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- Title
EFFECTS OF FUNGAL SECONDARY METABOLITES ON IN VITRO GROWTH OF PHYTOPHTHORA spp.
- Authors
Scanu, B.; Linaldeddu, B. T.; Franceschini, A.; Evidente, A.; Maddau, L.
- Abstract
The genus Phytophthora De Bary includes some of the most important pathogens causing disease to agricultural, forest, ornamental and natural systems world-wide. Within the disease management strategies, there is a need for new effective compounds owing to the development of fungicide resistance by pathogens and adverse effects on environmental ecosystems. Microbial bioactive secondary metabolites, which have historically been of great importance in medicine and agriculture, could be expected to overcome these critical points. In this study, seven bioactive metabolites produced by phytopathogenic fungi and/or biocontrol agents were examined against several Phytophthora species isolated from horticultural and forest ecosystems in Sardinia (Italy). The effects of these metabolites were assessed in vitro on mycelial growth. The fungicide metalaxyl-M (48% active ingredient) was used as positive control. All metabolites were assayed at increasing concentrations and EC50 values were evaluated. Interestingly, mycelial growth inhibition was observed, with sphaeropsidin A, which showed to be the most active metabolites. The EC50 for sphaeropsidin A was ranging 1-10 µg/ml depending on the Phytophthora species, and it was tenfold higher than that of metalaxyl-M in some species. The EC50 for the other metabolites tested exceeded 100 µg/ml. Although the chemical control of these pathogens is impractical in natural ecosystems, our results may provide a basis for the development of new compounds that may have useful applications in diseases control caused by Phytophthora spp. in agriculture and nurseries.
- Subjects
PHYTOPHTHORA; METABOLITES; PATHOGENIC microorganisms; PHYTOPATHOGENIC microorganisms; FUNGICIDE resistance
- Publication
Journal of Plant Pathology, 2012, Vol 94, Issue 4, pS4.78
- ISSN
1125-4653
- Publication type
Article