Works by Becker-Pauly, Christoph

Results: 58

Development of High Throughput Screening Assays and Pilot Screen for Inhibitors of Metalloproteases Meprin α and β.

Published in:

Biopolymers, 2014, v. 102, n. 5, p. 396, doi. 10.1002/bip.22527

By:

Madoux, Franck;
Tredup, Claudia;
Spicer, Timothy P.;
Scampavia, Louis;
Chase, Peter S.;
Hodder, Peter S.;
Fields, Gregg B.;
Becker‐Pauly, Christoph;
Minond, Dmitriy

Publication type:

Article

Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-37024-5

By:

Karmilin, Konstantin;
Schmitz, Carlo;
Kuske, Michael;
Körschgen, Hagen;
Olf, Mario;
Meyer, Katharina;
Hildebrand, André;
Felten, Matthias;
Fridrich, Sven;
Yiallouros, Irene;
Becker-Pauly, Christoph;
Weiskirchen, Ralf;
Jahnen-Dechent, Willi;
Floehr, Julia;
Stöcker, Walter

Publication type:

Article

Zymogenic latency in an ∼250‐million‐year‐old astacin metallopeptidase.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2022, v. 78, n. 11, p. 1347, doi. 10.1107/S2059798322009688

By:

Guevara, Tibisay;
Rodríguez-Banqueri, Arturo;
Stöcker, Walter;
Becker-Pauly, Christoph;
Gomis-Rüth, F. Xavier

Publication type:

Article

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease.

Published in:

Cells (2073-4409), 2020, v. 9, n. 7, p. 1605, doi. 10.3390/cells9071605

By:

Escrig, Anna;
Molinero, Amalia;
Méndez, Brenda;
Giralt, Mercedes;
Comes, Gemma;
Sanchis, Paula;
Fernández-Gayol, Olaya;
Giménez-Llort, Lydia;
Becker-Pauly, Christoph;
Rose-John, Stefan;
Hidalgo, Juan

Publication type:

Article

Evaluation of <sup>¹¹¹</sup>In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers.

Published in:

PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0123443

By:

Jodal, Andreas;
Pape, Fabienne;
Becker-Pauly, Christoph;
Maas, Ole;
Schibli, Roger;
Béhé, Martin

Publication type:

Article

Enhanced Activity of Meprin-α, a Pro-Migratory and Pro- Angiogenic Protease, in Colorectal Cancer.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0026450

By:

Lottaz, Daniel;
Maurer, Christoph A.;
Noël, Agnè s;
Blacher, Silvia;
Huguenin, Maya;
Nievergelt, Alexandra;
Niggli, Verena;
Kern, Alexander;
Müller, Stefan;
Seibold, Frank;
Friess, Helmut;
Becker-Pauly, Christoph;
Stöcker, Walter;
Sterchi, Erwin E.

Publication type:

Article

Role of Meprins to Protect Ileal Mucosa of Crohn's Disease Patients from Colonization by Adherent-Invasive E. coli.

Published in:

PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021199

By:

Vazeille, Emilie;
Bringer, Marie-Agnés;
Gardarin, Aurélie;
Chambon, Christophe;
Becker-Pauly, Christoph;
Pender, Sylvia L. F.;
Jakob, Christine;
Müller, Stefan;
Lottaz, Daniel;
Darfeuille-Michaud, Arlette

Publication type:

Article

Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α<sub>2</sub>.

Published in:

PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008835

By:

Schütte, André;
Hedrich, Jana;
Stöcker, Walter;
Becker-Pauly, Christoph

Publication type:

Article

Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis.

Published in:

PLoS ONE, 2008, v. 3, n. 5, p. 1, doi. 10.1371/journal.pone.0002278

By:

Oneda, Beatrice;
Lods, Nadège;
Lottaz, Daniel;
Becker-Pauly, Christoph;
Stöcker, Walter;
Pippin, Jeffrey;
Huguenin, Maya;
Ambort, Daniel;
Marti, Hans-Peter;
Sterchi, Erwin E.

