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Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.
- Published in:
- Nature, 1983, v. 306, n. 5944, p. 658, doi. 10.1038/306658a0
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- Publication type:
- Article
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes.
- Published in:
- Nature, 1982, v. 298, n. 5872, p. 343, doi. 10.1038/298343a0
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- Publication type:
- Article
Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-Ras<sup>G12V</sup>-induced lung cancer by induction of telomeric DNA damage.
- Published in:
- EMBO Molecular Medicine, 2015, v. 7, n. 7, p. 930, doi. 10.15252/emmm.201404497
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- Publication type:
- Article
La necesidad de un Pacto de Estado por la Ciencia en España.
- Published in:
- 2004
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- Publication type:
- Editorial
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.
- Published in:
- EMBO Journal, 2001, v. 20, n. 23, p. 6637, doi. 10.1093/emboj/20.23.6637
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- Publication type:
- Article
Limited overlapping roles of P15<sup>INK4b</sup> and P18<sup>INK4c</sup> cell cycle inhibitors in proliferation and tumorigenesis.
- Published in:
- EMBO Journal, 2000, v. 19, n. 13, p. 3496, doi. 10.1093/emboj/19.13.3496
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- Publication type:
- Article
Ephrins and their Eph receptors: multitalented directors of embryonic development.
- Published in:
- EMBO Journal, 1999, v. 18, n. 19, p. 5159, doi. 10.1093/emboj/18.19.5159
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- Publication type:
- Article
Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.
- Published in:
- EMBO Journal, 1997, v. 16, n. 11, p. 3106, doi. 10.1093/emboj/16.11.3106
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- Publication type:
- Article
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.
- Published in:
- 2008
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- Publication type:
- journal article
Structural and Functional Properties of the TRK Family of Neurotrophin Receptors.
- Published in:
- Annals of the New York Academy of Sciences, 1995, v. 766, n. 1, p. 442, doi. 10.1111/j.1749-6632.1995.tb26693.x
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- Publication type:
- Article
gag Gene of mammalian type-C RNA tumour viruses.
- Published in:
- Nature, 1976, v. 262, n. 5569, p. 554, doi. 10.1038/262554a0
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- Publication type:
- Article
UICC study group on basic and clinical cancer research: Growth factors, receptors and oncogenes. Meeting held at Woods Hole, MA, USA, September 27-30, 1987.
- Published in:
- International Journal of Cancer, 1988, v. 41, n. 1, p. 1, doi. 10.1002/ijc.2910410102
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- Publication type:
- Article
El DNI molecular del cáncer, el quid de la cuestión.
- Published in:
- Nuestro Tiempo, 2018, n. 700, p. 70
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- Publication type:
- Article
Cdk6-Dependent Regulation of G.
- Published in:
- Stem Cells, 2011, v. 29, n. 4, p. 712, doi. 10.1002/stem.616
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- Publication type:
- Article
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.
- Published in:
- Journal of Pathology, 2009, v. 219, n. 2, p. 205, doi. 10.1002/path.2585
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- Publication type:
- Article
p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.
- Published in:
- Nature Genetics, 2007, v. 39, n. 6, p. 750, doi. 10.1038/ng2037
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- Publication type:
- Article
The European dimension for the mouse genome mutagenesis program.
- Published in:
- Nature Genetics, 2004, v. 36, n. 9, p. 925, doi. 10.1038/ng0904-925
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- Publication type:
- Article
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.
- Published in:
- Nature Genetics, 2003, v. 35, n. 1, p. 25, doi. 10.1038/ng1232
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- Publication type:
- Article
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia.
- Published in:
- Nature Genetics, 1999, v. 22, n. 1, p. 44, doi. 10.1038/8751
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- Publication type:
- Article
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.
- Published in:
- Nature Structural & Molecular Biology, 2011, v. 18, n. 12, p. 1331, doi. 10.1038/nsmb.2189
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- Publication type:
- Article
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.
- Published in:
- Nature Structural & Molecular Biology, 2010, v. 17, n. 6, p. 718, doi. 10.1038/nsmb.1833
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- Publication type:
- Article
<i>Lkb1</i> Loss Promotes Tumor Progression of BRAF<sup>V600E</sup>-Induced Lung Adenomas.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0066933
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- Publication type:
- Article
Nerve Dependency of Developing and Mature Sensory Receptor Cells<sup>a</sup>.
- Published in:
- Annals of the New York Academy of Sciences, 1998, v. 855, n. 1, p. 14, doi. 10.1111/j.1749-6632.1998.tb10543.x
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- Publication type:
- Article
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.
- Published in:
- Nature, 1986, v. 319, n. 6056, p. 743, doi. 10.1038/319743a0
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- Publication type:
- Article
Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.
- Published in:
- Nature, 1985, v. 315, n. 6018, p. 382, doi. 10.1038/315382a0
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- Publication type:
- Article
Genetic rescue of Cdk4 null mice restores pancreatic ß-cell proliferation but not homeostatic cell number.
