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Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.
- Published in:
- PLoS Biology, 2017, v. 15, n. 1, p. 1, doi. 10.1371/journal.pbio.2000080
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- Publication type:
- Article
Discovery and Optimization of Selective Inhibitors of Meprin α (Part I).
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- Pharmaceuticals (14248247), 2021, v. 14, n. 3, p. 203, doi. 10.3390/ph14030203
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- Publication type:
- Article
Discovery and Optimization of Selective Inhibitors of Meprin α (Part II).
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- Pharmaceuticals (14248247), 2021, v. 14, n. 3, p. 197, doi. 10.3390/ph14030197
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- Publication type:
- Article
TNFα cleavage beyond TACE/ ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis.
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- EMBO Molecular Medicine, 2013, v. 5, n. 7, p. 902, doi. 10.1002/emmm.201302899
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- Publication type:
- Article
The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.
- Published in:
- Frontiers in Molecular Neuroscience, 2017, v. 9, p. 1, doi. 10.3389/fnmol.2016.00159
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- Publication type:
- Article
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.
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- International Journal of Molecular Sciences, 2019, v. 20, n. 15, p. 3677, doi. 10.3390/ijms20153677
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- Publication type:
- Article
Role of meprin metalloproteases in metastasis and tumor microenvironment.
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- Cancer & Metastasis Reviews, 2019, v. 38, n. 3, p. 347, doi. 10.1007/s10555-019-09805-5
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- Publication type:
- Article
Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice.
- Published in:
- Cell & Tissue Research, 2017, v. 367, n. 2, p. 351, doi. 10.1007/s00441-016-2498-3
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- Publication type:
- Article
Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
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- Biochemical Journal, 2015, v. 470, n. 1, p. 91, doi. 10.1042/BJ20141417
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- Publication type:
- Article
The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.
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- Biochemical Journal, 2013, v. 450, n. 2, p. 253, doi. 10.1042/BJ20121751
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- Publication type:
- Article
The metalloprotease meprin beta generates amino-terminally truncated beta-amyloid peptide species
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- 2012
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- Publication type:
- Abstract
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.
- Published in:
- Scientific Reports, 2017, p. 44053, doi. 10.1038/srep44053
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- Publication type:
- Article
Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43401-0
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- Publication type:
- Article
Evaluation of <sup>¹¹¹</sup>In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers.
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- PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0123443
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- Publication type:
- Article
Enhanced Activity of Meprin-α, a Pro-Migratory and Pro- Angiogenic Protease, in Colorectal Cancer.
- Published in:
- PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0026450
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- Publication type:
- Article
Role of Meprins to Protect Ileal Mucosa of Crohn's Disease Patients from Colonization by Adherent-Invasive E. coli.
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- PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021199
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- Publication type:
- Article
Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α<sub>2</sub>.
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- PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008835
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- Publication type:
- Article
Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis.
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- PLoS ONE, 2008, v. 3, n. 5, p. 1, doi. 10.1371/journal.pone.0002278
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- Publication type:
- Article
Meprin and ADAM proteases as triggers of systemic inflammation in sepsis .
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- FEBS Letters, 2022, v. 596, n. 5, p. 534, doi. 10.1002/1873-3468.14225
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- Publication type:
- Article
Meprin β: A novel regulator of blood–brain barrier integrity.
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- Journal of Cerebral Blood Flow & Metabolism, 2021, v. 41, n. 1, p. 31, doi. 10.1177/0271678X20905206
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- Publication type:
- Article
MT1‐MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties.
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- FEBS Journal, 2023, v. 290, n. 1, p. 93, doi. 10.1111/febs.16586
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- Publication type:
- Article
Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B.
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- FEBS Journal, 2019, v. 286, n. 5, p. 930, doi. 10.1111/febs.14698
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- Publication type:
- Article
A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes.
- Published in:
- Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05139-w
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- Publication type:
- Article
PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier.
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- Cellular & Molecular Life Sciences, 2022, v. 79, n. 4, p. 1, doi. 10.1007/s00018-022-04237-x
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- Publication type:
- Article
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease.
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- Cellular & Molecular Life Sciences, 2022, v. 79, n. 3, p. 1, doi. 10.1007/s00018-022-04205-5
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- Publication type:
- Article
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
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- Cellular & Molecular Life Sciences, 2020, v. 77, n. 2, p. 331, doi. 10.1007/s00018-019-03184-4
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- Publication type:
- Article
Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding.
