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Semaphorin 3F Antagonizes Neurotrophin-Induced PHophatidylinositol 3-Kinase and Mitogen-Activate Protein Kinase Kinase Signaling: A Mechanism for Growth Cone Collapse.
Published in:
Journal of Neuroscience, 2003, v. 23, n. 20, p. 7602, doi. 10.1523/JNEUROSCI.23-20-07602.2003
By:
- Atwal, Jasvinder K.;
- Singh, Karun K.;
- Tessier-Lavigne, Marc;
- Miller, Freda D.;
- Kaplan, David R.
Publication type:
Article
P1‐163: MOLECULAR MECHANISMS OF THE ALZHEIMER'S RISK GENE UNC5C IN NEURONAL DEATH.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P340, doi. 10.1016/j.jalz.2018.06.167
By:
- Karunakaran, Devi Krishna Priya;
- Sadleir, Katherine R.;
- Kemal, Shahrnaz;
- Cuddy, Leah K.;
- Watts, Ryan;
- Atwal, Jasvinder;
- Vassar, Robert J.
Publication type:
Article
Identification and Characterization of Reconstituted α-Synuclein, Amyloid-β and Tau Fibrils by Immunogold Negative Staining Electron Microscopy.
Published in:
Microscopy & Microanalysis, 2017, v. 23, p. 1312, doi. 10.1017/S143192761700722X
By:
- Reichelt, Mike;
- Bainbridge, Travis W.;
- Corpuz, Racquel;
- Lee, Seung H.;
- Ernst, James A.;
- Foreman, Oded;
- Sagolla, Meredith;
- Atwal, Jasvinder K.;
- Ayalon, Gai
Publication type:
Article
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Published in:
Nature Medicine, 2014, v. 20, n. 12, p. 1452, doi. 10.1038/nm.3736
By:
- Wetzel-Smith, Monica K;
- Hunkapiller, Julie;
- Bhangale, Tushar R;
- Srinivasan, Karpagam;
- Maloney, Janice A;
- Atwal, Jasvinder K;
- Sa, Susan M;
- B Yaylaoglu, Murat;
- Foreman, Oded;
- Ortmann, Ward;
- Rathore, Nisha;
- Hansen, David V;
- Tessier-Lavigne, Marc;
- Mayeux, Richard;
- Pericak-Vance, Margaret;
- Haines, Jonathan;
- Farrer, Lindsay A;
- Schellenberg, Gerard D;
- Goate, Alison;
- Behrens, Timothy W
Publication type:
Article
MATHEMATICAL MODEL OF AMYLOID BETA (Aβ) DYNAMICS TO ASSESS TARGET ENGAGEMENT OF SOLUBLE Aβ OLIGOMERS BY CRENEZUMAB IN THE ALZHEIMER’S DISEASE BRAIN.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P282, doi. 10.1016/j.jalz.2017.06.176
By:
- Ferl, Gregory Z.;
- Fuji, Reina N.;
- Atwal, Jasvinder;
- Ramanujan, Saroja;
- Quartino, Angelica
Publication type:
Article
Tau antibodies lacking effector function minimize inflammatory responses while effectively blocking spread of tau pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P503, doi. 10.1016/j.jalz.2015.06.591
By:
- Lee, Seung-Hye;
- Le Pichon, Claire;
- Adolfsson, Oskar;
- Gafner, Valérie;
- Pihlgren, Maria;
- Lin, Han;
- Solanoy, Hilda;
- Brendza, Robert;
- Ngu, Hai;
- Foreman, Oded;
- Chan, Ruby;
- Ernst, James;
- Dicara, Danielle;
- Hotzel, Isidro;
- Srinivasan, Karpagam;
- Hansen, David;
- Atwal, Jasvinder;
- Pfeifer, Andrea;
- Watts, Ryan;
- Muhs, Andreas
Publication type:
Article
Role of BACE1 and BACE2 in the production of endogenous mouse Aß
Published in:
2012
By:
- Meilandt, William;
- Atwal, Jasvinder;
- Solanoy, Hilda;
- Hoyte, Kwame;
- Luk, Wil;
- Lu, Yanmei;
- Watts, Ryan;
- Scearce-Levie, Kimberly
Publication type:
Abstract
Selection of an anti-Abeta antibody that binds various forms of Abeta and blocks toxicity both in vitro and in vivo
Published in:
2009
By:
- Watts, Ryan J.;
- Chen, Mark;
- Atwal, Jasvinder;
- Greve, Joan M.;
- Wu, Yongjian;
- Mortensen, Deborah L.;
- Varisco, Yvan;
- Aldolfsson, Oskar;
- Pihlgren, Maria;
- Pfeifer, Andrea;
- Muhs, Andreas
Publication type:
Abstract
Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin.
Published in:
Scientific Reports, 2016, p. 39374, doi. 10.1038/srep39374
By:
- Ultsch, Mark;
- Li, Bing;
- Maurer, Till;
- Mathieu, Mary;
- Adolfsson, Oskar;
- Muhs, Andreas;
- Pfeifer, Andrea;
- Pihlgren, Maria;
- Bainbridge, Travis W.;
- Reichelt, Mike;
- Ernst, James A.;
- Eigenbrot, Charles;
- Fuh, Germaine;
- Atwal, Jasvinder K.;
- Watts, Ryan J.;
- Wang, Weiru
Publication type:
Article
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.
