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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.
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- PLoS Biology, 2021, v. 19, n. 12, p. 1, doi. 10.1371/journal.pbio.3001474
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A structure-based designed small molecule depletes hRpn13<sup>Pru</sup> and a select group of KEN box proteins.
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- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46644-7
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- Article
Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants.
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- PLoS Genetics, 2023, v. 19, n. 9, p. 1, doi. 10.1371/journal.pgen.1010940
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- Article