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Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes.
- Published in:
- Cell Death & Disease, 2020, v. 11, n. 5, p. 1, doi. 10.1038/s41419-020-2505-1
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- Publication type:
- Article
Decitabine and Melphalan Fail to Reactivate p73 in p53 Deficient Myeloma Cells.
- Published in:
- International Journal of Molecular Sciences, 2018, v. 19, n. 1, p. 40, doi. 10.3390/ijms19010040
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- Publication type:
- Article
Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex.
- Published in:
- Oncogene, 2005, v. 24, n. 54, p. 8076, doi. 10.1038/sj.onc.1208949
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- Article
Venetoclax as Targeted Therapy for Relapsed/Refractory Multiple Myeloma.
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2017, v. 17, p. e27, doi. 10.1016/j.clml.2017.03.046
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- Publication type:
- Article
A Surface Glycoprotein Complex Related to the Adhesive Receptors of the VLA Family, Shared by Epidermal Langerhans Cells and Basal Keratinocytes.
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- Journal of Investigative Dermatology, 1989, v. 92, n. 5, p. 739, doi. 10.1016/0022-202X(89)90192-9
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- Publication type:
- Article
The peripheral CD138<sup>+</sup> population but not the CD138<sup>−</sup> population contains myeloma clonogenic cells in plasma cell leukaemia patients.
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- British Journal of Haematology, 2012, v. 156, n. 5, p. 679, doi. 10.1111/j.1365-2141.2011.08904.x
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- Publication type:
- Article
The imbalance between Survivin and Bim mediates tumour growth and correlates with poor survival in patients with multiple myeloma.
- Published in:
- British Journal of Haematology, 2009, v. 145, n. 2, p. 180, doi. 10.1111/j.1365-2141.2009.07608.x
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- Publication type:
- Article
Interferon alpha extends the survival of human myeloma cells through an upregulation of the Mcl-1 anti-apoptic molecule.
- Published in:
- British Journal of Haematology, 2001, v. 112, n. 2, p. 358, doi. 10.1046/j.1365-2141.2001.02575.x
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- Publication type:
- Article
BCLXL PROTAC degrader DT2216 targets secondary plasma cell leukemia addicted to BCLXL for survival.
- Published in:
- Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1196005
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- Publication type:
- Article
Apoptotic machinery diversity in multiple myeloma molecular subtypes.
- Published in:
- Frontiers in Immunology, 2013, v. 4, p. 1, doi. 10.3389/fimmu.2013.00467
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- Publication type:
- Article
Zoledronate Is a Potent Inhibitor of Myeloma Cell Growth and Secretion of IL-6 and MMP-1 by the Tumoral Environment.
- Published in:
- Journal of Bone & Mineral Research, 1999, v. 14, n. 12, p. 2048, doi. 10.1359/jbmr.1999.14.12.2048
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- Publication type:
- Article
Ectopic secretion of osteocalcin, the major non-collagenous bone protein, by the myeloma cell line NCI-H929.
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- Journal of Bone & Mineral Research, 1996, v. 11, n. 4, p. 466, doi. 10.1002/jbmr.5650110407
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- Publication type:
- Article
The selectivity of Marinopyrrole A to induce apoptosis in MCL1<sup>high</sup> BCL2<sup>low</sup> expressing myeloma cells is related to its ability to impair protein translation.
- Published in:
- British Journal of Haematology, 2018, v. 180, n. 1, p. 157, doi. 10.1111/bjh.14293
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- Publication type:
- Article
BH3 profiling as a tool to identify acquired resistance to venetoclax in multiple myeloma.
- Published in:
- British Journal of Haematology, 2017, v. 179, n. 4, p. 684, doi. 10.1111/bjh.14251
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- Article
Cereblon expression in multiple myeloma: not ready for prime time.
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- British Journal of Haematology, 2013, v. 163, n. 2, p. 282, doi. 10.1111/bjh.12478
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- Publication type:
- Article
A cellular model for myeloma cell growth and maturation based on an intraclonal CD45 hierarchy.
- Published in:
- Immunological Reviews, 2003, v. 194, n. 1, p. 105, doi. 10.1034/j.1600-065X.2003.00039.x
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- Article
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
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- Cytometry. Part A, 2015, v. 87, n. 4, p. 285, doi. 10.1002/cyto.a.22643
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- Publication type:
- Article
Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
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- Journal of Hematology & Oncology, 2018, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13045-018-0679-0
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- Publication type:
- Article
Targeting Oxidative Stress With Auranofin or Prima-1<sup>Met</sup> to Circumvent p53 or Bax/Bak Deficiency in Myeloma Cells.
- Published in:
- Frontiers in Oncology, 2019, p. N.PAG, doi. 10.3389/fonc.2019.00128
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- Publication type:
- Article
RITA (Reactivating p53 and Inducing Tumor abnormal Apoptosis) is efficient against TP53<sup>abnormal</sup> myeloma cells independently of the p53 pathway.
- Published in:
- BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-437
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- Publication type:
- Article
RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53<sup>abnormal</sup> myeloma cells independently of the p53 pathway.
- Published in:
- BMC Cancer, 2014, v. 14, p. 1, doi. 10.1186/1471-2407-14-437
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- Publication type:
- Article
RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway.
- Published in:
- 2014
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- Publication type:
- journal article
Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-x.
- Published in:
- European Journal of Immunology, 2005, v. 35, n. 3, p. 971, doi. 10.1002/eji.200425878
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- Publication type:
- Article
The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells.
- Published in:
- European Journal of Immunology, 2004, v. 34, n. 11, p. 3156, doi. 10.1002/eji.200424981
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- Publication type:
- Article
IL-6 up-regulates Mcl-1 in human myeloma cells through JAK / STAT rather than Ras / MAP kinase pathway.
- Published in:
- European Journal of Immunology, 1999, v. 29, n. 12, p. 3945, doi. 10.1002/(SICI)1521-4141(199912)29:12<3945::AID-IMMU3945>3.0.CO;2-O
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- Publication type:
- Article
Mcl-1 and Bcl-x[sub L ] are co-regulated by IL-6 in human myeloma cells.
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- British Journal of Haematology, 1999, v. 107, n. 2, p. 392, doi. 10.1046/j.1365-2141.1999.01705.x
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- Article
CD130 rather than CD126 expression is associated with disease activity in multiple myeloma.
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- British Journal of Haematology, 1999, v. 106, n. 2, p. 532, doi. 10.1046/j.1365-2141.1999.01563.x
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- Article
High incidence of deletions but infrequent inactivation of the retinoblastoma gene in human myeloma cells.
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- British Journal of Haematology, 1995, v. 91, n. 3, p. 664, doi. 10.1111/j.1365-2141.1995.tb05365.x
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- Publication type:
- Article
The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells.
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- British Journal of Haematology, 1995, v. 90, n. 3, p. 707, doi. 10.1111/j.1365-2141.1995.tb05605.x
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- Article
The MYRACLE protocol study: a multicentric observational prospective cohort study of patients with multiple myeloma.
- Published in:
- 2019
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- Publication type:
- journal article
Mcl-1<sup>128–350</sup> fragment induces apoptosis through direct interaction with Bax
- Published in:
- FEBS Letters, 2010, v. 584, n. 3, p. 487, doi. 10.1016/j.febslet.2009.11.094
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- Publication type:
- Article
The REFRACT-LYMA cohort study: a French observational prospective cohort study of patients with mantle cell lymphoma.
- Published in:
- BMC Cancer, 2016, v. 16, p. 1, doi. 10.1186/s12885-016-2844-6
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- Publication type:
- Article