Meaning of History in the Thought of Adam Smith, Karl Marx, and Alfred Marshall.
Published in:
2013
By:
- Cook, Simon J.
Publication type:
Essay
MEK Inhibitor U0126 Reverses Protection of Axons from Wallerian Degeneration Independently of MEK–ERK Signaling.
Published in:
PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076505
By:
- Evans, Catherine;
- Cook, Simon J.;
- Coleman, Michael P.;
- Gilley, Jonathan
Publication type:
Article
ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest.
Published in:
Oncogene, 2004, v. 23, n. 19, p. 3284, doi. 10.1038/sj.onc.1207467
By:
- Todd, Daniel E;
- Densham, Ruth M;
- Molton, Sarah A;
- Balmanno, Kathryn;
- Newson, Catherine;
- Weston, Claire R;
- Garner, Andrew P;
- Scott, Linda;
- Cook, Simon J
Publication type:
Article
Selective activation of the c-Jun N-terminal kinase (JNK) pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3'-kinase (PI3K) pathway is inhibited.
Published in:
Oncogene, 2003, v. 22, n. 30, p. 4690, doi. 10.1038/sj.onc.1206692
By:
- Molton, Sarah A;
- Todd, Daniel E;
- Cook, Simon J
Publication type:
Article
Activation of ERK1/2 by ?Raf-1?:?ER* represses Bim expression independently of the JNK or PI3K pathways.
Published in:
Oncogene, 2003, v. 22, n. 9, p. 1281, doi. 10.1038/sj.onc.1206261
By:
- Weston, Claire R;
- Balmanno, Kathryn;
- Chalmers, Claire;
- Hadfield, Kathryn;
- Molton, Sarah A;
- Ley, Rebecca;
- Wagner, Erwin F;
- Cook, Simon J
Publication type:
Article
ΔMEKK3:ER* activation induces a p38α/β2-dependent cell cycle arrest at the G2 checkpoint.
Published in:
Oncogene, 2002, v. 21, n. 53, p. 8089, doi. 10.1038/sj.onc.1206000
By:
- Garner, Andrew P;
- Weston, Claire R;
- Todd, Daniel E;
- Balmanno, Kathryn;
- Cook, Simon J
Publication type:
Article
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-12409-w
By:
- Sale, Matthew J.;
- Minihane, Emma;
- Monks, Noel R.;
- Gilley, Rebecca;
- Richards, Frances M.;
- Schifferli, Kevin P.;
- Andersen, Courtney L.;
- Davies, Emma J.;
- Vicente, Mario Aladren;
- Ozono, Eiko;
- Markovets, Aleksandra;
- Dry, Jonathan R.;
- Drew, Lisa;
- Flemington, Vikki;
- Proia, Theresa;
- Jodrell, Duncan I.;
- Smith, Paul D.;
- Cook, Simon J.
Publication type:
Article
MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09438-w
By:
- Sale, Matthew J.;
- Balmanno, Kathryn;
- Saxena, Jayeta;
- Ozono, Eiko;
- Wojdyla, Katarzyna;
- McIntyre, Rebecca E.;
- Gilley, Rebecca;
- Woroniuk, Anna;
- Howarth, Karen D.;
- Hughes, Gareth;
- Dry, Jonathan R.;
- Arends, Mark J.;
- Caro, Pilar;
- Oxley, David;
- Ashton, Susan;
- Adams, David J.;
- Saez-Rodriguez, Julio;
- Smith, Paul D.;
- Cook, Simon J.
Publication type:
Article
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.
Published in:
EMBO Journal, 2007, v. 26, n. 12, p. 2856, doi. 10.1038/sj.emboj.7601723
By:
- Ewings, Katherine E;
- Hadfield-Moorhouse, Kathryn;
- Wiggins, Ceri M;
- Wickenden, Julie A;
- Balmanno, Kathryn;
- Gilley, Rebecca;
- Degenhardt, Kurt;
- White, Eileen;
- Cook, Simon J
Publication type:
Article
Granulocyte/Macrophage Colony-Stimulating Factor Causes a Paradoxical Increase in the BH3-Only Pro-Apoptotic Protein Bim in Human Neutrophils.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2011, v. 44, n. 6, p. 879, doi. 10.1165/rcmb.2010-0101OC
By:
- Cowburn, Andrew S.;
- Summers, Charlotte;
- Dunmore, Benjamin J.;
- Farahi, Neda;
- Hayhoe, Richard P.;
- Print, Cristin G.;
- Cook, Simon J.;
- Chilvers, Edwin R.
Publication type:
Article
Progress and challenges in glacial lake outburst flood research (2017–2021): a research community perspective.
Published in:
Natural Hazards & Earth System Sciences, 2022, v. 22, n. 9, p. 3041, doi. 10.5194/nhess-22-3041-2022
By:
- Emmer, Adam;
- Allen, Simon K.;
- Carey, Mark;
- Frey, Holger;
- Huggel, Christian;
- Korup, Oliver;
- Mergili, Martin;
- Sattar, Ashim;
- Veh, Georg;
- Chen, Thomas Y.;
- Cook, Simon J.;
- Correas-Gonzalez, Mariana;
- Das, Soumik;
- Diaz Moreno, Alejandro;
- Drenkhan, Fabian;
- Fischer, Melanie;
- Immerzeel, Walter W.;
- Izagirre, Eñaut;
- Joshi, Ramesh Chandra;
- Kougkoulos, Ioannis
Publication type:
Article
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells.
