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Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer.
Published in:
Nucleic Acids Research, 2010, v. 38, n. 20, p. 6985, doi. 10.1093/nar/gkq579
By:
- Chmielecki, Juliann;
- Peifer, Martin;
- Jia, Peilin;
- Socci, Nicholas D.;
- Hutchinson, Katherine;
- Viale, Agnes;
- Zhao, Zhongming;
- Thomas, Roman K.;
- Pao, William
Publication type:
Article
Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22057-8
By:
- Vaclova, Tereza;
- Grazini, Ursula;
- Ward, Lewis;
- O'Neill, Daniel;
- Markovets, Aleksandra;
- Huang, Xiangning;
- Chmielecki, Juliann;
- Hartmaier, Ryan;
- Thress, Kenneth S.;
- Smith, Paul D.;
- Barrett, J. Carl;
- Downward, Julian;
- de Bruin, Elza C.
Publication type:
Article
Anchored multiplex PCR for targeted next-generation sequencing.
Published in:
Nature Medicine, 2014, v. 20, n. 12, p. 1479, doi. 10.1038/nm.3729
By:
- Zheng, Zongli;
- Liebers, Matthew;
- Zhelyazkova, Boryana;
- Cao, Yi;
- Panditi, Divya;
- Lynch, Kerry D;
- Chen, Juxiang;
- Robinson, Hayley E;
- Shim, Hyo Sup;
- Chmielecki, Juliann;
- Pao, William;
- Engelman, Jeffrey A;
- Iafrate, A John;
- Le, Long Phi
Publication type:
Article
Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.
Published in:
Nature Genetics, 2013, v. 45, n. 2, p. 131, doi. 10.1038/ng.2522
By:
- Chmielecki, Juliann;
- Crago, Aimee M;
- Rosenberg, Mara;
- O'Connor, Rachael;
- Walker, Sarah R;
- Ambrogio, Lauren;
- Auclair, Daniel;
- McKenna, Aaron;
- Heinrich, Michael C;
- Frank, David A;
- Meyerson, Matthew
Publication type:
Article
A phase Ib study of adavosertib, a selective Wee1 inhibitor, in patients with locally advanced or metastatic solid tumors.
Published in:
Investigational New Drugs, 2023, v. 41, n. 3, p. 493, doi. 10.1007/s10637-023-01371-6
By:
- Falchook, Gerald S;
- Sachdev, Jasgit;
- Imedio, Esteban Rodrigo;
- Kumar, Sanjeev;
- Mugundu, Ganesh M;
- Jenkins, Suzanne;
- Chmielecki, Juliann;
- Jones, Suzanne;
- Spigel, David R;
- Johnson, Melissa
Publication type:
Article
Biomarker-Directed Phase II Platform Study in Patients With EGFR Sensitizing Mutation-Positive Advanced/Metastatic Non-Small Cell Lung Cancer Whose Disease Has Progressed on First-Line Osimertinib Therapy (ORCHARD).
Published in:
Clinical Lung Cancer, 2021, v. 22, n. 6, p. 601, doi. 10.1016/j.cllc.2021.06.006
By:
- Yu, Helena A.;
- Goldberg, Sarah B.;
- Le, Xiuning;
- Piotrowska, Zofia;
- Goldman, Jonathan W.;
- De Langen, Adrianus J.;
- Okamoto, Isamu;
- Cho, Byoung Chul;
- Smith, Paul;
- Mensi, Ilhem;
- Ambrose, Helen;
- Kraljevic, Silvija;
- Maidment, Julie;
- Chmielecki, Juliann;
- Li-Sucholeiki, Xiaocheng;
- Doughton, Gail;
- Patel, Gargi;
- Jewsbury, Phil;
- Szekeres, Phil;
- Riess, Jonathan W.
Publication type:
Article
Author Correction: Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.
Published in:
2023
By:
- Chmielecki, Juliann;
- Gray, Jhanelle E.;
- Cheng, Ying;
- Ohe, Yuichiro;
- Imamura, Fumio;
- Cho, Byoung Chul;
- Lin, Meng-Chih;
- Majem, Margarita;
- Shah, Riyaz;
- Rukazenkov, Yuri;
- Todd, Alexander;
- Markovets, Aleksandra;
- Barrett, J. Carl;
- Hartmaier, Ryan J.;
- Ramalingam, Suresh S.
