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The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression.
Published in:
NPJ Aging, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41514-024-00172-2
By:
- Dasgupta, Nirmalya;
- Arnold, Rouven;
- Equey, Anais;
- Gandhi, Armin;
- Adams, Peter D.
Publication type:
Article
P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age.
Published in:
2016
By:
- Waaijer, Mariëtte E. C.;
- Gunn, David A.;
- Adams, Peter D.;
- Pawlikowski, Jeff S.;
- Griffiths, Christopher E. M.;
- van Heemst, Diana;
- Slagboom, P. Eline;
- Westendorp, Rudi G. J.;
- Maier, Andrea B.
Publication type:
journal article
Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37256-8
By:
- Missinato, Maria A.;
- Murphy, Sean;
- Lynott, Michaela;
- Yu, Michael S.;
- Kervadec, Anaïs;
- Chang, Yu-Ling;
- Kannan, Suraj;
- Loreti, Mafalda;
- Lee, Christopher;
- Amatya, Prashila;
- Tanaka, Hiroshi;
- Huang, Chun-Teng;
- Puri, Pier Lorenzo;
- Kwon, Chulan;
- Adams, Peter D.;
- Qian, Li;
- Sacco, Alessandra;
- Andersen, Peter;
- Colas, Alexandre R.
Publication type:
Article
Cytoplasmic chromatin fragments--from mechanisms to therapeutic potential.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.63728
By:
- Miller, Karl N.;
- Dasgupta, Nirmalya;
- Tianhui Liu;
- Adams, Peter D.;
- Vizioli, Maria Grazia
Publication type:
Article
Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity.
Published in:
Nucleic Acids Research, 2017, v. 45, n. 20, p. 11673, doi. 10.1093/nar/gkx771
By:
- Rai, Taranjit Singh;
- Glass, Mandy;
- Cole, John J.;
- Rather, Mohammad I.;
- Marsden, Morgan;
- Neilson, Matthew;
- Brock, Claire;
- Humphreys, Ian R.;
- Everett, Roger D.;
- Adams, Peter D.
Publication type:
Article
Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment.
Published in:
Stem Cell Research & Therapy, 2013, v. 4, n. 2, p. 1, doi. 10.1186/scrt192
By:
- Howard, Lynsey;
- Mackenzie, Ruth M.;
- Pchelintsev, Nikolay A.;
- McBryan, Tony;
- McClure, John D.;
- McBride, Martin W.;
- Kane, Nicole M.;
- Adams, Peter D.;
- Milligan, Graeme;
- Baker, Andrew H.
Publication type:
Article
Activation of Wnt signalling promotes development of dysplasia in Barrett's oesophagus.
Published in:
Journal of Pathology, 2012, v. 228, n. 1, p. 99, doi. 10.1002/path.4058
By:
- Moyes, Lisa H;
- McEwan, Hamish;
- Radulescu, Sorina;
- Pawlikowski, Jeff;
- Lamm, Catherine G;
- Nixon, Colin;
- Sansom, Owen J;
- Going, James J;
- Fullarton, Grant M;
- Adams, Peter D
Publication type:
Article
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.
Published in:
EMBO Journal, 2019, v. 38, n. 23, p. N.PAG, doi. 10.15252/embj.2019101982
By:
- Victorelli, Stella;
- Lagnado, Anthony;
- Halim, Jessica;
- Moore, Will;
- Talbot, Duncan;
- Barrett, Karen;
- Chapman, James;
- Birch, Jodie;
- Ogrodnik, Mikolaj;
- Meves, Alexander;
- Pawlikowski, Jeff S;
- Jurk, Diana;
- Adams, Peter D;
- Heemst, Diana;
- Beekman, Marian;
- Slagboom, P Eline;
- Gunn, David A;
- Passos, João F
Publication type:
Article
Structure of a human ASF1a–HIRA complex and insights into specificity of histone chaperone complex assembly.
