Works matching AU Lukacs, Gergely L.

Results: 43

Epithelial Anion Transport as Modulator of Chemokine Signaling.

Published in:

Mediators of Inflammation, 2016, p. 1, doi. 10.1155/2016/7596531

By:

Schnúr, Andrea;
Hegyi, Péter;
Rousseau, Simon;
Lukacs, Gergely L.;
Veit, Guido

Publication type:

Article

Importin 13 Regulates Nuclear Import of the Glucocorticoid Receptor in Airway Epithelial Cells.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2006, v. 35, n. 6, p. 668, doi. 10.1165/rcmb.2006-0073oc

By:

Tao Tao;
Jie Lan;
Lukacs, Gergely L.;
Haché, Robert J. G.;
Kaplan, Feige

Publication type:

Article

Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines.

Published in:

Cells (2073-4409), 2021, v. 10, n. 3, p. 495, doi. 10.3390/cells10030495

By:

Grund, Megan E.;
Choi Soo, Jeon;
Cote, Christopher K.;
Berisio, Rita;
Lukomski, Slawomir;
Lukacs, Gergely L.

Publication type:

Article

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Published in:

2005

By:

Pedemonte, Nicoletta;
Lukacs, Gergely L;
Du, Kai;
Caci, Emanuela;
Zegarra-Moran, Olga;
Galietta, Luis J V;
Verkman, A S

Publication type:

journal article

Small-molecule correctors of defective F508-CFTR cellular processing identified by high-throughput screening.

Published in:

Journal of Clinical Investigation, 2005, v. 115, n. 9, p. 2564, doi. 10.1172/JCI24898

By:

Pedemonte, Nicoletta;
Lukacs, Gergely L.;
Du, Kai;
Caci, Emanuela;
Zegarra-Moran, Olga;
Galietta, Luis J. V.;
Verkman, A. S.

Publication type:

Article

A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants.

Published in:

Journal of Personalized Medicine, 2021, v. 11, n. 7, p. 643, doi. 10.3390/jpm11070643

By:

Veit, Guido;
Velkov, Tony;
Xu, Haijin;
Vadeboncoeur, Nathalie;
Bilodeau, Lara;
Matouk, Elias;
Lukacs, Gergely L.

Publication type:

Article

A Christianson syndrome-linked deletion mutation (Δ287 ES288) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death.

Published in:

Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0129-9

By:

Ilie, Alina;
Gao, Andy Y. L.;
Reid, Jonathan;
Boucher, Annie;
McEwan, Cassandra;
Barrière, Hervé;
Lukacs, Gergely L.;
McKinney, R. Anne;
Orlowski, John

Publication type:

Article

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic.

Published in:

Journal of Cell Biology, 2009, v. 184, n. 6, p. 847, doi. 10.1083/jcb.200808124

By:

Glozman, Rina;
Okiyoneda, Tsukasa;
Mulvihill, Cory M.;
Rini, James M.;
Barriere, Herve;
Lukacs, Gergely L.

Publication type:

Article

Site-specific ubiquitination exposes a linear motif to promote interferon-α receptor endocytosis.

Published in:

Journal of Cell Biology, 2007, v. 179, n. 5, p. 935, doi. 10.1083/jcb.200706034

By:

Kumar, K. G. Suresh;
Barriere, Hervé;
Carbone, Christopher J.;
Liu, Jianghuai;
Swaminathan, Gayathri;
Xu, Ping;
Li, Ying;
Baker, Darren P.;
Peng, Junmin;
Lukacs, Gergely L.;
Fuchs, Serge Y.

Publication type:

Article

Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells.

Published in:

Journal of Cell Biology, 2004, v. 167, n. 5, p. 851, doi. 10.1083/jcb.200404105

By:

Lechardeur, Deiphine;
Ming Xu;
Lukacs, Gergely L.

Publication type:

Article

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.

