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Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist.
Published in:
Nature Medicine, 2002, v. 8, n. 8, p. 825, doi. 10.1038/nm741
By:
- Borowsky, Beth;
- Durkin, Margaret M.;
- Ogozalek, Kristine;
- Marzabadi, Mohammad R.;
- DeLeon, John;
- Heurich, Rainer;
- Lichtblau, Harvey;
- Shaposhnik, Zoya;
- Daniewska, Irena;
- Blackburn, Thomas P.;
- Branchek, Theresa A.;
- Gerald, Christophe;
- Vaysse, Pierre J.;
- Forray, Carlos
Publication type:
Article
The API Generation program: Biomarker phenotyping of cognitively unimpaired participants screened in Generation study 1 and Generation study 2: Alzheimer's Prevention Initiative (API) Generation program: Baseline characteristics and umibecestat results during treatment and follow‐up
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041143
By:
- Rouzade‐Dominguez, Marie‐Laure;
- Riviere, Marie‐Emmanuelle;
- Borowsky, Beth;
- Liu, Fonda;
- Cazorla, Pilar;
- Quinn, Matt;
- Seneca, Nicholas;
- Neumann, Ulf;
- Eichenlaub, Udo;
- Chien, Yuchen;
- Viglietta, Vissia;
- Reiman, Eric M.;
- Sui, Yihan;
- Caputo, Angelika;
- Graf, Ana
Publication type:
Article
The API Generation program: Umibecestat treatment and discontinuation effects on hippocampal and whole brain volumes in the overall population and amyloid‐negative APOE4 homozygotes: Alzheimer's Prevention Initiative (API) Generation program: Baseline characteristics and umibecestat results during treatment and follow‐up
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041142
By:
- Reiman, Eric M.;
- Tariot, Pierre N.;
- Borowsky, Beth;
- Liu, Fonda;
- Riviere, Marie‐Emmanuelle;
- Rouzade‐Dominguez, Marie‐Laure;
- Cazorla, Pilar;
- Quinn, Matt;
- Ricart, Javier;
- Langbaum, Jessica B.;
- Viglietta, Vissia;
- Sui, Yihan;
- Caputo, Angelika;
- Graf, Ana;
- Seneca, Nicholas;
- Neumann, Ulf;
- Eichenlaub, Udo;
- Chien, Yuchen;
- Arkuszewski, Michal;
- Piccard, Hernan
Publication type:
Article
The Generation program: Baseline characteristics of cognitively unimpaired APOE4 carriers recruited for Generation study 1 and Generation study 2: Alzheimer's Prevention Initiative (API) Generation program: Baseline characteristics and umibecestat results during treatment and follow‐up
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041139
By:
- Tariot, Pierre N.;
- Borowsky, Beth;
- Liu, Fonda;
- Riviere, Marie‐Emmanuelle;
- Rouzade‐Dominguez, Marie‐Laure;
- Cazorla, Pilar;
- Quinn, Matt;
- Ricart, Javier;
- Langbaum, Jessica B.;
- Viglietta, Vissia;
- Sui, Yihan;
- Caputo, Angelika;
- Reiman, Eric M.;
- Graf, Ana
Publication type:
Article
An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28653-6
By:
- Keller, Caroline Gubser;
- Shin, Youngah;
- Monteys, Alex Mas;
- Renaud, Nicole;
- Beibel, Martin;
- Teider, Natalia;
- Peters, Thomas;
- Faller, Thomas;
- St-Cyr, Sophie;
- Knehr, Judith;
- Roma, Guglielmo;
- Reyes, Alejandro;
- Hild, Marc;
- Lukashev, Dmitriy;
- Theil, Diethilde;
- Dales, Natalie;
- Cha, Jang-Ho;
- Borowsky, Beth;
- Dolmetsch, Ricardo;
- Davidson, Beverly L.
Publication type:
Article
Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease.