Publication type:

Article

Phosphorylation of meprin ß controls its cell surface abundance and subsequently diminishes ectodomain shedding.

Published in:

FASEB Journal, 2021, v. 35, n. 7, p. 1, doi. 10.1096/fj.202100271R

By:

Armbrust, Fred;
Bickenbach, Kira;
Koudelka, Tomas;
Tholey, Andreas;
Pietrzik, Claus;
Becker-Pauly, Christoph

Publication type:

Article

Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages.

Published in:

FASEB Journal, 2020, v. 34, n. 5, p. 6675, doi. 10.1096/fj.201902183R

By:

Berner, Dennis Kristopher;
Wessolowski, Luisa;
Armbrust, Fred;
Schneppenheim, Janna;
Schlepckow, Kai;
Koudelka, Tomas;
Scharfenberg, Franka;
Lucius, Ralph;
Tholey, Andreas;
Kleinberger, Gernot;
Haass, Christian;
Arnold, Philipp;
Becker‐Pauly, Christoph

Publication type:

Article

Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.

Published in:

FASEB Journal, 2019, v. 33, n. 11, p. 11925, doi. 10.1096/fj.201801371R

By:

Wichert, Rielana;
Scharfenberg, Franka;
Colmorgen, Cynthia;
Koudelka, Tomas;
Schwarz, Jeanette;
Wetzel, Sebastian;
Potempa, Barbara;
Potempa, Jan;
Bartsch, Jörg W.;
Sagi, Irit;
Tholey, Andreas;
Saftig, Paul;
Rose-John, Stefan;
Becker-Pauly, Christoph

Publication type:

Article

Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes.

Published in:

FASEB Journal, 2019, v. 33, n. 6, p. 7490, doi. 10.1096/fj.201802391R

By:

Peters, Florian;
Scharfenberg, Franka;
Colmorgen, Cynthia;
Armbrust, Fred;
Wichert, Rielana;
Arnold, Philipp;
Potempa, Barbara;
Potempa, Jan;
Pietrzik, Claus U.;
Häsler, Robert;
Rosenstiel, Philip;
Becker-Pauly, Christoph

Publication type:

Article

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.

Published in:

FASEB Journal, 2017, v. 31, n. 3, p. 1226, doi. 10.1096/fj.201601113R

By:

Bedau, Tillmann;
Peters, Florian;
Prox, Johannes;
Arnold, Philipp;
Schmidt, Frederike;
Finkernagel, Malin;
Köllmann, Sandra;
Wichert, Rielana;
Otte, Anna;
Ohler, Anke;
Stirnberg, Marit;
Lucius, Ralph;
Koudelka, Tomas;
Tholey, Andreas;
Biasin, Valentina;
Pietrzik, Claus U.;
Kwapiszewska, Grazyna;
Becker-Pauly, Christoph

Publication type:

Article

Calcium negatively regulates meprin β activity and attenuates substrate cleavage.

Published in:

FASEB Journal, 2015, v. 29, n. 8, p. 3549, doi. 10.1096/fj.15-272310

By:

Arnold, Philipp;
Schmidt, Frederike;
Prox, Johannes;
Zunke, Friederike;
Pietrzik, Claus;
Lucius, Ralph;
Becker-Pauly, Christoph

Publication type:

Article

Identifying causal serum protein–cardiometabolic trait relationships using whole genome sequencing.

Published in:

Human Molecular Genetics, 2023, v. 32, n. 8, p. 1266, doi. 10.1093/hmg/ddac275

By:

Png, Grace;
Gerlini, Raffaele;
Hatzikotoulas, Konstantinos;
Barysenka, Andrei;
Rayner, N William;
Klarić, Lucija;
Rathkolb, Birgit;
Aguilar-Pimentel, Juan A;
Rozman, Jan;
Fuchs, Helmut;
Gailus-Durner, Valerie;
Tsafantakis, Emmanouil;
Karaleftheri, Maria;
Dedoussis, George;
Pietrzik, Claus;
Wilson, James F;
Angelis, Martin Hrabe de;
Becker-Pauly, Christoph;
Gilly, Arthur;
Zeggini, Eleftheria

