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In the search for a lead structure among series of potent and selective hydantoin 5- HT<sub>7</sub>R agents: The drug-likeness in vitro study.
- Published in:
- Chemical Biology & Drug Design, 2017, v. 90, n. 6, p. 1295, doi. 10.1111/cbdd.13106
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- Article
Solid-Supported Synthesis and 5- HT<sub>7</sub>/5- HT<sub>1A</sub> Receptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5-dihydro-1,2,4-triazine-6-(1 H)-one.
- Published in:
- Chemical Biology & Drug Design, 2015, v. 86, n. 4, p. 697, doi. 10.1111/cbdd.12539
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- Publication type:
- Article
Synthesis, Antidepressant Evaluation and Docking Studies of Long-Chain Alkylnitroquipazines as Serotonin Transporter Inhibitors.
- Published in:
- Chemical Biology & Drug Design, 2013, v. 81, n. 6, p. 695, doi. 10.1111/cbdd.12116
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- Publication type:
- Article
Structure-Activity Relationship Studies of CNS Agents, Part 25: 4,6-Di(heteroaryl)-2-( N-methylpiperazino)pyrimidines as New, Potent 5-HT<sub>2A</sub> Receptor Ligands: A Verification of the Topographic Model.
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- Archiv der Pharmazie, 1995, v. 328, n. 9, p. 659, doi. 10.1002/ardp.19953280906
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- Publication type:
- Article
Structure-Activity Relationship Studies of CNS Agents, Part 23<sup>[1])</sup>: N-(3-Phenylpropyl)- and N-[3( E)-Cinnamyl]-1,2,3,4-tetrahydroisoquinoline Mimic 1-Phenylpiperazine at 5-HT<sub>1A</sub> Receptors.
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- Archiv der Pharmazie, 1995, v. 328, n. 7/8, p. 604, doi. 10.1002/ardp.19953280707
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- Publication type:
- Article
Structure-Activity Relationship Studies of CNS Agents, XXI: Two Derivatives of 1-( o-Methoxyphenyl)piperazine with an Opposite Function at 5-HT<sub>1A</sub> Receptors Struktur-Wirkung-Beziehungen ZNS-aktiver Substanzen, 21. Mitt.<sup>1)</sup>: Zwei Derivate von 1-( o-Methoxyphenyl)piperazin mit entgegengesetzter Wirkung auf 5-HT<sub>1A</sub> Rezeptoren
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- Archiv der Pharmazie, 1995, v. 328, n. 4, p. 381, doi. 10.1002/ardp.19953280417
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- Article
Structure-Activity Relationship Studies of CNS Agents, XIX: Quantitative Analysis of the Alkyl Chain Effects on the 5-HT<sub>1A</sub> and 5-HT<sub>2</sub> Receptor Affinities of 4-Alkyl-1-arylpiperazines and Their Analogs.
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- Archiv der Pharmazie, 1995, v. 328, n. 2, p. 143, doi. 10.1002/ardp.19953280210
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- Publication type:
- Article
A study on application of impregnated synthetic peptide TLC stationary phases for the screening of 5-HT<sub>1A</sub> ligands. Part 2.
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- Biomedical Chromatography, 2004, v. 18, n. 8, p. 542, doi. 10.1002/bmc.354
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- Publication type:
- Article
Preliminary study on application of impregnated synthetic peptide TLC stationary phases for the pre-screening of 5-HT<sub>1A</sub> ligands.
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- Biomedical Chromatography, 2003, v. 17, n. 5, p. 312, doi. 10.1002/bmc.224
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- Publication type:
- Article
Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT 6 and D 3 R Affinity in the 1 H -Pyrrolo[3,2- c ]quinoline Series.
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- Molecules, 2023, v. 28, n. 3, p. 1096, doi. 10.3390/molecules28031096
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- Article
Isomeric Activity Cliffs—A Case Study for Fluorine Substitution of Aminergic G Protein-Coupled Receptor Ligands.
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- Molecules, 2023, v. 28, n. 2, p. 490, doi. 10.3390/molecules28020490
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- Publication type:
- Article
Hydrogen Bonds with Fluorine in Ligand–Protein Complexes-the PDB Analysis and Energy Calculations.
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- Molecules, 2022, v. 27, n. 3, p. 1005, doi. 10.3390/molecules27031005
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- Publication type:
- Article
N -Skatyltryptamines—Dual 5-HT 6 R/D 2 R Ligands with Antipsychotic and Procognitive Potential.
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- Molecules, 2021, v. 26, n. 15, p. 4605, doi. 10.3390/molecules26154605
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- Article
Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl—Simulated Interaction Patterns Confronted with Experimental Data.
