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Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry.
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- EMBO Journal, 2002, v. 21, n. 10, p. 2323, doi. 10.1093/emboj/21.10.2323
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- Article
Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
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- BMC Structural Biology, 2012, v. 12, n. 1, p. 32, doi. 10.1186/1472-6807-12-32
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- Article
Structural basis for plazomicin antibiotic action and resistance.
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- Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02261-4
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Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.
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- Acta Crystallographica: Section F, Structural Biology Communications, 2014, v. 70, n. 3, p. 299, doi. 10.1107/S2053230X14002106
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- Article
Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance.
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- Frontiers in Cellular & Infection Microbiology, 2013, v. 3, p. 1, doi. 10.3389/fcimb.2013.00022
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Structural and functional insights into esterase-mediated macrolide resistance.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22016-3
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- Article
Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.
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- Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 288, doi. 10.1038/nsmb.1978
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Identifying Markers of Emerging SARS-CoV-2 Variants in Patients With Secondary Immunodeficiency.
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- Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.933983
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- Article
Structural Analysis of a Novel Cyclohexylamine Oxidase from <i>Brevibacterium oxydans</i> IH-35A.
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- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0060072
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Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor.
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- PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0019589
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- Article
The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation.
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- Proteins, 2008, v. 71, n. 4, p. 1984, doi. 10.1002/prot.21876
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- Article
TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06690-4
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- Article
The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-42866-8
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- Article
Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme.
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- FEBS Journal, 2016, v. 283, n. 16, p. 3029, doi. 10.1111/febs.13788
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- Article
Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.
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- Nature Communications, 2017, v. 8, n. 1, p. 14132, doi. 10.1038/ncomms14132
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- Article
Identification of the Adenovirus E4orf4 Protein Binding Site on the B55α and Cdc55 Regulatory Subunits of PP2A: Implications for PP2A Function, Tumor Cell Killing and Viral Replication.
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- PLoS Pathogens, 2013, v. 9, n. 11, p. 1, doi. 10.1371/journal.ppat.1003742
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Regio- and Chemoselective 6'-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6'-N-Acetyltransferases.
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- Angewandte Chemie, 2005, v. 117, n. 42, p. 7019, doi. 10.1002/ange.200501399
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- Article
Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2′) enzymes.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89446-3
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- Article
Look and Outlook on Enzyme-Mediated Macrolide Resistance.
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- Frontiers in Microbiology, 2018, p. N.PAG, doi. 10.3389/fmicb.2018.01942
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Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.
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- Nature Structural Biology, 2000, v. 7, n. 3, p. 238
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Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa.
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- PLoS ONE, 2022, v. 17, n. 8, p. 1, doi. 10.1371/journal.pone.0269684
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Regio- and Chemoselective 6′-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′-N-AcetyltransferasesThis work was supported by the National Science and Engineering Research Council of Canada (NSERC), by the Canadian Institute of Health Research (CIHR), and by the Cancer Research Center (CRC). F.G., X.Y., and O.M.B. were supported by scholarship awards from the Chemical Biology Strategic Training Initiative of CIHR. The authors are grateful to G. D. Wright at McMaster University for sharing his AAC(6′)-Ii expression plasmid.
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- Angewandte Chemie International Edition, 2005, v. 44, n. 42, p. 6859, doi. 10.1002/anie.200501399
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X-ray structure of the AAC(6′)-Ii antibiotic resistance enzyme at 1.8 Å resolution; examination of oligomeric arrangements in GNAT superfamily members.
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- Protein Science: A Publication of the Protein Society, 2003, v. 12, n. 3, p. 426, doi. 10.1110/ps.0233503
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Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
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- PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0186447
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Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2"-Ia.
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- Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 9, p. 1852, doi. 10.1002/pro.3224
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