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Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy.
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- Frontiers in Aging Neuroscience, 2021, v. 13, p. N.PAG, doi. 10.3389/fnagi.2021.647990
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- Article
ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5616, doi. 10.3390/ijms24065616
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- Article
Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5525, doi. 10.3390/ijms24065525
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RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform.
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- Cell Research, 2008, v. 18, n. 9, p. 921, doi. 10.1038/cr.2008.66
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- Article
Acyl-coenzyme A:cholesterol acyltransferase 1 - significance of single-nucleotide polymorphism at residue 526 and the role of Pro347 near the fifth transmembrane domain.
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- FEBS Journal, 2014, v. 281, n. 7, p. 1773, doi. 10.1111/febs.12739
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- Article
The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters.
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- Acta Biochimica et Biophysica Sinica, 2016, v. 48, n. 11, p. 990, doi. 10.1093/abbs/gmw095
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- Article
Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors.
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- Acta Biochimica et Biophysica Sinica, 2016, v. 48, n. 11, p. 980, doi. 10.1093/abbs/gmw091
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- Article
ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration.
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- Acta Biochimica et Biophysica Sinica, 2015, v. 47, n. 12, p. 951, doi. 10.1093/abbs/gmv101
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Two Human ACAT2 mRNA Variants Produced by Alternative Splicing and Coding for Novel Isoenzymes.
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- Acta Biochimica et Biophysica Sinica, 2005, v. 37, n. 12, p. 797, doi. 10.1111/j.1745-7270.2005.00118.x
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A Stable Upstream Stem-loop Structure Enhances Selection of the First 5′-ORF-AUG as a Main Start Codon for Translation Initiation of Human ACAT1 mRNA.
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- Acta Biochimica et Biophysica Sinica, 2004, v. 36, n. 4, p. 259, doi. 10.1093/abbs/36.4.259
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- Article
Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.
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- IUBMB Life, 2010, v. 62, n. 4, p. 261, doi. 10.1002/iub.305
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- Article
Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 17, p. 9151, doi. 10.3390/ijms25179151
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Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer's Disease Mice.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 11013, doi. 10.3390/ijms241311013
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- Article
Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor.
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- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16288-4
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- Article
Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1-42 Clearance.
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- Journal of Neuroscience, 2014, v. 34, n. 43, p. 14484, doi. 10.1523/JNEUROSCI.2567-14.2014
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- Article