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Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart.
Published in:
2019
By:
- Orini, Michele;
- Yanni, Joseph;
- Taggart, Peter;
- Hanson, Ben;
- Hayward, Martin;
- Smith, Andrew;
- Zhang, Henggui;
- Colman, Michael;
- Jones, Gareth;
- Jie, Xiao;
- Dobrzynski, Halina;
- Boyett, Mark R;
- Lambiase, Pier D
Publication type:
journal article
Atrioventricular node dysfunction in pressure overload-induced heart failure--Involvement of the immune system and transcriptomic remodelling.
Published in:
Frontiers in Pharmacology, 2023, v. 14, p. 01, doi. 10.3389/fphar.2023.1083910
By:
- Wilson, Claire;
- Min Zi;
- Smith, Matthew;
- Hussain, Munir;
- D'Souza, Alicia;
- Dobrzynski, Halina;
- Boyett, Mark R.
Publication type:
Article
Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia.
Published in:
Frontiers in Physiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.519382
By:
- Bidaud, Isabelle;
- D'Souza, Alicia;
- Forte, Gabriella;
- Torre, Eleonora;
- Greuet, Denis;
- Thirard, Steeve;
- Anderson, Cali;
- Chung You Chong, Antony;
- Torrente, Angelo G.;
- Roussel, Julien;
- Wickman, Kevin;
- Boyett, Mark R.;
- Mangoni, Matteo E.;
- Mesirca, Pietro
Publication type:
Article
Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart.
Published in:
Frontiers in Physiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.546508
By:
- Alghamdi, Aaazh M.;
- Boyett, Mark R.;
- Hancox, Jules C.;
- Zhang, Henggui
Publication type:
Article
Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study.
Published in:
Frontiers in Physiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.547577
By:
- Alghamdi, Azzah M.;
- Testrow, Craig P.;
- Whittaker, Dominic G.;
- Boyett, Mark R.;
- Hancox, Jules. C.;
- Zhang, Henggui
Publication type:
Article
A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels.
Published in:
Journal of Physiology, 2005, v. 568, n. 3, p. 749, doi. 10.1113/jphysiol.2005.085746
By:
- Makary, Samy M. Y.;
- Claydon, Tom W.;
- Enkvetchakul, Decha;
- Nichols, Colin G.;
- Boyett, Mark R.
Publication type:
Article
Ageing-related changes of connexins and conduction within the sinoatrial node.
Published in:
Journal of Physiology, 2004, v. 560, n. 2, p. 429, doi. 10.1113/jphysiol.2004.072108
By:
- Jones, Sandra A.;
- Lancaster, Matthew K.;
- Boyett, Mark R.
Publication type:
Article
Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking.
Published in:
Journal of Physiology, 2004, v. 559, n. 3, p. 835, doi. 10.1113/jphysiol.2004.068643
By:
- Ming Lei;
- Jones, Sandra A.;
- Jie Liu;
- Lancaster, Matthew K.;
- Fung, Simon S. -M.;
- Dobrzynski, Halina;
- Camelliti, Patrizia;
- Maier, Sebastian K. G.;
- Noble, Denis;
- Boyett, Mark R.
Publication type:
Article
Intracellular Ca2+ and pacemaking within the rabbit sinoatrial node: heterogeneity of role and control.
Published in:
Journal of Physiology, 2004, v. 556, n. 2, p. 481, doi. 10.1113/jphysiol.2003.057372
By:
- Lancaster, Matthew K.;
- Jones, Sandra A.;
- Harrison, Simon M.;
- Boyett, Mark R.
Publication type:
Article
Cyclical modulation of human ventricular repolarization by respiration.
Published in:
Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00379
By:
- Hanson, Ben;
- Gill, Jaswinder;
- Western, David;
- Gilbey, Michael P.;
- Bostock, Julian;
- Boyett, Mark R.;
- Zhang, Henggui;
- Coronel, Ruben;
- Taggart, Peter
Publication type:
Article
Modeling the chronotropic effect of isoprenaline on rabbit sinoatrial node.
Published in:
Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00241
By:
- Henggui Zhang;
- Butters, Timothy;
- Adeniran, Ismail;
- Higham, Jonathan;
- Holden, ArunV.;
- Boyett, Mark R.;
- Hancox, Jules C.
