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A Systems Biology Approach to Investigate Kinase Signal Transduction Networks That Are Involved in Triple Negative Breast Cancer Resistance to Cisplatin.
Published in:
Journal of Personalized Medicine, 2022, v. 12, n. 8, p. 1277, doi. 10.3390/jpm12081277
By:
- Mukherjee, Nupur;
- Browne, Alacoque;
- Ivers, Laura;
- Santra, Tapesh;
- Cremona, Mattia;
- Hennessy, Bryan T.;
- O'Donovan, Norma;
- Crown, John;
- Kolch, Walter;
- Fey, Dirk;
- Eustace, Alex J.
Publication type:
Article
In vitro development of chemotherapy and targeted therapy drug-resistant cancer cell lines: a practical guide with case studies.
Published in:
Frontiers in Oncology, 2014, v. 4, p. 1, doi. 10.3389/fonc.2014.00040
By:
- McDermott, Martina;
- Eustace, Alex J.;
- Busschots, Steven;
- Breen, Laura;
- Crown, John;
- Clynes, Martin;
- O'Donovan, Norma;
- Stordal, Britta
Publication type:
Article
The novel low molecular weight MYC antagonist MYCMI-6 inhibits proliferation and induces apoptosis in breast cancer cells.
Published in:
Investigational New Drugs, 2021, v. 39, n. 2, p. 587, doi. 10.1007/s10637-020-01018-w
By:
- AlSultan, Dalal;
- Kavanagh, Emma;
- O'Grady, Shane;
- Eustace, Alex J;
- Castell, Alina;
- Larsson, Lars-Gunnar;
- Crown, John;
- Madden, Stephen F;
- Duffy, Michael J
Publication type:
Article
Targeting c-Met in triple negative breast cancer: preclinical studies using the c-Met inhibitor, Cpd A.
Published in:
Investigational New Drugs, 2020, v. 38, n. 5, p. 1365, doi. 10.1007/s10637-020-00937-y
By:
- Breen, Laura;
- Gaule, Patricia B.;
- Canonici, Alexandra;
- Walsh, Naomi;
- Collins, Denis M.;
- Cremona, Mattia;
- Hennessy, Bryan T.;
- Duffy, Michael J.;
- Crown, John;
- Donovan, Norma O';
- Eustace, Alex J.
Publication type:
Article
The HSP90 inhibitor NVP-AUY922 inhibits growth of HER2 positive and trastuzumab-resistant breast cancer cells.
Published in:
Investigational New Drugs, 2018, v. 36, n. 4, p. 581, doi. 10.1007/s10637-017-0556-7
By:
- Canonici, Alexandra;
- Qadir, Zulfiqar;
- Conlon, Neil T.;
- Collins, Denis M.;
- O’Brien, Neil A.;
- Walsh, Naomi;
- Eustace, Alex J.;
- O’Donovan, Norma;
- Crown, John
Publication type:
Article
Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer.
Published in:
Therapeutic Advances in Medical Oncology, 2020, v. 12, p. 1, doi. 10.1177/1758835919897546
By:
- Canonici, Alexandra;
- Browne, Alacoque L.;
- Ibrahim, Mohamed F. K.;
- Fanning, Kevin P.;
- Roche, Sandra;
- Conlon, Neil T.;
- O'Neill, Fiona;
- Meiller, Justine;
- Cremona, Mattia;
- Morgan, Clare;
- Hennessy, Bryan T.;
- Eustace, Alex J.;
- Solca, Flavio;
- O'Donovan, Norma;
- Crown, John
Publication type:
Article
Precision Oncology, Artificial Intelligence, and Novel Therapeutic Advancements in the Diagnosis, Prevention, and Treatment of Cancer: Highlights from the 59th Irish Association for Cancer Research (IACR) Annual Conference.
Published in:
Cancers, 2024, v. 16, n. 11, p. 1989, doi. 10.3390/cancers16111989
By:
- Lynch, Seodhna M.;
- Heeran, Aisling B.;
- Burke, Caoimbhe;
- Lynam-Lennon, Niamh;
- Eustace, Alex J.;
- Dean, Kellie;
- Robson, Tracy;
- Rahman, Arman;
- Marcone, Simone
Publication type:
Article
Precision Medicine and Novel Therapeutic Strategies in Detection and Treatment of Cancer: Highlights from the 58th IACR Annual Conference.
