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Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34200-0
By:
- Fulton, Sasha L.;
- Wenderski, Wendy;
- Lepack, Ashley E.;
- Eagle, Andrew L.;
- Fanutza, Tomas;
- Bastle, Ryan M.;
- Ramakrishnan, Aarthi;
- Hays, Emma C.;
- Neal, Arianna;
- Bendl, Jaroslav;
- Farrelly, Lorna A.;
- Al-Kachak, Amni;
- Lyu, Yang;
- Cetin, Bulent;
- Chan, Jennifer C.;
- Tran, Tina N.;
- Neve, Rachael L.;
- Roper, Randall J.;
- Brennand, Kristen J.;
- Roussos, Panos
Publication type:
Article
Modeling Schizophrenia Using Induced Pluripotent Stem Cell–Derived and Fibroblast-Induced Neurons.
Published in:
2013
By:
- Tran, Ngoc N.;
- Ladran, Ian G.;
- Brennand, Kristen J.
Publication type:
Journal Article
Modeling Schizophrenia Using Induced Pluripotent Stem Cell–Derived and Fibroblast-Induced Neurons.
Published in:
Schizophrenia Bulletin, 2013, v. 39, n. 1, p. 4, doi. 10.1093/schbul/sbs127
By:
- Tran, Ngoc N.;
- Ladran, Ian G.;
- Brennand, Kristen J.
Publication type:
Article
Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons.
Published in:
2016
By:
- Roussos, Panos;
- Guennewig, Boris;
- Kaczorowski, Dominik C.;
- Barry, Guy;
- Brennand, Kristen J.
Publication type:
journal article
Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29922-0
By:
- Farrelly, Lorna A.;
- Zheng, Shuangping;
- Schrode, Nadine;
- Topol, Aaron;
- Bhanu, Natarajan V.;
- Bastle, Ryan M.;
- Ramakrishnan, Aarthi;
- Chan, Jennifer C;
- Cetin, Bulent;
- Flaherty, Erin;
- Shen, Li;
- Gleason, Kelly;
- Tamminga, Carol A.;
- Garcia, Benjamin A.;
- Li, Haitao;
- Brennand, Kristen J.;
- Maze, Ian
Publication type:
Article
Concise Review: The Promise of Human Induced Pluripotent Stem Cell-Based Studies of Schizophrenia.
Published in:
Stem Cells, 2011, v. 29, n. 12, p. 1915, doi. 10.1002/stem.762
By:
- Brennand, Kristen J.;
- Gage, Fred H.
Publication type:
Article
Brief Report: Efficient Generation of Hematopoietic Precursors and Progenitors from Human Pluripotent Stem Cell Lines.
Published in:
Stem Cells, 2011, v. 29, n. 7, p. 1158, doi. 10.1002/stem.657
By:
- Woods, Niels-Bjarne;
- Parker, Aaron S.;
- Moraghebi, Roksana;
- Lutz, Margaret K.;
- Firth, Amy L.;
- Brennand, Kristen J.;
- Berggren, W.Travis;
- Raya, Angel;
- Belmonte, Juan Carlos Izpisúa;
- Gage, Fred H.;
- Verma, Inder M.
Publication type:
Article
Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.
Published in:
Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02412-7
By:
- Hicks, Emily M.;
- Seah, Carina;
- Cote, Alanna;
- Marchese, Shelby;
- Brennand, Kristen J.;
- Nestler, Eric J.;
- Girgenti, Matthew J.;
- Huckins, Laura M.
Publication type:
Article
GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis.
Published in:
Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0642-x
By:
- Kajiwara, Yuji;
- Wang, Erming;
- Wang, Minghui;
- Sin, Wun Chey;
- Brennand, Kristen J.;
- Schadt, Eric;
- Naus, Christian C.;
- Buxbaum, Joseph;
- Zhang, Bin
Publication type:
Article
Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07326-3
By:
- Readhead, Benjamin;
- Hartley, Brigham J.;
- Eastwood, Brian J.;
- Collier, David A.;
- Evans, David;
- Farias, Richard;
- He, Ching;
- Hoffman, Gabriel;
- Sklar, Pamela;
- Dudley, Joel T.;
- Schadt, Eric E.;
- Savić, Radoslav;
- Brennand, Kristen J.
Publication type:
Article
Expression-based drug screening of neural progenitor cells from individuals with schizophrenia.
