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Berichtigung: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Published in:
Angewandte Chemie, 2016, v. 128, n. 36, p. 10704, doi. 10.1002/ange.201607032
By:
- Ismail, Hanafy M.;
- Barton, Victoria E.;
- Panchana, Matthew;
- Charoensutthivarakul, Sitthivut;
- Biagini, Giancarlo A.;
- Ward, Stephen A.;
- O'Neill, Paul M.
Publication type:
Article
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Published in:
Angewandte Chemie, 2016, v. 128, n. 22, p. 6511, doi. 10.1002/ange.201512062
By:
- Ismail, Hanafy M.;
- Barton, Victoria E.;
- Panchana, Matthew;
- Charoensutthivarakul, Sitthivut;
- Biagini, Giancarlo A.;
- Ward, Stephen A.;
- O'Neill, Paul M.
Publication type:
Article
Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing.
Published in:
Pharmaceutics, 2019, v. 11, n. 6, p. 278, doi. 10.3390/pharmaceutics11060278
By:
- Aljayyoussi, Ghaith;
- Donnellan, Samantha;
- Ward, Stephen A.;
- Biagini, Giancarlo A.
Publication type:
Article
Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Published in:
Angewandte Chemie International Edition, 2016, v. 55, n. 36, p. 10548, doi. 10.1002/anie.201607032
By:
- Ismail, Hanafy M.;
- Barton, Victoria E.;
- Panchana, Matthew;
- Charoensutthivarakul, Sitthivut;
- Biagini, Giancarlo A.;
- Ward, Stephen A.;
- O'Neill, Paul M.
Publication type:
Article
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Published in:
Angewandte Chemie International Edition, 2016, v. 55, n. 22, p. 6401, doi. 10.1002/anie.201512062
By:
- Ismail, Hanafy M.;
- Barton, Victoria E.;
- Panchana, Matthew;
- Charoensutthivarakul, Sitthivut;
- Biagini, Giancarlo A.;
- Ward, Stephen A.;
- O'Neill, Paul M.
Publication type:
Article
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Published in:
Molecular Microbiology, 2006, v. 62, n. 1, p. 238, doi. 10.1111/j.1365-2958.2006.05368.x
By:
- Bray, Patrick G.;
- Mungthin, Mathirut;
- Hastings, Ian M.;
- Biagini, Giancarlo A.;
- Saidu, Dauda K.;
- Lakshmanan, Viswanathan;
- Johnson, David J.;
- Hughes, Ruth H.;
- Stocks, Paul A.;
- O'Neill, Paul M.;
- Fidock, David A.;
- Warhurst, David C.;
- Ward, Stephen A.
Publication type:
Article
Attaching protein-adsorbing silica particles to the surface of cotton substrates for bioaerosol capture including SARS-CoV-2.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40696-x
By:
- Collings, Kieran;
- Boisdon, Cedric;
- Sham, Tung-Ting;
- Skinley, Kevin;
- Oh, Hyun-Kyung;
- Prince, Tessa;
- Ahmed, Adham;
- Pennington, Shaun H.;
- Brownridge, Philip J.;
- Edwards, Thomas;
- Biagini, Giancarlo A.;
- Eyers, Claire E.;
- Lamb, Amanda;
- Myers, Peter;
- Maher, Simon
Publication type:
Article
Loss of pH Control in Plasmodium falciparum Parasites Subjected to Oxidative Stress.
Published in:
PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0058933
By:
- van Schalkwyk, Donelly A.;
- Saliba, Kevin J.;
- Biagini, Giancarlo A.;
- Bray, Patrick G.;
- Kirk, Kiaran
Publication type:
Article
Open-Label Comparative Clinical Study of Chlorproguanil2Dapsone Fixed Dose Combination (Lapdap) Alone or with Three Different Doses of Artesunate for Uncomplicated Plasmodium falciparum Malaria.
Published in:
PLoS ONE, 2008, v. 3, n. 3, p. 1, doi. 10.1371/journal.pone.0001779
By:
- Wootton, Daniel G.;
- Opara, Hyginus;
- Biagini, Giancarlo A.;
- Kanjala, Maxwell K.;
- Duparc, Stephan;
- Kirby, Paula L.;
- Woessner, Mary;
- Neate, Colin;
- Nyirenda, Maggie;
- Blencowe, Hannah;
- Dube-Mbeye, Queen;
- Kanyok, Thomas;
- Ward, Stephen;
- Molyneux, Malcolm;
- Dunyo, Sam;
- Winstanley, Peter A.
Publication type:
Article
Antimalarial activity of primaquine operates via a two-step biochemical relay.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-11239-0
By:
- Camarda, Grazia;
- Jirawatcharadech, Piyaporn;
- Priestley, Richard S.;
- Saif, Ahmed;
- March, Sandra;
- Wong, Michael H. L.;
- Leung, Suet;
- Miller, Alex B.;
- Baker, David A.;
