Found: 31
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Visualization strategies to aid interpretation of high‐dimensional genotoxicity data.
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- Environmental & Molecular Mutagenesis, 2024, v. 65, n. 5, p. 156, doi. 10.1002/em.22604
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- Article
In vitro human cell‐based aneugen molecular mechanism assay.
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- Environmental & Molecular Mutagenesis, 2022, v. 63, n. 3, p. 151, doi. 10.1002/em.22480
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The use of benchmark dose uncertainty measurements for robust comparative potency analyses.
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- Environmental & Molecular Mutagenesis, 2021, v. 62, n. 3, p. 203, doi. 10.1002/em.22422
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Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds.
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- Environmental & Molecular Mutagenesis, 2020, v. 61, n. 4, p. 396, doi. 10.1002/em.22360
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3Rs‐friendly approach to exogenous metabolic activation that supports high‐throughput genetic toxicology testing.
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- Environmental & Molecular Mutagenesis, 2020, v. 61, n. 4, p. 408, doi. 10.1002/em.22361
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Application of the adverse outcome pathway framework to genotoxic modes of action.
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- Environmental & Molecular Mutagenesis, 2020, v. 61, n. 1, p. 114, doi. 10.1002/em.22339
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Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract.
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- Environmental & Molecular Mutagenesis, 2019, v. 60, n. 9, p. 845, doi. 10.1002/em.22334
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Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy.
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- Environmental & Molecular Mutagenesis, 2019, v. 60, n. 6, p. 513, doi. 10.1002/em.22274
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Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells.
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- Environmental & Molecular Mutagenesis, 2018, v. 59, n. 5, p. 416, doi. 10.1002/em.22182
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Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay.
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- Environmental & Molecular Mutagenesis, 2017, v. 58, n. 3, p. 146, doi. 10.1002/em.22083
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γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9.
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- Environmental & Molecular Mutagenesis, 2016, v. 57, n. 7, p. 546, doi. 10.1002/em.22028
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Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.
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- Environmental & Molecular Mutagenesis, 2016, v. 57, n. 3, p. 171, doi. 10.1002/em.21996
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- Article
Mouse Pig-a and micronucleus assays respond to N-ethyl- N-nitrosourea, benzo[ a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.
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- Environmental & Molecular Mutagenesis, 2016, v. 57, n. 1, p. 28, doi. 10.1002/em.21965
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Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents.
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- Environmental & Molecular Mutagenesis, 2014, v. 55, n. 7, p. 542, doi. 10.1002/em.21868
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Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: Protocol optimization and transferability assessment.
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- Environmental & Molecular Mutagenesis, 2013, v. 54, n. 3, p. 180, doi. 10.1002/em.21760
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In vivo flow cytometric Pig-a and micronucleus assays: Highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo( a)pyrene and pyrene using acute and repeated-dose designs.
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- Environmental & Molecular Mutagenesis, 2012, v. 53, n. 6, p. 420, doi. 10.1002/em.21709
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Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.
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- Environmental & Molecular Mutagenesis, 2011, v. 52, n. 9, p. 748, doi. 10.1002/em.20671
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Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action.
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- Environmental & Molecular Mutagenesis, 2011, v. 52, n. 4, p. 280, doi. 10.1002/em.20618
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High Content Flow Cytometric Micronucleus Scoring Method is Applicable to Attachment Cell Lines.
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- Environmental & Molecular Mutagenesis, 2010, v. 51, n. 3, p. 260, doi. 10.1002/em.20544
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In Vivo Mutation Assay Based on the Endogenous Pig-a Locus.
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- Environmental & Molecular Mutagenesis, 2008, v. 49, n. 4, p. 256, doi. 10.1002/em.20379
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In vitro micronucleus scoring by flow cytometry: Differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability.
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- Environmental & Molecular Mutagenesis, 2006, v. 47, n. 1, p. 56
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Flow cytometric evaluation of the contribution of ionic silver to genotoxic potential of nanosilver in human liver HepG2 and colon Caco2 cells.
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- Journal of Applied Toxicology, 2016, v. 36, n. 4, p. 521, doi. 10.1002/jat.3276
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Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by a flow cytometric in vitro micronucleus assay.
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- Journal of Applied Toxicology, 2014, v. 34, n. 11, p. 1226, doi. 10.1002/jat.3065
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Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity.
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- Mutagenesis, 2021, v. 36, n. 3, p. 255, doi. 10.1093/mutage/geab014
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Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data.
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- Mutagenesis, 2016, v. 31, n. 3, p. 277, doi. 10.1093/mutage/gev041
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Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals.
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- Toxicological Sciences, 2019, v. 170, n. 2, p. 382, doi. 10.1093/toxsci/kfz123
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Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells.
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- Toxicological Sciences, 2018, v. 163, n. 1, p. 214, doi. 10.1093/toxsci/kfy022
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Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals.
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- Toxicological Sciences, 2018, v. 162, n. 1, p. 146, doi. 10.1093/toxsci/kfx235
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Efficient Monitoring of In Vivo Pig-a Gene Mutation and Chromosomal Damage: Summary of 7 Published Studies and Results From 11 New Reference Compounds.
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- Toxicological Sciences, 2012, v. 130, n. 2, p. 328, doi. 10.1093/toxsci/kfs258
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Integration of Mutation and Chromosomal Damage Endpoints into 28-Day Repeat Dose Toxicology Studies.
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- Toxicological Sciences, 2010, v. 115, n. 2, p. 401, doi. 10.1093/toxsci/kfq070
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Pig-a Mutation: Kinetics in Rat Erythrocytes Following Exposure to Five Prototypical Mutagens.
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- Toxicological Sciences, 2010, v. 114, n. 1, p. 59, doi. 10.1093/toxsci/kfp289
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- Article