Published in:
Cancers, 2022, v. 14, n. 24, p. 6213, doi. 10.3390/cancers14246213
By:
- Kennedy, Sean P.;
- Treacy, Oliver;
- Allott, Emma H.;
- Eustace, Alex J.;
- Lynam-Lennon, Niamh;
- Buckley, Niamh;
- Robson, Tracy
Publication type:
Article
Dasatinib Treatment Increases Sensitivity to c-Met Inhibition in Triple-Negative Breast Cancer Cells.
Published in:
Cancers, 2019, v. 11, n. 4, p. 548, doi. 10.3390/cancers11040548
By:
- Gaule, Patricia;
- Mukherjee, Nupur;
- Corkery, Brendan;
- Eustace, Alex J.;
- Gately, Kathy;
- Roche, Sandra;
- O'Connor, Robert;
- O'Byrne, Kenneth J.;
- Walsh, Naomi;
- Duffy, Michael J.;
- Crown, John;
- O'Donovan, Norma
Publication type:
Article
Pilot study of bevacizumab in combination with docetaxel and cyclophosphamide as adjuvant treatment for patients with early stage HER-2 negative breast cancer, including analysis of candidate circulating markers of cardiac toxicity: ICORG 08–10 trial
Published in:
Therapeutic Advances in Medical Oncology, 2019, v. 11, p. 1, doi. 10.1177/1758835919864236
By:
- Gullo, Giuseppe;
- Eustace, Alex J.;
- Canonici, Alexandra;
- Collins, Denis M.;
- Kennedy, Michael J.;
- Grogan, Liam;
- Breathhnach, Oscar;
- McCaffrey, John;
- Keane, Maccon;
- Martin, Michael J.;
- Gupta, Rajnish;
- Leonard, Gregory;
- O'Connor, Miriam;
- Calvert, Paula M.;
- Donnellan, Paul;
- Walshe, Janice;
- McDermott, Enda;
- Scott, Kathleen;
- Hernando, Andres;
- Parker, Imelda
Publication type:
Article
Pilot study of bevacizumab in combination with docetaxel and cyclophosphamide as adjuvant treatment for patients with early stage HER-2 negative breast cancer, including analysis of candidate circulating markers of cardiac toxicity: ICORG 08–10 trial
Published in:
Therapeutic Advances in Medical Oncology, 2019, v. 11, p. N.PAG, doi. 10.1177/1758835919864236
By:
- Gullo, Giuseppe;
- Eustace, Alex J.;
- Canonici, Alexandra;
- Collins, Denis M.;
- Kennedy, Michael J.;
- Grogan, Liam;
- Breathhnach, Oscar;
- McCaffrey, John;
- Keane, Maccon;
- Martin, Michael J.;
- Gupta, Rajnish;
- Leonard, Gregory;
- O'Connor, Miriam;
- Calvert, Paula M.;
- Donnellan, Paul;
- Walshe, Janice;
- McDermott, Enda;
- Scott, Kathleen;
- Hernando, Andres;
- Parker, Imelda
Publication type:
Article
Pilot study of bevacizumab in combination with docetaxel and cyclophosphamide as adjuvant treatment for patients with early stage HER-2 negative breast cancer, including analysis of candidate circulating markers of cardiac toxicity: ICORG 08–10 trial
Published in:
Therapeutic Advances in Medical Oncology, 2019, v. 11, p. N.PAG, doi. 10.1177/1758835919864236
By:
- Gullo, Giuseppe;
- J. Eustace, Alex;
- Canonici, Alexandra;
- M. Collins, Denis;
- Kennedy, Michael J.;
- Grogan, Liam;
- Breathhnach, Oscar;
- McCaffrey, John;
- Keane, Maccon;
- Martin, Michael J.;
- Gupta, Rajnish;
- Leonard, Gregory;
- O'Connor, Miriam;
- Calvert, Paula M.;
- Donnellan, Paul;
- Walshe, Janice;
- McDermott, Enda;
- Scott, Kathleen;
- Hernando, Andres;
- Parker, Imelda
Publication type:
Article
Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers.
Published in:
Therapeutic Advances in Medical Oncology, 2018, v. 10, n. 1, p. 1, doi. 10.1177/1758834017746040
By:
- Milewska, Malgorzata;
- Cremona, Mattia;
- Morgan, Clare;
- O'Shea, John;
- Carr, Aoife;
- Vellanki, Sri HariKrishna;
- Hopkins, Ann M.;
- Toomey, Sinead;
- Madden, Stephen F.;
- Hennessy, Bryan T.;
- Eustace, Alex J.