Published in:
Nature Structural & Molecular Biology, 2006, v. 13, n. 10, p. 921, doi. 10.1038/nsmb1147
By:
- Tang, Yong;
- Poustovoitov, Maxim V.;
- Zhao, Kehao;
- Garfinkel, Megan;
- Canutescu, Adrian;
- Dunbrack, Roland;
- Adams, Peter D.;
- Marmorstein, Ronen
Publication type:
Article
The role of TP53 in acute myeloid leukemia: Challenges and opportunities.
Published in:
Genes, Chromosomes & Cancer, 2019, v. 58, n. 12, p. 875, doi. 10.1002/gcc.22796
By:
- Barbosa, Karina;
- Li, Sha;
- Adams, Peter D.;
- Deshpande, Aniruddha J.
Publication type:
Article
Hematopoiesis: a BETter understanding.
Published in:
EMBO Reports, 2023, v. 24, n. 10, p. 1, doi. 10.15252/embr.202357927
By:
- Dasgupta, Nirmalya;
- Adams, Peter D
Publication type:
Article
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11510-4
By:
- Costa, Tânia D. F.;
- Olofsson, Helene;
- Masia-Balague, Miriam;
- Rabieifar, Parisa;
- Spiess, Matthias;
- Hernández-Varas, Pablo;
- Rabenhorst, Uta;
- Gong, Xiaowei;
- Strömblad, Staffan;
- Zhuang, Ting;
- Zhao, Miao;
- Lorent, Julie;
- Ma, Ran;
- Hartman, Johan;
- Turco, Emilia;
- Defilippi, Paola;
- Robertson, Neil;
- Adams, Peter D.;
- Kuiper, Raoul;
- Sjölund, Jonas
Publication type:
Article
Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08128-3
By:
- Guida, Maria Clara;
- Birse, Ryan Tyge;
- Dall'Agnese, Alessandra;
- Toto, Paula Coutinho;
- Diop, Soda Balla;
- Mai, Antonello;
- Adams, Peter D.;
- Puri, Pier Lorenzo;
- Bodmer, Rolf
Publication type:
Article
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
Published in:
PLoS Pathogens, 2019, v. 15, n. 3, p. 1, doi. 10.1371/journal.ppat.1007667
By:
- McFarlane, Steven;
- Orr, Anne;
- Roberts, Ashley P. E.;
- Conn, Kristen L.;
- Iliev, Victor;
- Loney, Colin;
- da Silva Filipe, Ana;
- Smollett, Katherine;
- Gu, Quan;
- Robertson, Neil;
- Adams, Peter D.;
- Rai, Taranjit Singh;
- Boutell, Chris
Publication type:
Article
The San Diego Nathan Shock Center: tackling the heterogeneity of aging.
Published in:
GeroScience, 2021, v. 43, n. 5, p. 2139, doi. 10.1007/s11357-021-00426-x
By:
- Shadel, Gerald S.;
- Adams, Peter D.;
- Berggren, W. Travis;
- Diedrich, Jolene K.;
- Diffenderfer, Kenneth E.;
- Gage, Fred H.;
- Hah, Nasun;
- Hansen, Malene;
- Hetzer, Martin W.;
- Molina, Anthony J. A.;
- Manor, Uri;
- Marek, Kurt;
- O'Keefe, David D.;
- Pinto, Antonio F. M.;
- Sacco, Alessandra;
- Sharpee, Tatyana O.;
- Shokriev, Maxim N.;
- Zambetti, Stefania
Publication type:
Article
Senescent cells harbour features of the cancer epigenome.
Published in:
Nature Cell Biology, 2013, v. 15, n. 12, p. 1495, doi. 10.1038/ncb2879
By:
- Cruickshanks, Hazel A.;
- McBryan, Tony;
- Nelson, David M.;
- VanderKraats, Nathan D.;
- Shah, Parisha P.;
- van Tuyn, John;
- Singh Rai, Taranjit;
- Brock, Claire;
- Donahue, Greg;
- Dunican, Donncha S.;
- Drotar, Mark E.;
- Meehan, Richard R.;
- Edwards, John R.;
- Berger, Shelley L.;
- Adams, Peter D.
