OpenURL Connection Search

Select item for more details and to access through your institution.

Population pharmacokinetics and dosing implications for cobimetinib in patients with solid tumors.
Published in:
2015
By:
- Han, Kelong;
- Jin, Jin;
- Marchand, Mathilde;
- Eppler, Stephen;
- Choong, Nicholas;
- Hack, Stephen;
- Tikoo, Nalin;
- Bruno, Rene;
- Dresser, Mark;
- Musib, Luna;
- Budha, Nageshwar;
- Jin, Jin Y;
- Hack, Stephen P;
- Budha, Nageshwar R
Publication type:
journal article
Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation.
Published in:
2016
By:
- Budha, Nageshwar;
- Ji, Tao;
- Musib, Luna;
- Eppler, Steve;
- Dresser, Mark;
- Chen, Yuan;
- Jin, Jin;
- Budha, Nageshwar R;
- Jin, Jin Y
Publication type:
journal article
A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer.
Published in:
Biopharmaceutics & Drug Disposition, 2013, v. 34, n. 3, p. 141, doi. 10.1002/bdd.1830
By:
- Cheeti, Sravanthi;
- Budha, Nageshwar R.;
- Rajan, Sharmila;
- Dresser, Mark J.;
- Jin, Jin Y.
Publication type:
Article
Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9.
Published in:
AAPS Journal, 2015, v. 17, n. 4, p. 881, doi. 10.1208/s12248-015-9750-8
By:
- Budha, Nageshwar;
- Leabman, Maya;
- Jin, Jin;
- Wada, D.;
- Baruch, Amos;
- Peng, Kun;
- Tingley, Whittemore;
- Davis, John
Publication type:
Article
The Use of Betaine HCl to Enhance Dasatinib Absorption in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria.
Published in:
AAPS Journal, 2014, v. 16, n. 6, p. 1358, doi. 10.1208/s12248-014-9673-9
By:
- Yago, Marc;
- Frymoyer, Adam;
- Benet, Leslie;
- Smelick, Gillian;
- Frassetto, Lynda;
- Ding, Xiao;
- Dean, Brian;
- Salphati, Laurent;
- Budha, Nageshwar;
- Jin, Jin;
- Dresser, Mark;
- Ware, Joseph
Publication type:
Article
Comparative Performance of Cell Life Span and Cell Transit Models for Describing Erythropoietic Drug Effects.
Published in:
AAPS Journal, 2011, v. 13, n. 4, p. 650, doi. 10.1208/s12248-011-9302-9
By:
- Budha, Nageshwar;
- Kovar, Andreas;
- Meibohm, Bernd
Publication type:
Article
Pharmacokinetically-Guided Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents.
Published in:
AAPS Journal, 2008, v. 10, n. 1, p. 157, doi. 10.1208/s12248-008-9017-8
By:
- Budha, Nageshwar;
- Mehrotra, Nitin;
- Tangallapally, Rajendra;
- Rakesh;
- Qi, Jianjun;
- Daniels, Antwan;
- Lee, Richard;
- Meibohm, Bernd
Publication type:
Article
Dose Optimization in Oncology Drug Development: An International Consortium for Innovation and Quality in Pharmaceutical Development White Paper.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 531, doi. 10.1002/cpt.3298
By:
- Samineni, Divya;
- Venkatakrishnan, Karthik;
- Othman, Ahmed A.;
- Pithavala, Yazdi K.;
- Poondru, Srinivasu;
- Patel, Chirag;
- Vaddady, Pavan;
- Ankrom, Wendy;
- Ramanujan, Saroja;
- Budha, Nageshwar;
- Wu, Michael;
- Haddish‐Berhane, Nahor;
- Fritsch, Holger;
- Hussain, Azher;
- Kanodia, Jitendra;
- Li, Meng;
- Li, Mengyao;
- Melhem, Murad;
- Parikh, Apurvasena;
- Upreti, Vijay V.