Published in:

Journal of Cell Biology, 2004, v. 164, n. 6, p. 923, doi. 10.1083/jcb.200312018

By:

Sharma, Manu;
Pampinella, Francesca;
Nemes, Csilla;
Benharouga, Mohamed;
So, Jeffrey;
Kai Du;
Bache, Kristi G.;
Papsin, Blake;
Zerangue, Noa;
Stenmark, Harald;
Lukacs, Gergely L.

Publication type:

Article

COOH-terminal Truncations Promote Proteasome-dependent Degradation of Mature Cystic Fibrosis...

Published in:

Journal of Cell Biology, 2001, v. 153, n. 5, p. 957, doi. 10.1083/jcb.153.5.957

By:

Benharouga, Mohamed;
Haardt, Martin;
Kartner, Norbert;
Lukacs, Gergely L.

Publication type:

Article

Molecular Basis of Oligoubiquitin-Dependent Internalization of Membrane Proteins in Mammalian Cells.

Published in:

Traffic, 2006, v. 7, n. 3, p. 282, doi. 10.1111/j.1600-0854.2006.00384.x

By:

Barriere, Herve;
Nemes, Csilla;
Lechardeur, Delphine;
Khan-Mohammad, Mina;
Fruh, Klaus;
Lukacs, Gergely L.

Publication type:

Article

Dominant and Recessive Distal Renal Tubular Acidosis Mutations of Kidney Anion Exchanger 1 Induce Distinct Trafficking Defects in MDCK Cells.

Published in:

Traffic, 2006, v. 7, n. 2, p. 117, doi. 10.1111/j.1600-0854.2005.00366.x

By:

Cordat, Emmanuelle;
Kittanakom, Saranya;
Yenchitsomanus, Pa-thai;
Jing Li;
Kai Du;
Lukacs, Gergely L.;
Reithmeier, Reinhart A. F.

Publication type:

Article

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Published in:

Science Translational Medicine, 2014, v. 6, n. 246, p. 1, doi. 10.1126/scitranslmed.3008889

By:

Veit, Guido;
Avramescu, Radu G.;
Perdomo, Doranda;
Puay-Wah Phuan;
Bagdany, Miklos;
Apaja, Pirjo M.;
Borot, Florence;
Szollosi, Daniel;
Yu-Sheng Wu;
Finkbeiner, Walter E.;
Hegedus, Tamas;
Verkman, Alan S.;
Lukacs, Gergely L.

Publication type:

Article

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.

Published in:

Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 2, p. 343, doi. 10.1002/pro.3086

By:

Premchandar, Aiswarya;
Kupniewska, Anna;
Bonna, Arkadiusz;
Faure, Grazyna;
Fraczyk, Tomasz;
Roldan, Ariel;
Hoffmann, Brice;
Faria da Cunha, Mélanie;
Herrmann, Harald;
Lukacs, Gergely L.;
Edelman, Aleksander;
Dadlez, Michał

Publication type:

Article

Analysis of AlphaMissense data in different protein groups and structural context.

Published in:

Scientific Data, 2024, v. 11, n. 1, p. 1, doi. 10.1038/s41597-024-03327-8

By:

Tordai, Hedvig;
Torres, Odalys;
Csepi, Máté;
Padányi, Rita;
Lukács, Gergely L.;
Hegedűs, Tamás

Publication type:

Article

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46639-1

By:

Armirotti, Andrea;
Tomati, Valeria;
Matthes, Elizabeth;
Veit, Guido;
Cholon, Deborah M.;
Phuan, Puay-Wah;
Braccia, Clarissa;
Guidone, Daniela;
Gentzsch, Martina;
Lukacs, Gergely L.;
Verkman, Alan S.;
Galietta, Luis J. V.;
Hanrahan, John W.;
Pedemonte, Nicoletta

Publication type:

Article

Mutation-specific peripheral and ER quality control of hERG channel cell-surface expression.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-42331-6

By:

Foo, Brian;
Barbier, Camille;
Guo, Kevin;
Vasantharuban, Jaminie;
Lukacs, Gergely L.;
Shrier, Alvin

Publication type:

Article

Identification of Allosteric Inhibitors against Active Caspase-6.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41930-7

By:

Tubeleviciute-Aydin, Agne;
Beautrait, Alexandre;
Lynham, Jeffrey;
Sharma, Gyanesh;
Gorelik, Alexei;
Deny, Ludovic J.;
Soya, Naoto;
Lukacs, Gergely L.;
Nagar, Bhushan;
Marinier, Anne;
LeBlanc, Andrea C.

