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CT1812 biomarker signature from a meta‐analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 10, p. 6860, doi. 10.1002/alz.14152
By:
- Lizama, Britney N.;
- Williams, Claire;
- North, Hilary A.;
- Pandey, Kiran;
- Duong, Duc;
- Di Caro, Valentina;
- Mecca, Adam P.;
- Blennow, Kaj;
- Zetterberg, Henrik;
- Levey, Allan I.;
- Grundman, Michael;
- van Dyck, Christopher H.;
- Caggiano, Anthony O.;
- Seyfried, Nicholas T.;
- Hamby, Mary E.
Publication type:
Article
Brain transcriptomic and proteomic analyses in an in vivo AD model further elucidate the role of the sigma‐2 receptor modulator CT1812 in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.083209
By:
- Caro, Valentina Di;
- Cho, Eunah;
- Caldwell, Jill;
- Pandey, Kiran;
- Duong, Duc M.;
- Seyfried, Nicholas T;
- Caggiano, Anthony O;
- Hamby, Mary E
Publication type:
Article
CSF proteomics analysis to investigate the pharmacodynamic response of the S2R modulator CT1812 in Alzheimer's disease patients from the SPARC clinical trial.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.068166
By:
- Pandey, Kiran;
- Waybright, Lora;
- Duong, Duc M.;
- Malagise, Evi;
- Blennow, Kaj;
- Zetterberg, Henrik;
- Mecca, Adam P;
- van Dyck, Christopher H;
- Caggiano, Anthony O;
- Seyfried, Nicholas T.;
- Hamby, Mary E
Publication type:
Article
P4‐708: CLINICAL BIOMARKER EVIDENCE FOR TARGET ENGAGEMENT, REDUCTION OF SYNAPTIC DAMAGE AND DISEASE MODIFICATION IN ALZHEIMER'S PATIENTS TREATED WITH CT1812.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1603, doi. 10.1016/j.jalz.2019.09.072
By:
- Schneider, Lon S.;
- Caggiano, Anthony O.;
- Grundman, Michael;
- DeKosky, Steve;
- Morgan, Roger;
- Mozzoni, Kelsie;
- Izzo, Nicholas J.;
- Safferstein, Hank;
- Catalano, Susan
Publication type:
Article
Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6251, doi. 10.3390/ijms24076251
By:
- Lizama, Britney N.;
- Kahle, Jennifer;
- Catalano, Susan M.;
- Caggiano, Anthony O.;
- Grundman, Michael;
- Hamby, Mary E.
Publication type:
Article
A double-blind, placebo-controlled, single-ascending-dose intravenous infusion study of rHIgM22 in subjects with multiple sclerosis immediately following a relapse.
Published in:
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2022, p. 1, doi. 10.1177/20552173221091475
By:
- Greenberg, Benjamin M.;
- Bowen, James D.;
- Alvarez, Enrique;
- Rodriguez, Moses;
- Caggiano, Anthony O.;
- Warrington, Arthur E.;
- Zhao, Ping;
- Eisen, Andrew
Publication type:
Article
Pediatric Methadone Poisoning Revisited.
Published in:
Clinical Pediatrics, 2001, v. 40, n. 2, p. 119, doi. 10.1177/000992280104000212
By:
- Schwab, Joel;
- Caggiano, Anthony O.
Publication type:
Article
Intravenous Glial Growth Factor 2 (GGF2) Isoform of Neuregulin-1β Improves Left Ventricular Function, Gene and Protein Expression in Rats after Myocardial Infarction.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055741
By:
- Hill, Michael F.;
- Patel, Amish V.;
- Murphy, Abigail;
- Smith, Holly M.;
- Galindo, Cristi L.;
- Pentassuglia, Laura;
- Peng, Xuyang;
- Lenneman, Carrie G.;
- Odiete, Oghenerukevwe;
- Friedman, David B.;
- Kronenberg, Marvin W.;
- Zheng, Siyuen;
- Zhao, Zhongming;
- Song, Yanna;
- Harrell Jr, Frank E.;
- Srinivas, Maya;
- Ganguly, Anindita;
- Iaci, Jennifer;
- Parry, Tom J.;
- Caggiano, Anthony O.