- Published in:
- Oncogene, 2003, v. 22, n. 34, p. 5261, doi. 10.1038/sj.onc.1206506
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- Publication type:
- Article
Combined Inhibition of FOSL-1 and YAP Using siRNA-Lipoplexes Reduces the Growth of Pancreatic Tumor.
- Published in:
- Cancers, 2022, v. 14, n. 13, p. N.PAG, doi. 10.3390/cancers14133102
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- Publication type:
- Article
KRAS inhibitors: going noncovalent.
- Published in:
- Molecular Oncology, 2022, v. 16, n. 22, p. 3911, doi. 10.1002/1878-0261.13341
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- Publication type:
- Article
KSR induces RAS-independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors.
- Published in:
- Molecular Oncology, 2022, v. 16, n. 17, p. 3066, doi. 10.1002/1878-0261.13213
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- Publication type:
- Article
Targeting KRAS mutant lung cancer: light at the end of the tunnel.
- Published in:
- Molecular Oncology, 2022, v. 16, n. 5, p. 1057, doi. 10.1002/1878-0261.13168
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- Publication type:
- Article
Cyclin-Dependent Kinase 4 Regulates Adult Neural Stem Cell Proliferation and Differentiation in Response to Insulin.
- Published in:
- Stem Cells, 2017, v. 35, n. 12, p. 2403, doi. 10.1002/stem.2694
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- Publication type:
- Article
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
- Published in:
- EMBO Journal, 2012, v. 31, n. 11, p. 2498, doi. 10.1038/emboj.2012.94
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- Publication type:
- Article
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.
- Published in:
- EMBO Journal, 2010, v. 29, n. 6, p. 1091, doi. 10.1038/emboj.2010.7
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- Publication type:
- Article
Cdk1 is sufficient to drive the mammalian cell cycle.
- Published in:
- Nature, 2007, v. 448, n. 7155, p. 811, doi. 10.1038/nature06046
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- Publication type:
- Article
Cdk2 suppresses cellular senescence induced by the c-myc oncogene.
- Published in:
- Nature Cell Biology, 2010, v. 12, n. 1, p. 54, doi. 10.1038/ncb2004
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- Publication type:
- Article
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.
- Published in:
- Oncogene, 1997, v. 15, n. 21, p. 2511, doi. 10.1038/sj.onc.1201430
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- Publication type:
- Article
A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70.
- Published in:
- Oncogene, 1997, v. 15, n. 1, p. 1, doi. 10.1038/sj.onc.1201170
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- Publication type:
- Article
Definitive evidence for Club cells as progenitors for mutant Kras/Trp53‐deficient lung cancer.
- Published in:
- International Journal of Cancer, 2021, v. 149, n. 9, p. 1670, doi. 10.1002/ijc.33756
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- Publication type:
- Article
Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling.
- Published in:
- Nature Immunology, 2001, v. 2, n. 6, p. 548, doi. 10.1038/88756
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- Publication type:
- Article
Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin.
- Published in:
- International Journal of Cancer, 2006, v. 118, n. 2, p. 373, doi. 10.1002/ijc.21349
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- Publication type:
- Article
Using cells devoid of RAS proteins as tools for drug discovery.
- Published in:
- Molecular Carcinogenesis, 2009, v. 48, n. 11, p. 1038, doi. 10.1002/mc.20555
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- Publication type:
- Article
Tumour biology: Senescence in premalignant tumours.
- Published in:
- Nature, 2005, v. 436, n. 7051, p. 642, doi. 10.1038/436642a
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- Publication type:
- Article
Overall Cdk activity modulates the DNA damage response in mammalian cells.
- Published in:
- Journal of Cell Biology, 2009, v. 187, n. 6, p. 773, doi. 10.1083/jcb.200903033
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- Publication type:
- Article
Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice.
- Published in:
- European Journal of Neuroscience, 1998, v. 10, n. 1, doi. 10.1046/j.1460-9568.1998.00037.x
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- Publication type:
- Article
Severe Sensory Deficits but Normal CNS Development in Newborn Mice Lacking TrkB and TrkC Tyrosine Protein Kinase Receptors.
- Published in:
- European Journal of Neuroscience, 1997, v. 9, n. 10, p. 2045, doi. 10.1111/j.1460-9568.1997.tb01372.x
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- Publication type:
- Article
Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets.
- Published in:
- Journal of Molecular Medicine, 2016, v. 94, n. 2, p. 121, doi. 10.1007/s00109-015-1360-5
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- Publication type:
- Article
Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions.
- Published in:
- Oncologist, 2017, v. 22, n. 3, p. 335, doi. 10.1634/theoncologist.2016-0276
- By:
- Publication type:
- Article
A Catalyst for Change: The European Cancer Patient's Bill of Rights.
- Published in:
- 2014
- By:
- Publication type:
- Opinion
Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.
- Published in:
- Pigment Cell & Melanoma Research, 2010, v. 23, n. 5, p. 635, doi. 10.1111/j.1755-148X.2010.00732.x
- By:
- Publication type:
- Article
Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications.
- Published in:
- BMC Genomics, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2164-14-731
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- Publication type:
- Article