Publication type:

Article

Discovery of novel potent ΔF508- CFTR correctors that target the nucleotide binding domain.

Published in:

EMBO Molecular Medicine, 2013, v. 5, n. 10, p. 1484, doi. 10.1002/emmm.201302699

By:

Odolczyk, Norbert;
Fritsch, Janine;
Norez, Caroline;
Servel, Nathalie;
da Cunha, Melanie Faria;
Bitam, Sara;
Kupniewska, Anna;
Wiszniewski, Ludovic;
Colas, Julien;
Tarnowski, Krzysztof;
Tondelier, Danielle;
Roldan, Ariel;
Saussereau, Emilie L.;
Melin‐Heschel, Patricia;
Wieczorek, Grzegorz;
Lukacs, Gergely L.;
Dadlez, Michal;
Faure, Grazyna;
Herrmann, Harald;
Ollero, Mario

Publication type:

Article

Polyubiquitination of Prolactin Receptor Stimulates Its Internalization, Postinternalization Sorting, and Degradation via the Lysosomal Pathway.

Published in:

Molecular & Cellular Biology, 2008, v. 28, n. 17, p. 5275, doi. 10.1128/MCB.00350-08

By:

Varghese, Bentley;
Barriere, Herve;
Carbone, Christopher J.;
Banerjee, Anamika;
Swaminathan, Gayathri;
Plotnikov, Alexander;
Ping Xu;
Junmin Peng;
Goffin, Vincent;
Lukacs, Gergely L.;
Fuchs, Serge Y.

Publication type:

Article

Analysis of Differential Lipofection Efficiency in Primary and Established Myoblasts

Published in:

Molecular Therapy, 2002, v. 5, n. 2, p. 161, doi. 10.1006/mthe.2002.0528

By:

Pampinella, Francesca;
Lechardeur, Delphine;
Zanetti, Elena;
MacLachlan, Ian;
Benharouga, Mohammed;
Lukacs, Gergely L.;
Vitiello, Libero

Publication type:

Article

HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains.

Published in:

Journal of Cell Biology, 2024, v. 223, n. 7, p. 1, doi. 10.1083/jcb.202308003

By:

Yuka Kamada;
Yuko Ohnishi;
Chikako Nakashima;
Aika Fuji;
Mana Terakawa;
Ikuto Hamano;
Uta Nakayamada;
Saori Katoh;
Noriaki Hirata;
Hazuki Tateish;
Ryosuke Fukuda;
Hirotaka Takahashi;
Gergely L. Lukacs;
Tsukasa Okiyoneda

Publication type:

Article

Fixing cystic fibrosis by correcting CFTR domain assembly.

Published in:

Journal of Cell Biology, 2012, v. 199, n. 2, p. 199, doi. 10.1083/jcb.201208083

By:

Okiyoneda, Tsukasa;
Lukacs, Gergely L.

Publication type:

Article

Quality control for unfolded proteins at the plasma membrane.

Published in:

Journal of Cell Biology, 2010, v. 191, n. 3, p. 553, doi. 10.1083/jcb.201006012

By:

Apaja, Pirjo M.;
Haijin Xu;
Lukacs, Gergely L.

Publication type:

Article

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl− channel function and trafficking.