Publication type:
Article
Considerations for Industry—Preparing for the FDA Model‐Informed Drug Development (MIDD) Paired Meeting Program.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 2, p. 282, doi. 10.1002/cpt.3245
By:
- Galluppi, Gerald R.;
- Ahamadi, Malidi;
- Bhattacharya, Souvik;
- Budha, Nageshwar;
- Gheyas, Ferdous;
- Li, Chi‐Chung;
- Chen, Yuan;
- Dosne, Anne‐Gaëlle;
- Kristensen, Niels Rode;
- Magee, Mindy;
- Samtani, Mahesh N.;
- Sinha, Vikram;
- Taskar, Kunal;
- Upreti, Vijay V.;
- Yang, Jianning;
- Cook, Jack
Publication type:
Article
A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab‐Treated non‐small Cell Lung Cancer Patients.
Published in:
Clinical Pharmacology & Therapeutics, 2019, v. 105, n. 2, p. 486, doi. 10.1002/cpt.1198
By:
- Netterberg, Ida;
- Li, Chi‐Chung;
- Molinero, Luciana;
- Budha, Nageshwar;
- Sukumaran, Siddharth;
- Stroh, Mark;
- Jonsson, E. Niclas;
- Friberg, Lena E.
Publication type:
Article
Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0152 in human plasma using solid-phase extraction.
Published in:
Biomedical Chromatography, 2013, v. 27, n. 1, p. 102, doi. 10.1002/bmc.2754
By:
- Shin, Young G.;
- Jones, Steve A.;
- Murakami, Stan C.;
- Budha, Nageshwar;
- Ware, Joseph;
- Wong, Harvey;
- Buonarati, Michael H.;
- Dean, Brian;
- Hop, Cornelis E. C. A.
Publication type:
Article
Single- and multiple-dose pharmacokinetics, potential for CYP3A inhibition, and food effect in patients with cancer and healthy subjects receiving ipatasertib.
Published in:
Cancer Chemotherapy & Pharmacology, 2021, v. 88, n. 6, p. 921, doi. 10.1007/s00280-021-04344-9
By:
- Malhi, Vikram;
- Budha, Nageshwar;
- Sane, Rucha;
- Huang, Jian;
- Liederer, Bianca;
- Meng, Raymond;
- Patel, Premal;
- Deng, Yuzhong;
- Cervantes, Andres;
- Tabernero, Josep;
- Musib, Luna
Publication type:
Article
A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9.
Published in:
Clinical Cardiology, 2017, v. 40, n. 7, p. 503, doi. 10.1002/clc.22687
By:
- Baruch, Amos;
- Luca, Diana;
- Kahn, Robert S.;
- Cowan, Kyra J.;
- Leabman, Maya;
- Budha, Nageshwar R.;
- Chiu, Cecilia P.C.;
- Wu, Yan;
- Kirchhofer, Daniel;
- Peterson, Andrew;
- Davis Jr, John C.;
- Tingley, Whittemore G.
Publication type:
Article
Model‐based population pharmacokinetic analysis of tislelizumab in patients with advanced tumors.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 1, p. 95, doi. 10.1002/psp4.12880
By:
- Budha, Nageshwar;
- Wu, Chi‐Yuan;
- Tang, Zhiyu;
- Yu, Tian;
- Liu, Lucy;
- Xu, Fengyan;
- Gao, Yuying;
- Li, Ruiying;
- Zhang, Qiuyang;
- Wan, Ya;
- Sahasranaman, Srikumar
Publication type:
Article
Population repeated time‐to‐event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 10, p. 1221, doi. 10.1002/psp4.12690
By:
- Svensson, Robin J;
- Ribbing, Jakob;
- Kotani, Naoki;
- Dolton, Michael;
- Vadhavkar, Shweta;
- Cheung, Dorothy;
- Staton, Tracy;
- Choy, David F;
- Putnam, Wendy;
- Jin, Jin;
- Budha, Nageshwar;
- Karlsson, Mats O.;
- Quartino, Angelica;
- Zhu, Rui
Publication type:
Article
Exposure–Response‐Based Product Profile–Driven Clinical Utility Index for Ipatasertib Dose Selection in Prostate Cancer.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 4, p. 240, doi. 10.1002/psp4.12394
By:
- Zhu, Rui;
- Poland, Bill;
- Wada, Russ;
- Liu, Qi;
- Musib, Luna;
- Maslyar, Daniel;
- Cho, Eunpi;
- Yu, Wei;
- Ma, Han;
- Jin, Jin Yan;
- Budha, Nageshwar
Publication type:
Article
Combining 'Bottom-up' and 'Top-down' Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC-0941) Pharmacokinetics.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2017, v. 6, n. 11, p. 747, doi. 10.1002/psp4.12228
By:
- Lu, Tong;
- Fraczkiewicz, Grazyna;
- Salphati, Laurent;
- Budha, Nageshwar;
- Dalziel, Gena;
- Smelick, Gillian S.;
- Morrissey, Kari M.;
- Davis, John D.;
- Jin, Jin Y.;
- Ware, Joseph A.
