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Histidine 14 Modulates Membrane Binding and Neurotoxicity of the Alzheimer's Disease Amyloid-β Peptide.
Published in:
Journal of Alzheimer's Disease, 2010, v. 19, n. 4, p. 1387, doi. 10.3233/JAD-2010-1334
By:
- Smith, Danielle G.;
- Ciccotosto, Giuseppe D.;
- Tew, Deborah J.;
- Perez, Keyla;
- Curtain, Cyril C.;
- Boas, John F.;
- Masters, Colin L.;
- Cappai, Roberto;
- Barnham, Kevin J.
Publication type:
Article
Amyloid precursor protein and amyloid precursor‐like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.
Published in:
Glia, 2019, v. 67, n. 3, p. 525, doi. 10.1002/glia.23561
By:
- Truong, Phan H.;
- Ciccotosto, Giuseppe D.;
- Merson, Tobias D.;
- Spoerri, Loredana;
- Chuei, Mun Joo;
- Ayers, Margaret;
- Xing, Yao Lulu;
- Emery, Ben;
- Cappai, Roberto
Publication type:
Article
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.
Published in:
Nature Medicine, 2012, v. 18, n. 2, p. 291, doi. 10.1038/nm.2613
By:
- Lei, Peng;
- Ayton, Scott;
- Finkelstein, David I;
- Spoerri, Loredana;
- Ciccotosto, Giuseppe D;
- Wright, David K;
- Wong, Bruce X W;
- Adlard, Paul A;
- Cherny, Robert A;
- Lam, Linh Q;
- Roberts, Blaine R;
- Volitakis, Irene;
- Egan, Gary F;
- McLean, Catriona A;
- Cappai, Roberto;
- Duce, James A;
- Bush, Ashley I
Publication type:
Article
Stereospecific interactions are necessary for Alzheimer's disease amyloid-beta toxicity
Published in:
2009
By:
- Ciccotosto, Giuseppe D.;
- Tew, Deborah;
- Drew, Simon C.;
- Smith, Danielle G.;
- Johanssen, Timothy;
- Lal, Varsha;
- Lau, Tong-Lay;
- Perez, Keyla;
- Curtain, Cyril;
- Wade, John D.;
- Separovic, Frances;
- Masters, Colin L.;
- Smith, Jeffrey P.;
- Barnham, Kevin J.;
- Cappai, Roberto
Publication type:
Abstract
P2-293: Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease
Published in:
2008
By:
- Barnham, Kevin J.;
- Kenche, Vijaya B.;
- Ciccotosto, Giuseppe D.;
- Smith, David P.;
- Tew, Deborah J.;
- Liu, Xiang;
- Perez, Keyla;
- Cranston, Greg;
- Johanssen, Timothy;
- Volitakis, Irene;
- Bush, Ashley I.;
- Masters, Colin L.;
- White, Anthony R.;
- Smith, Jeffrey P.;
- Cherny, Robert A.;
- Cappai, Roberto
Publication type:
Abstract
P3-357: Abeta redox chemistry and neurotoxicity
Published in:
2006
By:
- Barnham, Kevin J.;
- Smith, David;
- Smith, Danielle G.;
- Curtain, Cyril C.;
- Boas, John F.;
- Pilbrow, John R.;
- Ciccotosto, Giuseppe D.;
- Lau, Tong-Lay;
- Tew, Deborah J.;
- Perez, Keyla;
- Drew, Simon C.;
- Separovic, Frances;
- Wade, John D.;
- Cherny, Robert A.;
- Bush, Ashley I.;
- Masters, Colin L.;
- Cappai, Roberto
Publication type:
Abstract
P3-357: Abeta redox chemistry and neurotoxicity
Published in:
2006
By:
- Barnham, Kevin J.;
- Smith, David;
- Smith, Danielle G.;
- Curtain, Cyril C.;
- Boas, John F.;
- Pilbrow, John R.;
- Ciccotosto, Giuseppe D.;
- Lau, Tong-Lay;
- Tew, Deborah J.;
- Perez, Keyla;
- Drew, Simon C.;
- Separovic, Frances;
- Wade, John D.;
- Cherny, Robert A.;
- Bush, Ashley I.;
- Masters, Colin L.;
- Cappai, Roberto
Publication type:
Abstract
Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein.
Published in:
PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061246
By:
- Tan, Jiang-Li;
- Li, Qiao-Xin;
- Ciccotosto, Giuseppe D.;
- Crouch, Peter John;
- Culvenor, Janetta Gladys;
- White, Anthony Robert;
- Evin, Genevieve
Publication type:
Article
Amyloid Precursor Protein Is Required for Normal Function of the Rod and Cone Pathways in the Mouse Retina.
Published in:
PLoS ONE, 2012, v. 7, n. 1, p. 1, doi. 10.1371/journal.pone.0029892
By:
- Ho, Tracy;
- Vessey, Kirstan A.;
- Cappai, Roberto;
- Dinet, Virginie;
- Mascarelli, Frédéric;
- Ciccotosto, Giuseppe D.;
- Fletcher, Erica L.
