Found: 16
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Effects of quinapril, losartan and hydralazine on cardiac hypertrophy and β-adrenergic neuroeffector mechanisms in transgenic (mREN2)27 rats.
- Published in:
- British Journal of Pharmacology, 1998, v. 123, n. 3, p. 405, doi. 10.1038/sj.bjp.0701615
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- Publication type:
- Article
Trifluoromethyl Dihydrothiazine‐Based β‐Secretase (BACE1) Inhibitors with Robust Central β‐Amyloid Reduction and Minimal Covalent Binding Burden.
- Published in:
- ChemMedChem, 2019, v. 14, n. 22, p. 1894, doi. 10.1002/cmdc.201900478
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- Article
PK/PD Modelling of the QT Interval: a Step Towards Defining the Translational Relationship Between In Vitro, Awake Beagle Dogs, and Humans.
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- AAPS Journal, 2016, v. 18, n. 4, p. 1000, doi. 10.1208/s12248-016-9920-3
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- Article
The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.
- Published in:
- Biomolecules (2218-273X), 2023, v. 13, n. 9, p. 1355, doi. 10.3390/biom13091355
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- Article
Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model.
- Published in:
- Frontiers in Pharmacology, 2019, v. 10, p. 1, doi. 10.3389/fphar.2019.01374
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- Article
β-Adrenergic signal transduction following carvedilol treatment in hypertensive cardiac hypertrophy.
- Published in:
- Cardiovascular Research, 1998, v. 40, n. 1, p. 146
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- Publication type:
- Article
Cardio-vascular safety beyond hERG: in silico modelling of a guinea pig right atrium assay.
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- Journal of Computer-Aided Molecular Design, 2009, v. 23, n. 12, p. 883, doi. 10.1007/s10822-009-9306-z
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- Article
Chronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes.
- Published in:
- 2017
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- Publication type:
- journal article
Propagation of Epileptiform Activity During Development of Amygdala Kindling in Rats: Linear and Non-linear Association Between lpsi- and Contralateral Sites.
- Published in:
- European Journal of Neuroscience, 1993, v. 5, n. 7, p. 944, doi. 10.1111/j.1460-9568.1993.tb00945.x
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- Article
Analysis of cross-over designs with serial correlation within periods using semi-parametric mixed models.
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- Statistics in Medicine, 2008, v. 27, n. 28, p. 6009, doi. 10.1002/sim.3363
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- Publication type:
- Article
Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2015, v. 42, n. 6, p. 659, doi. 10.1007/s10928-015-9434-0
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- Publication type:
- Article
High-Throughput Screening Assay for Detecting Drug-Induced Changes in Synchronized Neuronal Oscillations and Potential Seizure Risk Based on Ca 2+ Fluorescence Measurements in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neuronal 2D and 3D Cultures
- Published in:
- Cells (2073-4409), 2023, v. 12, n. 6, p. 958, doi. 10.3390/cells12060958
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- Publication type:
- Article
Identifying Acute Cardiac Hazard in Early Drug Discovery Using a Calcium Transient High-Throughput Assay in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
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- Frontiers in Physiology, 2022, v. 13, p. 1, doi. 10.3389/fphys.2022.838435
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- Publication type:
- Article
Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca 2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.
- Published in:
- Toxicological Sciences, 2019, v. 170, n. 2, p. 345, doi. 10.1093/toxsci/kfz102
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- Article
The Concordance between Nonclinical and Phase I Clinical Cardiovascular Assessment from a Cross-Company Data Sharing Initiative.
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- Toxicological Sciences, 2014, v. 142, n. 2, p. 427, doi. 10.1093/toxsci/kfu198
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- Publication type:
- Article
Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery.
- Published in:
- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1308547
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- Publication type:
- Article