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Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01049-7
By:
- Perez-Rando, Marta;
- Dujardin, Simon;
- Bennett, Rachel E.;
- Commins, Caitlin;
- Nibhanupudy, Tara;
- Hyman, Bradley T.
Publication type:
Article
APOE4 derived from astrocytes leads to blood-brain barrier impairment.
Published in:
2022
By:
- Jackson, Rosemary J;
- Meltzer, Jonah C;
- Nguyen, Huong;
- Commins, Caitlin;
- Bennett, Rachel E;
- Hudry, Eloise;
- Hyman, Bradley T
Publication type:
journal article
Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo.
Published in:
2018
By:
- DeVos, Sarah L.;
- Corjuc, Bianca T.;
- Commins, Caitlin;
- Dujardin, Simon;
- Bannon, Riley N.;
- Corjuc, Diana;
- Moore, Benjamin D.;
- Bennett, Rachel E.;
- Jorfi, Mehdi;
- Gonzales, Jose A.;
- Dooley, Patrick M.;
- Roe, Allyson D.;
- Pitstick, Rose;
- Irimia, Daniel;
- Frosch, Matthew P.;
- Carlson, George A.;
- Hyman, Bradley T.
Publication type:
journal article
Employing an in vitro biosensor assay to investigate tau seeding kinetics within cases of sporadic Alzheimer disease and in a model of tauopathy: Developing topics.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047169
By:
- Kamath, Tarun V;
- Commins, Caitlin;
- Klickstein, Naomi;
- Oakley, Derek;
- Hyman, Bradley T;
- Dujardin, Simon
Publication type:
Article
Tau propagation is dependent on the genetic background in multiple mouse strains: Molecular and cell biology/tau.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043059
By:
- Dujardin, Simon;
- De Los Santos, Mark;
- Fernandes, Analiese R.;
- Bannon, Riley N.;
- Kamath, Tarun V.;
- Commins, Caitlin;
- Hyman, Bradley T.
Publication type:
Article
O5‐04‐03: RELEVANCE OF TAU SEEDING FOR THE CLINICAL HETEROGENEITY OF ALZHEIMER'S DISEASE: IMPLICATION FOR THERAPEUTIC PERSPECTIVES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1623, doi. 10.1016/j.jalz.2019.06.4854
By:
- Dujardin, Simon;
- Commins, Caitlin;
- Kamath, Tarun V.;
- De Los Santos, Mark;
- Dooley, Patrick M.;
- Moore, Benjamin D.;
- Jean-Gilles, Dinorah;
- Clark, Ryan;
- Kennedy, Matthew;
- Hyman, Bradley T.
Publication type:
Article
Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.
Published in:
Frontiers in Neuroscience, 2018, p. 1, doi. 10.3389/fnins.2018.00267
By:
- DeVos, Sarah L.;
- Corjuc, Bianca T.;
- Oakley, Derek H.;
- Nobuhara, Chloe K.;
- Bannon, Riley N.;
- Chase, Alison;
- Commins, Caitlin;
- Gonzalez, Jose A.;
- Dooley, Patrick M.;
- Frosch, Matthew P.;
- Hyman, Bradley T.
Publication type:
Article
ADUCANUMAB TARGETS HIGH MOLECULAR WEIGHT SOLUBLE Aβ OLIGOMERS AND RESTORES CALCIUM TO NORMAL LEVELS IN TG2576 MICE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P413, doi. 10.1016/j.jalz.2016.06.780
By:
- Kastanenka, Ksenia;
- Bussière, Thierry;
- Wang, Xueying;
- Hou, Steven;
- Arbel, Michal;
- Takeda, Shuko;
- Commins, Caitlin;
- Qian, Fang;
- Weinreb, Paul;
- Rhodes, Kenneth;
- Bacskai, Brian
Publication type:
Article
A unique high-molecular-weight tau species is involved in propagation and accumulates in the cerebrospinal fluid of Alzheimer’s disease patients.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P644, doi. 10.1016/j.jalz.2015.06.938
By:
- Takeda, Shuko;
- Commins, Caitlin;
- Wegmann, Susanne;
- Roe, Allyson D.;
- Fan, Zhanyun;
- DeVos, Sarah L.;
- Costantino, Isabel;
- Trisini Lipsanopoulos, Ana;
- Frosch, Matthew P.;
- Hyman, Bradley T.
Publication type:
Article
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Published in:
Scientific Reports, 2015, p. 8490, doi. 10.1038/ncomms9490
By:
- Takeda, Shuko;
- Wegmann, Susanne;
- Cho, Hansang;
- DeVos, Sarah L.;
- Commins, Caitlin;
- Roe, Allyson D.;
- Nicholls, Samantha B.;
- Carlson, George A.;
- Pitstick, Rose;
- Nobuhara, Chloe K.;
- Costantino, Isabel;
- Frosch, Matthew P.;
- Müller, Daniel J.;
- Irimia, Daniel;
- Hyman, Bradley T.
Publication type:
Article
Tau protein liquid–liquid phase separation can initiate tau aggregation.