Publication type:
Article
Neuronal Nitric Oxide Synthase Expression Is Induced in Neocortical Astrocytes After Spreading Depression.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 1998, v. 18, n. 1, p. 75, doi. 10.1097/00004647-199801000-00008
By:
- Caggiano, Anthony O;
- Kraig, Richard P
Publication type:
Article
Long-term elevation of cyclooxygenase-2, but not lipoxygenase, in regions synaptically distant from spreading depression.
Published in:
Journal of Comparative Neurology, 1996, v. 376, n. 3, p. 447, doi. 10.1002/(SICI)1096-9861(19961216)376:3<447::AID-CNE7>3.0.CO;2-2
By:
- Caggiano, Anthony O.;
- Breder, Christopher D.;
- Kraig, Richard P.
Publication type:
Article
Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes.
Published in:
Journal of Comparative Neurology, 1996, v. 369, n. 1, p. 93, doi. 10.1002/(SICI)1096-9861(19960520)369:1<93::AID-CNE7>3.0.CO;2-F
By:
- Caggiano, Anthony O.;
- Kraig, Richard P.
Publication type:
Article
Anti-Remodeling and Anti-Fibrotic Effects of the Neuregulin-1β Glial Growth Factor 2 in a Large Animal Model of Heart Failure.
Published in:
Journal of the American Heart Association, 2015, v. 4, n. 1, p. 1, doi. 10.1161/JAHA.113.000773
By:
- Galindo, Cristi L.;
- Kasasbeh, Ehab;
- Murphy, Abigail;
- Ryzhov, Sergey;
- Lenihan, Sean;
- Ahmad, Farhaan A.;
- Williams, Philip;
- Nunnally, Amy;
- Adcock, Jamie;
- Yanna Song;
- Harrell, Frank E.;
- Tran, Truc-Linh;
- Parry, Tom J.;
- Iaci, Jen;
- Ganguly, Anindita;
- Feoktistov, Igor;
- Stephenson, Matthew K.;
- Caggiano, Anthony O.;
- Sawyer, Douglas B.;
- Cleator, John H.
Publication type:
Article
Anti-Remodeling and Anti-Fibrotic Effects of the Neuregulin-1β Glial Growth Factor 2 in a Large Animal Model of Heart Failure.
Published in:
Journal of the American Heart Association, 2014, v. 3, n. 5, p. 1, doi. 10.1161/JAHA.113.000773
By:
- Galindo, Cristi L.;
- Kasasbeh, Ehab;
- Murphy, Abigail;
- Ryzhov, Sergey;
- Lenihan, Sean;
- Ahmad, Farhaan A.;
- Williams, Philip;
- Nunnally, Amy;
- Adcock, Jamie;
- Song, Yanna;
- Harrell, Frank E.;
- Tran, Truc‐Linh;
- Parry, Tom J.;
- Iaci, Jen;
- Ganguly, Anindita;
- Feoktistov, Igor;
- Stephenson, Matthew K.;
- Caggiano, Anthony O.;
- Sawyer, Douglas B.;
- Cleator, John H.
Publication type:
Article
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease.
Published in:
Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-023-02679-6
By:
- Colom-Cadena, Martí;
- Toombs, Jamie;
- Simzer, Elizabeth;
- Holt, Kristjan;
- McGeachan, Robert;
- Tulloch, Jane;
- Jackson, Rosemary J.;
- Catterson, James H.;
- Spires-Jones, Maxwell P.;
- Rose, Jamie;
- Waybright, Lora;
- Caggiano, Anthony O.;
- King, Declan;
- Gobbo, Francesco;
- Davies, Caitlin;
- Hooley, Monique;
- Dunnett, Sophie;
- Tempelaar, Robert;
- Meftah, Soraya;
- Tzioras, Makis
Publication type:
Article
A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer's disease.