Publication type:
Article
Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.
Published in:
2018
By:
- Eustace, Alex J;
- Conlon, Neil T;
- McDermott, Martina S J;
- Browne, Brigid C;
- O'Leary, Patrick;
- Holmes, Frankie A;
- Espina, Virginia;
- Liotta, Lance A;
- O'Shaughnessy, Joyce;
- Gallagher, Clair;
- O'Driscoll, Lorraine;
- Rani, Sweta;
- Madden, Stephen F;
- O'Brien, Neil A;
- Ginther, Charles;
- Slamon, Dennis;
- Walsh, Naomi;
- Gallagher, William M;
- Zagozdzon, Radoslaw;
- Watson, William R
Publication type:
journal article
Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy.
Published in:
British Journal of Cancer, 2023, v. 129, n. 6, p. 1022, doi. 10.1038/s41416-023-02375-y
By:
- Gaynor, Nicola;
- Blanco, Alfonso;
- Madden, Stephen F.;
- Moran, Barry;
- Fletcher, Jean M.;
- Kaukonen, Damien;
- Ramírez, Javier Sánchez;
- Eustace, Alex J.;
- McDermott, Martina S. J.;
- Canonici, Alexandra;
- Toomey, Sinead;
- Teiserskiene, Ausra;
- Hennessy, Bryan T.;
- O'Donovan, Norma;
- Crown, John;
- Collins, Denis M.
Publication type:
Article
Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines.
Published in:
Journal of Translational Medicine, 2008, v. 6, p. 1, doi. 10.1186/1479-5876-6-53
By:
- Eustace, Alex J.;
- Crown, John;
- Clynes, Martin;
- O'Donovan, Norma
Publication type:
Article
Preclinical evaluation of Insulin-like growth factor receptor 1 (IGF1R) and Insulin Receptor (IR) as a therapeutic targets in triple negative breast cancer.
Published in:
PLoS ONE, 2023, v. 17, n. 3, p. 1, doi. 10.1371/journal.pone.0282512
By:
- Roche, Sandra;
- Gaule, Patricia;
- Winrow, Deirdre;
- Mukherjee, Nupur;
- O'Neill, Fiona;
- Conlon, Neil T.;
- Meiller, Justine;
- Collins, Denis M.;
- Canonici, Alexandra;
- Fawsi, Mohammed Ibrahim;
- Estepa-Fernández, Alejandra;
- Madden, Stephen F.;
- Crown, John;
- O'Donovan, Norma;
- Eustace, Alex J.
Publication type:
Article
Predictive modelling of response to neoadjuvant therapy in HER2+ breast cancer.
Published in:
NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00572-9
By:
- Cosgrove, Nicola;
- Eustace, Alex J.;
- O'Donovan, Peter;
- Madden, Stephen F.;
- Moran, Bruce;
- Crown, John;
- Moulton, Brian;
- Morris, Patrick G.;
- Grogan, Liam;
- Breathnach, Oscar;
- Power, Colm;
- Allen, Michael;
- Walshe, Janice M.;
- Hill, Arnold D.;
- Blümel, Anna;
- O'Connor, Darren;
- Das, Sudipto;
- Milewska, Małgorzata;
- Fay, Joanna;
- Kay, Elaine
Publication type:
Article
RE: RNA Disruption Assay as a Biomarker of Pathological Complete Response in Neoadjuvant Trastuzumab-Treated Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.
Published in:
2016
By:
- Toomey, Sinead;
- Eustace, Alex J.;
- Pritzker, Laura B.;
- Pritzker, Ken P. H.;
- Fay, Joanna;
- O'Grady, Anthony;
- Cummins, Robert;
- Grogan, Liam;
- Kennedy, John;
- O'Connor, Darran;
- Young, Leonie;
- Kay, Elaine W.;
- O'Donovan, Norma;
- Gallagher, William M.;
- Kalachand, Roshni;
- Crown, John;
- Hennessy, Bryan T.
Publication type:
Letter
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells.
Published in:
BMC Cancer, 2008, v. 8, p. 1, doi. 10.1186/1471-2407-8-9
By:
- Glynn, Sharon A.;
- O'Sullivan, Dermot;
- Eustace, Alex J.;
- Clynes, Martin;
- O'Donovan, Norma
Publication type:
Article

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