OpenURL Connection Search

Select item for more details and to access through your institution.

Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases.
Published in:
International Journal of Molecular Sciences, 2015, v. 16, n. 10, p. 24751, doi. 10.3390/ijms161024751
By:
- Kentaro Ishida;
- Peter Gee;
- Akitsu Hotta
Publication type:
Article
Genetic correction using engineered nucleases for gene therapy applications.
Published in:
Development, Growth & Differentiation, 2014, v. 56, n. 1, p. 63, doi. 10.1111/dgd.12107
By:
- Lisa Li, Hongmei;
- Nakano, Takao;
- Hotta, Akitsu
Publication type:
Article
Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-022-26614-z
By:
- Kawada, Ryu;
- Jonouchi, Tatsuya;
- Kagita, Akihiro;
- Sato, Masae;
- Hotta, Akitsu;
- Sakurai, Hidetoshi
Publication type:
Article
Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch.
Published in:
Nucleic Acids Research, 2017, v. 45, n. 13, p. 1, doi. 10.1093/nar/gkx309
By:
- Moe Hirosawa;
- Yoshihiko Fujita;
- Parr, Callum J. C.;
- Karin Hayashi;
- Shunnichi Kashida;
- Akitsu Hotta;
- Knut Woltjen;
- Hirohide Saito
Publication type:
Article
Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26714-w
By:
- Kenjo, Eriya;
- Hozumi, Hiroyuki;
- Makita, Yukimasa;
- Iwabuchi, Kumiko A.;
- Fujimoto, Naoko;
- Matsumoto, Satoru;
- Kimura, Maya;
- Amano, Yuichiro;
- Ifuku, Masataka;
- Naoe, Youichi;
- Inukai, Naoto;
- Hotta, Akitsu
Publication type:
Article
Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency.
Published in:
Nature Methods, 2009, v. 6, n. 5, p. 370, doi. 10.1038/nmeth.1325
By:
- Hotta, Akitsu;
- Cheung, Aaron Y. L.;
- Farra, Natalie;
- Vijayaragavan, Kausalia;
- Séguin, Cheryle A.;
- Draper, Jonathan S.;
- Pasceri, Peter;
- Maksakova, Irina A.;
- Mager, Dixie L.;
- Rossant, Janet;
- Bhatia, Mickie;
- Ellis, James
Publication type:
Article
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons.
Published in:
Scientific Reports, 2016, p. 34904, doi. 10.1038/srep34904
By:
- Imamura, Keiko;
- Sahara, Naruhiko;
- Kanaan, Nicholas M.;
- Tsukita, Kayoko;
- Kondo, Takayuki;
- Kutoku, Yumiko;
- Ohsawa, Yutaka;
- Sunada, Yoshihide;
- Kawakami, Koichi;
- Hotta, Akitsu;
- Yawata, Satoshi;
- Watanabe, Dai;
- Hasegawa, Masato;
- Trojanowski, John Q.;
- Lee, Virginia M.-Y.;
- Suhara, Tetsuya;
- Higuchi, Makoto;
- Inoue, Haruhisa
Publication type:
Article
Delivery of Full-Length Factor VIII Using a <i>piggyBac</i> Transposon Vector to Correct a Mouse Model of Hemophilia A.
Published in:
PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0104957
By:
- Matsui, Hideto;
- Fujimoto, Naoko;
- Sasakawa, Noriko;
- Ohinata, Yasuhide;
- Shima, Midori;
- Yamanaka, Shinya;
- Sugimoto, Mitsuhiko;
- Hotta, Akitsu
Publication type:
Article
Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy <i>In Vitro</i>.
Published in:
PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061540
By:
- Tanaka, Akihito;
- Woltjen, Knut;
- Miyake, Katsuya;
- Hotta, Akitsu;
- Ikeya, Makoto;
- Yamamoto, Takuya;
- Nishino, Tokiko;
- Shoji, Emi;
- Sehara-Fujisawa, Atsuko;
- Manabe, Yasuko;
- Fujii, Nobuharu;
- Hanaoka, Kazunori;
- Era, Takumi;
- Yamashita, Satoshi;
- Isobe, Ken-ichi;
- Kimura, En;
- Sakurai, Hidetoshi
Publication type:
Article
MECP2 Isoform-Specific Vectors with Regulated Expression for Rett Syndrome Gene Therapy.
Published in:
PLoS ONE, 2009, v. 4, n. 8, p. 1, doi. 10.1371/journal.pone.0006810
By:
- Rastegar, Mojgan;
- Hotta, Akitsu;
- Pasceri, Peter;
- Makarem, Maisam;
- Cheung, Aaron Y. L.;
- Elliott, Shauna;
- Park, Katya J.;
- Adachi, Megumi;
- Jones, Frederick S.;
- Clarke, Ian D.;
- Dirks, Peter;
- Ellis, James
Publication type:
Article
Retroviral vector silencing during iPS cell induction: An epigenetic beacon that signals distinct pluripotent states.
