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- Title
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
- Authors
Greene, Maxwell; Lai, Yongjie; Pajcini, Kostandin; Bailis, Will; Pear, Warren S.; Lancaster, Eric
- Abstract
Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.
- Subjects
EPIDERMAL growth factor receptors; NOTCH genes; MYOBLASTS; CELL differentiation; LIGANDS (Biochemistry); CELLULAR signal transduction
- Publication
PLoS ONE, 2016, Vol 11, Issue 9, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0161157