Publication type:
Article
Signalling the end of the line.
Published in:
Nature Cell Biology, 2012, v. 14, n. 4, p. 339, doi. 10.1038/ncb2476
By:
- van Tuyn, John;
- Adams, Peter D.
Publication type:
Article
A damage limitation exercise.
Published in:
Nature Cell Biology, 2011, v. 13, n. 3, p. 193, doi. 10.1038/ncb0311-193
By:
- Ivanov, Andrejs;
- Adams, Peter D.
Publication type:
Article
Deregulated expression of E2F-1 induces cyclin A- and E-associated kinase activities independently from cell cycle position.
Published in:
Oncogene, 1997, v. 14, n. 19, p. 2251, doi. 10.1038/sj.onc.1201061
By:
- Soucek, Thomas;
- Pusch, Oliver;
- Hengstschläger-Ottnad, Elke;
- Adams, Peter D;
- Hengstschläger, Markus
Publication type:
Article
DNA damage marker phosphorylated histone H2 AX is a potential predictive marker for progression of epithelial dysplasia of the oral cavity.
Published in:
Histopathology, 2017, v. 71, n. 4, p. 522, doi. 10.1111/his.13260
By:
- Leung, Elaine Y;
- McMahon, Jeremy D;
- McLellan, Douglas R;
- Syyed, Nazlie;
- McCarthy, Caroline E;
- Nixon, Colin;
- Orange, Clare;
- Brock, Claire;
- Hunter, Keith D;
- Adams, Peter D
Publication type:
Article
Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex.
Published in:
Nature Communications, 2015, v. 6, n. 7, p. 7711, doi. 10.1038/ncomms8711
By:
- Daniel Ricketts, M;
- Frederick, Brian;
- Hoff, Henry;
- Tang, Yong;
- Schultz, David C.;
- Singh Rai, Taranjit;
- Grazia Vizioli, Maria;
- Adams, Peter D.;
- Marmorstein, Ronen
Publication type:
Article
DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML.
Published in:
Genome Biology, 2014, v. 15, n. 7, p. 406, doi. 10.1186/s13059-014-0406-2
By:
- Lund, Kirstin;
- Cole, John J.;
- VanderKraats, Nathan D.;
- McBryan, Tony;
- Pchelintsev, Nikolay A.;
- Clark, William;
- Copland, Mhairi;
- Edwards, John R.;
- Adams, Peter D.
Publication type:
Article
Senescent mouse cells fail to overtly regulate theHIRA histone chaperone and do not form robustSenescence Associated Heterochromatin Foci.
Published in:
Cell Division, 2010, v. 5, p. 16, doi. 10.1186/1747-1028-5-16
By:
- Kennedy, Alyssa L.;
- McBryan, Tony;
- Enders, Greg H.;
- Johnson, F. Brad;
- Rugang Zhang;
- Adams, Peter D.
Publication type:
Article
Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.
Published in:
Journal of Investigative Dermatology, 2015, v. 135, n. 11, p. 2902, doi. 10.1038/jid.2015.230
By:
- Pawlikowski, Jeffrey S;
- Brock, Claire;
- Chen, Sheau-Chiann;
- Al-Olabi, Lara;
- Nixon, Colin;
- McGregor, Fiona;
- Paine, Simon;
- Chanudet, Estelle;
- Lambie, Wendy;
- Holmes, William M;
- Mullin, James M;
- Richmond, Ann;
- Wu, Hong;
- Blyth, Karen;
- King, Ayala;
- Kinsler, Veronica A;
- Adams, Peter D
Publication type:
Article
Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.