Publication type:

Article

Meprin β: A novel regulator of blood–brain barrier integrity.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2021, v. 41, n. 1, p. 31, doi. 10.1177/0271678X20905206

By:

Gindorf, Markus;
Storck, Steffen E;
Ohler, Anke;
Scharfenberg, Franka;
Becker-Pauly, Christoph;
Pietrzik, Claus U

Publication type:

Article

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

Published in:

PLoS Biology, 2017, v. 15, n. 1, p. 1, doi. 10.1371/journal.pbio.2000080

By:

Riethmueller, Steffen;
Ehlers, Johanna C.;
Flynn, Charlotte M.;
Lokau, Juliane;
Agthe, Maria;
Düsterhöft, Stefan;
Zhu, Yijue;
Grötzinger, Joachim;
Lorenzen, Inken;
Yamamoto, Kosuke;
Pickhinke, Ute;
Rose-John, Stefan;
Garbers, Christoph;
Somasundaram, Prasath;
Hung, Chien-Wen;
Koudelka, Tomas;
Tholey, Andreas;
Wichert, Rielana;
Becker-Pauly, Christoph;
Rädisch, Marisa

Publication type:

Article

Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.

Published in:

Genetics, 2021, v. 219, n. 4, p. 1, doi. 10.1093/genetics/iyab160

By:

Grainger, Andrew T.;
Pilar, Nathanael;
Jun Li;
Mei-Hua Chen;
Abramson, Ashley M.;
Becker-Pauly, Christoph;
Weibin Shi

Publication type:

Article

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Published in:

Scientific Reports, 2017, p. 44053, doi. 10.1038/srep44053

By:

Arnold, Philipp;
Boll, Inga;
Rothaug, Michelle;
Schumacher, Neele;
Schmidt, Frederike;
Wichert, Rielana;
Schneppenheim, Janna;
Lokau, Juliane;
Pickhinke, Ute;
Koudelka, Tomas;
Tholey, Andreas;
Rabe, Björn;
Scheller, Jürgen;
Lucius, Ralph;
Garbers, Christoph;
Rose-John, Stefan;
Becker-Pauly, Christoph

Publication type:

Article

The metalloprotease meprin beta generates amino-terminally truncated beta-amyloid peptide species

Published in:

2012

By:

Bien, Jessica;
Jefferson, Tamara;
Causevic, Mirsada;
Jumpertz, Thorsten;
Munter, Lisa M.;
Multhaup, Gerd;
Weggen, Sascha;
Becker-Pauly, Christoph;
Pietrzik, Claus

Publication type:

Abstract

MT1‐MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties.

Published in:

FEBS Journal, 2023, v. 290, n. 1, p. 93, doi. 10.1111/febs.16586

By:

Werny, Ludwig;
Grogro, Antonia;
Bickenbach, Kira;
Bülck, Cynthia;
Armbrust, Fred;
Koudelka, Tomas;
Pathak, Kriti;
Scharfenberg, Franka;
Sammel, Martin;
Sheikhouny, Farah;
Tholey, Andreas;
Linder, Stefan;
Becker‐Pauly, Christoph

Publication type:

Article

Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B.

Published in:

FEBS Journal, 2019, v. 286, n. 5, p. 930, doi. 10.1111/febs.14698

By:

Boon, Lise;
Ugarte‐Berzal, Estefania;
Martens, Erik;
Vandooren, Jennifer;
Rybakin, Vasily;
Colau, Didier;
Gordon‐Alonso, Monica;
Bruggen, Pierre;
Stöcker, Walter;
Becker‐Pauly, Christoph;
Witters, Peter;
Morava, Eva;
Jaeken, Jaak;
Proost, Paul;
Opdenakker, Ghislain

Publication type:

Article

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-77884-4

By:

Flynn, Charlotte M.;
Garbers, Yvonne;
Düsterhöft, Stefan;
Wichert, Rielana;
Lokau, Juliane;
Lehmann, Christian H. K.;
Dudziak, Diana;
Schröder, Bernd;
Becker-Pauly, Christoph;
Rose-John, Stefan;
Aparicio-Siegmund, Samadhi;
Garbers, Christoph

Publication type:

Article

Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity.