Published in:

Journal of Physiology, 2017, v. 595, n. 22, p. 6993, doi. 10.1113/JP275087

By:

Gaitán‐Peñas, Héctor;
Apaja, Pirjo M;
Arnedo, Tanit;
Castellanos, Aida;
Elorza‐Vidal, Xabier;
Soto, David;
Gasull, Xavier;
Lukacs, Gergely L;
Estévez, Raúl

Publication type:

Article

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00444-4

By:

Bagdany, Miklos;
Veit, Guido;
Fukuda, Ryosuke;
Avramescu, Radu G.;
Okiyoneda, Tsukasa;
Baaklini, Imad;
Singh, Jay;
Sovak, Guy;
Haijin Xu;
Apaja, Pirjo M.;
Sattin, Sara;
Beitel, Lenore K.;
Roldan, Ariel;
Colombo, Giorgio;
Balch, William;
Young, Jason C.;
Lukacs, Gergely L.

Publication type:

Article

Introduction / Introduction.

Published in:

Biochemistry & Cell Biology, 2010, v. 88, n. 2, p. v, doi. 10.1139/O09-911

By:

Hue Sun Chan;
Lukacs, Gergely L.

Publication type:

Article

The?F508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 1, p. 17, doi. 10.1038/nsmb882

By:

Du, Kai;
Sharma, Manu;
Lukacs, Gergely L.

Publication type:

Article

Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutations.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1389586

By:

Premchandar, Aiswarya;
Ming, Ruiji;
Baiad, Abed;
Da Fonte, Dillon F.;
Haijin Xu;
Faubert, Denis;
Veit, Guido;
Lukacs, Gergely L.

Publication type:

Article

Control of membrane protein homeostasis by a chaperone-like glial cell adhesion molecule at multiple subcellular locations.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97777-4

By:

Xu, Haijin;
Isenmann, Sandra;
López-Hernández, Tania;
Estévez, Raúl;
Lukacs, Gergely L.;
Apaja, Pirjo M.

Publication type:

Article

Mechanism-based corrector combination restores ΔF508-CFTR folding and function.

Published in:

Nature Chemical Biology, 2013, v. 9, n. 7, p. 444, doi. 10.1038/nchembio.1253

By:

Okiyoneda, Tsukasa;
Veit, Guido;
Dekkers, Johanna F;
Bagdany, Miklos;
Soya, Naoto;
Xu, Haijin;
Roldan, Ariel;
Verkman, Alan S;
Kurth, Mark;
Simon, Agnes;
Hegedus, Tamas;
Beekman, Jeffrey M;
Lukacs, Gergely L

Publication type:

Article

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

Published in:

Nature Chemical Biology, 2010, v. 6, n. 1, p. 25, doi. 10.1038/nchembio.275

By:

Hutt, Darren M.;
Herman, David;
Rodrigues, Ana P. C.;
Noel, Sabrina;
Pilewski, Joseph M.;
Matteson, Jeanne;
Hoch, Ben;
Kellner, Wendy;
Kelly, Jeffery W.;
Schmidt, Andre;
Thomas, Philip J.;
Matsumura, Yoshihiro;
Skach, William R.;
Gentzsch, Martina;
Riordan, John R.;
Sorscher, Eric J.;
Okiyoneda, Tsukasa;
Yates III, John R.;
Lukacs, Gergely L.;
Frizzell, Raymond A.

Publication type:

Article

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.

Published in:

PLoS Biology, 2016, v. 14, n. 5, p. 1, doi. 10.1371/journal.pbio.1002462

By:

Veit, Guido;
Oliver, Kathryn;
Apaja, Pirjo M.;
Perdomo, Doranda;
Bidaud-Meynard, Aurélien;
Lin, Sheng-Ting;
Guo, Jingyu;
Icyuz, Mert;
Sorscher, Eric J.;
Hartman IV, John L.;
Lukacs, Gergely L.

Publication type:

Article

PINK1 autophosphorylation is required for ubiquitin recognition.