Publication type:
Correction Notice
A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in <i>U2AF1</i> Reveals Commonly Altered Splicing Events.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0087361
By:
- Brooks, Angela N.;
- Choi, Peter S.;
- de Waal, Luc;
- Sharifnia, Tanaz;
- Imielinski, Marcin;
- Saksena, Gordon;
- Pedamallu, Chandra Sekhar;
- Sivachenko, Andrey;
- Rosenberg, Mara;
- Chmielecki, Juliann;
- Lawrence, Michael S.;
- DeLuca, David S.;
- Getz, Gad;
- Meyerson, Matthew
Publication type:
Article
Comprehensive genomic profiling of inflammatory breast cancer cases reveals a high frequency of clinically relevant genomic alterations.
Published in:
Breast Cancer Research & Treatment, 2015, v. 154, n. 1, p. 155, doi. 10.1007/s10549-015-3592-z
By:
- Ross, Jeffrey;
- Ali, Siraj;
- Wang, Kai;
- Khaira, Depinder;
- Palma, Norma;
- Chmielecki, Juliann;
- Palmer, Gary;
- Morosini, Deborah;
- Elvin, Julia;
- Fernandez, Sandra;
- Miller, Vincent;
- Stephens, Philip;
- Cristofanilli, Massimo
Publication type:
Article
Meningioma transcription factors link cell lineage with systemic metabolic cues.
Published in:
Neuro-Oncology, 2018, v. 20, n. 10, p. 1331, doi. 10.1093/neuonc/noy057
By:
- Du, Ziming;
- Brewster, Ryan;
- Merrill, Parker H;
- Chmielecki, Juliann;
- Francis, Josh;
- Aizer, Ayal;
- Abedalthagafi, Malak;
- Sholl, Lynette M;
- Geffers, Lars;
- Alexander, Brian
Publication type:
Article
Longitudinal Circulating Tumor DNA Modeling to Predict Disease Progression in First‐Line Mutant Epidermal Growth Factor Receptor Non‐Small Cell Lung Cancer.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 2, p. 349, doi. 10.1002/cpt.3113
By:
- Johnson, Martin;
- Serra Traynor, Carlos;
- Vishwanathan, Karthick;
- Overend, Philip;
- Hartmaier, Ryan;
- Markovets, Aleksandra;
- Chmielecki, Juliann;
- Mugundu, Ganesh M.;
- Barrett, J. Carl;
- Tomkinson, Helen;
- Ramalingam, Suresh S.
Publication type:
Article
The distribution of BRAF gene fusions in solid tumors and response to targeted therapy.
Published in:
International Journal of Cancer, 2016, v. 138, n. 4, p. 881, doi. 10.1002/ijc.29825
By:
- Ross, Jeffrey S.;
- Wang, Kai;
- Chmielecki, Juliann;
- Gay, Laurie;
- Johnson, Adrienne;
- Chudnovsky, Jacob;
- Yelensky, Roman;
- Lipson, Doron;
- Ali, Siraj M;
- Elvin, Julia A.;
- Vergilio, Jo‐Anne;
- Roels, Steven;
- Miller, Vincent A;
- Nakamura, Brooke N.;
- Gray, Adam;
- Wong, Michael K;
- Stephens, Philip J
Publication type:
Article
Optimization of Dosing for EGFR-Mutant Non-Small Cell Lung Cancer with Evolutionary Cancer Modeling.
Published in:
Science Translational Medicine, 2011, v. 3, n. 90, p. 1, doi. 10.1126/scitranslmed.3002356
By:
- Chmielecki, Juliann;
- Jasmine Foo;
- Oxnard, Geoffrey R.;
- Hutchinson, Katherine;
- Ohashi, Kadoaki;
- Somwar, Romel;
- Lu Wang;
- Amato, Katherine R.;
- Arcila, Maria;
- Sos, Martin L.;
- Socci, Nicholas D.;
- Viale, Agnes;
- de Stanchina, Elisa;
- Ginsberg, Michelle S.;
- Thomas, Roman K.;
- Kris, Mark G.;
- Inoue, Akira;
- Ladanyi, Marc;
- Miller, Vincent A.;
- Michor, Franziska
Publication type:
Article
FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors.