Publication type:
Article
Modelling the chronotropic effect of isoprenaline on rabbit sinoatrial node.
Published in:
Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00241
By:
- Butters, Timothy;
- Adeniran, Ismail;
- Higham, Jonathan;
- Holden, Arun V.;
- Boyett, Mark R.;
- Hancox, Jules C.;
- Henggui Zhang
Publication type:
Article
The anatomy of the cardiac conduction system.
Published in:
Clinical Anatomy, 2009, v. 22, n. 1, p. 99, doi. 10.1002/ca.20700
By:
- Anderson, Robert H.;
- Yanni, Joseph;
- Boyett, Mark R.;
- Chandler, Natalie J.;
- Dobrzynski, Halina
Publication type:
Article
Engineering virtual cardiac tissue.
Published in:
Briefings in Bioinformatics, 2001, v. 2, n. 3, p. 233, doi. 10.1093/bib/2.3.233
By:
- Boyett, Mark R.;
- Holden, Arun V.;
- Zhang, Henggui
Publication type:
Article
Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit.
Published in:
PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0141452
By:
- Nikolaidou, Theodora;
- Cai, Xue J.;
- Stephenson, Robert S.;
- Yanni, Joseph;
- Lowe, Tristan;
- Atkinson, Andrew J.;
- Jones, Caroline B.;
- Sardar, Rida;
- Corno, Antonio F.;
- Dobrzynski, Halina;
- Withers, Philip J.;
- Jarvis, Jonathan C.;
- Hart, George;
- Boyett, Mark R.
Publication type:
Article
Three-Dimensional Computer Model of the Right Atrium Including the Sinoatrial and Atrioventricular Nodes Predicts Classical Nodal Behaviours.
Published in:
PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112547
By:
- Li, Jue;
- Inada, Shin;
- Schneider, Jurgen E.;
- Zhang, Henggui;
- Dobrzynski, Halina;
- Boyett, Mark R.
Publication type:
Article
Importance of Gradients in Membrane Properties and Electrical Coupling in Sinoatrial Node Pacing.
Published in:
PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094565
By:
- Inada, Shin;
- Zhang, Henggui;
- Tellez, James O.;
- Shibata, Nitaro;
- Nakazawa, Kazuo;
- Kamiya, Kaichiro;
- Kodama, Itsuo;
- Mitsui, Kazuyuki;
- Dobrzynski, Halina;
- Boyett, Mark R.;
- Honjo, Haruo
Publication type:
Article
Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells.
Published in:
PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067247
By:
- Monfredi, Oliver;
- Maltseva, Larissa A.;
- Spurgeon, Harold A.;
- Boyett, Mark R.;
- Lakatta, Edward G.;
- Maltsev, Victor A.
Publication type:
Article
Contrast Enhanced Micro-Computed Tomography Resolves the 3-Dimensional Morphology of the Cardiac Conduction System in Mammalian Hearts.
Published in:
PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035299
By:
- Stephenson, Robert S.;
- Boyett, Mark R.;
- Hart, George;
- Nikolaidou, Theodora;
- Cai, Xue;
- Corno, Antonio F.;
- Alphonso, Nelson;
- Jeffery, Nathan;
- Jonathan C. Jarvis
Publication type:
Article
hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment.
Published in:
Journal of Cardiovascular Electrophysiology, 2014, v. 25, n. 2, p. 197, doi. 10.1111/jce.12289
By:
- VEROLI, GIOVANNI Y.;
- DAVIES, MARK R.;
- ZHANG, HENGGUI;
- ABI‐GERGES, NAJAH;
- BOYETT, MARK R.
Publication type:
Article
One-Dimensional Rabbit Sinoatrial Node Models: Benefits and Limitations.
Published in:
Journal of Cardiovascular Electrophysiology, 2003, v. 14, p. S121, doi. 10.1046/j.1540.8167.90301.x
By:
- GARNY, ALAN;
- KOHL, PETER;
- HUNTER, PETER J.;
- BOYETT, MARK R.;
- NOBLE, DENIS
Publication type:
Article
Sophisticated Architecture is Required for the Sinoatrial Node to Perform Its Normal Pacemaker Function.
