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Works by Brealey, David

Results: 39
    1

    Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study.

    Published in:
    2021
    By:
    • Pugin, Jérôme;
    • Daix, Thomas;
    • Pagani, Jean-Luc;
    • Morri, Davide;
    • Giacomucci, Angelo;
    • Dequin, Pierre-François;
    • Guitton, Christophe;
    • Que, Yok-Ai;
    • Zani, Gianluca;
    • Brealey, David;
    • Lepape, Alain;
    • Creagh-Brown, Ben;
    • Wyncoll, Duncan;
    • Silengo, Daniela;
    • Irincheeva, Irina;
    • Girard, Laurie;
    • Rebeaud, Fabien;
    • Maerki, Iwan;
    • Eggimann, Philippe;
    • François, Bruno
    Publication type:
    journal article
    2

    INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia

    Published in:
    Intensive Care Medicine, 2025, v. 51, n. 2, p. 272, doi. 10.1007/s00134-024-07772-2
    By:
    • Enne, Virve I.;
    • Stirling, Susan;
    • Barber, Julie A.;
    • High, Juliet;
    • Russell, Charlotte;
    • Brealey, David;
    • Dhesi, Zaneeta;
    • Colles, Antony;
    • Singh, Suveer;
    • Parker, Robert;
    • Peters, Mark;
    • Cherian, Benny P.;
    • Riley, Peter;
    • Dryden, Matthew;
    • Simpson, Ruan;
    • Patel, Nehal;
    • Cassidy, Jane;
    • Martin, Daniel;
    • Welters, Ingeborg D.;
    • Page, Valerie
    Publication type:
    Article
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    Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

    Published in:
    2020
    By:
    • Ranieri, V. Marco;
    • Pettilä, Ville;
    • Karvonen, Matti K.;
    • Jalkanen, Juho;
    • Nightingale, Peter;
    • Brealey, David;
    • Mancebo, Jordi;
    • Ferrer, Ricard;
    • Mercat, Alain;
    • Patroniti, Nicolò;
    • Quintel, Michael;
    • Vincent, Jean-Louis;
    • Okkonen, Marjatta;
    • Meziani, Ferhat;
    • Bellani, Giacomo;
    • MacCallum, Niall;
    • Creteur, Jacques;
    • Kluge, Stefan;
    • Artigas-Raventos, Antonio;
    • Maksimow, Mikael
    Publication type:
    journal article
    9

    Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.

    Published in:
    2018
    By:
    • Pickkers, Peter;
    • Mehta, Ravindra L.;
    • Murray, Patrick T.;
    • Joannidis, Michael;
    • Molitoris, Bruce A.;
    • Kellum, John A.;
    • Bachler, Mirjam;
    • Hoste, Eric A. J.;
    • Hoiting, Oscar;
    • Krell, Kenneth;
    • Ostermann, Marlies;
    • Rozendaal, Wim;
    • Valkonen, Miia;
    • Brealey, David;
    • Beishuizen, Albertus;
    • Meziani, Ferhat;
    • Murugan, Raghavan;
    • de Geus, Hilde;
    • Payen, Didier;
    • van den Berg, Erik
    Publication type:
    journal article
    10

    Optimal intensive care outcome prediction over time using machine learning.

    Published in:
    PLoS ONE, 2018, v. 13, n. 11, p. 1, doi. 10.1371/journal.pone.0206862
    By:
    • Meiring, Christopher;
    • Dixit, Abhishek;
    • Harris, Steve;
    • MacCallum, Niall S.;
    • Brealey, David A.;
    • Watkinson, Peter J.;
    • Jones, Andrew;
    • Ashworth, Simon;
    • Beale, Richard;
    • Brett, Stephen J.;
    • Singer, Mervyn;
    • Ercole, Ari
    Publication type:
    Article
    11

    Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial.

    Published in:
    2017
    By:
    • Bellingan, Geoff;
    • Brealey, David;
    • Mancebo, Jordi;
    • Mercat, Alain;
    • Patroniti, Nicolò;
    • Pettilä, Ville;
    • Quintel, Michael;
    • Vincent, Jean-Louis;
    • Maksimow, Mikael;
    • Jalkanen, Markku;
    • Piippo, Ilse;
    • Ranieri, V. Marco
    Publication type:
    journal article
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    Discontinuation vs. continuation of renin–angiotensin system inhibition before non-cardiac surgery: the SPACE trial.