Published in:
Journal of Translational Medicine, 2016, v. 14, p. 1, doi. 10.1186/s12967-016-1075-6
By:
- Shi, Eileen;
- Chmielecki, Juliann;
- Chih-Min Tang;
- Kai Wang;
- Heinrich, Michael C.;
- Corless, Christopher L.;
- Hong, David;
- Fero, Katherine E.;
- Murphy, James D.;
- Fanta, Paul T.;
- Ali, Siraj M.;
- De Siena, Martina;
- Burgoyne, Adam M.;
- Movva, Sujana;
- Madlensky, Lisa;
- Heestand, Gregory M.;
- Trent, Jonathan C.;
- Kurzrock, Razelle;
- Morosini, Deborah;
- Ross, Jeffrey S.
Publication type:
Article
Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis.
Published in:
Genes, Chromosomes & Cancer, 2015, v. 54, n. 10, p. 606, doi. 10.1002/gcc.22272
By:
- Crago, Aimee M.;
- Chmielecki, Juliann;
- Rosenberg, Mara;
- O'Connor, Rachael;
- Byrne, Caitlin;
- Wilder, Fatima G.;
- Thorn, Katherine;
- Agius, Phaedra;
- Kuk, Deborah;
- Socci, Nicholas D.;
- Qin, Li‐Xuan;
- Meyerson, Matthew;
- Hameed, Meera;
- Singer, Samuel
Publication type:
Article
Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.
Published in:
Genes, Chromosomes & Cancer, 2012, v. 51, n. 1, p. 54, doi. 10.1002/gcc.20930
By:
- Chmielecki, Juliann;
- Peifer, Martin;
- Viale, Agnes;
- Hutchinson, Katherine;
- Giltnane, Jennifer;
- Socci, Nicholas D.;
- Hollis, Clayton J.;
- Dean, Rebecca S.;
- Yenamandra, Ashwini;
- Jagasia, Madan;
- Kim, Annette S.;
- Davé, Utpal P.;
- Thomas, Roman K.;
- Pao, William
Publication type:
Article
STUMP un"stumped": anti-tumor response to anaplastic lymphoma kinase (ALK) inhibitor based targeted therapy in uterine inflammatory myofibroblastic tumor with myxoid features harboring DCTN1-ALK fusion.
Published in:
Journal of Hematology & Oncology, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13045-015-0160-2
By:
- Subbiah, Vivek;
- McMahon, Caitlin;
- Patel, Shreyaskumar;
- Zinner, Ralph;
- Silva, Elvio G.;
- Elvin, Julia A.;
- Subbiah, Ishwaria M.;
- Ohaji, Chimela;
- Ganeshan, Dhakshina Moorthy;
- Anand, Deepa;
- Levenback, Charles F.;
- Berry, Jenny;
- Brennan, Tim;
- Chmielecki, Juliann;
- Chalmers, Zachary R.;
- Mayfield, John;
- Miller, Vincent A.;
- Stephens, Philip J.;
- Ross, Jeffrey S.;
- Ali, Siraj M.
Publication type:
Article
A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors.
Published in:
Targeted Oncology, 2023, v. 18, n. 4, p. 517, doi. 10.1007/s11523-023-00965-7
By:
- Bauer, Todd M.;
- Moore, Kathleen N.;
- Rader, Janet S.;
- Simpkins, Fiona;
- Mita, Alain C.;
- Beck, J. Thaddeus;
- Hart, Lowell;
- Chu, Quincy;
- Oza, Amit;
- Tinker, Anna V.;
- Imedio, Esteban Rodrigo;
- Kumar, Sanjeev;
- Mugundu, Ganesh;
- Jenkins, Suzanne;
- Chmielecki, Juliann;
- Jones, Suzanne;
- Spigel, David;
- Fu, Siqing
Publication type:
Article
Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies.
Published in:
2016
By:
- Ross, Jeffrey S.;
- Gay, Laurie M.;
- Wang, Kai;
- Ali, Siraj M.;
- Chumsri, Saranya;
- Elvin, Julia A.;
- Bose, Ron;
- Vergilio, Jo‐Anne;
- Suh, James;
- Yelensky, Roman;
- Lipson, Doron;
- Chmielecki, Juliann;
- Waintraub, Stanley;
- Leyland‐Jones, Brian;
- Miller, Vincent A.;
- Stephens, Philip J.