Published in:

FEBS Open Bio, 2018, v. 8, n. 12, p. 2011, doi. 10.1002/2211-5463.12540

By:

Talantikite, Maya;
Lécorché, Pascaline;
Beau, Fabrice;
Damour, Odile;
Becker‐Pauly, Christoph;
Ho, Wen‐Bin;
Dive, Vincent;
Vadon‐Le Goff, Sandrine;
Moali, Catherine

Publication type:

Article

Mapping orphan proteases by proteomics: Meprin metalloproteases deciphered as potential therapeutic targets.

Published in:

Proteomics - Clinical Applications, 2014, v. 8, n. 5/6, p. 382, doi. 10.1002/prca.201300079

By:

Becker‐Pauly, Christoph;
Broder, Claudia;
Prox, Johannes;
Koudelka, Tomas;
Tholey, Andreas

Publication type:

Article

Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage.

Published in:

Journal of Biochemistry, 2016, v. 159, n. 3, p. 305, doi. 10.1093/jb/mvv102

By:

Yoshitaka Sato;
Daichi Kobayashi;
Takao Kohno;
Yujiro Kidani;
Prox, Johannes;
Becker-Pauly, Christoph;
Mitsuharu Hattori

Publication type:

Article

Generation of aggregation prone Nterminally truncated amyloid ß peptides by meprin ß depends on the sequence specificity at the cleavage site.

Published in:

Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0084-5

By:

Schönherr, Caroline;
Bien, Jessica;
Isbert, Simone;
Wichert, Rielana;
Prox, Johannes;
Altmeppen, Hermann;
Kumar, Sathish;
Walter, Jochen;
Lichtenthaler, Stefan F.;
Weggen, Sascha;
Glatzel, Markus;
Becker-Pauly, Christoph;
Pietrzik, Claus U.

Publication type:

Article

TNFα cleavage beyond TACE/ ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis.

Published in:

EMBO Molecular Medicine, 2013, v. 5, n. 7, p. 902, doi. 10.1002/emmm.201302899

By:

Becker‐Pauly, Christoph;
Rose‐John, Stefan

Publication type:

Article

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.

Published in:

Frontiers in Molecular Neuroscience, 2017, v. 9, p. 1, doi. 10.3389/fnmol.2016.00159

By:

Becker-Pauly, Christoph;
Pietrzik, Claus U.

Publication type:

Article

Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3

Published in:

FEBS Letters, 2012, v. 586, n. 24, p. 4264, doi. 10.1016/j.febslet.2012.10.033

By:

Geurts, Nathalie;
Becker-Pauly, Christoph;
Martens, Erik;
Proost, Paul;
Van den Steen, Philippe E.;
Stöcker, Walter;
Opdenakker, Ghislain

Publication type:

Article

Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?

Published in:

Journal of Investigative Dermatology, 2010, v. 130, n. 12, p. 2727, doi. 10.1038/jid.2010.202

By:

Kronenberg, Daniel;
Bruns, Bernd C.;
Moali, Catherine;
Vadon-Le Goff, Sandrine;
Sterchi, Erwin E.;
Traupe, Heiko;
Böhm, Markus;
Hulmes, David J. S.;
Stöcker, Walter;
Becker-Pauly, Christoph

Publication type:

Article

Transglutaminase-1 and Bathing Suit Ichthyosis: Molecular Analysis of Gene/Environment Interactions.

Published in:

2009

By:

Aufenvenne, Karin;
Oji, Vinzenz;
Walker, Tatjana;
Becker-Pauly, Christoph;
Hennies, Hans Christian;
Stöcker, Walter;
Traupe, Heiko

Publication type:

Letter

The α and β Subunits of the Metalloprotease Meprin Are Expressed in Separate Layers of Human Epidermis, Revealing Different Functions in Keratinocyte Proliferation and Differentiation.

