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- Title
The effect of hydroxyapatite filler on biodegradable poly(sorbitol sebacate malate) composites.
- Authors
Yusoff, Noor Izyan Syazana Mohd; Tham, Weng Hong; Wahit, Mat Uzir; Abdul Kadir, Mohammed Rafiq; Wong, Tuck‐Whye
- Abstract
Biodegradable poly(sorbitol sebacate malate)/hydroxyapatite (PSSM/HA) composites were successfully synthesized through one step catalyst‐free polycondensation of sorbitol, sebacic acid, malic acid, and HA powder as filler for the composites. The addition of HA improved the tensile modulus and strength of the materials compared with pure PSSM. The elongation at break of the composites was slightly reduced with increasing HA content. The PSSM and HA showed good compatibility, which was evidenced by good distributions of HA particles in the matrix. In vitro degradation and cytotoxicity tests were conducted to investigate the degradation profile and the toxicity of the biocomposites, respectively. The biocomposites also degraded nearly up to ~50% after 6 weeks of study and the degradation products were shown non‐cytotoxic. It was observed that the biocomposites were soft, elastic with Young's modulus and also biodegradable which is potential to be used in biomedical fields such as tissue engineering application.
- Subjects
HYDROXYAPATITE; SORBITOL; YOUNG'S modulus; STRENGTH of materials; MALIC acid; TISSUE engineering; TENSILE strength; MALATE dehydrogenase
- Publication
Journal of Applied Polymer Science, 2022, Vol 139, Issue 36, p1
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.52862