Publication type:
journal article
Comprehensive Genomic Profiling of Clinically Advanced Medullary Thyroid Carcinoma.
Published in:
Oncology, 2016, v. 90, n. 6, p. 339, doi. 10.1159/000445978
By:
- Heilmann, andreas M.;
- Subbiah, Vivek;
- Wang, Kai;
- Sun, James X.;
- Elvin, Julia a.;
- Chmielecki, Juliann;
- Sherman, Steven I.;
- Murthy, Ravi;
- Busaidy, Naifa L.;
- Subbiah, Ishwaria;
- Yelensky, Roman;
- Nangia, Chaitali;
- Vergilio, Jo-anne;
- Khan, Saad a.;
- Erlich, Rachel L.;
- Lipson, Doron;
- Ross, Jeffrey S.;
- Miller, Vincent a.;
- Shah, Manisha H.;
- ali, Siraj M.
Publication type:
Article
Comprehensive Genomic Profiling Facilitates Implementation of the National Comprehensive Cancer Network Guidelines for Lung Cancer Biomarker Testing and Identifies Patients Who May Benefit From Enrollment in Mechanism-Driven Clinical Trials.
Published in:
Oncologist, 2016, v. 21, n. 6, p. 684, doi. 10.1634/theoncologist.2016-0030
By:
- Suh, James H.;
- Johnson, Adrienne;
- Albacker, Lee;
- Wang, Kai;
- Chmielecki, Juliann;
- Frampton, Garrett;
- Gay, Laurie;
- Elvin, Julia A.;
- Vergilio, Jo‐Anne;
- Ali, Siraj;
- Miller, Vincent A.;
- Stephens, Philip J.;
- Ross, Jeffrey S.
Publication type:
Article
Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-ResponsiveALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization.
Published in:
Oncologist, 2016, v. 21, n. 6, p. 762, doi. 10.1634/theoncologist.2015-0497
By:
- Ali, Siraj M.;
- Hensing, Thomas;
- Schrock, Alexa B.;
- Allen, Justin;
- Sanford, Eric;
- Gowen, Kyle;
- Kulkarni, Atul;
- He, Jie;
- Suh, James H.;
- Lipson, Doron;
- Elvin, Julia A.;
- Yelensky, Roman;
- Chalmers, Zachary;
- Chmielecki, Juliann;
- Peled, Nir;
- Klempner, Samuel J.;
- Firozvi, Kashif;
- Frampton, Garrett M.;
- Molina, Julian R.;
- Menon, Smitha
Publication type:
Article
Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations.
Published in:
Oncologist, 2016, v. 21, n. 1, p. 33, doi. 10.1634/theoncologist.2015-0241
By:
- Ali, Siraj M.;
- Pal, Sumanta K.;
- Wang, Kai;
- Palma, Norma A.;
- Sanford, Eric;
- Bailey, Mark;
- He, Jie;
- Elvin, Julia A.;
- Chmielecki, Juliann;
- Squillace, Rachel;
- Dow, Edward;
- Morosini, Deborah;
- Buell, Jamie;
- Yelensky, Roman;
- Lipson, Doron;
- Frampton, Garrett M.;
- Howley, Peter;
- Ross, Jeffrey S.;
- Stephens, Philip J.;
- Miller, Vincent A.
Publication type:
Article
Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences.
Published in:
Oncologist, 2015, v. 20, n. 10, p. 1132, doi. 10.1634/theoncologist.2015-0156
By:
- Wang, Kai;
- Johnson, Adrienne;
- Ali, Siraj M.;
- Klempner, Samuel J.;
- Bekaii‐Saab, Tanios;
- Vacirca, Jeffrey L.;
- Khaira, Depinder;
- Yelensky, Roman;
- Chmielecki, Juliann;
- Elvin, Julia A.;
- Lipson, Doron;
- Miller, Vincent A.;
- Stephens, Philip J.;
- Ross, Jeffrey S.
Publication type:
Article
Prospective Comprehensive Genomic Profiling of Advanced Gastric Carcinoma Cases Reveals Frequent Clinically Relevant Genomic Alterations and New Routes for Targeted Therapies.
