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The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
- Published in:
- Journal of Neurochemistry, 2011, v. 119, n. 1, p. 220, doi. 10.1111/j.1471-4159.2011.07402.x
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- Publication type:
- Article
Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation.
- Published in:
- Journal of Neurochemistry, 2009, v. 108, n. 5, p. 1198, doi. 10.1111/j.1471-4159.2009.05870.x
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- Publication type:
- Article
The President and the Assassin: McKinley, Terror, and Empire at the Dawn of the American Century - By Scott Miller.
- Published in:
- 2012
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- Publication type:
- Book Review
Decreased serum zinc is an effect of ageing and not Alzheimer's disease.
- Published in:
- Metallomics, 2014, v. 6, n. 7, p. 1216, doi. 10.1039/c4mt00060a
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- Publication type:
- Article
Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain.
- Published in:
- Metallomics, 2010, n. 11, p. 745, doi. 10.1039/c0mt00039f
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- Publication type:
- Article
Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution.
- Published in:
- Journal of Neuroscience Research, 2014, v. 92, n. 6, p. 732, doi. 10.1002/jnr.23349
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- Publication type:
- Article
Copper in the brain and Alzheimer’s disease.
- Published in:
- Journal of Biological Inorganic Chemistry (JBIC), 2010, v. 15, n. 1, p. 61, doi. 10.1007/s00775-009-0600-y
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- Publication type:
- Article
Iron inhibits neurotoxicity induced by trace copper and biological reductants.
- Published in:
- Journal of Biological Inorganic Chemistry (JBIC), 2004, v. 9, n. 3, p. 269, doi. 10.1007/s00775-004-0521-8
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- Publication type:
- Article
Utility of an improved model of amyloid-beta (Aβ<sub>1-42</sub>) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.
- Published in:
- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 57, doi. 10.1186/1750-1326-7-57
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- Publication type:
- Article
Intracellular Accumulation of Detergent-Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice.
- Published in:
- Journal of Neurochemistry, 1999, v. 72, n. 6, p. 2479, doi. 10.1046/j.1471-4159.1999.0722479.x
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- Publication type:
- Article
Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein.
- Published in:
- Journal of Neuroscience, 2015, v. 35, n. 8, p. 3591, doi. 10.1523/JNEUROSCI.3439-14.2015
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- Publication type:
- Article
AN EXPLORATORY MOLECULAR IMAGING STUDY TARGETING Aβ WITH A NOVEL 8-OH QUINOLINE IN ALZHEIMER’S DISEASE (THE PBT2-204 IMAGINE STUDY).
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P417, doi. 10.1016/j.jalz.2016.06.789
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- Publication type:
- Article
Metal chaperones: An integrated approach to the treatment of Alzheimer's disease
- Published in:
- 2012
- By:
- Publication type:
- Abstract
The Alzheimer's therapeutic PBT2 achieves cognitive benefit by combining neuroprotection with neurorestoration: studies in animal models of Alzheimer's disease and Huntington's disease
- Published in:
- 2011
- By:
- Publication type:
- Abstract
Glutaminyl cyclase activity is decreased in Alzheimer's cerebrospinal fluid
- Published in:
- 2011
- By:
- Publication type:
- Abstract
The role of autophagy in potentially therapeutic copper complexes
- Published in:
- 2009
- By:
- Publication type:
- Abstract
P3-396: Zinc transport across SH-SY5Y plasma membranes
- Published in:
- 2008
- By:
- Publication type:
- Abstract
P2-416: Clioquinol mediates the cellular uptake of Alzheimer's disease amyloid-β peptide and copper
- Published in:
- 2008
- By:
- Publication type:
- Abstract
P2-293: Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease
- Published in:
- 2008
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- Publication type:
- Abstract
P2-292: Second generation MPAC PBT2 inhibits tau phosphorylation and promotes Aβ degradation
- Published in:
- 2008
- By:
- Publication type:
- Abstract
O3-05-04: The 8-hydroxyquinoline analog PBT2 rapidly restores cognition and reduces soluble Abeta in Alzheimer transgenic mice
- Published in:
- 2008
- By:
- Publication type:
- Abstract
P4-435: PBT2, a novel MPAC for the treatment of Alzheimer’s disease
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-283: Clioquinol inhibits the metal-mediated generation of dityrosine and pyroglutamate variants of Abeta
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-274: Copper-dependent uptake of clioquinol in neuronal cells is promoted by β-amyloid
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-033: Oxidatively modified soluble Aβ oligomers accumulate progressively in APP-overexpressing mice
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-019: Positive correlation of brain zinc with Alzheimer’s disease β-amyloid burden
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-446: Significant reduction in 6-hydroxy-dopamine nigral lesion size by administration of clioquinol
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-362: Mitochondrial oxidative stress modulates amyloid pathology and the hyperphosphorylation of tau
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-357: Abeta redox chemistry and neurotoxicity
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-313: Copper induces accumulation of tau and phosphorylated tau in lipid rafts
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P2-036: Inhibition of Alzheimer’s disease amyloid-β production causes copper deficiency and decreased Cu/Zn SOD activity
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P2-025: Copper depletion by menkes ATP7A over-expression dramatically alters the metabolism of APP and APLP2 in cell culture
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P1-384: Association of AD neuropathological hallmarks with biological metals
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P1-056: Aβ overexpression is associated with acceleration of motor impairment and superoxide dismutase 1 aggregation in a mouse model co-expressing APP-C100 and mutant SOD1
- Published in:
- 2006
- By:
- Publication type:
- Abstract
O3-03-06: Copper sensitively induces presenilin 1 lipid raft localization with increased amyloidogenic processing of the amyloid precursor protein
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-435: PBT2, a novel MPAC for the treatment of Alzheimer’s disease
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-283: Clioquinol inhibits the metal-mediated generation of dityrosine and pyroglutamate variants of Abeta
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-274: Copper-dependent uptake of clioquinol in neuronal cells is promoted by β-amyloid
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-033: Oxidatively modified soluble Aβ oligomers accumulate progressively in APP-overexpressing mice
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-019: Positive correlation of brain zinc with Alzheimer’s disease β-amyloid burden
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-446: Significant reduction in 6-hydroxy-dopamine nigral lesion size by administration of clioquinol
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-362: Mitochondrial oxidative stress modulates amyloid pathology and the hyperphosphorylation of tau
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-357: Abeta redox chemistry and neurotoxicity
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-313: Copper induces accumulation of tau and phosphorylated tau in lipid rafts
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P2-036: Inhibition of Alzheimer’s disease amyloid-β production causes copper deficiency and decreased Cu/Zn SOD activity
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P2-025: Copper depletion by menkes ATP7A over-expression dramatically alters the metabolism of APP and APLP2 in cell culture
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P1-384: Association of AD neuropathological hallmarks with biological metals
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P1-056: Aβ overexpression is associated with acceleration of motor impairment and superoxide dismutase 1 aggregation in a mouse model co-expressing APP-C100 and mutant SOD1
- Published in:
- 2006
- By:
- Publication type:
- Abstract
O3-03-06: Copper sensitively induces presenilin 1 lipid raft localization with increased amyloidogenic processing of the amyloid precursor protein
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Decreased Copper in Alzheimer's Disease Brain Is Predominantly in the Soluble Extractable Fraction.
- Published in:
- 2013
- By:
- Publication type:
- Journal Article