Published in:
Journal of Cardiovascular Electrophysiology, 2003, v. 14, n. 1, p. 104, doi. 10.1046/j.1540-8167.2003.02307.x
By:
- BOYETT, MARK R.;
- DOBRZYNSKI, HALINA;
- LANCASTER, MATTHEW K.;
- JONES, SANDRA A.;
- HONJO, HARUO;
- KODAMA, ITSUO
Publication type:
Article
Are We Lost in the Labyrinth of the Sinoatrial Node Pacemaker Mechanism?
Published in:
Journal of Cardiovascular Electrophysiology, 2002, v. 13, n. 12, p. 1303, doi. 10.1046/j.1540-8167.2002.01303.x
By:
- Kodama, Itsuo;
- Honjo, Haruo;
- Boyett, Mark R.;
- Rudy, Yoram
Publication type:
Article
Sustained Inward Current and Pacemaker Activity of Mammalian Sinoatrial Node.
Published in:
Journal of Cardiovascular Electrophysiology, 2002, v. 13, n. 8, p. 809, doi. 10.1046/j.1540-8167.2002.00809.x
By:
- Henggui Zhang;
- Holden, Arun V.;
- Boyett, Mark R.
Publication type:
Article
Analysis of the Chronotropic Effect of Acetylcholine on Sinoatrial Node Cells.
Published in:
Journal of Cardiovascular Electrophysiology, 2002, v. 13, n. 5, p. 465, doi. 10.1046/j.1540-8167.2002.00465.x
By:
- Henggui Zhang;
- Holden, Arun V.;
- Noble, Denis;
- Boyett, Mark R.
Publication type:
Article
Simulation of ventricular rate control during atrial fibrillation using ionic channel blockers.
Published in:
Journal of Arrhythmia, 2017, v. 33, n. 4, p. 302, doi. 10.1016/j.joa.2016.12.002
By:
- Inada, Shin;
- Shibata, MD, PhD, Nitaro;
- Iwata, PhD, Michiaki;
- Haraguchi, PhD, Ryo;
- Ashihara MD, PhD, Takashi;
- Ikeda, MD, PhD, Takanori;
- Mitsui, PhD, Kazuyuki;
- Dobrzynski, PhD, Halina;
- Boyett, PhD, Mark R.;
- Nakazawa, PhD, Kazuo
Publication type:
Article
Characterization of a right atrial subsidiary pacemaker and acceleration of the pacing rate by HCN over-expression.
Published in:
Cardiovascular Research, 2013, v. 100, n. 1, p. 160, doi. 10.1093/cvr/cvt164
By:
- Morris, Gwilym M.;
- D'Souza, Alicia;
- Dobrzynski, Halina;
- Lei, Ming;
- Choudhury, Moinuddin;
- Billeter, Rudi;
- Kryukova, Yelena;
- Robinson, Richard B.;
- Kingston, Paul A.;
- Boyett, Mark R.
Publication type:
Article
Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat.
Published in:
Cardiovascular Research, 2009, v. 81, n. 3, p. 546
By:
- Urszula Mackiewicz;
- Michal Maczewski;
- Anna Konior;
- James O. Tellez;
- Dominika Nowis;
- Halina Dobrzynski;
- Mark R. Boyett;
- Bohdan Lewartowski
Publication type:
Article
Organisation of the mouse sinoatrial node: structure and expression of HCN channels
Published in:
Cardiovascular Research, 2007, v. 73, n. 4, p. 729, doi. 10.1016/j.cardiores.2006.11.016
By:
- Liu, Jie;
- Dobrzynski, Halina;
- Yanni, Joseph;
- Boyett, Mark R.;
- Lei, Ming
Publication type:
Article
Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45
Published in:
Cardiovascular Research, 2006, v. 72, n. 2, p. 271, doi. 10.1016/j.cardiores.2006.07.026
By:
- Yamamoto, Mitsuru;
- Dobrzynski, Halina;
- Tellez, James;
- Niwa, Ryoko;
- Billeter, Rudi;
- Honjo, Haruo;
- Kodama, Itsuo;
- Boyett, Mark R.
Publication type:
Article
Heterogeneous expression of connexins in rabbit sinoatrial node cells: correlation between connexin isotype and cell size.