Published in:
Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-06515-4
By:
- Readhead, Benjamin;
- Hartley, Brigham J.;
- Eastwood, Brian J.;
- Collier, David A.;
- Evans, David;
- Farias, Richard;
- He, Ching;
- Hoffman, Gabriel;
- Sklar, Pamela;
- Dudley, Joel T.;
- Schadt, Eric E.;
- Savić, Radoslav;
- Brennand, Kristen J.
Publication type:
Article
Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells.
Published in:
Frontiers in Cellular Neuroscience, 2017, p. 1, doi. 10.3389/fncel.2017.00360
By:
- Prytkova, Iya;
- Brennand, Kristen J.
Publication type:
Article
Modelling schizophrenia using human induced pluripotent stem cells.
Published in:
Nature, 2011, v. 473, n. 7346, p. 221, doi. 10.1038/nature09915
By:
- Brennand, Kristen J.;
- Simone, Anthony;
- Jou, Jessica;
- Gelboin-Burkhart, Chelsea;
- Ngoc Tran;
- Sangar, Sarah;
- Yan Li;
- Yangling Mu;
- Gong Chen;
- Yu, Diana;
- McCarthy, Shane;
- Sebat, Jonathan;
- Gage, Fred H.
Publication type:
Article
THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders.
Published in:
Translational Psychiatry, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41398-018-0137-3
By:
- Guennewig, Boris;
- Bitar, Maina;
- Obiorah, Ifeanyi;
- Hanks, James;
- O’Brien, Elizabeth A.;
- Kaczorowski, Dominik C.;
- Hurd, Yasmin L.;
- Roussos, Panos;
- Brennand, Kristen J.;
- Barry, Guy
Publication type:
Article
Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders.
Published in:
Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00252
By:
- Schadt, Eric E.;
- Buchanan, Sean;
- Brennand, Kristen J.;
- Merchant, Kalpana M.;
- Auld, Douglas;
- Solomon, Jonathan M.
Publication type:
Article
Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.
Published in:
Human Molecular Genetics, 2011, v. 20, n. R2, p. R109, doi. 10.1093/hmg/ddr336
By:
- Marchetto, Maria C.;
- Brennand, Kristen J.;
- Boyer, Leah F.;
- Gage, Fred H.
Publication type:
Article
The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample.
Published in:
BMC Psychiatry, 2016, v. 16, p. 1, doi. 10.1186/s12888-016-0732-x
By:
- Oedegaard, Ketil J.;
- Alda, Martin;
- Anand, Anit;
- Andreassen, Ole A.;
- Balaraman, Yokesh;
- Berrettini, Wade H.;
- Bhattacharjee, Abesh;
- Brennand, Kristen J.;
- Burdick, Katherine E.;
- Calabrese, Joseph R.;
- Calkin, Cynthia V.;
- Claasen, Ana;
- Coryell, William H.;
- Craig, David;
- DeModena, Anna;
- Frye, Mark;
- Gage, Fred H.;
- Keming Gao;
- Garnham, Julie;
- Gershon, Elliot
Publication type:
Article
Modelling schizophrenia using human induced pluripotent stem cells.
Published in:
2011
By:
- Brennand, Kristen J.;
- Simone, Anthony;
- Jou, Jessica;
- Gelboin-Burkhart, Chelsea;
- Tran, Ngoc;
- Sangar, Sarah;
- Li, Yan;
- Mu, Yangling;
- Chen, Gong;
- Yu, Diana;
- McCarthy, Shane;
- Sebat, Jonathan;
- Gage, Fred H.
Publication type:
Correction Notice
Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models.
Published in:
Cells (2073-4409), 2020, v. 9, n. 6, p. 1406, doi. 10.3390/cells9061406
By:
- Gregory, James A.;
- Hoelzli, Emily;
- Abdelaal, Rawan;
- Braine, Catherine;
- Cuevas, Miguel;
- Halpern, Madeline;
- Barretto, Natalie;
- Schrode, Nadine;
- Akbalik, Güney;
- Kang, Kristy;
- Cheng, Esther;
- Bowles, Kathryn;
- Lotz, Steven;
- Goderie, Susan;
- Karch, Celeste M.;
- Temple, Sally;
- Goate, Alison;
- Brennand, Kristen J.;
- Phatnani, Hemali
Publication type:
Article
Lineage specific 3D genome structure in the adult human brain and neurodevelopmental changes in the chromatin interactome.
