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GelMA, Click-Chemistry Gelatin and Bioprinted Polyethylene Glycol-Based Hydrogels as 3D Ex Vivo Drug Testing Platforms for Patient-Derived Breast Cancer Organoids.
Published in:
Pharmaceutics, 2023, v. 15, n. 1, p. 261, doi. 10.3390/pharmaceutics15010261
By:
- Bock, Nathalie;
- Forouz, Farzaneh;
- Hipwood, Luke;
- Clegg, Julien;
- Jeffery, Penny;
- Gough, Madeline;
- van Wyngaard, Tirsa;
- Pyke, Christopher;
- Adams, Mark N.;
- Bray, Laura J.;
- Croft, Laura;
- Thompson, Erik W.;
- Kryza, Thomas;
- Meinert, Christoph
Publication type:
Article
Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small-Cell Lung Cancer (NSCLC).
Published in:
Pharmaceuticals (14248247), 2020, v. 13, n. 10, p. 273, doi. 10.3390/ph13100273
By:
- O'Leary, Connor;
- Gasper, Harry;
- Sahin, Katherine B.;
- Tang, Ming;
- Kulasinghe, Arutha;
- Adams, Mark N.;
- Richard, Derek J.;
- O'Byrne, Ken J.
Publication type:
Article
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02136-8
By:
- Kildey, Katrina;
- Gandhi, Neha S.;
- Sahin, Katherine B.;
- Shah, Esha T.;
- Boittier, Eric;
- Duijf, Pascal H. G.;
- Molloy, Christopher;
- Burgess, Joshua T.;
- Beard, Sam;
- Bolderson, Emma;
- Suraweera, Amila;
- Richard, Derek J.;
- O'Byrne, Kenneth J.;
- Adams, Mark N.
Publication type:
Article
COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-01998-2
By:
- Suraweera, Amila;
- Gandhi, Neha S.;
- Beard, Sam;
- Burgess, Joshua T.;
- Croft, Laura V.;
- Bolderson, Emma;
- Naqi, Ali;
- Ashton, Nicholas W.;
- Adams, Mark N.;
- Savage, Kienan I.;
- Zhang, Shu-Dong;
- O'Byrne, Kenneth J.;
- Richard, Derek J.
Publication type:
Article
The expression and role of the Lem-D proteins Ankle2, Emerin, Lemd2, and TMPO in triple-negative breast cancer cell growth.
Published in:
Frontiers in Oncology, 2024, p. 1, doi. 10.3389/fonc.2024.1222698
By:
- Rose, Maddison;
- Burgess, Joshua T.;
- Chee Man Cheong;
- Adams, Mark N.;
- Shahrouzi, Parastoo;
- O'Byrne, Kenneth J.;
- Richard, Derek J.;
- Bolderson, Emma
Publication type:
Article
A data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization.
Published in:
Nucleic Acids Research, 2017, v. 45, n. 14, p. 8609, doi. 10.1093/nar/gkx526
By:
- Touma, Christine;
- Adams, Mark N.;
- Ashton, Nicholas W.;
- Mizzi, Michael;
- El-Kamand, Serene;
- Richard, Derek J.;
- Cubeddu, Liza;
- Gamsjaeger, Roland
Publication type:
Article
A structural analysis of DNA binding by hSSBI (NABP2/OBFC2B) in solution.
Published in:
Nucleic Acids Research, 2016, v. 44, n. 16, p. 7963, doi. 10.1093/nar/gkw617
By:
- Touma, Christine;
- Kariawasam, Ruvini;
- Gimenez, Adrian X.;
- Bernardo, Ray E.;
- Ashton, Nicholas W.;
- Adams, Mark N.;
- Paquet, Nicolas;
- Croll, Tristan I.;
- O'Byrne, Kenneth J.;
- Richard, Derek J.;
- Cubeddu, Liza;
- Gamsjaeger, Roland
Publication type:
Article
hSSB1 (NABP2/OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.
Published in:
Nucleic Acids Research, 2015, v. 43, n. 18, p. 8817, doi. 10.1093/nar/gkv790
By:
- Paquet, Nicolas;
- Adams, Mark N.;
- Leong, Vincent;
- Ashton, Nicholas W.;
- Touma, Christine;
- Gamsjaeger, Roland;
- Cubeddu, Liza;
- Beard, Sam;
- Burgess, Joshua T.;
- Bolderson, Emma;
- O'Byrne, Ken J.;
- Richard, Derek J.
Publication type:
Article
hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.
Published in:
Scientific Reports, 2016, p. 27446, doi. 10.1038/srep27446
By:
- Paquet, Nicolas;
- Adams, Mark N.;
- Ashton, Nicholas W.;
- Touma, Christine;
- Gamsjaeger, Roland;
- Cubeddu, Liza;
- Leong, Vincent;
- Beard, Sam;
- Bolderson, Emma;
- Botting, Catherine H.;
- O'Byrne, Kenneth J.;
- Richard, Derek J.
Publication type:
Article
The Role of Palmitoylation in Signalling, Cellular Trafficking and Plasma Membrane Localization of Protease-Activated Receptor-2.
Published in:
PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0028018
By:
- Adams, Mark N.;
- Christensen, Melinda E.;
- Yaowu He;
- Waterhouse, Nigel J.;
- Hooper, John D.
Publication type:
Article
Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13167-5
By:
- Bolderson, Emma;
- Burgess, Joshua T.;
- Li, Jun;
- Gandhi, Neha S.;
- Boucher, Didier;
- Croft, Laura V.;
- Beard, Samuel;
- Plowman, Jennifer J.;
- Suraweera, Amila;
- Adams, Mark N.;
- Naqi, Ali;
- Zhang, Shu-Dong;
- Sinclair, David A.;
- O'Byrne, Kenneth J.;
- Richard, Derek J.
Publication type:
Article
3D Breast Tumor Models for Radiobiology Applications.
Published in:
Cancers, 2021, v. 13, n. 22, p. 5714, doi. 10.3390/cancers13225714
By:
- Ravichandran, Akhilandeshwari;
- Clegg, Julien;
- Adams, Mark N.;
- Hampson, Madison;
- Fielding, Andrew;
- Bray, Laura J.
Publication type:
Article
COMMD1, from the Repair of DNA Double Strand Breaks, to a Novel Anti-Cancer Therapeutic Target.
Published in:
Cancers, 2021, v. 13, n. 4, p. 830, doi. 10.3390/cancers13040830
By:
- Suraweera, Amila;
- Duijf, Pascal H. G.;
- Jekimovs, Christian;
- Schrobback, Karsten;
- Liu, Cheng;
- Adams, Mark N.;
- O'Byrne, Kenneth J.;
- Richard, Derek J.;
- Alfieri, Roberta
Publication type:
Article
Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response.
Published in:
Journal of Translational Medicine, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12967-024-05409-y
By:
- Sadeghirad, Habib;
- Monkman, James;
- Tan, Chin Wee;
- Liu, Ning;
- Yunis, Joseph;
- Donovan, Meg L.;
- Moradi, Afshin;
- Jhaveri, Niyati;
- Perry, Chris;
- Adams, Mark N.;
- O’Byrne, Ken;
- Warkiani, Majid E.;
- Ladwa, Rahul;
- Hughes, Brett G.M.;
- Kulasinghe, Arutha
Publication type:
Article
Spatial Profiling Identifies Prognostic Features of Response to Adjuvant Therapy in Triple Negative Breast Cancer (TNBC).
Published in:
Frontiers in Oncology, 2022, v. 11, p. 1, doi. 10.3389/fonc.2021.798296
By:
- Kulasinghe, Arutha;
- Monkman, James;
- Shah, Esha T.;
- Matigian, Nicholas;
- Adams, Mark N.;
- O'Byrne, Ken
Publication type:
Article
Identification of Proteins Deregulated by Platinum-Based Chemotherapy as Novel Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer.
Published in:
Frontiers in Oncology, 2021, v. 11, p. N.PAG, doi. 10.3389/fonc.2021.615967
By:
- Ryan, Sarah-Louise;
- Dave, Keyur A.;
- Beard, Sam;
- Gyimesi, Martina;
- McTaggart, Matthew;
- Sahin, Katherine B.;
- Molloy, Christopher;
- Gandhi, Neha S.;
- Boittier, Eric;
- O'Leary, Connor G.;
- Shah, Esha T.;
- Bolderson, Emma;
- Baird, Anne-Marie;
- Richard, Derek J.;
- O'Byrne, Kenneth J.;
- Adams, Mark N.
Publication type:
Article
Compartmentalized spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma identifies immune checkpoint molecules and tumor necrosis factor receptor superfamily members as biomarkers of response to immunotherapy.
Published in:
Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1135489
By:
- Sadeghirad, Habib;
- Ning Liu;
- Monkman, James;
- Ma, Ning;
- Cheikh, Bassem Ben;
- Jhaveri, Niyati;
- Tan, Chin Wee;
- Warkiani, Majid Ebrahimi;
- Adams, Mark N.;
- Quan Nguyen;
- Ladwa, Rahul;
- Braubach, Oliver;
- O'Byrne, Ken;
- Davis, Melissa;
- Hughes, Brett G. M.;
- Kulasinghe, Arutha
Publication type:
Article
Compartmentalized spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma identifies immune checkpoint molecules and tumor necrosis factor receptor superfamily members as biomarkers of response to immunotherapy.
Published in:
Frontiers in Immunology, 2023, v. 14, p. 01, doi. 10.3389/fimmu.2023.1135489
By:
- Sadeghirad, Habib;
- Ning Liu;
- Monkman, James;
- Ning Ma;
- Cheikh, Bassem Ben;
- Jhaveri, Niyati;
- Chin Wee Tan;
- Warkiani, Majid Ebrahimi;
- Adams, Mark N.;
- Quan Nguyen;
- Ladwa, Rahul;
- Braubach, Oliver;
- O'Byrne, Ken;
- Davis, Melissa;
- Hughes, Brett G. M.;
- Kulasinghe, Arutha
Publication type:
Article
Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer.
Published in:
2016
By:
- Harrington, Brittney S;
- He, Yaowu;
- Davies, Claire M;
- Wallace, Sarah J;
- Adams, Mark N;
- Beaven, Elizabeth A;
- Roche, Deborah K;
- Kennedy, Catherine;
- Chetty, Naven P;
- Crandon, Alexander J;
- Flatley, Christopher;
- Oliveira, Niara B;
- Shannon, Catherine M;
- deFazio, Anna;
- Tinker, Anna V;
- Gilks, C Blake;
- Gabrielli, Brian;
- Brennan, Donal J;
- Coward, Jermaine I;
- Armes, Jane E
Publication type:
journal article
SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-75625-1
By:
- Burgess, Joshua T.;
- Bolderson, Emma;
- Adams, Mark N.;
- Duijf, Pascal H. G.;
- Zhang, Shu-Dong;
- Gray, Steven G.;
- Wright, Gavin;
- Richard, Derek J.;
- O'Byrne, Kenneth J.
Publication type:
Article
An Exploration of Small Molecules That Bind Human Single-Stranded DNA Binding Protein 1.
Published in:
Biology (2079-7737), 2023, v. 12, n. 11, p. 1405, doi. 10.3390/biology12111405
By:
- Schuurs, Zachariah P.;
- Martyn, Alexander P.;
- Soltau, Carl P.;
- Beard, Sam;
- Shah, Esha T.;
- Adams, Mark N.;
- Croft, Laura V.;
- O'Byrne, Kenneth J.;
- Richard, Derek J.;
- Gandhi, Neha S.
Publication type:
Article
Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response.
Published in:
Cell Death & Disease, 2016, v. 7, n. 11, p. e2469, doi. 10.1038/cddis.2016.364
By:
- Burgess, Joshua T;
- Bolderson, Emma;
- Adams, Mark N;
- Baird, Anne-Marie;
- Zhang, Shu-Dong;
- Gately, Kathy A;
- Umezawa, Kazuo;
- O'Byrne, Kenneth J;
- Richard, Derek J
Publication type:
Article
Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells.
Published in:
British Journal of Cancer, 2024, v. 130, n. 7, p. 1196, doi. 10.1038/s41416-024-02584-z
By:
- Shah, Esha T.;
- Molloy, Christopher;
- Gough, Madeline;
- Kryza, Thomas;
- Samuel, Selwin G.;
- Tucker, Amos;
- Bhatia, Maneet;
- Ferguson, Genevieve;
- Heyman, Rebecca;
- Vora, Shivam;
- Monkman, James;
- Bolderson, Emma;
- Kulasinghe, Arutha;
- He, Yaowu;
- Gabrielli, Brian;
- Hooper, John D.;
- Richard, Derek J.;
- O'Byrne, Kenneth J.;
- Adams, Mark N.
Publication type:
Article
Correction: Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer.
Published in:
2021
By:
- Suraweera, Amila;
- Duff, Alex;
- Adams, Mark N.;
- Jekimovs, Christian;
- Duijf, Pascal H. G.;
- Liu, Cheng;
- McTaggart, Matthew;
- Beard, Sam;
- O'Byrne, Kenneth J.;
- Richard, Derek J.
Publication type:
corrected article
Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer.
Published in:
2020
By:
- Suraweera, Amila;
- Duff, Alex;
- Adams, Mark N.;
- Jekimovs, Christian;
- Duijf, Pascal H. G.;
- Liu, Cheng;
- McTaggart, Matthew;
- Beard, Sam;
- Byrne, Kenneth J. O';
- Richard, Derek J.;
- O'Byrne, Kenneth J
Publication type:
journal article
Understanding the tumor microenvironment in head and neck squamous cell carcinoma.
Published in:
Clinical & Translational Immunology, 2022, v. 11, n. 6, p. 1, doi. 10.1002/cti2.1397
By:
- Rad, Habib Sadeghi;
- Shiravand, Yavar;
- Radfar, Payar;
- Ladwa, Rahul;
- Perry, Chris;
- Han, Xiaoyuan;
- Warkiani, Majid Ebrahimi;
- Adams, Mark N;
- Hughes, Brett GM;
- O'Byrne, Ken;
- Kulasinghe, Arutha
Publication type:
Article
Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity.
Published in:
Nucleic Acids Research, 2021, v. 49, n. 6, p. 3294, doi. 10.1093/nar/gkab110
By:
- Burgess, Joshua T;
- Cheong, Chee Man;
- Suraweera, Amila;
- Sobanski, Thais;
- Beard, Sam;
- Dave, Keyur;
- Rose, Maddison;
- Boucher, Didier;
- Croft, Laura V;
- Adams, Mark N;
- O'Byrne, Kenneth;
- Richard, Derek J;
- Bolderson, Emma
Publication type:
Article
Multi‐omic and spatial dissection of immunotherapy response groups in non‐small cell lung cancer.
Published in:
Immunology, 2023, v. 169, n. 4, p. 487, doi. 10.1111/imm.13646
By:
- Monkman, James;
- Kim, Honesty;
- Mayer, Aaron;
- Mehdi, Ahmed;
- Matigian, Nicholas;
- Cumberbatch, Marie;
- Bhagat, Milan;
- Ladwa, Rahul;
- Mueller, Scott N.;
- Adams, Mark N.;
- O'Byrne, Ken;
- Kulasinghe, Arutha
Publication type:
Article
hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen‐induced transcriptional response in prostate cancer.
Published in:
Prostate, 2023, v. 83, n. 7, p. 628, doi. 10.1002/pros.24496
By:
- Adams, Mark N.;
- Croft, Laura V.;
- Urquhart, Aaron;
- Saleem, Mohamed Ashick Mohamed;
- Rockstroh, Anja;
- Duijf, Pascal H. G.;
- Thomas, Patrick B.;
- Ferguson, Genevieve P.;
- Najib, Idris Mohd;
- Shah, Esha T.;
- Bolderson, Emma;
- Nagaraj, Shivashankar;
- Williams, Elizabeth D.;
- Nelson, Colleen C.;
- O'Byrne, Kenneth J.;
- Richard, Derek J.
Publication type:
Article
CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy.
Published in:
Theranostics, 2022, v. 12, n. 16, p. 6915, doi. 10.7150/thno.78171
By:
- Khan, Tashbib;
- Lyons, Nicholas J.;
- Gough, Madeline;
- Kwah, Kayden K. X.;
- Cuda, Tahleesa J.;
- Snell, Cameron E.;
- Tse, Brian W.;
- Sokolowski, Kamil A.;
- Pearce, Lesley A.;
- Adams, Timothy E.;
- Rose, Stephen E.;
- Puttick, Simon;
- Pajic, Marina;
- Adams, Mark N.;
- Yaowu He;
- Hooper, John D.;
- Kryza, Thomas
Publication type:
Article
Nucleophosmin: from structure and function to disease development.
Published in:
BMC Molecular Biology, 2016, v. 17, p. 1, doi. 10.1186/s12867-016-0073-9
By:
- Box, Joseph K.;
- Paquet, Nicolas;
- Adams, Mark N.;
- Boucher, Didier;
- Bolderson, Emma;
- O'Byrne, Kenneth J.;
- Richard, Derek J.
Publication type:
Article
The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-41133-1
By:
- Sobanski, Thais;
- Suraweera, Amila;
- Burgess, Joshua T.;
- Richard, Iain;
- Cheong, Chee Man;
- Dave, Keyur;
- Rose, Maddison;
- Adams, Mark N.;
- O'Byrne, Kenneth J.;
- Richard, Derek J.;
- Bolderson, Emma
Publication type:
Article
The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-41133-1
By:
- Sobanski, Thais;
- Suraweera, Amila;
- Burgess, Joshua T.;
- Richard, Iain;
- Cheong, Chee Man;
- Dave, Keyur;
- Rose, Maddison;
- Adams, Mark N.;
- O'Byrne, Kenneth J.;
- Richard, Derek J.;
- Bolderson, Emma
Publication type:
Article
The molecular details of a novel phosphorylation‐dependent interaction between MRN and the SOSS complex.
Published in:
Protein Science: A Publication of the Protein Society, 2023, v. 32, n. 10, p. 1, doi. 10.1002/pro.4782
By:
- El‐Kamand, Serene;
- Adams, Mark N.;
- Matthews, Jacqueline M.;
- Du Plessis, Mar‐Dean;
- Crossett, Ben;
- Connolly, Angela;
- Breen, Natasha;
- Dudley, Alexander;
- Richard, Derek J.;
- Gamsjaeger, Roland;
- Cubeddu, Liza
Publication type:
Article
Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases.
Published in:
Biological Chemistry, 2014, v. 395, n. 9, p. 977, doi. 10.1515/hsz-2014-0147
By:
- Ying Dong;
- Harrington, Brittney S.;
- Adams, Mark N.;
- Wortmann, Andreas;
- Stephenson, Sally-Anne;
- Lisle, Jessica;
- Herington, Adrian;
- Hooper, John D.;
- Clements, Judith A.
Publication type:
Article
Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs).
Published in:
Biological Chemistry, 2008, v. 389, n. 6, p. 653, doi. 10.1515/BC.2008.078
By:
- Ramsay, Andrew J.;
- Reid, Janet C.;
- Adams, Mark N.;
- Samaratunga, Hemamali;
- Dong, Ying;
- Clements, Judith A.;
- Hooper, John D.
Publication type:
Article

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