Found: 15

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  • TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity.

    Published in:
    2006
    By:
    • Fusheng Chen;
    • Hasegawa, Hiroshi;
    • Schmitt-Ulms, Gerold;
    • Kawarai, Toshitaka;
    • Bohm, Christopher;
    • Katayama, Taiichi;
    • Yongjun Gu;
    • Sanjo, Nobuo;
    • Glista, Michael;
    • Rogaeva, Ekaterina;
    • Wakutani, Yosuke;
    • Pardossi-Piquard, Raphaëlle;
    • Xueying Ruan;
    • Tandon, Anurag;
    • Checler, Frédéric;
    • Marambaud, Philippe;
    • Hansen, Kirk;
    • Westaway, David;
    • St. George-Hyslop, Peter;
    • Fraser, Paul
    Publication type:
    Letter

  • ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism.

    Published in:
    Human Molecular Genetics, 2012, v. 21, n. 1, p. 1, doi. 10.1093/hmg/ddr417
    By:
    • Murakami, Tetsuro;
    • Yang, Seung-Pil;
    • Xie, Lin;
    • Kawano, Taizo;
    • Fu, Donald;
    • Mukai, Asuka;
    • Bohm, Christopher;
    • Chen, Fusheng;
    • Robertson, Janice;
    • Suzuki, Hiroshi;
    • Tartaglia, Gian Gaetano;
    • Vendruscolo, Michele;
    • Kaminski Schierle, Gabriele S.;
    • Chan, Fiona T.S.;
    • Moloney, Aileen;
    • Crowther, Damian;
    • Kaminski, Clemens F.;
    • Zhen, Mei;
    • St George-Hyslop, Peter
    Publication type:
    Article

  • Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway.

    Published in:
    2021
    By:
    • Zhang, Yalun;
    • Zhang, Yi;
    • Aman, Yahyah;
    • Ng, Cheung Toa;
    • Chau, Wing-Hin;
    • Zhang, Zhigang;
    • Yue, Ming;
    • Bohm, Christopher;
    • Jia, Yizhen;
    • Li, Siwen;
    • Yuan, Qiuju;
    • Griffin, Jennifer;
    • Chiu, Kin;
    • Wong, Dana S M;
    • Wang, Binbin;
    • Jin, Dongyan;
    • Rogaeva, Ekaterina;
    • Fraser, Paul E;
    • Fang, Evandro F;
    • George-Hyslop, Peter St
    Publication type:
    journal article

  • Coding mutations in SORL1 and Alzheimer disease.

    Published in:
    2015
    By:
    • Vardarajan, Badri N;
    • Zhang, Yalun;
    • Lee, Joseph H;
    • Cheng, Rong;
    • Bohm, Christopher;
    • Ghani, Mahdi;
    • Reitz, Christiane;
    • Reyes-Dumeyer, Dolly;
    • Shen, Yufeng;
    • Rogaeva, Ekaterina;
    • St George-Hyslop, Peter;
    • Mayeux, Richard
    Publication type:
    journal article

  • Coding mutations in SORL 1 and Alzheimer disease.

    Published in:
    Annals of Neurology, 2015, v. 77, n. 2, p. 215, doi. 10.1002/ana.24305
    By:
    • Vardarajan, Badri N.;
    • Zhang, Yalun;
    • Lee, Joseph H.;
    • Cheng, Rong;
    • Bohm, Christopher;
    • Ghani, Mahdi;
    • Reitz, Christiane;
    • Reyes‐Dumeyer, Dolly;
    • Shen, Yufeng;
    • Rogaeva, Ekaterina;
    • St George‐Hyslop, Peter;
    • Mayeux, Richard
    Publication type:
    Article

  • Structural biology of presenilin 1 complexes.

    Published in:
    Molecular Neurodegeneration, 2014, v. 9, n. 1, p. 1, doi. 10.1186/1750-1326-9-59
    By:
    • Yi Li;
    • Bohm, Christopher;
    • Dodd, Roger;
    • Fusheng Chen;
    • Qamar, Seema;
    • Schmitt-Ulms, Gerold;
    • Fraser, Paul E.;
    • St George-Hyslop, Peter H.
    Publication type:
    Article

  • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

    Published in:
    Nature Genetics, 2007, v. 39, n. 2, p. 168, doi. 10.1038/ng1943
    By:
    • Rogaeva, Ekaterina;
    • Yan Meng;
    • Lee, Joseph H.;
    • Yongjun Gu;
    • Kawarai, Toshitaka;
    • Fanggeng Zou;
    • Katayama, Taiichi;
    • Baldwin, Clinton T.;
    • Cheng, Rong;
    • Hasegawa, Hiroshi;
    • Fusheng Chen;
    • Shibata, Nobuto;
    • Lunetta, Kathryn L.;
    • Pardossi-Piquard, Raphaelle;
    • Bohm, Christopher;
    • Wakutani, Yosuke;
    • Cupples, L. Adrienne;
    • Cuenco, Karen T.;
    • Green, Robert C.;
    • Pinessi, Lorenzo
    Publication type:
    Article