Published in:

Journal of Investigative Dermatology, 2007, v. 127, n. 5, p. 1115, doi. 10.1038/sj.jid.5700675

By:

Becker-Pauly, Christoph;
Höwel, Markus;
Walker, Tatjana;
Vlad, Annica;
Aufenvenne, Karin;
Oji, Vinzenz;
Lottaz, Daniel;
Sterchi, Erwin E.;
Debela, Mekdes;
Magdolen, Viktor;
Traupe, Heiko;
Stöcker, Walter

Publication type:

Article

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I).

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 3, p. 203, doi. 10.3390/ph14030203

By:

Hou, Shurong;
Diez, Juan;
Wang, Chao;
Becker-Pauly, Christoph;
Fields, Gregg B.;
Bannister, Thomas;
Spicer, Timothy P.;
Scampavia, Louis D.;
Minond, Dmitriy;
Santamaria, Salvatore

Publication type:

Article

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II).

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 3, p. 197, doi. 10.3390/ph14030197

By:

Wang, Chao;
Diez, Juan;
Park, Hajeung;
Becker-Pauly, Christoph;
Fields, Gregg B.;
Spicer, Timothy P.;
Scampavia, Louis D.;
Minond, Dmitriy;
Bannister, Thomas D.;
Santamaria, Salvatore

Publication type:

Article

Meprin β Modulates Brevican Proteolysis Impairing Neural Plasticity and Memory Formation.

Published in:

FASEB Journal, 2025, v. 39, n. 10, p. 1, doi. 10.1096/fj.202500017R

By:

Keller, Maximilian;
Gallagher, Celine;
Kreiselmaier, Simon;
Bickenbach, Kira;
Schmitt, Ulrich;
Marengo, Liana;
Taghikhah, Dayan;
Abukhalaf, Mohammad;
Tholey, Andreas;
Becker‐Pauly, Christoph;
Mittmann, Thomas;
Pietrzik, Claus U.

Publication type:

Article

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 15, p. 3677, doi. 10.3390/ijms20153677

By:

Sammel, Martin;
Peters, Florian;
Lokau, Juliane;
Scharfenberg, Franka;
Werny, Ludwig;
Linder, Stefan;
Garbers, Christoph;
Rose-John, Stefan;
Becker-Pauly, Christoph

Publication type:

Article

The putative pleiotropic functions of meprin β in gastric cancer.

Published in:

Gastric Cancer, 2023, v. 26, n. 4, p. 542, doi. 10.1007/s10120-023-01385-2

By:

Siemsen, Wiebke;
Halske, Christine;
Behrens, Hans-Michael;
Krüger, Sandra;
Becker-Pauly, Christoph;
Röcken, Christoph

Publication type:

Article

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.

Published in:

Biochemical Journal, 2015, v. 470, n. 1, p. 91, doi. 10.1042/BJ20141417

By:

Jäckie, Felix;
Schmidt, Frederike;
Wiehert, Rielana;
Arnoldf, Philipp;
Prox, Johannes;
Mangold, Martin;
Ohler, Anke;
Pietrzik, Claus U.;
Koudelka, Tomas;
Tholey, Andreas;
Gütschow, Michael;
Stirnberg, Marit;
Becker-Pauly, Christoph

Publication type:

Article

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.

Published in:

Biochemical Journal, 2013, v. 450, n. 2, p. 253, doi. 10.1042/BJ20121751

By:

BRODER, Claudia;
BECKER-PAULY, Christoph

Publication type:

Article

Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43401-0

By:

Vadon-Le Goff, Sandrine;
Tessier, Agnès;
Napoli, Manon;
Dieryckx, Cindy;
Bauer, Julien;
Dussoyer, Mélissa;
Lagoutte, Priscillia;
Peyronnel, Célian;
Essayan, Lucie;
Kleiser, Svenja;
Tueni, Nicole;
Bettler, Emmanuel;
Mariano, Natacha;
Errazuriz-Cerda, Elisabeth;
Fruchart Gaillard, Carole;
Ruggiero, Florence;
Becker-Pauly, Christoph;
Allain, Jean-Marc;
Bruckner-Tuderman, Leena;
Nyström, Alexander

Publication type:

Article

Role of meprin metalloproteases in metastasis and tumor microenvironment.