- Alano, Pietro;
- Paine, Mark J. I.;
- Bhatia, Sangeeta N.;
- O'Neill, Paul M.;
- Ward, Stephen A.;
- Biagini, Giancarlo A.
Publication type:
Article
SARS‐CoV‐2 infects an upper airway model derived from induced pluripotent stem cells.
Published in:
Stem Cells, 2021, v. 39, n. 10, p. 1310, doi. 10.1002/stem.3422
By:
- Djidrovski, Ivo;
- Georgiou, Maria;
- Hughes, Grant L.;
- Patterson, Edward I.;
- Casas‐Sanchez, Aitor;
- Pennington, Shaun H.;
- Biagini, Giancarlo A.;
- Moya‐Molina, Marina;
- van den Bor, Jelle;
- Smit, Martine J.;
- Chung, Git;
- Lako, Majlinda;
- Armstrong, Lyle
Publication type:
Article
Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model.
Published in:
PLoS Neglected Tropical Diseases, 2019, v. 13, n. 12, p. N.PAG, doi. 10.1371/journal.pntd.0007955
By:
- Jin, Celina;
- Gibani, Malick M.;
- Pennington, Shaun H.;
- Liu, Xinxue;
- Ardrey, Alison;
- Aljayyoussi, Ghaith;
- Moore, Maria;
- Angus, Brian;
- Parry, Christopher M.;
- Biagini, Giancarlo A.;
- Feasey, Nicholas A.;
- Pollard, Andrew J.
Publication type:
Article
Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.
Published in:
Viruses (1999-4915), 2024, v. 16, n. 6, p. 863, doi. 10.3390/v16060863
By:
- Clark, Jordan J.;
- Penrice-Randal, Rebekah;
- Sharma, Parul;
- Dong, Xiaofeng;
- Pennington, Shaun H.;
- Marriott, Amy E.;
- Colombo, Stefano;
- Davidson, Andrew;
- Kavanagh Williamson, Maia;
- Matthews, David A.;
- Turtle, Lance;
- Prince, Tessa;
- Hughes, Grant L.;
- Patterson, Edward I.;
- Shawli, Ghada;
- Mega, Daniele F.;
- Subramaniam, Krishanthi;
- Sharp, Jo;
- Turner, Joseph D.;
- Biagini, Giancarlo A.
Publication type:
Article
Targeting the Ubiquinol-Reduction (Q i) Site of the Mitochondrial Cytochrome bc 1 Complex for the Development of Next Generation Quinolone Antimalarials.
Published in:
Biology (2079-7737), 2022, v. 11, n. 8, p. N.PAG, doi. 10.3390/biology11081109
By:
- Amporndanai, Kangsa;
- Pinthong, Nattapon;
- O'Neill, Paul M.;
- Hong, W. David;
- Amewu, Richard K.;
- Pidathala, Chandrakala;
- Berry, Neil G.;
- Leung, Suet C.;
- Ward, Stephen A.;
- Biagini, Giancarlo A.;
- Hasnain, S. Samar;
- Antonyuk, Svetlana V.
Publication type:
Article
Resisting resistance: dealing with the irrepressible problem of malaria.
Published in:
British Journal of Clinical Pharmacology, 2006, v. 61, n. 6, p. 690, doi. 10.1111/j.1365-2125.2006.02674.x
By:
- Edwards, Geoffrey;
- Biagini, Giancarlo A.
Publication type:
Article
OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.
Published in:
Malaria Journal, 2016, v. 15, p. 1, doi. 10.1186/s12936-016-1401-8
By:
- Aljayyoussi, Ghaith;
- Kay, Katherine;
- Ward, Stephen A.;
- Biagini, Giancarlo A.
Publication type:
Article
The cytochrome bc1 complex as an antipathogenic target.
Published in:
FEBS Letters, 2020, v. 594, n. 18, p. 2935, doi. 10.1002/1873-3468.13868
By:
- Fisher, Nicholas;
- Meunier, Brigitte;
- Biagini, Giancarlo A.
Publication type:
Article
Synthesis and Antimalarial Activities of a Diverse Set of Triazole-Containing Furamidine Analogues.
Published in:
ChemMedChem, 2011, v. 6, n. 11, p. 2094, doi. 10.1002/cmdc.201100265
By:
- Berger, Olivier;
- Kaniti, Archana;
- van Ba, Christophe Tran;
- Vial, Henri;
- Ward, Stephen A.;
- Biagini, Giancarlo A.;
- Bray, Patrick G.;
- O'Neill, Paul M.
Publication type:
Article
Trichomonas vaginalis and Giardia intestinalis Produce Nitric Oxide and Display NO-Synthase Activity.
Published in:
Journal of Eukaryotic Microbiology, 2006, v. 53, p. S182, doi. 10.1111/j.1550-7408.2006.00224.x
By:
- HARRIS, KRISTINA M.;
- GOLDBERG, BURT;
- BIAGINI, GIANCARLO A.;
- LLOYD, DAVID
Publication type:
Article
Oxygen Uptake and Antioxidant Responses of the Free-Living Diplomonad Hexamita sp.
Published in:
Journal of Eukaryotic Microbiology, 1997, v. 44, n. 5, p. 447, doi. 10.1111/j.1550-7408.1997.tb05722.x
By:
- BIAGINI, GIANCARLO A.;
- SULLER, MARC T. E.;
- FINLAY, BLAND J.;
- LLOYD, DAVID
Publication type:
Article
A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection.
Published in:
Journal of Infectious Diseases, 2023, v. 227, n. 5, p. 708, doi. 10.1093/infdis/jiac491
By:
- Donnellan, Samantha;
- Pennington, Shaun H;
- Ruggiero, Alessandra;
- Martinez-Rodriguez, Carmen;
- Pouget, Marion;
- Thomas, Jordan;
- Ward, Steve A;
- Pollakis, Georgios;
- Biagini, Giancarlo A;
- Paxton, William A
Publication type:
Article
A yeast expression system for functional and pharmacological studies of the malaria parasite Ca2+/H+ antiporter.
Published in:
Malaria Journal, 2012, v. 11, n. 1, p. 254, doi. 10.1186/1475-2875-11-254
By:
- Salcedo-Sora, J. Enrique;
- Ward, Steve A.;
- Biagini, Giancarlo A.
Publication type:
Article
Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH: quinone oxidoreductase.
Published in:
2010
By:
- Biagini, Giancarlo A.;
- Hill, Alasdair;
- Mbekeani, Alison;
- Shone, Alison;
- Nixon, Gemma;
- Stocks, Paul;
- Gibbons, Peter;
- Amewu, Richard;
- Hong, David W.;
- Barton, Victoria;
- Pidathala, Chandra;
- Chadwick, James;
- Le Pensee, Louise;
- Warman, Ashley;
- Sharma, Raman;
- Fisher, Nick;
- Berry, Neil G.;
- O'Neill, Paul M.;
- Ward, Steve A.
Publication type:
Abstract
A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum.
Published in:
2010
By:
- Ward, Steve A.;
- Fisher, Nicholas;
- Hill, Alasdair;
- Mbekeani, Alison;
- Shone, Alison;
- Nixon, Gemma;
- Stocks, Paul;
- Gibbons, Peter;
- Amewu, Richard;
- Hong, David W.;
- Barton, Victoria;
- Pidathala, Chandra;
- Chadwick, James;
- Le Pensee, Louise;
- Warman, Ashley;
- Sharma, Raman;
- Berry, Neil G.;
- O'Neill, Paul M.;
- Biagini, Giancarlo A.
Publication type:
Abstract
Glycerol: An unexpected major metabolite of energy metabolism by the human malaria parasite.
Published in:
Malaria Journal, 2009, v. 8, p. 1, doi. 10.1186/1475-2875-8-38
By:
- Lu-Yun Lian;
- Al-Helal, Mohammed;
- Roslaini, Abd Majid;
- Fisher, Nicholas;
- Bray, Patrick G.;
- Ward, Stephen A.;
- Biagini, Giancarlo A.
Publication type:
Article
The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest.
Published in:
2020
By:
- Ullah, Imran;
- Sharma, Raman;
- Mete, Antonio;
- Biagini, Giancarlo A;
- Wetzel, Dawn M;
- Horrocks, Paul D
Publication type:
journal article
A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials.
Published in:
2017
By:
- Ullah, Imran;
- Sharma, Raman;
- Biagini, Giancarlo A.;
- Horrocks, Paul
Publication type:
journal article
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential.
Published in:
Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 4, p. 1005, doi. 10.1093/jac/dkt486
By:
- Antoine, Thomas;
- Fisher, Nicholas;
- Amewu, Richard;
- O'Neill, Paul M.;
- Ward, Stephen A.;
- Biagini, Giancarlo A.
Publication type:
Article
Antimalarial pharmacology and therapeutics of atovaquone.
Published in:
Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 5, p. 977, doi. 10.1093/jac/dks504
By:
- Nixon, Gemma L.;
- Moss, Darren M.;
- Shone, Alison E.;
- Lalloo, David G.;
- Fisher, Nicholas;
- O'Neill, Paul M.;
- Ward, Stephen A.;
- Biagini, Giancarlo A.
Publication type:
Article
Antitubercular pharmacodynamics of phenothiazines.
Published in:
Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 4, p. 869, doi. 10.1093/jac/dks483
By:
- Warman, Ashley J.;
- Rito, Teresa S.;
- Fisher, Nicholas E.;
- Moss, Darren M.;
- Berry, Neil G.;
- O'Neill, Paul M.;
- Ward, Stephen A.;
- Biagini, Giancarlo A.
Publication type:
Article
Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs.
Published in:
Angewandte Chemie International Edition, 2007, v. 46, n. 33, p. 6278, doi. 10.1002/anie.200604697
By:
- Stocks, Paul A.;
- Bray, Patrick G.;
- Barton, Victoria E.;
- Al-Helal, Mohammed;
- Jones, Michael;
- Araujo, Nuna C.;
- Gibbons, Peter;
- Ward, Stephen A.;
- Hughes, Ruth H.;
- Biagini, Giancarlo A.;
- Davies, Jill;
- Amewu, Richard;
- Mercer, Amy E.;
- Ellis, Gemma;
- O'Neill, Paul M.
Publication type:
Article