Published in:
Journal of Investigative Dermatology, 2015, v. 135, n. 8, p. 2093, doi. 10.1038/jid.2015.114
By:
- Pawlikowski, Jeffrey S;
- Brock, Claire;
- Chen, Sheau-Chiann;
- Al-Olabi, Lara;
- Nixon, Colin;
- McGregor, Fiona;
- Paine, Simon;
- Chanudet, Estelle;
- Lambie, Wendy;
- Holmes, William M;
- Mullin, James M;
- Richmond, Ann;
- Wu, Hong;
- Blyth, Karen;
- King, Ayala;
- Kinsler, Veronica A;
- Adams, Peter D
Publication type:
Article
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.
Published in:
2020
By:
- Casciano, Jessica C.;
- Perry, Caroline;
- Cohen-Nowak, Adam J.;
- Miller, Katelyn D.;
- Vande Voorde, Johan;
- Zhang, Qifeng;
- Chalmers, Susan;
- Sandison, Mairi E.;
- Liu, Qin;
- Hedley, Ann;
- McBryan, Tony;
- Tang, Hsin-Yao;
- Gorman, Nicole;
- Beer, Thomas;
- Speicher, David W.;
- Adams, Peter D.;
- Liu, Xuefeng;
- Schlegel, Richard;
- McCarron, John G.;
- Wakelam, Michael J. O.
Publication type:
journal article
Critical Parameters for Efficient Sonication and Improved Chromatin Immunoprecipitation of High Molecular Weight Proteins.
Published in:
PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0148023
By:
- Pchelintsev, Nikolay A.;
- Adams, Peter D.;
- Nelson, David M.
Publication type:
Article
Autophagy mediates degradation of nuclear lamina.
Published in:
Nature, 2015, v. 527, n. 7576, p. 105, doi. 10.1038/nature15548
By:
- Dou, Zhixun;
- Xu, Caiyue;
- Donahue, Greg;
- Shimi, Takeshi;
- Pan, Ji-An;
- Zhu, Jiajun;
- Ivanov, Andrejs;
- Capell, Brian C.;
- Drake, Adam M.;
- Shah, Parisha P.;
- Catanzaro, Joseph M.;
- Daniel Ricketts, M.;
- Lamark, Trond;
- Adam, Stephen A.;
- Marmorstein, Ronen;
- Zong, Wei-Xing;
- Johansen, Terje;
- Goldman, Robert D.;
- Adams, Peter D.;
- Berger, Shelley L.
Publication type:
Article
p53 status determines the role of autophagy in pancreatic tumour development.
Published in:
Nature, 2013, v. 504, n. 7479, p. 296, doi. 10.1038/nature12865
By:
- Rosenfeldt, Mathias T.;
- O'Prey, Jim;
- Morton, Jennifer P.;
- Nixon, Colin;
- MacKay, Gillian;
- Mrowinska, Agata;
- Au, Amy;
- Rai, Taranjit Singh;
- Zheng, Liang;
- Ridgway, Rachel;
- Adams, Peter D.;
- Anderson, Kurt I.;
- Gottlieb, Eyal;
- Sansom, Owen J.;
- Ryan, Kevin M.
Publication type:
Article
Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment.
Published in:
Genome Biology, 2017, v. 18, p. 1, doi. 10.1186/s13059-017-1186-2
By:
- Tina Wang;
- Tsui, Brian;
- Kreisberg, Jason F.;
- Robertson, Neil A.;
- Gross, Andrew M.;
- Ku Yu, Michael;
- Carter, Hannah;
- Brown-Borg, Holly M.;
- Adams, Peter D.;
- Ideker, Trey
Publication type:
Article
Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.
Published in:
Genome Biology, 2017, v. 18, p. 1, doi. 10.1186/s13059-017-1185-3
By:
- Cole, John J.;
- Robertson, Neil A.;
- Rather, Mohammed Iqbal;
- Thomson, John P.;
- McBryan, Tony;
- Sproul, Duncan;
- Tina Wang;
- Brock, Claire;
- Clark, William;
- Ideker, Trey;
- Meehan, Richard R.;
- Miller, Richard A.;
- Brown-Borg, Holly M.;
- Adams, Peter D.
