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Methamphetamine Dependence: Medication Development Efforts Based on the Dual Deficit Model of Stimulant Addiction.
- Published in:
- Annals of the New York Academy of Sciences, 2000, v. 914, n. 1, p. 71, doi. 10.1111/j.1749-6632.2000.tb05185.x
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- Article
Attenuated nicotine-like effects of varenicline but not other nicotinic ACh receptor agonists in monkeys receiving nicotine daily.
- Published in:
- 2016
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- Publication type:
- journal article
Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter.
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- 2009
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- Publication type:
- journal article
Molecular mechanism of biased signaling at the kappa opioid receptor.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37041-7
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- Publication type:
- Article
Designer drugs: a medicinal chemistry perspective.
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- Annals of the New York Academy of Sciences, 2012, v. 1248, n. 1, p. 18, doi. 10.1111/j.1749-6632.2011.06199.x
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- Publication type:
- Article
Antagonists at Metabotropic Glutamate Receptor Subtype 5.
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- Annals of the New York Academy of Sciences, 2008, v. 1141, p. 221, doi. 10.1196/annals.1441.015
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- Publication type:
- Article
Development of imaging agents for the dopamine transporter.
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- Medicinal Research Reviews, 1995, v. 15, n. 5, p. 419, doi. 10.1002/med.2610150503
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- Article
A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants.
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- Neuropsychopharmacology, 2006, v. 31, n. 2, p. 351, doi. 10.1038/sj.npp.1300795
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- Publication type:
- Article
Synthesis of Enantiopure PZM21: A Biased Agonist of the Mu‐Opioid Receptor.
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- European Journal of Organic Chemistry, 2018, v. 2018, n. 29, p. 4006, doi. 10.1002/ejoc.201800517
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- Publication type:
- Article
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model.
- Published in:
- 2017
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- Publication type:
- journal article
Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse.
- Published in:
- Synapse, 2000, v. 35, n. 3, p. 222, doi. 10.1002/(SICI)1098-2396(20000301)35:3<222::AID-SYN7>3.0.CO;2-K
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- Publication type:
- Article
Opioid peptide receptor studies, 11: Involvement of Tyr148, Trp318 and His319 of the rat μ-opioid receptor in binding of μ-selective ligands.
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- Synapse, 1999, v. 32, n. 1, p. 23, doi. 10.1002/(SICI)1098-2396(199904)32:1<23::AID-SYN3>3.0.CO;2-N
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- Publication type:
- Article
Studies of the Biogenic Amine Transporters. VII. Characterization of a Novel Cocaine Binding Site Identified With [125I]RTI-SS in Membranes Prepared From Human, Monkey, and Guinea Pig Caudate
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- Synapse, 1998, v. 28, n. 4, p. 322
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- Publication type:
- Article
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat μ opioid receptor.
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- Synapse, 1998, v. 28, n. 2, p. 117, doi. 10.1002/(SICI)1098-2396(199802)28:2<117::AID-SYN2>3.0.CO;2-E
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- Publication type:
- Article
RTI-352: A 3α analogue of RTI-55 as an in vivo dopamine transporter binding ligand.
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- Synapse, 1997, v. 25, n. 4, p. 389, doi. 10.1002/(SICI)1098-2396(199704)25:4<389::AID-SYN10>3.0.CO;2-Q
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- Publication type:
- Article
N-substituted phenyltropanes as in vivo binding ligands for rapid imaging studies of the dopamine transporter.
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- Synapse, 1997, v. 25, n. 4, p. 345, doi. 10.1002/(SICI)1098-2396(199704)25:4<345::AID-SYN5>3.0.CO;2-A
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- Publication type:
- Article
Mapping nicotinic acetylcholine receptors with PET.
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- Synapse, 1996, v. 24, n. 4, p. 403, doi. 10.1002/(SICI)1098-2396(199612)24:4<403::AID-SYN8>3.0.CO;2-H
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- Publication type:
- Article
RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [<sup>3</sup>H]1-[1-(2 thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain.
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- Synapse, 1994, v. 16, n. 1, p. 59, doi. 10.1002/syn.890160107
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- Publication type:
- Article
In vivo binding of [<sup>125</sup>I] RTI-55 to dopamine transporters: Pharmacology and regional distribution with autoradiography.
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- Synapse, 1992, v. 12, n. 1, p. 37, doi. 10.1002/syn.890120105
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- Publication type:
- Article
[<sup>123/125</sup>I]RTI-55, an in vivo label for the serotonin transporter.
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- Synapse, 1992, v. 11, n. 2, p. 134, doi. 10.1002/syn.890110206
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- Publication type:
- Article
In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine-123 labeled RTI-55.
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- Synapse, 1992, v. 10, n. 2, p. 169, doi. 10.1002/syn.890100210
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- Publication type:
- Article
Facile synthesis of (±)-, (+)-, and (-)-galanthamine.
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- Journal of Heterocyclic Chemistry, 1995, v. 32, n. 1, p. 195, doi. 10.1002/jhet.5570320132
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- Publication type:
- Article
Synthesis and structural determination of 5 H-benzocyclohepten-5,8-imines.
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- Journal of Heterocyclic Chemistry, 1994, v. 31, n. 1, p. 187, doi. 10.1002/jhet.5570310131
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- Publication type:
- Article
A practical synthesis of (+)-cocaine.
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- Journal of Heterocyclic Chemistry, 1987, v. 24, n. 1, p. 19, doi. 10.1002/jhet.5570240104
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- Publication type:
- Article
Synthesis and spectral properties of optically active 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine: Primary methadone metabolite.
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- Journal of Heterocyclic Chemistry, 1986, v. 23, n. 2, p. 369, doi. 10.1002/jhet.5570230212
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- Publication type:
- Article
Synthesis of naphthyridinone derivatives as potential antimalarials.