Published in:

Cancer & Metastasis Reviews, 2019, v. 38, n. 3, p. 347, doi. 10.1007/s10555-019-09805-5

By:

Peters, Florian;
Becker-Pauly, Christoph

Publication type:

Article

Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice.

Published in:

Cell & Tissue Research, 2017, v. 367, n. 2, p. 351, doi. 10.1007/s00441-016-2498-3

By:

Arnold, Philipp;
Koopmann, Lara;
Peters, Florian;
Birkenfeld, Falk;
Goff, Sandrine;
Damm, Timo;
Qin, Chunlin;
Moali, Catherine;
Lucius, Ralph;
Becker-Pauly, Christoph

Publication type:

Article

The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 2, p. 239, doi. 10.1007/s00401-018-1929-5

By:

Walter, Susanne;
Jumpertz, Thorsten;
Hüttenrauch, Melanie;
Ogorek, Isabella;
Gerber, Hermeto;
Storck, Steffen E.;
Zampar, Silvia;
Dimitrov, Mitko;
Lehmann, Sandra;
Lepka, Klaudia;
Berndt, Carsten;
Wiltfang, Jens;
Becker-Pauly, Christoph;
Beher, Dirk;
Pietrzik, Claus U.;
Fraering, Patrick C.;
Wirths, Oliver;
Weggen, Sascha

Publication type:

Article

Meprin and ADAM proteases as triggers of systemic inflammation in sepsis .

Published in:

FEBS Letters, 2022, v. 596, n. 5, p. 534, doi. 10.1002/1873-3468.14225

By:

Rahn, Sascha;
Becker-Pauly, Christoph

Publication type:

Article

A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes.

Published in:

Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05139-w

By:

Armbrust, Fred;
Bickenbach, Kira;
Altmeppen, Hermann;
Foggetti, Angelica;
Winkelmann, Anne;
Wulff, Peer;
Glatzel, Markus;
Pietrzik, Claus U.;
Becker-Pauly, Christoph

Publication type:

Article

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 4, p. 1, doi. 10.1007/s00018-022-04237-x

By:

Mazura, Alexander D.;
Ohler, Anke;
Storck, Steffen E.;
Kurtyka, Magdalena;
Scharfenberg, Franka;
Weggen, Sascha;
Becker-Pauly, Christoph;
Pietrzik, Claus U.

Publication type:

Article

Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 3, p. 1, doi. 10.1007/s00018-022-04205-5

By:

Marengo, Liana;
Armbrust, Fred;
Schoenherr, Caroline;
Storck, Steffen E.;
Schmitt, Ulrich;
Zampar, Silvia;
Wirths, Oliver;
Altmeppen, Hermann;
Glatzel, Markus;
Kaether, Christoph;
Weggen, Sascha;
Becker-Pauly, Christoph;
Pietrzik, Claus U.

Publication type:

Article

Degradome of soluble ADAM10 and ADAM17 metalloproteases.

Published in:

Cellular & Molecular Life Sciences, 2020, v. 77, n. 2, p. 331, doi. 10.1007/s00018-019-03184-4

By:

Scharfenberg, Franka;
Helbig, Andreas;
Sammel, Martin;
Benzel, Julia;
Schlomann, Uwe;
Peters, Florian;
Wichert, Rielana;
Bettendorff, Maximilian;
Schmidt-Arras, Dirk;
Rose-John, Stefan;
Moali, Catherine;
Lichtenthaler, Stefan F.;
Pietrzik, Claus U.;
Bartsch, Jörg W.;
Tholey, Andreas;
Becker-Pauly, Christoph

Publication type:

Article