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- Cellular & Molecular Life Sciences, 2019, v. 76, n. 16, p. 3193, doi. 10.1007/s00018-019-03179-1
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- Publication type:
- Article
Phosphorylation of meprin ß controls its cell surface abundance and subsequently diminishes ectodomain shedding.
- Published in:
- FASEB Journal, 2021, v. 35, n. 7, p. 1, doi. 10.1096/fj.202100271R
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- Publication type:
- Article
Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages.
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- FASEB Journal, 2020, v. 34, n. 5, p. 6675, doi. 10.1096/fj.201902183R
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- Publication type:
- Article
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
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- FASEB Journal, 2019, v. 33, n. 11, p. 11925, doi. 10.1096/fj.201801371R
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- Publication type:
- Article
Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes.
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- FASEB Journal, 2019, v. 33, n. 6, p. 7490, doi. 10.1096/fj.201802391R
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- Publication type:
- Article
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.
- Published in:
- FASEB Journal, 2017, v. 31, n. 3, p. 1226, doi. 10.1096/fj.201601113R
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- Publication type:
- Article
Calcium negatively regulates meprin β activity and attenuates substrate cleavage.
- Published in:
- FASEB Journal, 2015, v. 29, n. 8, p. 3549, doi. 10.1096/fj.15-272310
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- Publication type:
- Article
Identifying causal serum protein–cardiometabolic trait relationships using whole genome sequencing.
- Published in:
- Human Molecular Genetics, 2023, v. 32, n. 8, p. 1266, doi. 10.1093/hmg/ddac275
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- Article
Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage.
- Published in:
- Journal of Biochemistry, 2016, v. 159, n. 3, p. 305, doi. 10.1093/jb/mvv102
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- Publication type:
- Article
Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?
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- Journal of Investigative Dermatology, 2010, v. 130, n. 12, p. 2727, doi. 10.1038/jid.2010.202
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- Article
Transglutaminase-1 and Bathing Suit Ichthyosis: Molecular Analysis of Gene/Environment Interactions.
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- 2009
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- Publication type:
- Letter
The α and β Subunits of the Metalloprotease Meprin Are Expressed in Separate Layers of Human Epidermis, Revealing Different Functions in Keratinocyte Proliferation and Differentiation.
- Published in:
- Journal of Investigative Dermatology, 2007, v. 127, n. 5, p. 1115, doi. 10.1038/sj.jid.5700675
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- Publication type:
- Article
Zymogenic latency in an ∼250‐million‐year‐old astacin metallopeptidase.
- Published in:
- Acta Crystallographica: Section D, Structural Biology, 2022, v. 78, n. 11, p. 1347, doi. 10.1107/S2059798322009688
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- Publication type:
- Article
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-77884-4
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- Publication type:
- Article
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
- Published in:
- Cellular & Molecular Life Sciences, 2013, v. 70, n. 2, p. 309, doi. 10.1007/s00018-012-1106-2
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- Publication type:
- Article
The putative pleiotropic functions of meprin β in gastric cancer.
- Published in:
- Gastric Cancer, 2023, v. 26, n. 4, p. 542, doi. 10.1007/s10120-023-01385-2
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- Publication type:
- Article
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
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- Acta Neuropathologica, 2019, v. 137, n. 2, p. 239, doi. 10.1007/s00401-018-1929-5
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- Publication type:
- Article
Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.
- Published in:
- Genetics, 2021, v. 219, n. 4, p. 1, doi. 10.1093/genetics/iyab160
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- Publication type:
- Article
IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease.
- Published in:
- Cells (2073-4409), 2020, v. 9, n. 7, p. 1605, doi. 10.3390/cells9071605
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- Publication type:
- Article
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3
- Published in:
- FEBS Letters, 2012, v. 586, n. 24, p. 4264, doi. 10.1016/j.febslet.2012.10.033
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- Publication type:
- Article
Generation of aggregation prone Nterminally truncated amyloid ß peptides by meprin ß depends on the sequence specificity at the cleavage site.
- Published in:
- Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0084-5
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- Publication type:
- Article
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-37024-5
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- Publication type:
- Article
Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity.
- Published in:
- FEBS Open Bio, 2018, v. 8, n. 12, p. 2011, doi. 10.1002/2211-5463.12540
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- Publication type:
- Article
Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains.
- Published in:
- Biological Chemistry, 2016, v. 397, n. 9, p. 857, doi. 10.1515/hsz-2016-0126
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- Publication type:
- Article