  • PATHOGENIC SORL1 MUTATIONS AND PARKINSONIAN FEATURES IN ALZHEIMER'S DISEASE.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P451, doi. 10.1016/j.jalz.2016.06.874
    By:
    • Cuccaro, Michael L.;
    • Carney, Regina M.;
    • Cukier, Holly N.;
    • Kunkle, Brian W.;
    • Vardarajan, Badri N.;
    • Bohm, Christopher;
    • Zhang, Yalun;
    • St George-Hyslop, Peter;
    • Mayeux, Richard;
    • Pericak-Vance, Margaret A.
    Publication type:
    Article

  • P4-219: TMP21 association with the γ-secretase complex and its regulation of protease activity

    Published in:
    2008
    By:
    • Pardossi-Piquard, Raphaelle;
    • Chen, Fusheng;
    • Bohm, Christopher;
    • Checler, Frédéric;
    • St George-Hyslop, Peter;
    • Fraser, Paul
    Publication type:
    Abstract

  • P3-376: Gene expression profiling in a transgenic mouse model of Alzheimer's disease

    Published in:
    2008
    By:
    • Wakutani, Yosuke;
    • Pardossi-Piquard, Raphaelle;
    • Gu, Yongjun;
    • Murakami, Tetsuro;
    • Yang, Seung-Pil;
    • Bohm, Christopher;
    • Chen, Fusheng;
    • Yip, Edwin;
    • Rogaeva, Ekaterina;
    • Fraser, Paul;
    • Westaway, David;
    • St-George Hyslop, Peter
    Publication type:
    Abstract

  • P3-392: p24 family proteins have different function in APP processing

    Published in:
    2006
    By:
    • Hasegawa, Hiroshi;
    • Chen, Fusheng;
    • Schmitt-Ulms, Gerold;
    • Kawarai, Toshitaka;
    • Bohm, Christopher;
    • Katayama, Taiichi;
    • Gu, Yong-Jun;
    • Fraser, Paul E.;
    • St. George-Hyslop, Peter
    Publication type:
    Abstract

  • O1-02-01: A novel presenilin complex component which modulates gamma- but not epsilon-secretase activity

    Published in:
    2006
    By:
    • Fraser, Paul;
    • Chen, Fusheng;
    • Hasegawa, Hiroshi;
    • Schmitt-Ulms, Gerold;
    • Kawarai, Toshitaka;
    • Bohm, Christopher;
    • Katayama, Taiichi;
    • Gu, Yongju;
    • Sanjo, Nobuo;
    • Glista, Michael;
    • Rogaeva, Ekaterina;
    • Wakutani, Yosuke;
    • Piquard, Raphaelle Pardossi;
    • Ruan, Xueying;
    • Tandon, Anurag;
    • Checler, Frederic;
    • Marambaud, Philippe;
    • Hansen, Kirk;
    • Westaway, David;
    • St George-Hyslop, Peter
    Publication type:
    Abstract

  • P3-392: p24 family proteins have different function in APP processing

    Published in:
    2006
    By:
    • Hasegawa, Hiroshi;
    • Chen, Fusheng;
    • Schmitt-Ulms, Gerold;
    • Kawarai, Toshitaka;
    • Bohm, Christopher;
    • Katayama, Taiichi;
    • Gu, Yong-Jun;
    • Fraser, Paul E.;
    • St. George-Hyslop, Peter
    Publication type:
    Abstract

  • O1-02-01: A novel presenilin complex component which modulates gamma- but not epsilon-secretase activity

    Published in:
    2006
    By:
    • Fraser, Paul;
    • Chen, Fusheng;
    • Hasegawa, Hiroshi;
    • Schmitt-Ulms, Gerold;
    • Kawarai, Toshitaka;
    • Bohm, Christopher;
    • Katayama, Taiichi;
    • Gu, Yongju;
    • Sanjo, Nobuo;
    • Glista, Michael;
    • Rogaeva, Ekaterina;
    • Wakutani, Yosuke;
    • Piquard, Raphaelle Pardossi;
    • Ruan, Xueying;
    • Tandon, Anurag;
    • Checler, Frederic;
    • Marambaud, Philippe;
    • Hansen, Kirk;
    • Westaway, David;
    • St George-Hyslop, Peter
    Publication type:
    Abstract

  • Vigilin interacts with signal peptide peptidase.

    Published in:
    Proteome Science, 2012, v. 10, n. 1, p. 33, doi. 10.1186/1477-5956-10-33
    By:
    • Lu, Stephen Hsueh-Jeng;
    • Jeon, Amy Hye Won;
    • Schmitt-Ulms, Gerold;
    • Qamar, Seema;
    • Dodd, Roger;
    • McDonald, Beth;
    • Yi Li;
    • Meadows, William;
    • Cox, Katie;
    • Bohm, Christopher;
    • Chen, Fusheng;
    • Fraser, Paul;
    • St George-Hyslop, Peter
    Publication type:
    Article