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- Journal of Heterocyclic Chemistry, 1981, v. 18, n. 5, p. 941, doi. 10.1002/jhet.5570180519
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- Publication type:
- Article
Structure of the human ?-opioid receptor in complex with JDTic.
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- Nature, 2012, v. 485, n. 7398, p. 327, doi. 10.1038/nature10939
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- Publication type:
- Article
Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice.
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- Journal of Psychopharmacology, 2022, v. 36, n. 11, p. 1280, doi. 10.1177/02698811221132214
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- Publication type:
- Article
[<sup>125</sup>I]RTI-55 Binding to Cocaine-Sensitive Dopaminergic and Serotonergic Uptake Sites in the Human Brain.
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- Journal of Neurochemistry, 1993, v. 61, n. 6, p. 1996, doi. 10.1111/j.1471-4159.1993.tb07435.x
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- Publication type:
- Article
[<sup>3</sup>H]WIN 35,065-2: A Ligand for Cocaine Receptors in Striatum.
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- Journal of Neurochemistry, 1990, v. 55, n. 5, p. 1556, doi. 10.1111/j.1471-4159.1990.tb04938.x
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- Publication type:
- Article
PET and SPECT in medication development.
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- Drug Development Research, 2003, v. 59, n. 2, p. 191, doi. 10.1002/ddr.10218
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- Publication type:
- Article
Opportunities for Medication Development in Obesity.
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- Drug Development Research, 2000, v. 51, n. 2, p. 49, doi. 10.1002/1098-2299(200010)51:2<49::AID-DDR1>3.0.CO;2-0
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- Publication type:
- Article
Effects of Chronic Varenicline Treatment on Nicotine, Cocaine, and Concurrent Nicotine+Cocaine Self-Administration.
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- Neuropsychopharmacology, 2014, v. 39, n. 5, p. 1222, doi. 10.1038/npp.2013.325
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- Publication type:
- Article
Corticotropin-Releasing Factor (CRF)-Induced Disruption of Attention in Rats Is Blocked by the κ-Opioid Receptor Antagonist JDTic.
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- Neuropsychopharmacology, 2012, v. 37, n. 13, p. 2809, doi. 10.1038/npp.2012.151
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- Publication type:
- Article
From rapid In Vitro screening to rapid In Vivo screening in the drug discovery process.
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- Neuropsychopharmacology, 2009, v. 34, n. 1, p. 251, doi. 10.1038/npp.2008.160
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- Publication type:
- Article
Blood levels of T-Cell Receptor Excision Circles (TRECs) provide an index of exposure to traumatic stress in mice and humans.
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- Translational Psychiatry, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41398-022-02159-7
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- Publication type:
- Article
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats.
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- Psychopharmacology, 2005, v. 183, n. 1, p. 118, doi. 10.1007/s00213-005-0167-4
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- Publication type:
- Article
Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats.
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- Psychopharmacology, 2002, v. 164, n. 2, p. 168, doi. 10.1007/s00213-002-1192-1
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- Publication type:
- Article
Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat.
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- Psychopharmacology, 2001, v. 159, n. 1, p. 58, doi. 10.1007/s002130100891
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- Publication type:
- Article
Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys: interaction with methamphetamine.
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- Psychopharmacology, 2000, v. 153, n. 1, p. 103, doi. 10.1007/s002130000602
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- Publication type:
- Article
Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain.
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- Journal of Neuroscience, 2019, v. 39, n. 21, p. 4162, doi. 10.1523/JNEUROSCI.0274-19.2019
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- Publication type:
- Article
Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism.
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- Journal of Neuroscience, 2017, v. 37, n. 32, p. 7656, doi. 10.1523/JNEUROSCI.0885-17.2017
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- Publication type:
- Article
Designer drugs: a medicinal chemistry perspective (II).
- Published in:
- Annals of the New York Academy of Sciences, 2021, v. 1489, n. 1, p. 48, doi. 10.1111/nyas.14349
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- Publication type:
- Article
The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.
- Published in:
- Addiction Biology, 2012, v. 17, n. 3, p. 634, doi. 10.1111/j.1369-1600.2012.00455.x
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- Publication type:
- Article
Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters.
- Published in:
- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0070701
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- Publication type:
- Article
High specific activity (+)-amphetamine and (+)-methamphetamine.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2009, v. 52, n. 11, p. 457, doi. 10.1002/jlcr.1659
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- Publication type:
- Article
Preparation of carbon-14-labeled (3 R)-7-hydroxy- N-(1 S)-1-{[(3 R,4 R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl-1,2,3,4-tetrahydroisoquinolinecarboxamide (JDTic).
- Published in:
- Journal of Labelled Compounds & Radiopharmaceuticals, 2009, v. 52, n. 12, p. 518, doi. 10.1002/jlcr.1677
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- Publication type:
- Article
Preparation of carbon-14 labeled (3 R)-7-hydroxy-N-(1 S)-1-{[(3 R,4 R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl-1,2,3,4-tetrahydroisoquinolinecarboxamide (JDTic).
- Published in:
- Journal of Labelled Compounds & Radiopharmaceuticals, 2008, v. 51, n. 14, p. 440, doi. 10.1002/jlcr.1560
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- Publication type:
- Article
Tritiation of the cannabinoid receptor antagonist SR144528 involving lithium aluminum tritide reduction; assessment of the kinetic isotope effect by <sup>3</sup>H-NMR.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2005, v. 48, n. 8, p. 589, doi. 10.1002/jlcr.952
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- Publication type:
- Article
Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats.
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- International Journal of Neuropsychopharmacology, 2019, v. 22, n. 11, p. 735, doi. 10.1093/ijnp/pyz054
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- Publication type:
- Article