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Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
Published in:
Biochemical Journal, 2022, v. 479, n. 3, p. 401, doi. 10.1042/BCJ20210615
By:
- Clerk, Angela;
- Meijles, Daniel N.;
- Hardyman, Michelle A.;
- Fuller, Stephen J.;
- Chothani, Sonia P.;
- Cull, Joshua J.;
- Cooper, Susanna T. E.;
- Alharbi, Hajed O.;
- Vanezis, Konstantinos;
- Felkin, Leanne E.;
- Markou, Thomais;
- Leonard, Samuel J.;
- Shaw, Spencer W.;
- Rackham, Owen J. L.;
- Cook, Stuart A.;
- Glennon, Peter E.;
- Sheppard, Mary N.;
- Sembrat, John C.;
- Rojas, Mauricio;
- McTiernan, Charles F.
Publication type:
Article
Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease.
Published in:
FASEB Journal, 2020, v. 34, n. 9, p. 11802, doi. 10.1096/fj.202001045RR
By:
- Ng, Benjamin;
- Jinrui Dong;
- Viswanathan, Sivakumar;
- Widjaja, Anissa A.;
- Paleja, Bhairav S.;
- Adami, Eleonora;
- Ko, Nicole S. J.;
- Mao Wang;
- Lim, Stella;
- Tan, Jessie;
- Chothani, Sonia P.;
- Albani, Salvatore;
- Schafer, Sebastian;
- Cook, Stuart A.
Publication type:
Article
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.
Published in:
Science Translational Medicine, 2019, v. 11, n. 511, p. 1, doi. 10.1126/scitranslmed.aaw1237
By:
- Ng, Benjamin;
- Dong, Jinrui;
- D'Agostino, Giuseppe;
- Viswanathan, Sivakumar;
- Widjaja, Anissa A.;
- Lim, Wei-Wen;
- Ko, Nicole S. J.;
- Tan, Jessie;
- Chothani, Sonia P.;
- Huang, Benjamin;
- Xie, Chen;
- Pua, Chee Jian;
- Chacko, Ann-Marie;
- Guimarães-Camboa, Nuno;
- Evans, Sylvia M.;
- Byrne, Adam J.;
- Maher, Toby M.;
- Liang, Jiurong;
- Jiang, Dianhua;
- Noble, Paul W.
Publication type:
Article
Differences in 5'untranslated regions highlight the importance of translational regulation of dosage sensitive genes.
Published in:
Genome Biology, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s13059-024-03248-0
By:
- Wieder, Nechama;
- D'Souza, Elston N.;
- Martin-Geary, Alexandra C.;
- Lassen, Frederik H.;
- Talbot-Martin, Jonathan;
- Fernandes, Maria;
- Chothani, Sonia P.;
- Rackham, Owen J. L.;
- Schafer, Sebastian;
- Aspden, Julie L.;
- MacArthur, Daniel G.;
- Davies, Robert W.;
- Whiffin, Nicola
Publication type:
Article
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-93623-9
By:
- Ng, Benjamin;
- Widjaja, Anissa A.;
- Viswanathan, Sivakumar;
- Dong, Jinrui;
- Chothani, Sonia P.;
- Lim, Stella;
- Shekeran, Shamini G.;
- Tan, Jessie;
- McGregor, Narelle E.;
- Walker, Emma C.;
- Sims, Natalie A.;
- Schafer, Sebastian;
- Cook, Stuart A.
Publication type:
Article
Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.
Published in:
Human Molecular Genetics, 2019, v. 28, n. 12, p. 1971, doi. 10.1093/hmg/ddz033
By:
- Zhou, Jin;
- Ng, Benjamin;
- Ko, Nicole S J;
- Fiedler, Lorna R;
- Khin, Ester;
- Lim, Andrea;
- Sahib, Norliza E;
- Wu, Yajun;
- Chothani, Sonia P;
- Schafer, Sebastian;
- Bay, Boon-Huat;
- Sinha, Rohit A;
- Cook, Stuart A;
- Yen, Paul M
Publication type:
Article
Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo.
Published in:
Clinical Science, 2024, v. 138, n. 10, p. 573, doi. 10.1042/CS20240496
By:
- Cull, Joshua J.;
- Cooper, Susanna T. E.;
- Alharbi, Hajed O.;
- Chothani, Sonia P.;
- Rackham, Owen J. L.;
- Meijles, Daniel N.;
- Dash, Philip R.;
- Kerkelä, Risto;
- Ruparelia, Neil;
- Sugden, Peter H.;
- Clerk, Angela
Publication type:
Article
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
Published in:
Science Translational Medicine, 2021, v. 13, n. 597, p. 1, doi. 10.1126/scitranslmed.aba8146
By:
- Widjaja, Anissa A.;
- Dong, Jinrui;
- Adami, Eleonora;
- Viswanathan, Sivakumar;
- Ng, Benjamin;
- Pakkiri, Leroy S.;
- Chothani, Sonia P.;
- Singh, Brijesh K.;
- Lim, Wei Wen;
- Zhou, Jin;
- Shekeran, Shamini G.;
- Tan, Jessie;
- Lim, Sze Yun;
- Goh, Joyce;
- Wang, Mao;
- Holgate, Robert;
- Hearn, Arron;
- Felkin, Leanne E.;
- Yen, Paul M.;
- Dear, James W.
Publication type:
Article
LASER server: ancestry tracing with genotypes or sequence reads.
Published in:
Bioinformatics, 2017, v. 33, n. 13, p. 2056, doi. 10.1093/bioinformatics/btx075
By:
- Taliun, Daniel;
- Chothani, Sonia P.;
- Schönherr, Sebastian;
- Forer, Lukas;
- Boehnke, Michael;
- Abecasis, Gonçalo R.;
- Chaolong Wang
Publication type:
Article
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20303-z
By:
- Dong, Jinrui;
- Viswanathan, Sivakumar;
- Adami, Eleonora;
- Singh, Brijesh K.;
- Chothani, Sonia P.;
- Ng, Benjamin;
- Lim, Wei Wen;
- Zhou, Jin;
- Tripathi, Madhulika;
- Ko, Nicole S. J.;
- Shekeran, Shamini G.;
- Tan, Jessie;
- Lim, Sze Yun;
- Wang, Mao;
- Lio, Pei Min;
- Yen, Paul M.;
- Schafer, Sebastian;
- Cook, Stuart A.;
- Widjaja, Anissa A.
Publication type:
Article

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