    Published in:
    European Heart Journal, 2024, v. 45, n. 13, p. 1146, doi. 10.1093/eurheartj/ehad716
    By:
    • Ackland, Gareth L;
    • Patel, Akshaykumar;
    • Abbott, Tom E F;
    • Begum, Salma;
    • Dias, Priyanthi;
    • Crane, David R;
    • Somanath, Sameer;
    • Middleditch, Alexander;
    • Cleland, Stuart;
    • Arroyo, Ana Gutierrez del;
    • Brealey, David;
    • Pearse, Rupert M;
    • investigators, the Stopping Perioperative ACE-inhibitors or angiotensin-II receptor blockers (SPACE) trial
    Publication type:
    Article
    20

    Plasma exchange for COVID‐19 thrombo‐inflammatory disease.

    Published in:
    EJHaem, 2021, v. 2, n. 1, p. 26, doi. 10.1002/jha2.140
    By:
    • Arulkumaran, Nishkantha;
    • Thomas, Mari;
    • Brealey, David;
    • Alwan, Ferras;
    • Singh, Deepak;
    • Lunn, Michael;
    • Welch, Anna;
    • Clark, Samuel;
    • Raith, Eamon;
    • Reddy, Ugan;
    • Low, Ryan;
    • Leverett, David;
    • Singer, Mervyn;
    • Scully, Marie
    Publication type:
    Article
    21

    Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.

    Published in:
    JAMA: Journal of the American Medical Association, 2025, v. 334, n. 1, p. 32, doi. 10.1001/jama.2025.7200
    By:
    • Walsh, Timothy S.;
    • Parker, Richard A.;
    • Aitken, Leanne M.;
    • McKenzie, Cathrine A.;
    • Emerson, Lydia;
    • Boyd, Julia;
    • Macdonald, Alix;
    • Beveridge, Gayle;
    • Giddings, Annabel;
    • Hope, David;
    • Irvine, Sîan;
    • Tuck, Sharon;
    • Lone, Nazir I.;
    • Kydonaki, Kalliopi;
    • Norrie, John;
    • Brealey, David;
    • Antcliffe, David;
    • Reay, Michael;
    • Williams, Alan;
    • Bewley, Jeremy
    Publication type:
    Article
    22

    Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.

    Published in:
    JAMA: Journal of the American Medical Association, 2025, v. 333, n. 8, p. 682, doi. 10.1001/jama.2024.26458
    By:
    • Dark, Paul;
    • Hossain, Anower;
    • McAuley, Daniel F.;
    • Brealey, David;
    • Carlson, Gordon;
    • Clayton, Jonathan C.;
    • Felton, Timothy W.;
    • Ghuman, Belinder K.;
    • Gordon, Anthony C.;
    • Hellyer, Thomas P.;
    • Lone, Nazir I.;
    • Manazar, Uzma;
    • Richards, Gillian;
    • McCullagh, Iain J.;
    • McMullan, Ronan;
    • McNamee, James J.;
    • McNeil, Hannah C.;
    • Mouncey, Paul R.;
    • Naisbitt, Micheal J.;
    • Parker, Robert J.
    Publication type:
    Article
    23

    INHALE: the impact of using FilmArray Pneumonia Panel molecular diagnostics for hospital-acquired and ventilator-associated pneumonia on antimicrobial stewardship and patient outcomes in UK Critical Care-study protocol for a multicentre randomised controlled trial.

    Published in:
    2021
    By:
    • High, Juliet;
    • Enne, Virve I.;
    • Barber, Julie A.;
    • Brealey, David;
    • Turner, David A.;
    • Horne, Robert;
    • Peters, Mark;
    • Dhesi, Zaneeta;
    • Wagner, Adam P.;
    • Pandolfo, Alyssa M.;
    • Stirling, Sue;
    • Russell, Charlotte;
    • O'Grady, Justin;
    • Swart, Ann Marie;
    • Gant, Vanya;
    • Livermore, David M.;
    • INHALE Study Group
    Publication type:
    journal article
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    Intensivists' beliefs about rapid multiplex molecular diagnostic testing and its potential role in improving prescribing decisions and antimicrobial stewardship: a qualitative study.