Published in:
Nucleic Acids Research, 2023, v. 51, n. 20, p. 11142, doi. 10.1093/nar/gkad798
By:
- Rahman, Samir;
- Dong, Pengfei;
- Apontes, Pasha;
- Fernando, Michael B;
- Kosoy, Roman;
- Townsley, Kayla G;
- Girdhar, Kiran;
- Bendl, Jaroslav;
- Shao, Zhiping;
- Misir, Ruth;
- Tsankova, Nadia;
- Kleopoulos, Steven P;
- Brennand, Kristen J;
- Fullard, John F;
- Roussos, Panos
Publication type:
Article
Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02330-5
By:
- Hoffman, Gabriel E.;
- Hartley, Brigham J.;
- Flaherty, Erin;
- Ladran, Ian;
- Gochman, Peter;
- Ruderfer, Douglas M.;
- Stahl, Eli A.;
- Rapoport, Judith;
- Sklar, Pamela;
- Brennand, Kristen J.
Publication type:
Article
Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems.
Published in:
Journal of Neuroscience, 2020, v. 40, n. 6, p. 1176, doi. 10.1523/JNEUROSCI.0518-19.2019
By:
- Rehbach, Kristina;
- Fernando, Michael B.;
- Brennand, Kristen J.
Publication type:
Article
Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor.
Published in:
Human Mutation, 2021, v. 42, n. 6, p. 685, doi. 10.1002/humu.24201
By:
- Webb, Bryn D.;
- Evans, Anthony;
- Naidich, Thomas P.;
- Bird, Lynne;
- Parikh, Sumit;
- Fernandez Garcia, Meilin;
- Henderson, Lindsay B.;
- Millan, Francisca;
- Si, Yue;
- Brennand, Kristen J.;
- Hung, Peter;
- Rucker, Janet C.;
- Wheeler, Patricia G.;
- Schadt, Eric E.
Publication type:
Article
Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes.
Published in:
Human Mutation, 2018, v. 39, n. 7, p. 939, doi. 10.1002/humu.23537
By:
- Grochowski, Christopher M.;
- Gu, Shen;
- Yuan, Bo;
- TCW, Julia;
- Brennand, Kristen J.;
- Sebat, Jonathan;
- Malhotra, Dheeraj;
- McCarthy, Shane;
- Rudolph, Uwe;
- Lindstrand, Anna;
- Chong, Zechen;
- Levy, Deborah L.;
- Lupski, James R.;
- Carvalho, Claudia M. B.
Publication type:
Article
Analysis framework and experimental design for evaluating synergy-driving gene expression.
Published in:
Nature Protocols, 2021, v. 16, n. 2, p. 812, doi. 10.1038/s41596-020-00436-7
By:
- Schrode, Nadine;
- Seah, Carina;
- Deans, P. J. Michael;
- Hoffman, Gabriel;
- Brennand, Kristen J.
Publication type:
Article
Functional annotation of rare structural variation in the human brain.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16736-1
By:
- Han, Lide;
- Zhao, Xuefang;
- Benton, Mary Lauren;
- Perumal, Thaneer;
- Collins, Ryan L.;
- Hoffman, Gabriel E.;
- Johnson, Jessica S.;
- Sloofman, Laura;
- Wang, Harold Z.;
- Stone, Matthew R.;
- CommonMind Consortium;
- Akbarian, Schahram;
- Bendl, Jaroslav;
- Breen, Michael;
- Brennand, Kristen J.;
- Brown, Leanne;
- Browne, Andrew;
- Buxbaum, Joseph D.;
- Charney, Alexander;
- Chess, Andrew
Publication type:
Article
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.
Published in:
Genome Medicine, 2016, v. 8, p. 1, doi. 10.1186/s13073-016-0355-3
By:
- Minghui Wang;
- Roussos, Panos;
- McKenzie, Andrew;
- Xianxiao Zhou;
- Kajiwara, Yuji;
- Brennand, Kristen J.;
- De Luca, Gabriele C.;
- Crary, John F.;
- Casaccia, Patrizia;
- Buxbaum, Joseph D.;
- Ehrlich, Michelle;
- Gandy, Sam;
- Goate, Alison;
- Katsel, Pavel;
- Schadt, Eric;
- Haroutunian, Vahram;
- Bin Zhang
Publication type:
Article

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