Published in:
Journal of the International Neuropsychological Society, 2016, v. 22, n. 6, p. 595, doi. 10.1017/S1355617716000321
By:
- Labuschagne, Izelle;
- Cassidy, Amy Mulick;
- Scahill, Rachael I.;
- Johnson, Eileanoir B.;
- Rees, Elin;
- O'Regan, Alison;
- Queller, Sarah;
- Frost, Chris;
- Leavitt, Blair R.;
- Dürr, Alexandra;
- Roos, Raymond;
- Owen, Gail;
- Borowsky, Beth;
- Tabrizi, Sarah J.;
- Stout, Julie C.
Publication type:
Article
Natural variation in sensory-motor white matter organization influences manifestations of Huntington's disease.
Published in:
Human Brain Mapping, 2016, v. 37, n. 12, p. 4615, doi. 10.1002/hbm.23332
By:
- Orth, Michael;
- Gregory, Sarah;
- Scahill, Rachael I;
- Mayer, Isabella SM;
- Minkova, Lora;
- Klöppel, Stefan;
- Seunarine, Kiran K;
- Boyd, Lara;
- Borowsky, Beth;
- Reilmann, Ralf;
- Bernhard Landwehrmeyer, G.;
- Leavitt, Blair R;
- Roos, Raymund AC;
- Durr, Alexandra;
- Rees, Geraint;
- Rothwell, John C;
- Langbehn, Douglas;
- Tabrizi, Sarah J
Publication type:
Article
Functional changes during working memory in Huntington's disease: 30-month longitudinal data from the IMAGE-HD study.
Published in:
Brain Structure & Function, 2015, v. 220, n. 1, p. 501, doi. 10.1007/s00429-013-0670-z
By:
- Poudel, Govinda;
- Stout, Julie;
- Domínguez D, Juan;
- Gray, Marcus;
- Salmon, Louisa;
- Churchyard, Andrew;
- Chua, Phyllis;
- Borowsky, Beth;
- Egan, Gary;
- Georgiou-Karistianis, Nellie
Publication type:
Article
Association of CAG Repeats With Long-term Progression in Huntington Disease.
Published in:
JAMA Neurology, 2019, v. 76, n. 11, p. 1375, doi. 10.1001/jamaneurol.2019.2368
By:
- Langbehn, Douglas R.;
- Stout, Julie C.;
- Gregory, Sarah;
- Mills, James A.;
- Durr, Alexandra;
- Leavitt, Blair R.;
- Roos, Raymund A. C.;
- Long, Jeffrey D.;
- Owen, Gail;
- Johnson, Hans J.;
- Borowsky, Beth;
- Craufurd, David;
- Reilmann, Ralf;
- Landwehrmeyer, G. Bernhard;
- Scahill, Rachael I.;
- Tabrizi, Sarah J.
Publication type:
Article
Medication Use in Early-HD Participants in TrackHD: an Investigation of its Effects on Clinical Performance.
Published in:
PLoS Currents, 2016, p. 280, doi. 10.1371/currents.hd.8060298fac1801b01ccea6acc00f97cb
By:
- Keogh, Ruth;
- Frost, Chris;
- Owen, Gail;
- Daniel, Rhian M.;
- Langbehn, Doug R.;
- Leavitt, Blair;
- Durr, Alexandra;
- Roos, Raymund A. C.;
- Landwehrmeyer, G. Bernhard;
- Reilmann, Ralf;
- Borowsky, Beth;
- Stout, Julie;
- Craufurd, David;
- Tabrizi, Sarah J.
Publication type:
Article
Assessment of Motor Symptoms and Functional Impact in Prodromal and Early Huntington Disease.
Published in:
PLoS Currents, 2011, p. 200, doi. 10.1371/currents.RRN1244
By:
- Vaccarino, Anthony L.;
- Sills, Terrence;
- Anderson, Karen E.;
- Biglan, Kevin;
- Borowsky, Beth;
- Giuliano, Joseph;
- Guttman, Mark;
- Ho, Aileen K.;
- Kennard, Christopher;
- Kupchak, Peter;
- Landwehrmeyer, G. Bernhard;
- Michell, Andrew;
- Paulsen, Jane S.;
- Reilmann, Ralf;
- van Kammen, Daniel P.;
- Warner, John H.;
- Evans, Ken
Publication type:
Article
Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease.