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- Molecules, 2020, v. 25, n. 20, p. 4636, doi. 10.3390/molecules25204636
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- Article
In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds.
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- Molecules, 2019, v. 24, n. 5, p. 935, doi. 10.3390/molecules24050935
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- Article
Substructural Connectivity Fingerprint and Extreme Entropy Machines—A New Method of Compound Representation and Analysis.
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- Molecules, 2018, v. 23, n. 6, p. 1242, doi. 10.3390/molecules23061242
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- Article
Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands.
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- Molecules, 2018, v. 23, n. 5, p. 1137, doi. 10.3390/molecules23051137
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- Publication type:
- Article
Spiro[pyrrolidine-3,3'-oxindoles] and Their Indoline Analogues as New 5-HT6 Receptor Chemotypes.
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- Molecules, 2017, v. 22, n. 12, p. 2221, doi. 10.3390/molecules22122221
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- Publication type:
- Article
Synthesis and Structure-Activity Relationship Analysis of 5-HT7 Receptor Antagonists: Piperazin-1-yl Substituted Unfused Heterobiaryls.
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- Molecules, 2016, v. 21, n. 4, p. 433, doi. 10.3390/molecules21040433
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- Publication type:
- Article
Extremely Randomized Machine Learning Methods for Compound Activity Prediction.
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- Molecules, 2015, v. 20, n. 11, p. 20107, doi. 10.3390/molecules201119679
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- Publication type:
- Article
Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents.
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- Molecules, 2011, v. 16, n. 5, p. 4104, doi. 10.3390/molecules16054104
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- Publication type:
- Article
Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu 7 Receptor Modulation Activity and Antipsychotic-Like Properties.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 1981, doi. 10.3390/ijms24031981
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- Article
In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 7238, doi. 10.3390/ijms22137238
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- Publication type:
- Article
Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 3, p. 1035, doi. 10.3390/ijms22031035
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- Article
Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
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- International Journal of Molecular Sciences, 2018, v. 19, n. 10, p. 3260, doi. 10.3390/ijms19103260
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- Article
Evaluation of 1-arylpiperazine derivative of hydroxybenzamides as 5-HT.
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- Journal of Heterocyclic Chemistry, 2011, v. 48, n. 1, p. 192, doi. 10.1002/jhet.526
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- Publication type:
- Article
Synthesis of 4-substituted 2-(4-methylpiperazino)pyrimidines and quinazoline analogs as serotonin 5-HT<sub>2A</sub> receptor ligands.
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- Journal of Heterocyclic Chemistry, 2009, v. 46, n. 6, p. 1259, doi. 10.1002/jhet.236
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- Publication type:
- Article
The synthesis of cyclic and acyclic long-chain arylpiperazine derivatives of salicylamide as serotonin receptor ligands.
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- Journal of Heterocyclic Chemistry, 2008, v. 45, n. 1, p. 209, doi. 10.1002/jhet.5570450125
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- Publication type:
- Article
Synthesis and biological properties of 1,8-naphthalimidebutylamines. Serotonin 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> binding data and pass-assisted search.
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- Journal of Heterocyclic Chemistry, 2007, v. 44, n. 4, p. 889, doi. 10.1002/jhet.5570440423
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- Publication type:
- Article
Conformational analysis of 4-(2′-furyl)-2-(methylamino)pyrimidine.
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- Journal of Heterocyclic Chemistry, 1996, v. 33, n. 4, p. 1207, doi. 10.1002/jhet.5570330434
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- Article
Allosteric Inhibition of Serotonin 5-HT<sub>7</sub> Receptors by Zinc Ions.
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- Molecular Neurobiology, 2018, v. 55, n. 4, p. 2897, doi. 10.1007/s12035-017-0536-0
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- Article
Influence of Fluorine Substitution on Nonbonding Interactions in Selected Para‐Halogeno Anilines.
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- ChemPhysChem, 2021, v. 22, n. 20, p. 2115, doi. 10.1002/cphc.202100383
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- Publication type:
- Article
Structure-5-HT/D<sub>2</sub> Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1 H-purine-2,6(3 H,7 H)-dione.
- Published in:
- Archiv der Pharmazie, 2016, v. 349, n. 10, p. 774, doi. 10.1002/ardp.201600162
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- Publication type:
- Article
New Arylpiperazinylalkyl Derivatives of 8-Alkoxy-purine-2,6-dione and Dihydro[1,3]oxazolo[2,3- f]purinedione Targeting the Serotonin 5-HT<sub>1A</sub>/5-HT<sub>2A</sub>/5-HT<sub>7</sub> and Dopamine D<sub>2</sub> Receptors.
