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- Title
Use of Organomolybdenum Compounds for Promoted Hydrolysis of Phosphoester Bonds in Aqueous Media.
- Authors
Gomes, Ana C.; Gamelas, Carla A.; Fernandes, José A.; Almeida Paz, Filipe A.; Nunes, Patrique; Pillinger, Martyn; Gonçalves, Isabel S.; Romão, Carlos C.; Abrantes, Marta
- Abstract
The dissolution of the indenyl (Ind) complex [{(η5-Ind)Mo(CO)2(μ-Cl)}2] ( 1) in N, N′-dimethylformamide (DMF) gives the ring-slipped complex [(η3-Ind)Mo(CO)2Cl(DMF)2] ( 2). The aerial oxidation of 2 leads to the formation of the dinuclear oxomolybdenum(V) chloride [Mo2O2(DMF)4(μ-O)2Cl2] ( 3). The structures of 2 and 3·DMF have been determined by single-crystal X-ray diffraction. Compounds 1 and 3 were examined as promoters of phosphoester bond hydrolysis in para-nitrophenylphosphate ( pNPP), which was used as a model substrate. The reactions were performed in aqueous solution at 55 °C and followed by 1H NMR spectroscopy. For assays performed with 30-100 mol-% of 1 or 3 relative to pNPP, both compounds promote the production of para-nitrophenol ( pNPh) from pNPP. Compound 3 is especially active in promoting the hydrolytic cleavage of the phosphoester bond ( t1/2 < 80 min).
- Subjects
LIGANDS (Chemistry); MOLYBDENUM; PEROXYNITRITE; PHOSPHATASES; HYDROLYSIS
- Publication
European Journal of Inorganic Chemistry, 2014, Vol 2014, Issue 23, p3681
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.201402071