    Published in:
    Antimicrobial Resistance & Infection Control, 2021, v. 10, n. 1, p. 1, doi. 10.1186/s13756-021-00961-4
    By:
    • Pandolfo, Alyssa M.;
    • Horne, Robert;
    • Jani, Yogini;
    • Reader, Tom W.;
    • Bidad, Natalie;
    • Brealey, David;
    • Enne, Virve I.;
    • Livermore, David M.;
    • Gant, Vanya;
    • Brett, Stephen J.;
    • the INHALE WP2 Study Group;
    • Barber, Julie;
    • Shallcross, Laura;
    • Cuesta, Jeronimo;
    • Peters, Mark;
    • Klein, Nigel;
    • Moondi, Parvez;
    • O'Grady, Justin;
    • High, Juliet;
    • Russell, Charlotte
    Publication type:
    Article
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    Immunophenotyping patients with sepsis and underlying haematological malignancy reveals defects in monocyte and lymphocyte function.

    Published in:
    Intensive Care Medicine Experimental, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40635-023-00578-4
    By:
    • Snow, Timothy Arthur Chandos;
    • Serisier, Aimee;
    • Brealey, David;
    • Singer, Mervyn;
    • Arulkumaran, Nishkantha;
    • University College London Hospitals Critical Care Research Team;
    • Saleem, Naveed;
    • Cesar, Antonio;
    • Waller, Alessia V.;
    • Ryckaert, Francis;
    • Smyth, Deborah;
    • Bercades, Georgia;
    • Hass, Ingrid;
    • Zapata Martinez, Alexandra;
    • Gallagher, Laura;
    • Martir, Gladys
    Publication type:
    Article
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    Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial) A Multicenter, Randomized, Controlled Clinical Trial.

    Published in:
    American Journal of Respiratory & Critical Care Medicine, 2023, v. 208, n. 3, p. 256, doi. 10.1164/rccm.202302-0297OC
    By:
    • Gorman, Ellen A.;
    • Rynne, Jennifer;
    • Gardiner, Hannah J.;
    • Rostron, Anthony J.;
    • Bannard-Smith, Jonathan;
    • Bentley, Andrew M.;
    • Brealey, David;
    • Campbell, Christina;
    • Curley, Gerard;
    • Clarke, Mike;
    • Dushianthan, Ahilanadan;
    • Hopkins, Phillip;
    • Jackson, Colette;
    • Kefela, Kallirroi;
    • Krasnodembskaya, Anna;
    • Laffey, John G.;
    • McDowell, Cliona;
    • McFarland, Margaret;
    • McFerran, Jamie;
    • McGuigan, Peter
    Publication type:
    Article
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    The impact of hospitalization on dental plaque accumulation: an observational study.

    Published in:
    Journal of Clinical Periodontology, 2012, v. 39, n. 11, p. 1011, doi. 10.1111/j.1600-051X.2012.01939.x
    By:
    • Needleman, Ian;
    • Hyun-Ryu, Jung;
    • Brealey, David;
    • Sachdev, Mishal;
    • Moskal-Fitzpatrick, Donna;
    • Bercades, Georgia;
    • Nagle, Janette;
    • Lewis, Katherine;
    • Agudo, Elisa;
    • Petrie, Aviva;
    • Suvan, Jean;
    • Donos, Nikos;
    • Singer, Mervyn
    Publication type:
    Article
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    Safety and Pharmacokinetics of Intravenous Zanamivir Treatment in Hospitalized Adults With Influenza: An Open-label, Multicenter, Single-Arm, Phase II Study.

    Published in:
    Journal of Infectious Diseases, 2014, v. 209, n. 4, p. 542, doi. 10.1093/infdis/jit467
    By:
    • Marty, Francisco M.;
    • Man, Choy Y.;
    • van der Horst, Charles;
    • Francois, Bruno;
    • Garot, Denis;
    • Máňez, Rafael;
    • Thamlikitkul, Visanu;
    • Lorente, José A.;
    • Álvarez-Lerma, Francisco;
    • Brealey, David;
    • Zhao, Henry H.;
    • Weller, Steve;
    • Yates, Phillip J.;
    • Peppercorn, Amanda F.
    Publication type:
    Article