Published in:
EMBO Journal, 2018, v. 37, n. 7, p. 1, doi. 10.15252/embj.201798049
By:
- Wegmann, Susanne;
- Eftekharzadeh, Bahareh;
- Tepper, Katharina;
- Zoltowska, Katarzyna M.;
- Bennett, Rachel E.;
- Dujardin, Simon;
- Laskowski, Pawel R.;
- MacKenzie, Danny;
- Kamath, Tarun;
- Commins, Caitlin;
- Vanderburg, Charles;
- Roe, Allyson D.;
- Fan, Zhanyun;
- Molliex, Amandine M.;
- Hernandez‐Vega, Amayra;
- Muller, Daniel;
- Hyman, Anthony A.;
- Mandelkow, Eckhard;
- Taylor, J. Paul;
- Hyman, Bradley T.
Publication type:
Article
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Published in:
Nature Communications, 2015, v. 6, n. 10, p. 8490, doi. 10.1038/ncomms9490
By:
- Takeda, Shuko;
- Wegmann, Susanne;
- Cho, Hansang;
- DeVos, Sarah L.;
- Commins, Caitlin;
- Roe, Allyson D.;
- Nicholls, Samantha B.;
- Carlson, George A.;
- Pitstick, Rose;
- Nobuhara, Chloe K.;
- Costantino, Isabel;
- Frosch, Matthew P.;
- Müller, Daniel J.;
- Irimia, Daniel;
- Hyman, Bradley T.
Publication type:
Article
Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid.
Published in:
Brain Pathology, 2022, v. 32, n. 2, p. 1, doi. 10.1111/bpa.13035
By:
- Petrozziello, Tiziana;
- Amaral, Ana C.;
- Dujardin, Simon;
- Farhan, Sali M. K.;
- Chan, James;
- Trombetta, Bianca A.;
- Kivisäkk, Pia;
- Mills, Alexandra N.;
- Bordt, Evan A.;
- Kim, Spencer E.;
- Dooley, Patrick M.;
- Commins, Caitlin;
- Connors, Theresa R.;
- Oakley, Derek H.;
- Ghosal, Anubrata;
- Gomez‐Isla, Teresa;
- Hyman, Bradley T.;
- Arnold, Steven E.;
- Spires‐Jones, Tara;
- Cudkowicz, Merit E.
Publication type:
Article
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Published in:
2016
By:
- Takeda, Shuko;
- Commins, Caitlin;
- DeVos, Sarah L.;
- Nobuhara, Chloe K.;
- Wegmann, Susanne;
- Roe, Allyson D.;
- Costantino, Isabel;
- Fan, Zhanyun;
- Nicholls, Samantha B.;
- Sherman, Alexis E.;
- Trisini Lipsanopoulos, Ana T.;
- Scherzer, Clemens R.;
- Carlson, George A.;
- Pitstick, Rose;
- Peskind, Elaine R.;
- Raskind, Murray A.;
- Li, Ge;
- Montine, Thomas J.;
- Frosch, Matthew P.;
- Hyman, Bradley T.
Publication type:
journal article
Tau propagation is dependent on the genetic background of mouse strains.
Published in:
Brain Communications, 2022, v. 4, n. 2, p. 1, doi. 10.1093/braincomms/fcac048
By:
- Dujardin, Simon;
- Fernandes, Analiese;
- Bannon, Riley;
- Commins, Caitlin;
- De Los Santos, Mark;
- Kamath, Tarun V.;
- Mansuo Hayashi;
- Hyman, Bradley T.
Publication type:
Article
Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau.
Published in:
Acta Neuropathologica, 2023, v. 146, n. 2, p. 191, doi. 10.1007/s00401-023-02600-1
By:
- Mate De Gerando, Anastasie;
- Welikovitch, Lindsay A.;
- Khasnavis, Anita;
- Commins, Caitlin;
- Glynn, Calina;
- Chun, Joshua E.;
- Perbet, Romain;
- Hyman, Bradley T.
Publication type:
Article
Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons.
Published in:
Journal of Neuroscience, 2021, v. 41, n. 19, p. 4335, doi. 10.1523/JNEUROSCI.2590-20.2021
By:
- Oakley, Derek H.;
- Klickstein, Naomi;
- Commins, Caitlin;
- Chung, Mirra;
- Dujardin, Simon;
- Bennett, Rachel E.;
- Hyman, Bradley T.;
- Frosch, Matthew P.
Publication type:
Article
Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells.
Published in:
Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00643-2
By:
- Lathuiliere, Aurelien;
- Jo, Youhwa;
- Perbet, Romain;
- Donahue, Cameron;
- Commins, Caitlin;
- Quittot, Noé;
- Fan, Zhanyun;
- Bennett, Rachel E.;
- Hyman, Bradley T.
Publication type:
Article
Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.
Published in:
PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177914
By:
- Nicholls, Samantha B.;
- DeVos, Sarah L.;
- Commins, Caitlin;
- Nobuhara, Chloe;
- Bennett, Rachel E.;
- Corjuc, Diana L.;
- Maury, Eduardo;
- Eftekharzadeh, Bahareh;
- Akingbade, Ololade;
- Fan, Zhanyun;
- Roe, Allyson D.;
- Takeda, Shuko;
- Wegmann, Susanne;
- Hyman, Bradley T.
Publication type:
Article

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