- Published in:
- Archiv der Pharmazie, 2015, v. 348, n. 4, p. 242, doi. 10.1002/ardp.201500015
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- Publication type:
- Article
Structure-5-HT Receptor Affinity Relationship in a New Group of 7-Arylpiperazynylalkyl and 7-Tetrahydroisoquinolinylalkyl Derivatives of 8-Amino-1,3-dimethyl-1 H-purine-2,6(3 H,7 H)-dione.
- Published in:
- Archiv der Pharmazie, 2015, v. 348, n. 4, p. 229, doi. 10.1002/ardp.201400392
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- Publication type:
- Article
New Arylpiperazines with Flexible versus Partly Constrained Linker as Serotonin 5-HT<sub>1A</sub>/5-HT<sub>7</sub> Receptor Ligands.
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- Archiv der Pharmazie, 2013, v. 346, n. 5, p. 339, doi. 10.1002/ardp.201300011
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- Article
Quinolinesulfonamides of Aryloxy-/Arylthio-ethyl Piperidines: Influence of an Arylether Fragment on 5-HT<sub>1A</sub>/5-HT<sub>7</sub> Receptor Selectivity.
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- Archiv der Pharmazie, 2013, v. 346, n. 3, p. 180, doi. 10.1002/ardp.201200322
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- Publication type:
- Article
Novel Mannich Bases, 5-Arylimidazolidine-2,4-dione Derivatives with Dual 5-HT<sub>1A</sub> Receptor and Serotonin Transporter Affinity.
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- Archiv der Pharmazie, 2013, v. 346, n. 2, p. 98, doi. 10.1002/ardp.201200378
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- Publication type:
- Article
Conformational Restriction in Novel NAN-190 and MP3022 Analogs and Their 5-HT1A Receptor Activity.
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- Archiv der Pharmazie, 2006, v. 339, n. 9, p. 498
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- Publication type:
- Article
Modification of the Structure of 4, 6-Disubstituted 2-(4-Alkyl-1-piperazinyl)pyridines: Synthesis and Their 5-HT<sub>2A</sub> Receptor Activity.
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- Archiv der Pharmazie, 2003, v. 336, n. 2, p. 104, doi. 10.1002/ardp.200390006
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- Publication type:
- Article
Novel 1,4-Benzoxazin-3( 4H)-one, 1,2-Benzoxazolin-3-one and 1,3-Benzoxazolin-2,4-dione Arylpiperazine Derivatives with Different 5-HT<sub>1A</sub> and Antagonistic 5-HT<sub>2A</sub> Activities.
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- Archiv der Pharmazie, 1999, v. 332, n. 11, p. 373, doi. 10.1002/(SICI)1521-4184(199911)332:11<373::AID-ARDP373>3.0.CO;2-L
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- Publication type:
- Article
Crystal and Molecular Structure of 4-[ω-(Benzotriazolyl)alkyl]-1-(2-methoxyphenyl)piperazines with a Different Pharmacological Activity.
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- Archiv der Pharmazie, 1998, v. 331, n. 10, p. 299, doi. 10.1002/(sici)1521-4184(199810)331:10<299::aid-ardp299>3.3.co;2-v
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- Article
Robust optimization of SVM hyperparameters in the classification of bioactive compounds.
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- Journal of Cheminformatics, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13321-015-0088-0
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- Publication type:
- Article
Multiple conformational states in retrospective virtual screening - homology models vs. crystal structures: beta-2 adrenergic receptor case study.
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- Journal of Cheminformatics, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13321-015-0062-x
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- Publication type:
- Article
The influence of negative training set size on machine learning-based virtual screening.
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- Journal of Cheminformatics, 2014, v. 6, n. 1, p. 1, doi. 10.1186/1758-2946-6-32
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- Article
The influence of the inactives subset generation on the performance of machine learning methods.
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- Journal of Cheminformatics, 2013, v. 5, n. 1, p. 1, doi. 10.1186/1758-2946-5-17
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- Publication type:
- Article
Application of Structural Interaction Fingerpints (SIFts) into post-docking analysis - insight into activity and selectivity.
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- 2013
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- Publication type:
- Conference Paper
The influence of hashed fingerprints density on the machine learning methods performance.
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- 2013
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- Publication type:
- Conference Paper
The influence of training actives/inactives ratio on machine learning performance.
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- 2013
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- Publication type:
- Conference Paper
The importance of template choice in homology modeling. A 5-HT<sub>6</sub>R case study.
- Published in:
- Journal of Cheminformatics, 2013, v. 5, n. S1, p. 1, doi. 10.1186/1758-2946-5-S1-P8
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- Publication type:
- Article