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Structure‐Based Design of a Macrocyclic PROTAC.
- Published in:
- Angewandte Chemie, 2020, v. 132, n. 4, p. 1744, doi. 10.1002/ange.201914396
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- Publication type:
- Article
Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.
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- Biochemical Journal, 2017, v. 474, n. 10, p. 1633, doi. 10.1042/BCJ20161053
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- Publication type:
- Article
The biochemical properties of the two Arabidopsis thaliana isochorismate synthases.
- Published in:
- Biochemical Journal, 2017, v. 474, n. 10, p. 1579, doi. 10.1042/BCJ20161069
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- Publication type:
- Article
Biophysical characterization of laforin–carbohydrate interaction.
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- Biochemical Journal, 2016, v. 473, n. 3, p. 335, doi. 10.1042/BJ20141555
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- Publication type:
- Article
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.
- Published in:
- Biochemical Journal, 2015, v. 467, n. 3, p. 365, doi. 10.1042/BJ20141450
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- Publication type:
- Article
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29670-1
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- Publication type:
- Article
The 17<sup>th</sup> EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders.
- Published in:
- ChemMedChem, 2023, v. 18, n. 20, p. 1, doi. 10.1002/cmdc.202300464
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- Publication type:
- Article
Front Cover: Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (ChemMedChem 20/2022).
- Published in:
- ChemMedChem, 2022, v. 17, n. 20, p. 1, doi. 10.1002/cmdc.202200343
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- Publication type:
- Article
Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain.
- Published in:
- ChemMedChem, 2022, v. 17, n. 20, p. 1, doi. 10.1002/cmdc.202200343
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- Publication type:
- Article
The 2<sup>nd</sup> Alpine Winter Conference on Medicinal and Synthetic Chemistry.
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- ChemMedChem, 2021, v. 16, n. 15, p. 2417, doi. 10.1002/cmdc.202100372
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- Publication type:
- Article
Niedermolekulare Inhibitoren der Wechselwirkung zwischen der E3-Ligase VHL und HIF1α.
- Published in:
- Angewandte Chemie, 2012, v. 124, n. 46, p. 11630, doi. 10.1002/ange.201206231
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- Publication type:
- Article
Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121.
- Published in:
- Angewandte Chemie, 2012, v. 124, n. 37, p. 9445, doi. 10.1002/ange.201202544
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- Publication type:
- Article
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41894-3
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- Publication type:
- Article
Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.
- Published in:
- PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0131218
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- Publication type:
- Article
Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns.
- Published in:
- EMBO Reports, 2024, v. 25, n. 9, p. 4062, doi. 10.1038/s44319-024-00224-4
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- Publication type:
- Article
Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.
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- EMBO Reports, 2017, v. 18, n. 7, p. 1108, doi. 10.15252/embr.201643534
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- Publication type:
- Article
Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10190-4
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- Publication type:
- Article
Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology.
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- Clinical & Translational Medicine, 2022, v. 12, n. 7, p. 1, doi. 10.1002/ctm2.961
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- Publication type:
- Article
Ternary Complex‐Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo‐PROTACs.
- Published in:
- Angewandte Chemie, 2024, v. 136, n. 25, p. 1, doi. 10.1002/ange.202319456
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- Publication type:
- Article
The pro-drug C13 activates AMPK by two distinct mechanisms.
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- Biochemical Journal, 2024, v. 481, n. 18, p. 1203, doi. 10.1042/BCJ20240425
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- Publication type:
- Article
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.
- Published in:
- Nature Communications, 2016, v. 7, n. 11, p. 13312, doi. 10.1038/ncomms13312
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- Publication type:
- Article
Ternary Complex‐Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo‐PROTACs.
- Published in:
- Angewandte Chemie International Edition, 2024, v. 63, n. 25, p. 1, doi. 10.1002/anie.202319456
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- Publication type:
- Article
Structure‐Based Design of a Macrocyclic PROTAC.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 4, p. 1727, doi. 10.1002/anie.201914396
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- Publication type:
- Article
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
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- 2017
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- Publication type:
- journal article
Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.
- Published in:
- Essays in Biochemistry, 2017, v. 61, n. 5, p. 505, doi. 10.1042/EBC20170041
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- Publication type:
- Article
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00954-1
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- Publication type:
- Article
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52871-9
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- Publication type:
- Article
Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases.
- Published in:
- ChemMedChem, 2017, v. 12, n. 18, p. 1491, doi. 10.1002/cmdc.201700359
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- Publication type:
- Article
Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions.
- Published in:
- ChemMedChem, 2016, v. 11, n. 8, p. 787, doi. 10.1002/cmdc.201500450
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- Publication type:
- Article
Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis.
- Published in:
- ChemMedChem, 2016, v. 11, n. 1, p. 38, doi. 10.1002/cmdc.201500414
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- Publication type:
- Article
A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry.
- Published in:
- ChemBioChem, 2009, v. 10, n. 17, p. 2772, doi. 10.1002/cbic.200900537
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- Publication type:
- Article
Inside Cover: A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (ChemBioChem 17/2009).
- Published in:
- ChemBioChem, 2009, v. 10, n. 17, p. 2678, doi. 10.1002/cbic.200990077
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- Publication type:
- Article
Inhibition of Mycobacterium tuberculosis Pantothenate Synthetase by Analogues of the Reaction Intermediate.
- Published in:
- ChemBioChem, 2008, v. 9, n. 16, p. 2606, doi. 10.1002/cbic.200800437
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- Publication type:
- Article
Nucleophile Selectivity of Chorismate-Utilizing Enzymes.
- Published in:
- ChemBioChem, 2007, v. 8, n. 6, p. 622, doi. 10.1002/cbic.200700019
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- Publication type:
- Article
Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α.
- Published in:
- Angewandte Chemie International Edition, 2012, v. 51, n. 46, p. 11463, doi. 10.1002/anie.201206231
- By:
- Publication type:
- Article
Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121.
- Published in:
- Angewandte Chemie International Edition, 2012, v. 51, n. 37, p. 9311, doi. 10.1002/anie.201202544
- By:
- Publication type:
- Article
Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase.
- Published in:
- Angewandte Chemie International Edition, 2009, v. 48, n. 45, p. 8452, doi. 10.1002/anie.200903821
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- Publication type:
- Article