Published in:
Journal of Cellular Biochemistry, 2008, v. 105, n. 4, p. 940, doi. 10.1002/jcb.21912
By:
- Hotta, Akitsu;
- Ellis, James
Publication type:
Article
CRISPR-Cas3 induces broad and unidirectional genome editing in human cells.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-13226-x
By:
- Morisaka, Hiroyuki;
- Yoshimi, Kazuto;
- Okuzaki, Yuya;
- Gee, Peter;
- Kunihiro, Yayoi;
- Sonpho, Ekasit;
- Xu, Huaigeng;
- Sasakawa, Noriko;
- Naito, Yuki;
- Nakada, Shinichiro;
- Yamamoto, Takashi;
- Sano, Shigetoshi;
- Hotta, Akitsu;
- Takeda, Junji;
- Mashimo, Tomoji
Publication type:
Article
CRISPR-Cas3 induces broad and unidirectional genome editing in human cells.
Published in:
Nature Communications, 2019, p. 1, doi. 10.1038/s41467-019-13226-x
By:
- Hiroyuki Morisaka;
- Kazuto Yoshimi;
- Yuya Okuzaki;
- Gee, Peter;
- Yayoi Kunihiro;
- Sonpho, Ekasit;
- Huaigeng Xu;
- Noriko Sasakawa;
- Yuki Naito;
- Shinichiro Nakada;
- Takashi Yamamoto;
- Shigetoshi Sano;
- Akitsu Hotta;
- Junji Takeda;
- Tomoji Mashimo
Publication type:
Article
Constitutive heterochromatin reorganization during somatic cell reprogramming.
Published in:
EMBO Journal, 2011, v. 30, n. 9, p. 1778, doi. 10.1038/emboj.2011.96
By:
- Fussner, Eden;
- Djuric, Ugljesa;
- Strauss, Mike;
- Hotta, Akitsu;
- Perez-Iratxeta, Carolina;
- Lanner, Fredrik;
- Dilworth, F Jeffrey;
- Ellis, James;
- Bazett-Jones, David P
Publication type:
Article
Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy.
Published in:
Stem Cells International, 2017, p. 1, doi. 10.1155/2017/8765154
By:
- Gee, Peter;
- Xu, Huaigeng;
- Hotta, Akitsu
Publication type:
Article
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
Published in:
Science Translational Medicine, 2017, v. 9, n. 391, p. 1, doi. 10.1126/scitranslmed.aaf3962
By:
- Keiko Imamura;
- Yuishin Izumi;
- Akira Watanabe;
- Kayoko Tsukita;
- Knut Woltjen;
- Takuya Yamamoto;
- Akitsu Hotta;
- Takayuki Kondo;
- Shiho Kitaoka;
- Akira Ohta;
- Akito Tanaka;
- Dai Watanabe;
- Mitsuya Morita;
- Hiroshi Takuma;
- Akira Tamaoka;
- Tilo Kunath;
- Selina Wray;
- Hirokazu Furuya;
- Takumi Era;
- Kouki Makioka
Publication type:
Article
A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4.
Published in:
Human Molecular Genetics, 2018, v. 27, n. 23, p. 4024, doi. 10.1093/hmg/ddy293
By:
- Sasaki-Honda, Mitsuru;
- Jonouchi, Tatsuya;
- Arai, Meni;
- Hotta, Akitsu;
- Mitsuhashi, Satomi;
- Nishino, Ichizo;
- Matsuda, Ryoichi;
- Sakurai, Hidetoshi
Publication type:
Article
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 11, p. 2103, doi. 10.1093/hmg/ddr093
By:
- Cheung, Aaron Y.L.;
- Horvath, Lindsay M.;
- Grafodatskaya, Daria;
- Pasceri, Peter;
- Weksberg, Rosanna;
- Hotta, Akitsu;
- Carrel, Laura;
- Ellis, James
Publication type:
Article
Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells.
Published in:
Scientific Reports, 2013, p. 1, doi. 10.1038/srep01978
By:
- Yamashita, Akihiro;
- Liu, Shiying;
- Knut Woltjen;
- Thomas, Bradley;
- Meng, Guoliang;
- Akitsu Hotta;
- Kazutoshi Takahashi;
- Ellis, James;
- Shinya Yamanaka;
- Rancourt, Derrick E.
Publication type:
Article
Contractile Activity of Myotubes Derived from Human Induced Pluripotent Stem Cells: A Model of Duchenne Muscular Dystrophy.