Published in:
PLoS Currents, 2011, p. 189, doi. 10.1371/currents.RRN1242
By:
- Vaccarino, Anthony L.;
- Sills, Terrence;
- Anderson, Karen E.;
- Bachoud-Lévi, Anne-Catherine;
- Borowsky, Beth;
- Craufurd, David;
- Duff, Kevin;
- Giuliano, Joseph;
- Groves, Mark;
- Guttman, Mark;
- Kupchak, Peter;
- Ho, Aileen K.;
- Paulsen, Jane S.;
- Pedersen, Kenn Freddy;
- van Duijn, Erik;
- van Kammen, Daniel P.;
- Evans, Ken
Publication type:
Article
Assessment of Cognitive Symptoms in Prodromal and Early Huntington Disease.
Published in:
PLoS Currents, 2011, p. 167, doi. 10.1371/currents.RRN1250
By:
- Vaccarino, Anthony L.;
- Sills, Terrence;
- Anderson, Karen E.;
- Borowsky, Beth;
- Craufurd, David;
- Giuliano, Joseph;
- Goodman, LaVonne;
- Guttman, Mark;
- Kupchak, Peter;
- Ho, Aileen K.;
- Paulsen, Jane S.;
- Stout, Julie C.;
- van Kammen, Daniel P.;
- Evans, Ken
Publication type:
Article
Assessing Behavioural Manifestations Prior to Clinical Diagnosis of Huntington Disease: "Anger and Irritability" and "Obsessions and Compulsions".
Published in:
PLoS Currents, 2011, p. 158, doi. 10.1371/currents.RRN1241
By:
- Vaccarino, Anthony L.;
- Anderson, Karen E.;
- Borowsky, Beth;
- Coccaro, Emil;
- Craufurd, David;
- Endicott, Jean;
- Giuliano, Joseph;
- Groves, Mark;
- Guttman, Mark;
- Ho, Aileen K.;
- Kupchak, Peter;
- Paulsen, Jane S.;
- Stanford, Matthew S.;
- van Kammen, Daniel P.;
- Watson, David;
- Wu, Kevin D.;
- Evans, Ken
Publication type:
Article
AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents.
Published in:
Psychopharmacology, 2011, v. 215, n. 1, p. 149, doi. 10.1007/s00213-010-2124-0
By:
- Black, Mark;
- Stevens, Rachel;
- Rogacki, Nancy;
- Featherstone, Robert;
- Senyah, Yaw;
- Giardino, Odessa;
- Borowsky, Beth;
- Stemmelin, Jeanne;
- Cohen, Caroline;
- Pichat, Philippe;
- Arad, Michal;
- Barak, Segev;
- Levie, Amaya;
- Weiner, Ina;
- Griebel, Guy;
- Varty, Geoffrey
Publication type:
Article
Sleep deficits but no metabolic deficits in premanifest Huntington's disease.
Published in:
2015
By:
- Lazar, Alpar S.;
- Panin, Francesca;
- Goodman, Anna O. G.;
- Lazic, Stanley E.;
- Lazar, Zsolt I.;
- Mason, Sarah L.;
- Rogers, Lorraine;
- Murgatroyd, Peter R.;
- Watson, Laura P. E.;
- Singh, Priya;
- Borowsky, Beth;
- Shneerson, John M.;
- Barker, Roger A.
Publication type:
journal article
A PET-CT study on neuroinflammation in Huntington's disease patients participating in a randomized trial with laquinimod.
