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- Title
Influencia epigenómica de la actividad/inactividad física en el origen de la Diabetes mellitus tipo 2.
- Authors
Luis Márquez Andrade, José; Antonio Salazar Navarrete, Luis
- Abstract
Contrary to the model centered in the mutations, which assumes that alterations in the function are consequence of somatic or inherited mutations in the sequence of the DNA, the epigenetic model implies dysregulation of one or more genes. A critical component of epigenome is its distribution patterns of the methylated cytosines in CpG sequences. This methylation marks to genes for their inactivation interfering with the union of methylated DNA-sensible transcription factors or recruiting proteins that group corepressor complexes and histone deacetylases around of chromatin. These epigenetic marks are propagated soon mitotic and in some cases meioticaly, result in a stable inheritance of regulatory states. Today it is known that diet or other environmental factors are a control point for the regulation of the gene expression and that during critical periods of development, the chromatin would be particularly sensible to epigenomics modifications. This way, an epigenomic explanation of the fetal origin of adult's chronic diseases seems reasonable. The present review explains how physical activity/inactivity of the mother or the lineage in early stages can ready to Diabetes mellitus type 2 in the adult life through this mechanism.
- Subjects
DIABETES; GENES; CARBOHYDRATE intolerance; PROTEINS; HEREDITY; SILICATE minerals; DEOXYRIBOSE; DIABETIC acidosis; MICA
- Publication
RICYDE. Revista Internacional de Ciencias del Deporte, 2009, Vol 5, Issue 16, p1
- ISSN
1885-3137
- Publication type
Article