Published in:

EMBO Reports, 2018, v. 19, n. 4, p. 1, doi. 10.15252/embr.201744981

By:

Rasool, Shafqat;
Soya, Naoto;
Truong, Luc;
Croteau, Nathalie;
Lukacs, Gergely L.;
Trempe, Jean‐François

Publication type:

Article

Mutation-specific downregulation of CFTR2 variants by gating potentiators.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 24, p. 4873, doi. 10.1093/hmg/ddx367

By:

Avramescu, Radu G.;
Yukari Kai;
Haijin Xu;
Bidaud-Meynard, Aurélien;
Schnúr, Andrea;
Frenkiel, Saul;
Matouk, Elias;
Veit, Guido;
Lukacs, Gergely L.

Publication type:

Article

Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents.

Published in:

Human Molecular Genetics, 2013, v. 22, n. 21, p. 4405, doi. 10.1093/hmg/ddt290

By:

Capdevila-Nortes, Xavier;
López-Hernández, Tania;
Apaja, Pirjo M.;
López de Heredia, Miguel;
Sirisi, Sònia;
Callejo, Gerard;
Arnedo, Tanit;
Nunes, Virginia;
Lukacs, Gergely L.;
Gasull, Xavier;
Estévez, Raúl

Publication type:

Article

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 3, p. 623, doi. 10.1093/hmg/ddr496

By:

Colas, Julien;
Faure, Grazyna;
Saussereau, Emilie;
Trudel, Stéphanie;
Rabeh, Wael M.;
Bitam, Sara;
Guerrera, Ida Chiara;
Fritsch, Janine;
Sermet-Gaudelus, Isabelle;
Davezac, Noëlie;
Brouillard, Franck;
Lukacs, Gergely L.;
Herrmann, Harald;
Ollero, Mario;
Edelman, Aleksander

Publication type:

Article

Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects.

Published in:

Human Molecular Genetics, 2008, v. 17, n. 23, p. 3728, doi. 10.1093/hmg/ddn269

By:

Duarri, Anna;
Teijido, Oscar;
López-Hernández, Tania;
Scheper, Gert C.;
Barriere, Herve;
Boor, Ilja;
Aguado, Fernando;
Zorzano, Antonio;
Palacín, Manuel;
Martínez, Albert;
Lukacs, Gergely L.;
van der Knaap, Marjo S.;
Nunes, Virginia;
Estévez, Raúl

Publication type:

Article

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.

Published in:

mAbs (1942-0862), 2016, v. 8, n. 6, p. 1167, doi. 10.1080/19420862.2016.1186320

By:

Gakhal, Amandeep K.;
Jensen, Timothy J.;
Bozoky, Zoltan;
Roldan, Ariel;
Lukacs, Gergely L.;
Forman-Kay, Julie;
Riordan, John R.;
Sidhu, Sachdev S.

Publication type:

Article

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 9, p. 1, doi. 10.1007/s00018-022-04528-3

By:

Pranke, Iwona Maria;
Chevalier, Benoit;
Premchandar, Aiswarya;
Baatallah, Nesrine;
Tomaszewski, Kamil F.;
Bitam, Sara;
Tondelier, Danielle;
Golec, Anita;
Stolk, Jan;
Lukacs, Gergely L.;
Hiemstra, Pieter S.;
Dadlez, Michal;
Lomas, David A.;
Irving, James A.;
Delaunay-Moisan, Agnes;
van Anken, Eelco;
Hinzpeter, Alexandre;
Sermet-Gaudelus, Isabelle;
Edelman, Aleksander

Publication type:

Article

Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 3, p. 1, doi. 10.1007/s00018-022-04191-8

By:

Wang, Ben B.;
Xu, Haijin;
Isenmann, Sandra;
Huang, Cheng;
Elorza-Vidal, Xabier;
Rychkov, Grigori Y.;
Estévez, Raúl;
Schittenhelm, Ralf B.;
Lukacs, Gergely L.;
Apaja, Pirjo M.

Publication type:

Article