Published in:
Oncogene, 1999, v. 18, n. 20, p. 3085, doi. 10.1038/sj.onc.1202647
By:
- Balmanno, Kathryn;
- Cook, Simon J
Publication type:
Article
The Expression of Faërie.
Published in:
Tolkien Studies, 2020, v. 17, p. N.PAG
By:
- Cook(bio), Simon J.
Publication type:
Article
The Cauldron at the Outer Edge: Tolkien on the Oldest English Fairy Tales.
Published in:
Tolkien Studies, 2016, v. 13, p. 9, doi. 10.1353/tks.2016.0004
By:
- COOK, SIMON J.
Publication type:
Article
The Peace of Frodo: On the Origin of an English Mythology.
Published in:
2015
By:
- COOK, SIMON J.
Publication type:
Essay
Origin and significance of 'dispersed facies' basal ice: Svínafellsjökull, Iceland.
Published in:
Journal of Glaciology, 2011, v. 57, n. 204, p. 710, doi. 10.3189/002214311797409703
By:
- COOK, Simon J.;
- SWIFT, Darrel A.;
- GRAHAM, David J.;
- MIDGLEY, Nicholas G.
Publication type:
Article
De‐RSKing ERK – regulation of ERK1/2‐RSK dissociation by phosphorylation within a disordered motif.
Published in:
FEBS Journal, 2018, v. 285, n. 1, p. 42, doi. 10.1111/febs.14344
By:
- Kidger, Andrew M.;
- Cook, Simon J.
Publication type:
Article
Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.
Published in:
FEBS Journal, 2017, v. 284, n. 24, p. 4177, doi. 10.1111/febs.14122
By:
- Cook, Simon J.;
- Stuart, Kate;
- Gilley, Rebecca;
- Sale, Matthew J.
Publication type:
Article
Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics.
Published in:
FEBS Journal, 2009, v. 276, n. 21, p. 6050, doi. 10.1111/j.1742-4658.2009.07329.x
By:
- Gillings, Annette S.;
- Balmanno, Kathryn;
- Wiggins, Ceri M.;
- Johnson, Mark;
- Cook, Simon J.
Publication type:
Article
Shaking up Assumptions: Earthquakes Have Rarely Triggered Andean Glacier Lake Outburst Floods.
Published in:
Geophysical Research Letters, 2024, v. 51, n. 7, p. 1, doi. 10.1029/2023GL105578
By:
- Wood, Joanne L.;
- Harrison, Stephan;
- Wilson, Ryan;
- Emmer, Adam;
- Kargel, Jeffrey S.;
- Cook, Simon J.;
- Glasser, Neil F.;
- Reynolds, John M.;
- Shugar, Dan H.;
- Yarleque, Christian
Publication type:
Article
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway.
Published in:
Biochemical Journal, 2024, v. 481, n. 6, p. 405, doi. 10.1042/BCJ20240015
By:
- Weatherdon, Laura;
- Stuart, Kate;
- Cassidy, Megan;
- de la Gándara, Alberto Moreno;
- Okkenhaug, Hanneke;
- Muellener, Markus;
- Mckenzie, Grahame;
- Cook, Simon J.;
- Gilley, Rebecca
Publication type:
Article
ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.
Published in:
Biochemical Journal, 2023, v. 480, n. 9, p. 587, doi. 10.1042/BCJ20220598
By:
- Balmanno, Kathryn;
- Kidger, Andrew M.;
- Byrne, Dominic P.;
- Sale, Matthew J.;
- Nassman, Nejma;
- Eyers, Patrick A.;
- Cook, Simon J.
Publication type:
Article
Progress and challenges in glacial lake outburst flood research (2017-2021): a research community perspective.
Published in:
Natural Hazards & Earth System Sciences Discussions, 2022, p. 1, doi. 10.5194/nhess-2022-143
By:
- Emmer, Adam;
- Allen, Simon K.;
- Carey, Mark;
- Frey, Holger;
- Huggel, Christian;
- Korup, Oliver;
- Mergili, Martin;
- Sattar, Ashim;
- Veh, Georg;
- Chen, Thomas Y.;
- Cook, Simon J.;
- Correas-Gonzalez, Mariana;
- Das, Soumik;
- Moreno, Alejandro Diaz;
- Drenkhan, Fabian;
- Fischer, Melanie;
- Immerzeel, Walter W.;
- Izagirre, Eñaut;
- Joshi, Ramesh Chandra;
- Kougkoulos, Ioannis
Publication type:
Article
Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast.