Published in:
Cardiovascular Research, 2002, v. 53, n. 1, p. 89, doi. 10.1016/S0008-6363(01)00421-7
By:
- Honjo, Haruo;
- Boyett, Mark R;
- Coppen, Steven R;
- Takagishi, Yoshiko;
- Opthof, Tobias;
- Severs, Nicholas J;
- Kodama, Itsuo
Publication type:
Article
The Relation Between Contraction and Intracellular Sodium in Voltage-Clamped Sheep Purkinje Fibers.
Published in:
Journal of Cardiovascular Electrophysiology, 1991, v. 2, n. 2, p. 134, doi. 10.1111/j.1540-8167.1991.tb01312.x
By:
- Levi, Allan J.;
- Boyett, Mark R.
Publication type:
Article
Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-48276-0
By:
- Logantha, Sunil Jit R. J.;
- Kharche, Sanjay R.;
- Zhang, Yu;
- Atkinson, Andrew J.;
- Hao, Guoliang;
- Boyett, Mark R.;
- Dobrzynski, Halina
Publication type:
Article
The Anatomy and Physiology of the Sinoatrial Node-A Contemporary Review MONFREDI, ET AL. SINOATRIAL NODAL ANATOMY AND PHYSIOLOGY.
Published in:
Pacing & Clinical Electrophysiology, 2010, v. 33, n. 11, p. 1392, doi. 10.1111/j.1540-8159.2010.02838.x
By:
- MONFREDI, OLIVER;
- DOBRZYNSKI, HALINA;
- MONDAL, TAPAS;
- BOYETT, MARK R.;
- MORRIS, GWILYM M.
Publication type:
Article
Perspectives — biological pacing, a clinical reality?
Published in:
Therapeutic Advances in Cardiovascular Disease, 2009, v. 3, n. 6, p. 479, doi. 10.1177/1753944709345792
By:
- Morris, Gwilym M.;
- Boyett, Mark R.
Publication type:
Article
Exercise training reduces resting heart rate via downregulation of the funny channel HCN4.
Published in:
Nature Communications, 2014, v. 5, n. 5, p. 3775, doi. 10.1038/ncomms4775
By:
- D'Souza, Alicia;
- Bucchi, Annalisa;
- Johnsen, Anne Berit;
- Logantha, Sunil Jit R.J.;
- Monfredi, Oliver;
- Yanni, Joseph;
- Prehar, Sukhpal;
- Hart, George;
- Cartwright, Elizabeth;
- Wisloff, Ulrik;
- Dobryznski, Halina;
- DiFrancesco, Dario;
- Morris, Gwilym M.;
- Boyett, Mark R.
Publication type:
Article
Post-Myocardial Infarction T-tubules Form Enlarged Branched Structures With Dysregulation of Junctophilin-2 and Bridging Integrator 1 (BIN-1).
Published in:
2017
By:
- Pinali, Christian;
- Malik, Nadim;
- Davenport, J. Bernard;
- Allan, Laurence J.;
- Murfitt, Lucy;
- Iqbal, Mohammad M.;
- Boyett, Mark R.;
- Wright, Elizabeth J.;
- Walker, Rachel;
- Zhang, Yu;
- Dobryznski, Halina;
- Holt, Cathy M.;
- Kitmitto, Ashraf
Publication type:
journal article
RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-82202-7
By:
- Wang, Yanwen;
- Anderson, Cali;
- Dobrzynski, Halina;
- Hart, George;
- D'Souza, Alicia;
- Boyett, Mark R.
Publication type:
Article
RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-82202-7
By:
- Wang, Yanwen;
- Anderson, Cali;
- Dobrzynski, Halina;
- Hart, George;
- D'Souza, Alicia;
- Boyett, Mark R.
Publication type:
Article
Messenger RNAデータを基に構築したヒト房室結節活動電位モデルの構築とコンピュータシミュレーションによる興奮伝導解析
Published in:
Journal of the Physiological Society of Japan / Nihon Seirigaku Zasshi, 2014, v. 76, n. 1, p. 15
By:
- Inada Shin;
- Iwata Michiaki;
- Haraguchi Ryo;
- Nakazawa Kazuo;
- Ono Takako;
- Mitsui Kazuyuki;
- Suzuki Tōru;
- Shibata Nitarō;
- Boyett, Mark R;
- Dobrzynski, Halina
Publication type:
Article
Rebuttal from Alicia D'Souza, Sanjay Sharma and Mark R. Boyett.