Publication type:
Article
METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49745-5
By:
- Wang, Chen;
- Tanizawa, Hideki;
- Hill, Connor;
- Havas, Aaron;
- Zhang, Qiang;
- Liao, Liping;
- Hao, Xue;
- Lei, Xue;
- Wang, Lu;
- Nie, Hao;
- Qi, Yuan;
- Tian, Bin;
- Gardini, Alessandro;
- Kossenkov, Andrew V.;
- Goldman, Aaron;
- Berger, Shelley L.;
- Noma, Ken-ichi;
- Adams, Peter D.;
- Zhang, Rugang
Publication type:
Article
DNA methylation aging clocks: challenges and recommendations.
Published in:
Genome Biology, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s13059-019-1824-y
By:
- Bell, Christopher G.;
- Lowe, Robert;
- Adams, Peter D.;
- Baccarelli, Andrea A.;
- Beck, Stephan;
- Bell, Jordana T.;
- Christensen, Brock C.;
- Gladyshev, Vadim N.;
- Heijmans, Bastiaan T.;
- Horvath, Steve;
- Ideker, Trey;
- Issa, Jean-Pierre J.;
- Kelsey, Karl T.;
- Marioni, Riccardo E.;
- Reik, Wolf;
- Relton, Caroline L.;
- Schalkwyk, Leonard C.;
- Teschendorff, Andrew E.;
- Wagner, Wolfgang;
- Zhang, Kang
Publication type:
Article
Modifiable Factors to Prevent Prolonged Length of Stay after Sleeve Gastrectomy.
Published in:
Obesity Surgery, 2019, v. 29, n. 6, p. 1751, doi. 10.1007/s11695-019-03757-z
By:
- Meneveau, Max;
- Mehaffey, J. Hunter;
- Adams, Peter D.;
- Turrentine, Florence E.;
- Schirmer, Bruce;
- Hallowell, Peter T.
Publication type:
Article
Large‐scale genetic screens identify BET‐1 as a cytoskeleton regulator promoting actin function and life span.
Published in:
Aging Cell, 2023, v. 22, n. 1, p. 1, doi. 10.1111/acel.13742
By:
- Garcia, Gilberto;
- Bar‐Ziv, Raz;
- Averbukh, Maxim;
- Dasgupta, Nirmalya;
- Dutta, Naibedya;
- Zhang, Hanlin;
- Fan, Wudi;
- Moaddeli, Darius;
- Tsui, C. Kimberly;
- Castro Torres, Toni;
- Alcala, Athena;
- Moehle, Erica A.;
- Hoang, Sally;
- Shalem, Ophir;
- Adams, Peter D.;
- Thorwald, Max A.;
- Higuchi‐Sanabria, Ryo
Publication type:
Article
Age-associated increase in heterochromatic marks in murine and primate tissues.
Published in:
Aging Cell, 2011, v. 10, n. 2, p. 292, doi. 10.1111/j.1474-9726.2010.00666.x
By:
- Kreiling, Jill A.;
- Tamamori-Adachi, Mimi;
- Sexton, Alec N.;
- Jeyapalan, Jessie C.;
- Munoz-Najar, Ursula;
- Peterson, Abigail L.;
- Manivannan, Jayameenakshi;
- Rogers, Elizabeth S.;
- Pchelintsev, Nikolay A.;
- Adams, Peter D.;
- Sedivy, John M.
Publication type:
Article
Remodeling chromatin for senescence.
Published in:
Aging Cell, 2007, v. 6, n. 4, p. 425, doi. 10.1111/j.1474-9726.2007.00313.x
By:
- Adams, Peter D.
Publication type:
Article

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