Published in:
Alzheimer's Research & Therapy, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13195-024-01382-2
By:
- van Dyck, Christopher H.;
- Mecca, Adam P.;
- O'Dell, Ryan S.;
- Bartlett, Hugh H.;
- Diepenbrock, Nina G.;
- Huang, Yiyun;
- Hamby, Mary E.;
- Grundman, Michael;
- Catalano, Susan M.;
- Caggiano, Anthony O.;
- Carson, Richard E.
Publication type:
Article
A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer's disease using an indwelling CSF catheter.
Published in:
2023
By:
- LaBarbera, Kelsie M.;
- Sheline, Yvette I.;
- Izzo, Nicholas J.;
- Yuede, Carla M.;
- Waybright, Lora;
- Yurko, Raymond;
- Edwards, Hannah M.;
- Gardiner, Woodrow D.;
- Blennow, Kaj;
- Zetterberg, Henrik;
- Börjesson-Hanson, Anne;
- Morgan, Roger;
- Davis, Charles S.;
- Guttendorf, Robert J.;
- Schneider, Lon S.;
- DeKosky, Steven;
- LeVine III, Harry;
- Grundman, Michael;
- Caggiano, Anthony O.;
- Cirrito, John R.
Publication type:
Abstract
Mammalian-produced chondroitinase AC mitigates axon inhibition by chondroitin sulfate proteoglycans.
Published in:
Journal of Neurochemistry, 2007, v. 102, n. 1, p. 275, doi. 10.1111/j.1471-4159.2007.04530.x
By:
- Curinga, Gabrielle M.;
- Snow, Diane M.;
- Mashburn, Charles;
- Kohler, Katharina;
- Thobaben, Rebecca;
- Caggiano, Anthony O.;
- Smith, George M.
Publication type:
Article
Prostaglandin E Receptor Subtypes in Cultured Rat Microglia and Their Role in Reducing Lipopolysaccharide-Induced Interleukin-1 β Production.
Published in:
Journal of Neurochemistry, 1999, v. 72, n. 2, p. 565, doi. 10.1046/j.1471-4159.1999.0720565.x
By:
- Caggiano, Anthony O;
- Kraig, Richard P
Publication type:
Article
Prostaglandin E<sub>2</sub> and 4-Aminopyridine Prevent the Lipopolysaccharide-Induced Outwardly Rectifying Potassium Current and Interleukin-1β Production in Cultured Rat Microglia.
Published in:
Journal of Neurochemistry, 1998, v. 70, n. 6, p. 2357, doi. 10.1046/j.1471-4159.1998.70062357.x
By:
- Caggiano, Anthony O.;
- Kraig, Richard P.
Publication type:
Article
KP544 amplifies the effects of nerve growth factor on cell differentiation and is neuroprotectivePreliminary reports of part of this work were presented at the Abstracts of the Society for Neuroscience meeting, New Orleans, LA, 2003.
Published in:
Drug Development Research, 2004, v. 62, n. 1, p. 49, doi. 10.1002/ddr.10385
By:
- James A. Fyfe;
- Lilia M. Beauchamp;
- Anthony O. Caggiano;
- Raymond D. Price;
- Takayuki Yamaji;
- Nobuya Matsuoka;
- Thomas A. Krenitsky
Publication type:
Article
Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).
Published in:
Toxicological Sciences, 2018, v. 161, n. 2, p. 401, doi. 10.1093/toxsci/kfx222
By:
- Mosedale, Merrie;
- Button, Donald;
- Jackson, Jonathan P;
- Freeman, Kimberly M;
- Brouwer, Kenneth R;
- Caggiano, Anthony O;
- Eisen, Andrew;
- Iaci, Jennifer F;
- Parry, Tom J;
- Stanulis, Ric
Publication type:
Article

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