Publication type:
Article
A domain level interaction network of amyloid precursor protein and Aβ of Alzheimer's disease.
Published in:
Proteomics, 2010, v. 10, n. 12, p. 2377, doi. 10.1002/pmic.200900773
By:
- Perreau, Victoria M.;
- Orchard, Sandra;
- Adlard, Paul A.;
- Bellingham, Shayne A.;
- Cappai, Roberto;
- Ciccotosto, Giuseppe D.;
- Cowie, Tiffany F.;
- Crouch, Peter J.;
- Duce, James A.;
- Evin, Genevieve;
- Faux, Noel G.;
- Hill, Andrew F.;
- Hung, Ya Hui;
- James, Simon A.;
- Li, Qiao-Xin;
- Mok, Su San;
- Tew, Deborah J.;
- White, Anthony R.;
- Bush, Ashley I.;
- Hermjakob, Henning
Publication type:
Article
Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 4, p. 1494, doi. 10.1523/JNEUROSCI.4675-09.2010
By:
- Harikrishnan, K. N.;
- Bayles, Richard;
- Ciccotosto, Giuseppe D.;
- Maxwell, Scott;
- Cappai, Roberto;
- Pelka, Gregory J.;
- Tam, Patrick P. L.;
- Christodoulou, John;
- El-Osta, Assam
Publication type:
Article
Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity.
Published in:
Journal of Neuroscience, 2008, v. 28, n. 46, p. 11950, doi. 10.1523/JNEUROSCI.3916-08.2008
By:
- Lin Wai Hung;
- Ciccotosto, Giuseppe D.;
- Giannakis, Eleni;
- Tew, Deborah J.;
- Perez, Keyla;
- Masters, Colin L.;
- Cappai, Roberto;
- Wade, John D.;
- Barnham, Kevin J.
Publication type:
Article
Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid-β<sub>1-42</sub>.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 3, p. 672, doi. 10.1523/JNEUROSCI.4276-04.2005
By:
- Crouch, Peter J.;
- Blake, Rachel;
- Duce, James A.;
- Ciccotosto, Giuseppe D.;
- Qiao-Xin Li;
- Barnham, Kevin J.;
- Curtain, Cyril C.;
- Cherny, Robert A.;
- Cappai, Roberto;
- Dyrks, Thomas;
- Masters, Colin L.;
- Trounce, Ian A.
Publication type:
Article
Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.
Published in:
Cellular & Molecular Life Sciences, 2021, v. 78, n. 19/20, p. 6605, doi. 10.1007/s00018-021-03924-5
By:
- Truong, Phan H.;
- Crouch, Peter J.;
- Hilton, James B. W.;
- McLean, Catriona A.;
- Cappai, Roberto;
- Ciccotosto, Giuseppe D.
Publication type:
Article
Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue.
Published in:
Metallomics, 2014, v. 6, n. 10, p. 1894, doi. 10.1039/c4mt00176a
By:
- Ciccotosto, Giuseppe D.;
- James, Simon A.;
- Altissimo, Matteo;
- Paterson, David;
- Vogt, Stefan;
- Lai, Barry;
- de Jonge, Martin D.;
- Howard, Daryl L.;
- Bush, Ashley I.;
- Cappai, Roberto
Publication type:
Article
Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.
Published in:
Metallomics, 2014, v. 6, n. 3, p. 598, doi. 10.1039/c3mt00358b
By:
- Needham, B. Elise;
- Ciccotosto, Giuseppe D.;
- Cappai, Roberto
Publication type:
Article
Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex.
Published in:
Neurochemical Research, 2019, v. 44, n. 6, p. 1356, doi. 10.1007/s11064-018-2669-6
By:
- Truong, Phan H.;
- Ciccotosto, Giuseppe D.;
- Cappai, Roberto
Publication type:
Article
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β-amyloid.
Published in:
FASEB Journal, 2004, v. 18, n. 12, p. 1427, doi. 10.1096/fj.04-1890fje
By:
- Barnham, Kevin J.;
- Haeffner, Fredrik;
- Ciccotosto, Giuseppe D.;
- Curtain, Cyril C.;
- Tew, Deborah;
- Mavros, Christine;
- Beyreuther, Konrad;
- Carrington, Darryl;
- Masters, Colin L.;
- Cherny, Robert A.;
- Cappai, Roberto;
- Bush, Ashley I.
Publication type:
Article
Membrane-bound tetramer and trimer Aβ oligomeric species correlate with toxicity towards cultured neurons.
Published in:
Journal of Neurochemistry, 2016, v. 136, n. 3, p. 594, doi. 10.1111/jnc.13443
By:
- Jana, Metta K.;
- Cappai, Roberto;
- Pham, Chi L. L.;
- Ciccotosto, Giuseppe D.
Publication type:
Article
Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death.