Published in:
Journal of Physiology, 2015, v. 593, n. 8, p. 1755, doi. 10.1113/JP270256
By:
- D'Souza, Alicia;
- Sharma, Sanjay;
- Boyett, Mark R.
Publication type:
Article
CrossTalk opposing view: Bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node.
Published in:
Journal of Physiology, 2015, v. 593, n. 8, p. 1749, doi. 10.1113/jphysiol.2014.284356
By:
- D'Souza, Alicia;
- Sharma, Sanjay;
- Boyett, Mark R.
Publication type:
Article
Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria.
Published in:
Journal of Physiology, 2013, v. 591, n. 17, p. 4249, doi. 10.1113/jphysiol.2013.254987
By:
- Colman, Michael A.;
- Aslanidi, Oleg V.;
- Kharche, Sanjay;
- Boyett, Mark R.;
- Garratt, Clifford;
- Hancox, Jules C.;
- Zhang, Henggui
Publication type:
Article
Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling.
Published in:
Journal of Physiology, 2012, v. 590, n. 18, p. 4501, doi. 10.1113/jphysiol.2012.229146
By:
- Kharche, Sanjay;
- Adeniran, Ismail;
- Stott, Jonathan;
- Law, Phillip;
- Boyett, Mark R.;
- Hancox, Jules C.;
- Zhang, Henggui
Publication type:
Article
Left ventricle structural remodelling in the prediabetic Goto-Kakizaki rat.
Published in:
Experimental Physiology, 2011, v. 96, n. 9, p. 875, doi. 10.1113/expphysiol.2011.058271
By:
- D'Souza, Alicia;
- Howarth, Frank C.;
- Yanni, Joseph;
- Dobryznski, Halina;
- Boyett, Mark R.;
- Adeghate, Ernest;
- Bidasee, Keshore R;
- Singh, Jaipaul
Publication type:
Article
Changes in the expression of ion channels, connexins and Ca.
Published in:
Experimental Physiology, 2011, v. 96, n. 4, p. 426, doi. 10.1113/expphysiol.2010.055780
By:
- Allah, Eman Abd;
- Tellez, James O.;
- Yanni, Joseph;
- Nelson, Thomas;
- Monfredi, Oliver;
- Boyett, Mark R.;
- Dobrzynski, Halina
Publication type:
Article
‘And the beat goes on’ The cardiac conduction system: the wiring system of the heart.
Published in:
Experimental Physiology, 2009, v. 94, n. 10, p. 1035, doi. 10.1113/expphysiol.2009.046920
By:
- Boyett, Mark R.
Publication type:
Article
Pacemaker shift in the rabbit sinoatrial node in response to vagal nerve stimulation.
Published in:
Experimental Physiology, 2001, v. 86, n. 2, p. 177, doi. 10.1113/eph8602100
By:
- Shibata, Nitaro;
- Inada, Shin;
- Mitsui, Kazuyuki;
- Honjo, Haruo;
- Yamamoto, Mitsuru;
- Niwa, Ryoko;
- Boyett, Mark R.;
- Kodama, Itsuo
Publication type:
Article
Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart.
Published in:
Frontiers in Physiology, 2019, p. 1, doi. 10.3389/fphys.2019.00826
By:
- Zhang, Yu;
- Wang, Yanwen;
- Yanni, Joseph;
- Qureshi, Mohammed Anwar;
- Logantha, Sunil Jit R. J.;
- Kassab, Sarah;
- Boyett, Mark R.;
- Gardiner, Natalie J.;
- Sun, Hong;
- Howarth, Frank Christopher;
- Dobrzynski, Halina
Publication type:
Article
The Functional Role of Hyperpolarization Activated Current (I f) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study.
Published in:
Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.582037
By:
- Bai, Xiangyun;
- Wang, Kuanquan;
- Boyett, Mark R.;
- Hancox, Jules C.;
- Zhang, Henggui
Publication type:
Article

Found: 52