Published in:
Nature Communications, 2014, v. 5, n. 11, p. 5538, doi. 10.1038/ncomms6538
By:
- Cambuli, Francesco;
- Murray, Alexander;
- Dean, Wendy;
- Dudzinska, Dominika;
- Krueger, Felix;
- Andrews, Simon;
- Senner, Claire E.;
- Cook, Simon J.;
- Hemberger, Myriam
Publication type:
Article
Glacial Lake Outburst Floods (GLOFs) in the Cordillera Huayhuash, Peru: Historic Events and Current Susceptibility.
Published in:
Water (20734441), 2020, v. 12, n. 10, p. 2664, doi. 10.3390/w12102664
By:
- Baťka, Jan;
- Vilímek, Vít;
- Štefanová, Eva;
- Cook, Simon J.;
- Emmer, Adam
Publication type:
Article
Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance.
Published in:
NAR Cancer, 2022, v. 4, n. 4, p. 1, doi. 10.1093/narcan/zcac032
By:
- Channathodiyil, Prasanna;
- May, Kieron;
- Segonds-Pichon, Anne;
- Smith, Paul D.;
- Cook, Simon J.;
- Houseley, Jonathan
Publication type:
Article
Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.
Published in:
International Journal of Cancer, 2009, v. 125, n. 10, p. 2332, doi. 10.1002/ijc.24604
By:
- Balmanno, Kathryn;
- Chell, Simon D.;
- Gillings, Annette S.;
- Hayat, Shaista;
- Cook, Simon J.
Publication type:
Article
Inhibition of RAF dimers: it takes two to tango.
Published in:
Biochemical Society Transactions, 2021, v. 49, n. 1, p. 237, doi. 10.1042/BST20200485
By:
- Cook, Frazer A.;
- Cook, Simon J.
Publication type:
Article
Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for...
Published in:
Biochemical Society Transactions, 2020, v. 48, n. 5, p. 1859, doi. 10.1042/BST20190338
By:
- Cook, Simon J.;
- Tucker, Julie A.;
- Lochhead, Pamela A.
Publication type:
Article
Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer.
Published in:
Biochemical Society Transactions, 2014, v. 42, n. 4, p. 776, doi. 10.1042/BST20140129
By:
- Sale, Matthew J.;
- Cook, Simon J.
Publication type:
Article
Adaptation to chronic mTOR inhibition in cancer and in aging.
Published in:
Biochemical Society Transactions, 2013, v. 41, n. 4, p. 956, doi. 10.1042/BST20130080
By:
- Gilley, Rebecca;
- Balmanno, Kathryn;
- Cope, Claire L.;
- Cook, Simon J.
Publication type:
Article
Subglacial processes in the terminus region of Findelengletscher, Switzerland, inferred from bed geometry, borehole hydrology, glaciofluvial sediment transport and proglacial landform investigation.
Published in:
Geophysical Research Abstracts, 2018, v. 20, p. 7849
By:
- Swift, Darrel A.;
- Higson, William J.;
- Tallentire, Guy D.;
- Cook, Simon J.;
- Farinotti, Daniel;
- Werder, Mauro A.;
- Bryant, Robert G.;
- Rutter, Nick;
- Mchale, Kaylee;
- Witherick, Alice
Publication type:
Article
Volumetric changes of glaciers in the Bolivian Andes between 1986 and 2017.
Published in:
Geophysical Research Abstracts, 2018, v. 20, p. 461
By:
- Kougkoulos, Ioannis;
- Cook, Simon J.;
- Clarke, Leon J.;
- Symeonakis, Elias;
- Edwards, Laura A.;
- Dortch, Jason M.
Publication type:
Article
Glacial lake outburst flood risk in the Bolivian Andes.
Published in:
Geophysical Research Abstracts, 2018, v. 20, p. 42
By:
- Kougkoulos, Ioannis;
- Clarke, Leon;
- Cook, Simon J.;
- Dortch, Jason M.;
- Edwards, Laura A.;
- Jomelli, Vincent;
- Merad, Myriam;
- Symeonakis, Elias
Publication type:
Article
Floods in Provence-Alpes-Côte d'Azur and lessons for French flood risk governance.
Published in:
Natural Hazards, 2021, v. 109, n. 2, p. 1959, doi. 10.1007/s11069-021-04905-4
By:
- Kougkoulos, Ioannis;
- Merad, Myriam;
- Cook, Simon J.;
- Andredakis, Ioannis
Publication type:
Article
Modelling glacial lake outburst flood impacts in the Bolivian Andes.
Published in:
Natural Hazards, 2018, v. 94, n. 3, p. 1415, doi. 10.1007/s11069-018-3486-6
By:
- Kougkoulos, Ioannis;
- Cook, Simon J.;
- Edwards, Laura A.;
- Clarke, Leon J.;
- Symeonakis, Elias;
- Dortch, Jason M.;
- Nesbitt, Kathleen
Publication type:
Article
Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors.
Published in:
Cells (2073-4409), 2018, v. 7, n. 9, p. 115, doi. 10.3390/cells7090115
By:
- Prescott, Jack A.;
- Cook, Simon J.
Publication type:
Article
That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance.
Published in:
British Journal of Pharmacology, 2013, v. 169, n. 8, p. 1708, doi. 10.1111/bph.12220
By:
- Sale, Matthew J;
- Cook, Simon J
Publication type:
Article

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