Published in:
Oncologist, 2015, v. 20, n. 5, p. 499, doi. 10.1634/theoncologist.2014-0378
By:
- Ali, Siraj M.;
- Sanford, Eric M.;
- Klempner, Samuel J.;
- Rubinson, Douglas A.;
- Wang, Kai;
- Palma, Norma A.;
- Chmielecki, Juliann;
- Yelensky, Roman;
- Palmer, Gary A.;
- Morosini, Deborah;
- Lipson, Doron;
- Catenacci, Daniel V.;
- Braiteh, Fadi;
- Erlich, Rachel;
- Stephens, Philip J.;
- Ross, Jeffrey S.;
- Ou, Sai‐Hong Ignatius;
- Miller, Vincent A.
Publication type:
Article
OncogenicAlterations in ERBB2/HER2Represent Potential Therapeutic Targets Across Tumors From Diverse Anatomic Sites of Origin.
Published in:
Oncologist, 2015, v. 20, n. 1, p. 7, doi. 10.1634/theoncologist.2014-0234
By:
- Chmielecki, Juliann;
- Ross, Jeffrey S.;
- Wang, Kai;
- Frampton, Garrett M.;
- Palmer, Gary A.;
- Ali, Siraj M.;
- Palma, Norma;
- Morosini, Deborah;
- Miller, Vincent A.;
- Yelensky, Roman;
- Lipson, Doron;
- Stephens, Philip J.
Publication type:
Article
A metastatic colon adenocarcinoma harboring BRAF V600E has a durable major response to dabrafenib/trametinib and chemotherapy.
Published in:
OncoTargets & Therapy, 2015, v. 8, p. 3561, doi. 10.2147/OTT.S90766
By:
- Williams, Casey B.;
- Mc Mahon, Caitlin;
- Ali, Siraj M.;
- Abramovitz, Mark;
- Williams, Kirstin A.;
- Klein, Jessica;
- McKean, Heidi;
- Yelensky, Roman;
- George Jr., Thomas J.;
- Elvin, Julia A.;
- Soman, Salil;
- Lipson, Doron;
- Chmielecki, Juliann;
- Morosini, Deborah;
- Miller, Vincent A.;
- Stephens, Philip J.;
- Ross, Jeffrey S.;
- Leyland-Jones, Brian
Publication type:
Article
Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas.
Published in:
PLoS Medicine, 2007, v. 4, n. 10, p. e294, doi. 10.1371/journal.pmed.0040294
By:
- Yixuan Gong;
- Somwar, Romel;
- Politi, Katerina;
- Balak, Marissa;
- Chmielecki, Juliann;
- Xuejun Jiang;
- Pao, William
Publication type:
Article
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer.
Published in:
2010
By:
- Pao, William;
- Chmielecki, Juliann
Publication type:
journal article
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.
Published in:
Genome Medicine, 2017, v. 9, p. 1, doi. 10.1186/s13073-017-0424-2
By:
- Chalmers, Zachary R.;
- Connelly, Caitlin F.;
- Fabrizio, David;
- Gay, Laurie;
- Ali, Siraj M.;
- Ennis, Riley;
- Schrock, Alexa;
- Campbell, Brittany;
- Shlien, Adam;
- Chmielecki, Juliann;
- Huang, Franklin;
- Yuting He;
- Sun, James;
- Tabori, Uri;
- Kennedy, Mark;
- Lieber, Daniel S.;
- Roels, Steven;
- White, Jared;
- Otto, Geoffrey A.;
- Ross, Jeffrey S.
Publication type:
Article
Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies.
Published in:
Genome Medicine, 2017, v. 9, p. 1, doi. 10.1186/s13073-017-0408-2
By:
- Hartmaier, Ryan J.;
- Charo, Jehad;
- Fabrizio, David;
- Goldberg, Michael E.;
- Albacker, Lee A.;
- Pao, William;
- Chmielecki, Juliann
Publication type:
Article
Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion.
Published in:
PLoS ONE, 2017, v. 12, n. 11, p. 1, doi. 10.1371/journal.pone.0176181
By:
- Albacker, Lee A.;
- Wu, Jeremy;
- Smith, Peter;
- Warmuth, Markus;
- Stephens, Philip J.;
- Zhu, Ping;
- Yu, Lihua;
- Chmielecki, Juliann
Publication type:
Article

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