Published in:
Brain Communications, 2023, v. 5, n. 2, p. 1, doi. 10.1093/braincomms/fcad084
By:
- Roussakis, Andreas-Antonios;
- Gennaro, Marta;
- Gordon, Mark Forrest;
- Reilmann, Ralf;
- Borowsky, Beth;
- Rynkowski, Gail;
- Lao-Kaim, Nicholas P.;
- Papoutsou, Zoe;
- Savola, Juha-Matti;
- Hayden, Michael R.;
- Owen, David R.;
- Kalk, Nicola;
- Lingford-Hughes, Anne;
- Gunn, Roger N.;
- Searle, Graham;
- Tabrizi, Sarah J.;
- Piccini, Paola
Publication type:
Article
A Computational Cognitive Biomarker for Early-Stage Huntington’s Disease.
Published in:
PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0148409
By:
- Wiecki, Thomas V.;
- Antoniades, Chrystalina A.;
- Stevenson, Alexander;
- Kennard, Christopher;
- Borowsky, Beth;
- Owen, Gail;
- Leavitt, Blair;
- Roos, Raymund;
- Durr, Alexandra;
- Tabrizi, Sarah J.;
- Frank, Michael J.
Publication type:
Article
Design optimization for clinical trials in early-stage manifest Huntington's disease.
Published in:
2017
By:
- Frost, Chris;
- Mulick, Amy;
- Scahill, Rachael I.;
- Owen, Gail;
- Aylward, Elizabeth;
- Leavitt, Blair R.;
- Durr, Alexandra;
- Roos, Raymund A. C.;
- Borowsky, Beth;
- Stout, Julie C.;
- Reilmann, Ralf;
- Langbehn, Douglas R.;
- Tabrizi, Sarah J.;
- Sampaio, Cristina;
- TRACK-HD Investigators
Publication type:
journal article
Clinical trials in Huntington's disease: Interventions in early clinical development and newer methodological approaches.
Published in:
2014
By:
- Sampaio, Cristina;
- Borowsky, Beth;
- Reilmann, Ralf
Publication type:
Journal Article
Clinical trials in Huntington's disease: Interventions in early clinical development and newer methodological approaches.
Published in:
Movement Disorders, 2014, v. 29, n. 11, p. 1419, doi. 10.1002/mds.26021
By:
- Sampaio, Cristina;
- Borowsky, Beth;
- Reilmann, Ralf
Publication type:
Article
HD-CAB: A cognitive assessment battery for clinical trials in Huntington's disease<sup>1,2,3</sup>.
Published in:
Movement Disorders, 2014, v. 29, n. 10, p. 1281, doi. 10.1002/mds.25964
By:
- Stout, Julie C.;
- Queller, Sarah;
- Baker, Kalyca N.;
- Cowlishaw, Sean;
- Sampaio, Cristina;
- Fitzer‐Attas, Cheryl;
- Borowsky, Beth
Publication type:
Article
An item response analysis of the motor and behavioral subscales of the unified Huntington's disease rating scale in huntington disease gene expansion carriers.
Published in:
Movement Disorders, 2011, v. 26, n. 5, p. 877, doi. 10.1002/mds.23574
By:
- Vaccarino, Anthony L.;
- Anderson, Karen;
- Borowsky, Beth;
- Duff, Kevin;
- Giuliano, Joseph;
- Guttman, Mark;
- Ho, Aileen K.;
- Orth, Michael;
- Paulsen, Jane S.;
- Sills, Terrence;
- van Kammen, Daniel P.;
- Evans, Kenneth R.
Publication type:
Article
GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2.
Published in:
Nature, 1998, v. 396, n. 6712, p. 674, doi. 10.1038/25348
By:
- Jones, Kenneth A.;
- Borowsky, Beth;
- Tamm, Joe A.;
- Craig, Douglas A.;
- Durkin, Margaret M.;
- Meng Dai;
- Wen-Jeng Yao;
- Johnson, Mary;
- Gunwaldsen, Caryn;
- Ling-Yan Huang;
- Cheng Tang;
- Quanrong Shen;
- Salon, John A.;
- Morse, Kelley;
- Laz, Thomas;
- Smith, Kelli E.;
- Nagarathnam, Dhanapalan;
- Noble, Stewart A.;
- Branchek, Theresa A.;
- Gerald, Christophe
Publication type:
Article

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