Published in:
Cells (2073-4409), 2021, v. 10, n. 10, p. 2556, doi. 10.3390/cells10102556
By:
- Yoshioka, Kantaro;
- Ito, Akira;
- Horie, Masanobu;
- Ikeda, Kazushi;
- Kataoka, Sho;
- Sato, Keiichiro;
- Yoshigai, Taichi;
- Sakurai, Hidetoshi;
- Hotta, Akitsu;
- Kawabe, Yoshinori;
- Kamihira, Masamichi
Publication type:
Article
Srf destabilizes cellular identity by suppressing celltype-specific gene expression programs.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03748-1
By:
- Takashi Ikeda;
- Takafusa Hikichi;
- Hirofumi Shibata;
- Kanae Mitsunaga;
- Keisuke Okita;
- Yosuke Yamada;
- Knut Woltjen;
- Yasuhiro Yamada;
- Akitsu Hotta;
- Takuya Yamamoto;
- Shinji Masui;
- Hisashi Miura;
- Ichiro Hiratani;
- Kei Miyamoto
Publication type:
Article
Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae.
Published in:
Journal of Tissue Engineering & Regenerative Medicine, 2017, v. 11, n. 6, p. 1766, doi. 10.1002/term.2072
By:
- Ishikawa, Masaaki;
- Ohnishi, Hiroe;
- Skerleva, Desislava;
- Sakamoto, Tatsunori;
- Yamamoto, Norio;
- Hotta, Akitsu;
- Ito, Juichi;
- Nakagawa, Takayuki
Publication type:
Article
MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.
Published in:
Clinical Science, 2019, v. 133, n. 4, p. 583, doi. 10.1042/CS20180980
By:
- Fumiko Nakazeki;
- Itaru Tsuge;
- Takahiro Horie;
- Keiko Imamura;
- Kayoko Tsukita;
- Akitsu Hotta;
- Osamu Baba;
- Yasuhide Kuwabara;
- Tomohiro Nishino;
- Tetsushi Nakao;
- Masataka Nishiga;
- Hitoo Nishi;
- Yasuhiro Nakashima;
- Yuya Ide;
- Satoshi Koyama;
- Masahiro Kimura;
- Shuhei Tsuji;
- Motoko Naitoh;
- Shigehiko Suzuki;
- Yuishin Izumi
Publication type:
Article
β-Globin LCR and Intron Elements Cooperate and Direct Spatial Reorganization for Gene Therapy.
Published in:
PLoS Genetics, 2008, v. 4, n. 4, p. 1, doi. 10.1371/journal.pgen.1000051
By:
- Buzina, Alla;
- Lo, Mandy Y. M.;
- Moffett, Angela;
- Hotta, Akitsu;
- Fussner, Eden;
- Bharadwaj, Rikki R.;
- Pasceri, Peter;
- Garcia-Martinez, J. Victor;
- Bazett-Jones, David P.;
- Ellis, James
Publication type:
Article
CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells.
Published in:
Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-05809-2
By:
- Nakanishi-Koakutsu, Misato;
- Miki, Kenji;
- Naka, Yuki;
- Sasaki, Masako;
- Wakimizu, Takayuki;
- Napier, Stephanie C.;
- Okubo, Chikako;
- Narita, Megumi;
- Nishikawa, Misato;
- Hata, Reo;
- Chonabayashi, Kazuhisa;
- Hotta, Akitsu;
- Imahashi, Kenichi;
- Nishimoto, Tomoyuki;
- Yoshida, Yoshinori
Publication type:
Article
iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05203-4
By:
- Hirayama, Ryuichiro;
- Toyohara, Kosuke;
- Watanabe, Kei;
- Otsuki, Takeya;
- Araoka, Toshikazu;
- Mae, Shin-Ichi;
- Horinouchi, Tomoko;
- Yamamura, Tomohiko;
- Okita, Keisuke;
- Hotta, Akitsu;
- Iijima, Kazumoto;
- Nozu, Kandai;
- Osafune, Kenji
Publication type:
Article
Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.
Published in:
Aging Cell, 2017, v. 16, n. 4, p. 870, doi. 10.1111/acel.12621
By:
- Chen, Zhaoyi;
- Chang, Wing Y.;
- Etheridge, Alton;
- Strickfaden, Hilmar;
- Jin, Zhigang;
- Palidwor, Gareth;
- Cho, Ji‐Hoon;
- Wang, Kai;
- Kwon, Sarah Y.;
- Doré, Carole;
- Raymond, Angela;
- Hotta, Akitsu;
- Ellis, James;
- Kandel, Rita A.;
- Dilworth, F. Jeffrey;
- Perkins, Theodore J.;
- Hendzel, Michael J.;
- Galas, David J.;
- Stanford, William L.
Publication type:
Article
iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.
Published in:
Stem Cell Research & Therapy, 2024, v. 15, n. 1, p. 1, doi. 10.1186/s13287-024-03691-7
By:
- Gao, Pan;
- Inada, Yoshiko;
- Hotta, Akitsu;
- Sakurai, Hidetoshi;
- Ikeya, Makoto
Publication type:
Article

Found: 28