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- Title
Potassium and norepinephrine- or angiotensin-mediated pressor control in pre-hypertension.
- Authors
Bianchetti, Mario G.; Weidmann, Peter; Beretta-Piccoli, Carlo; Ferrier, Claudia
- Abstract
Blood pressure (BP), plasma electrolytes, renin, aldosterone, angiotensin 11 (AII) or catecholamines, the chronotropic effects of intravenous isoproterenol. norepinephrine (NE)or AII, the pressor responses to NE or AII, and the relationship between plasma AII and aldosterone concentrations were studied before and after 10 days of dietary supplementation with potassium 100 mmol/day. in normotensive members of normotensive (N = 12) or hypertensive (N = 12) families, and 11 patients with borderline essential hypertension. Under control conditions, the pressor responsiveness to NE was significantly enhanced in normotensive with positive family history for hypertension and hypertensive subjects; the other variables were comparable in the groups. After potassium supplementation, plasma potassium, renin, aldosterone or AII, and the relationship between AII and aldosterone levels increased significantly, while body weight. plasma catecholamines, the chronutropic effects of isoproterenol. AII or NE, the pressor effects of AII and plasma clearance of AII or NE were unchanged in all groups. In normotensive members of hypertensive families and patients with hypertension. BP was decreased and the exaggerated pressor responsiveness to NE was normalized; these variables were not modified in normotensive members of normotensive families. These observations are consistent with a potassium-remediable disturbance in NE- but not AII-dependent regulation of BP in the pathogenesis of essential hypertension.
- Subjects
HYPERTENSION; BLOOD circulation disorders; ISOPROTERENOL; BLOOD pressure; ANGIOTENSIN II; ALDOSTERONE
- Publication
Kidney International, 1987, Vol 31, Issue 4, p956
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1987.92