Published in:
Science Translational Medicine, 2014, v. 6, n. 261, p. 1, doi. 10.1126/scitranslmed.3009835
By:
- Yu, Y. Joy;
- Atwal, Jasvinder K.;
- Yin Zhang;
- Tong, Raymond K.;
- Wildsmith, Kristin R.;
- Tan, Christine;
- Bien-Ly, Nga;
- Hersom, Maria;
- Maloney, Janice A.;
- Meilandt, William J.;
- Bumbaca, Daniela;
- Gadkar, Kapil;
- Hoyte, Kwame;
- Luk, Wilman;
- Yanmei Lu;
- Ernst, James A.;
- Scearce-Levie, Kimberly;
- Couch, Jessica A.;
- Dennis, Mark S.;
- Watts, Ryan J.
Publication type:
Article
Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.
Published in:
Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 4, p. 826, doi. 10.1002/cpt.2531
By:
- Sadekar, Shraddha S.;
- Bowen, Mayumi;
- Cai, Hao;
- Jamalian, Samira;
- Rafidi, Hanine;
- Shatz‐Binder, Whitney;
- Lafrance‐Vanasse, Julien;
- Chan, Pamela;
- Meilandt, William J.;
- Oldendorp, Amy;
- Sreedhara, Alavattam;
- Daugherty, Ann;
- Crowell, Susan;
- Wildsmith, Kristin R.;
- Atwal, Jasvinder;
- Fuji, Reina N.;
- Horvath, Joshua
Publication type:
Article
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 1, p. 62, doi. 10.1002/psp4.12876
By:
- Ramakrishnan, Vidya;
- Friedrich, Christina;
- Witt, Colleen;
- Sheehan, Robert;
- Pryor, Meghan;
- Atwal, Jasvinder K.;
- Wildsmith, Kristin;
- Kudrycki, Katherine;
- Lee, Seung‐Hye;
- Mazer, Norman;
- Hofmann, Carsten;
- Fuji, Reina N.;
- Jin, Jin Y.;
- Ramanujan, Saroja;
- Dolton, Michael;
- Quartino, Angelica
Publication type:
Article
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target.
Published in:
Science Translational Medicine, 2011, v. 3, n. 84, p. 1, doi. 10.1126/scitranslmed.3002230
By:
- Y. Joy Yu;
- Yin Zhang;
- Kenrick, Margaret;
- Kwame Hoyte;
- Wilman Luk;
- Yanmei Lu;
- Atwal, Jasvinder;
- Elliott, J. Michael;
- Prabhu, Saileta;
- Watts, Ryan J.;
- Dennis, Mark S.
Publication type:
Article
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.
Published in:
Nature, 2012, v. 488, n. 7409, p. 96, doi. 10.1038/nature11283
By:
- Jonsson, Thorlakur;
- Atwal, Jasvinder K.;
- Steinberg, Stacy;
- Snaedal, Jon;
- Jonsson, Palmi V.;
- Bjornsson, Sigurbjorn;
- Stefansson, Hreinn;
- Sulem, Patrick;
- Gudbjartsson, Daniel;
- Maloney, Janice;
- Hoyte, Kwame;
- Gustafson, Amy;
- Liu, Yichin;
- Lu, Yanmei;
- Bhangale, Tushar;
- Graham, Robert R.;
- Huttenlocher, Johanna;
- Bjornsdottir, Gyda;
- Andreassen, Ole A.;
- Jönsson, Erik G.
Publication type:
Article
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Published in:
Science Translational Medicine, 2021, v. 13, n. 593, p. 1, doi. 10.1126/scitranslmed.abb2639
By:
- Ayalon, Gai;
- Lee, Seung-Hye;
- Adolfsson, Oskar;
- Foo-Atkins, Corinne;
- Atwal, Jasvinder K.;
- Blendstrup, Mira;
- Booler, Helen;
- Bravo, Joseph;
- Brendza, Robert;
- Brunstein, Flavia;
- Chan, Ruby;
- Chandra, Priya;
- Couch, Jessica A.;
- Datwani, Akash;
- Demeule, Barthélemy;
- DiCara, Danielle;
- Erickson, Rich;
- Ernst, James A.;
- Foreman, Oded;
- He, Dongping
Publication type:
Article
Spatially Coordinated Kinase Signaling Regulates Local Axon Degeneration.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 39, p. 13439, doi. 10.1523/JNEUROSCI.2039-12.2012
By:
- Chen, Mark;
- Maloney, Janice A.;
- Kallop, Dara Y.;
- Atwal, Jasvinder K.;
- Tam, Stephen J.;
- Baer, Kristin;
- Kissel, Holger;
- Kaminker, Joshua S.;
- Lewcock, Joseph W.;
- Weimer, Robby M.;
- Watts, Ryan J.
Publication type:
Article
An Effector-Reduced Anti-&bgr;-Amyloid (A&bgr;) Antibody with Unique A&bgr; Binding Properties Promotes Neuroprotection and Glial Engulfment of A&bgr;.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 28, p. 9677, doi. 10.1523/JNEUROSCI.4742-11.2012
By:
- Adolfsson, Oskar;
- Pihlgren, Maria;
- Toni, Nicolas;
- Varisco, Yvan;
- Buccarello, Anna Lucia;
- Antoniello, Katia;
- Lohmann, Sophie;
- Piorkowska, Kasia;
- Gafner, Valerie;
- Atwal, Jasvinder K.;
- Maloney, Janice;
- Chen, Mark;
- Gogineni, Alvin;
- Weimer, Robby M.;
- Mortensen, Deborah L.;
- Friesenhahn, Michel;
- Ho, Carole;
- Paul, Robert;
- Pfeifer, Andrea;
- Muhs, Andreas
Publication type:
Article

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