Found: 31

Berichtigung: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing.

Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

Attaching protein-adsorbing silica particles to the surface of cotton substrates for bioaerosol capture including SARS-CoV-2.

Loss of pH Control in <i>Plasmodium falciparum</i> Parasites Subjected to Oxidative Stress.

Open-Label Comparative Clinical Study of Chlorproguanil2Dapsone Fixed Dose Combination (Lapdap) Alone or with Three Different Doses of Artesunate for Uncomplicated Plasmodium falciparum Malaria.

Antimalarial activity of primaquine operates via a two-step biochemical relay.

SARS‐CoV‐2 infects an upper airway model derived from induced pluripotent stem cells.

Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model.

Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.

Targeting the Ubiquinol-Reduction (Q i) Site of the Mitochondrial Cytochrome bc 1 Complex for the Development of Next Generation Quinolone Antimalarials.

Resisting resistance: dealing with the irrepressible problem of malaria.

OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.

The cytochrome bc<sub>1</sub> complex as an antipathogenic target.

Synthesis and Antimalarial Activities of a Diverse Set of Triazole-Containing Furamidine Analogues.

Trichomonas vaginalis and Giardia intestinalis Produce Nitric Oxide and Display NO-Synthase Activity.

Oxygen Uptake and Antioxidant Responses of the Free-Living Diplomonad Hexamita sp.

A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection.

A yeast expression system for functional and pharmacological studies of the malaria parasite Ca<sup>2+</sup>/H<sup>+</sup> antiporter.

Development of a novel drug for uncomplicated malaria targeting the mitochondrial NADH: quinone oxidoreductase.

A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum.

Glycerol: An unexpected major metabolite of energy metabolism by the human malaria parasite.

The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest.

A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials.

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential.

Antimalarial pharmacology and therapeutics of atovaquone.

Antitubercular pharmacodynamics of phenothiazines.

Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs.