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Comparing the efficacy and safety of weekly somatrogon with daily somatropin to treat children with growth hormone deficiency: a plain language summary of publication from that of daily somatropin injections to treat children who don't make enough growth hormone to grow adequately. ○ Efficacy refers to how well a drug works in a clinical trial. ○ Children treated with weekly somatrogon had an increased growth rate, similar to that of children treated with daily somatropin. • The safety of weekly somatrogon injections was similar to that of daily somatropin injections. The original scientific article on which this summary is based was published in The Journal of Clinical Endocrinology & Metabolism and can be accessed for free at:https://academic.oup.com/jcem/article/107/7/e2717/6566444. The details of the original article are as follows: Cheri L. Deal, Joel Steelman, Elpis Vlachopapadopoulou, Renata Stawerska, Lawrence A Silverman, Moshe Phillip, Ho-Seong Kim, CheolWoo Ko, Oleg Malievskiy, Jose F. Cara, Carl L. Roland, Carrie Turich Taylor, Srinivas Rao Valluri, Michael P. Wajnrajch, Aleksandra Pastrak, and Bradley S. Miller. Efficacy and safety of weekly somatrogon vs daily somatropin in children with growth hormone deficiency: a phase 3 study. J Clin Endocrinol Metab 2022; 107(7): e2717–e2728. The purpose of this plain language summary is to help you to understand the findings from recent research. • Somatrogon is used to treat growth hormone deficiency (the condition under study that is discussed in this summary). Approval varies by country; please check with your local healthcare provider for more details. • The results of this study may differ from those of other studies. Physicians/providers should make treatment decisions based on all available evidence and not on the results of a single study.
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- Therapeutic Advances in Endocrinology & Metabolism, 2024, p. 1, doi. 10.1177/20420188241277404
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Exacerbation of disordered eating behaviors in adolescents with type 1 diabetes during the COVID-19 pandemic: reply.
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Exacerbation of disordered eating behaviors in adolescents with type 1 diabetes during the COVID-19 pandemic.
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Association between Glycemic Control and Clinic Attendance in Emerging Adults with Type 1 Diabetes: A Tertiary Center Experience.
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Preface.
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Combined clonidine-short-ACTH test for the simultaneous assessment of growth hormone reserve and hypothalamic- pituitary-adrenal axis integrity in children.
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- Journal of Clinical Endocrinology & Metabolism, 2022, v. 107, n. 8, p. e3264, doi. 10.1210/clinem/dgac288
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Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study.
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- Journal of Clinical Endocrinology & Metabolism, 2022, v. 107, n. 7, p. e2717, doi. 10.1210/clinem/dgac220
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Endocrine Effects of Valproate in Adolescent Girls with Epilepsy.
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Mediastinal Tumor in a Boy With GnRH-Independent Precocious Puberty and Fluctuating β-HCG Levels.
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Psychosocial factors associated with depressive mood in Israeli obese adolescents.
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Leptin Acts as a Growth Factor on the Chondrocytes of Skeletal Growth Centers.
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Pediatric Thyroid Cancer: Postoperative Classifications and Response to Initial Therapy as Prognostic Factors.
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Treated and untreated women with idiopathic precocious puberty: BMI evolution, metabolic outcome, and general health between third and fifth decades.
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A Novel Loss-of-Function Mutation in GPR54/KISS1R Leads to Hypogonadotropic Hypogonadism in a Highly Consanguineous Family.
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The Digital/Virtual Diabetes Clinic: The Future Is Now-Recommendations from an International Panel on Diabetes Digital Technologies Introduction.
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- Journal of Molecular Neuroscience, 2004, v. 22, n. 3, p. 179, doi. 10.1385/JMN:22:3:179
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Correction to: Consensus guidance for monitoring individuals with islet autoantibody‑positive pre‑stage 3 type 1 diabetes.
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- 2024
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Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes.
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- Diabetologia, 2024, v. 67, n. 9, p. 1731, doi. 10.1007/s00125-024-06205-5
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Closed-loop glucose control in young people with type 1 diabetes during and after unannounced physical activity: a randomised controlled crossover trial.
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- Diabetologia, 2017, v. 60, n. 11, p. 2157, doi. 10.1007/s00125-017-4395-z
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Reduced Worries of Hypoglycaemia, High Satisfaction, and Increased Perceived Ease of Use after Experiencing Four Nights of MD-Logic Artificial Pancreas at Home (DREAM4).
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- Journal of Diabetes Research, 2015, v. 2015, p. 1, doi. 10.1155/2015/590308
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Disordered eating behaviours in adolescents with type 1 diabetes can be influenced by their weight at diagnosis and rapid weight gain subsequently.
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- Diabetic Medicine, 2023, v. 40, n. 11, p. 1, doi. 10.1111/dme.15166
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Fear of hyperglycaemia in parents of children with type 1 diabetes mellitus – A multi‐centre multinational study.
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- Diabetic Medicine, 2023, v. 40, n. 7, p. 1, doi. 10.1111/dme.15114
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Improved postprandial glucose control with ultra rapid lispro versus lispro with continuous subcutaneous insulin infusion in type 1 diabetes: PRONTO‐Pump‐2.
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- Diabetes, Obesity & Metabolism, 2021, v. 23, n. 7, p. 1552, doi. 10.1111/dom.14368
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Add‐on therapy with dapagliflozin under full closed loop control improves time in range in adolescents and young adults with type 1 diabetes: The DAPADream study.
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- Diabetes, Obesity & Metabolism, 2021, v. 23, n. 2, p. 599, doi. 10.1111/dom.14258
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Long‐term efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes: pooled 52‐week outcomes from the DEPICT‐1 and ‐2 studies.
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- Diabetes, Obesity & Metabolism, 2021, v. 23, n. 2, p. 549, doi. 10.1111/dom.14248
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Benefit/risk profile of dapagliflozin 5 mg in the DEPICT-1 and -2 trials in individuals with type 1 diabetes and body mass index ≥27 kg/m².
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- Diabetes, Obesity & Metabolism, 2020, v. 22, n. 11, p. 2151, doi. 10.1111/dom.14144
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Long‐term efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (the DEPICT‐2 study): 52‐week results from a randomized controlled trial.
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- Diabetes, Obesity & Metabolism, 2020, v. 22, n. 9, p. 1516, doi. 10.1111/dom.14060
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MD-Logic overnight type 1 diabetes control in home settings: A multicentre, multinational, single blind randomized trial.
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Craniopharyngioma Presenting as Precocious Puberty and Accelerated Growth.
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- Clinical Pediatrics, 2003, v. 42, n. 2, p. 181, doi. 10.1177/000992280304200213
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Obesity and Cardiometabolic Risk Factors in Children and Young Adults With Non-classical 21-Hydroxylase Deficiency.
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- Frontiers in Endocrinology, 2019, p. 1, doi. 10.3389/fendo.2019.00698
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Compromised Adult Height in Females with Non-Classical Congenital Adrenal Hyperplasia Diagnosed in Childhood.
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- Hormone Research in Paediatrics, 2023, v. 96, n. 5, p. 465, doi. 10.1159/000529772
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Natural History of Thyroid Function Tests over 5 Years in a Large Pediatric Cohort.
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Children referred for signs of early puberty warrant endocrine evaluation and follow-up.
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Familial Central Precocious Puberty Suggests Autosomal Dominant Inheritance.
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A Novel Mutation Causing Complete Thyroxine-Binding Globulin Deficiency (TBG-CD-Negev) among the Bedouins in Southern Israel.
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- Journal of Clinical Endocrinology & Metabolism, 2000, v. 85, n. 10, p. 3687, doi. 10.1210/jcem.85.10.6899
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Relationship between changes in thyroid hormone level and severity of the postoperative course in neonates undergoing open-heart surgery.
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Integrated plasma cortisol concentration in children with asthma receiving long-term inhaled corticosteroids.
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- Pediatric Pulmonology, 1992, v. 12, n. 2, p. 84, doi. 10.1002/ppul.1950120205
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A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency.
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- Human Genetics, 2010, v. 127, n. 6, p. 721, doi. 10.1007/s00439-010-0820-9
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Plasma IGFBP-3 and its relationship with quantitative growth hormone secretion in short children.
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- Clinical Endocrinology, 1993, v. 39, n. 4, p. 427, doi. 10.1111/j.1365-2265.1993.tb02389.x
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Children with idiopathic short stature have significantly different gut microbiota than their normal height siblings: a case-control study.
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- Frontiers in Endocrinology, 2024, p. 01, doi. 10.3389/fendo.2024.1343337
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Gonadotropin releasing hormone analogue therapy in girls with idiopathic precocious puberty/early-fast puberty: dynamics in adiposity indices, eating habits and quality of life.
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- Journal of Pediatric Endocrinology & Metabolism, 2021, v. 34, n. 3, p. 373, doi. 10.1515/jpem-2020-0471
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