Publication type:
Article
Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug-Drug Interaction Prediction.
Published in:
2016
By:
- Chen, Yuan;
- Ma, Fang;
- Lu, Tong;
- Budha, Nageshwar;
- Jin, Jin;
- Kenny, Jane;
- Wong, Harvey;
- Hop, Cornelis;
- Mao, Jialin;
- Jin, Jin Yan;
- Kenny, Jane R;
- Hop, Cornelis E C A
Publication type:
journal article
A Phase 1/2 study of the PD-L1 inhibitor, BGB-A333, alone and in combination with the PD-1 inhibitor, tislelizumab, in patients with advanced solid tumours.
Published in:
British Journal of Cancer, 2023, v. 128, n. 8, p. 1418, doi. 10.1038/s41416-022-02128-3
By:
- Desai, Jayesh;
- Fong, Peter;
- Moreno, Victor;
- Frentzas, Sophia;
- Meniawy, Tarek;
- Markman, Ben;
- Voskoboynik, Mark;
- Rahman, Tahmina;
- Budha, Nageshwar;
- Wu, John;
- Marlow, Jin;
- Yang, Silu;
- Calvo, Emiliano;
- Martin-Liberal, Juan
Publication type:
Article
Methods and strategies for assessing uncontrolled drug-drug interactions in population pharmacokinetic analyses: results from the International Society of Pharmacometrics (ISOP) Working Group.
Published in:
Journal of Pharmacokinetics & Pharmacodynamics, 2016, v. 43, n. 2, p. 123, doi. 10.1007/s10928-016-9464-2
By:
- Bonate, Peter;
- Ahamadi, Malidi;
- Budha, Nageshwar;
- Peña, Amparo;
- Earp, Justin;
- Hong, Ying;
- Karlsson, Mats;
- Ravva, Patanjali;
- Ruiz-Garcia, Ana;
- Struemper, Herbert;
- Wade, Janet
Publication type:
Article
Targeting TIGIT for Immunotherapy of Cancer: Update on Clinical Development.
Published in:
Biomedicines, 2021, v. 9, n. 9, p. 1277, doi. 10.3390/biomedicines9091277
By:
- Rotte, Anand;
- Sahasranaman, Srikumar;
- Budha, Nageshwar
Publication type:
Article
Clinical dose rationale of tislelizumab in patients with solid or hematological advanced tumors.
Published in:
CTS: Clinical & Translational Science, 2024, v. 17, n. 3, p. 1, doi. 10.1111/cts.13769
By:
- Yu, Tian;
- Liu, Xiangyu;
- Wu, Chi‐Yuan;
- Tang, Zhiyu;
- Wang, Hongwei;
- Schnell, Patrick;
- Wan, Ya;
- Wang, Kun;
- Liu, Lucy;
- Gao, Yuying;
- Sahasranaman, Srikumar;
- Budha, Nageshwar
Publication type:
Article
Dogs Are More Sensitive to Antagonists of Inhibitor of Apoptosis Proteins Than Rats and Humans: A Translational Toxicokinetic/Toxicodynamic Analysis.
Published in:
Toxicological Sciences, 2012, v. 130, n. 1, p. 205, doi. 10.1093/toxsci/kfs235
By:
- Wong, Harvey;
- Budha, Nageshwar R.;
- West, Kristina;
- Blackwood, Elizabeth;
- Ware, Joseph A.;
- Yu, Ron;
- Darbonne, Walter C.;
- Gould, Stephen E.;
- Steigerwalt, Ronald;
- Erickson, Rebecca;
- Hop, Cornelis E. A. C.;
- LoRusso, Patricia;
- Eckhardt, S. Gail;
- Wagner, Andrew;
- Chan, Iris T.;
- Mamounas, Michael;
- Flygare, John A.;
- Fairbrother, Wayne J.
Publication type:
Article

Found: 23