Published in:
Cell Death & Disease, 2019, v. 10, n. 3, p. 1, doi. 10.1038/s41419-019-1445-0
By:
- Hoque, Ashfaqul;
- Williamson, Nicholas A.;
- Ameen, S. Sadia;
- Ciccotosto, Giuseppe D.;
- Hossain, M. Iqbal;
- Oakhill, Jonathan S.;
- Ng, Dominic C. H.;
- Ang, Ching-Seng;
- Cheng, Heung-Chin
Publication type:
Article
Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics.
Published in:
Molecular Brain, 2016, v. 9, p. 1, doi. 10.1186/s13041-016-0245-z
By:
- Dinet, Virginie;
- Ciccotosto, Giuseppe D.;
- Delaunay, Kimberley;
- Borras, Céline;
- Ranchon-Cole, Isabelle;
- Kostic, Corinne;
- Savoldelli, Michèle;
- El Sanharawi, Mohamed;
- Jonet, Laurent;
- Pirou, Caroline;
- Na An;
- Abitbol, Marc;
- Arsenijevic, Yvan;
- Behar-Cohen, Francine;
- Cappai, Roberto;
- Mascarelli, Frédéric
Publication type:
Article
Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses.
Published in:
Nature Neuroscience, 2009, v. 12, n. 12, p. 1567, doi. 10.1038/nn.2433
By:
- Abramov, Efrat;
- Dolev, Iftach;
- Fogel, Hilla;
- Ciccotosto, Giuseppe D.;
- Ruff, Eyal;
- Slutsky, Inna
Publication type:
Article
Chronic Oral Inoculation of Porphyromonas gingivalis and Treponema denticola Induce Different Brain Pathologies in a Mouse Model of Alzheimer Disease.
Published in:
Journal of Infectious Diseases, 2024, v. 230, p. S109, doi. 10.1093/infdis/jiae286
By:
- Ciccotosto, Giuseppe D;
- Mohammed, Ali I;
- Paolini, Rita;
- Bijlsma, Elly;
- Toulson, Su;
- Holden, James;
- Reynolds, Eric C;
- Dashper, Stuart G;
- Butler, Catherine A
Publication type:
Article
Bacterial Membrane Vesicles: The Missing Link Between Bacterial Infection and Alzheimer Disease.
Published in:
Journal of Infectious Diseases, 2024, v. 230, p. S87, doi. 10.1093/infdis/jiae228
By:
- Butler, Catherine A;
- Ciccotosto, Giuseppe D;
- Rygh, Nathaniel;
- Bijlsma, Elly;
- Dashper, Stuart G;
- Brown, Angela C
Publication type:
Article
Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts.
Published in:
Journal of Neurochemistry, 2004, v. 91, n. 2, p. 423, doi. 10.1111/j.1471-4159.2004.02731.x
By:
- Bellingham, Shayne A.;
- Ciccotosto, Giuseppe D.;
- Needham, B. Elise;
- Fodero, Lisa R.;
- White, Anthony R.;
- Masters, Colin L.;
- Cappai, Roberto;
- Camakaris, James
Publication type:
Article
Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.
Published in:
Molecular Neurobiology, 2019, v. 56, n. 1, p. 13, doi. 10.1007/s12035-018-1070-4
By:
- Luu, Luan;
- Ciccotosto, Giuseppe D.;
- Vella, Laura J.;
- Cheng, Lesley;
- Roisman, Laila C.;
- Multhaup, Gerhard;
- Hill, Andrew F.;
- Munter, Lisa-Marie;
- Cappai, Roberto
Publication type:
Article
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Published in:
Molecular Neurobiology, 2018, v. 55, n. 1, p. 421, doi. 10.1007/s12035-016-0276-6
By:
- Dai, Chongshan;
- Ciccotosto, Giuseppe D.;
- Cappai, Roberto;
- Tang, Shusheng;
- Li, Daowen;
- Xie, Sanlei;
- Xiao, Xilong;
- Velkov, Tony
Publication type:
Article
Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress.
Published in:
2017
By:
- Chongshan Dai;
- Ciccotosto, Giuseppe D.;
- Cappai, Roberto;
- Yang Wang;
- Shusheng Tang;
- Xilong Xiao;
- Velkov, Tony;
- Dai, Chongshan;
- Wang, Yang;
- Tang, Shusheng;
- Xiao, Xilong
Publication type:
journal article
A domain level interaction network of amyloid precursor protein and Aβ of Alzheimer's disease.
Published in:
Proteomics - Clinical Applications, 2010, v. 4, n. 10/11, p. 851, doi. 10.1002/prca.201090068
By:
- Perreau, Victoria M.;
- Orchard, Sandra;
- Adlard, Paul A.;
- Bellingham, Shayne A.;
- Cappai, Roberto;
- Ciccotosto, Giuseppe D.;
- Cowie, Tiffany F.;
- Crouch, Peter J.;
- Duce, James A.;
- Evin, Genevieve;
- Faux, Noel G.;
- Hill, Andrew F.;
- Hung, Ya Hui;
- James, Simon A.;
- Li, Qiao-Xin;
- Mok, Su San;
- Tew, Deborah J.;
- White, Anthony R.;
- Bush, Ashley I.;
- Hermjakob, Henning
Publication type:
Article

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