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Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.
- Published in:
- Science Translational Medicine, 2019, v. 11, n. 478, p. N.PAG, doi. 10.1126/scitranslmed.aau8866
- By:
- Publication type:
- Article
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.
- Published in:
- Science Translational Medicine, 2017, v. 9, n. 413, p. 1, doi. 10.1126/scitranslmed.aao4583
- By:
- Publication type:
- Article
Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma.
- Published in:
- Liver International, 2013, v. 33, n. 5, p. 780, doi. 10.1111/liv.12126
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- Publication type:
- Article
Interaction with p53 explains a pro-proliferative function for VHL in cancer.
- Published in:
- Journal of Molecular Medicine, 2020, v. 98, n. 9, p. 1269, doi. 10.1007/s00109-020-01951-6
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- Publication type:
- Article
SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes.
- Published in:
- 2021
- By:
- Publication type:
- journal article
p53-Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology.
- Published in:
- 2020
- By:
- Publication type:
- letter