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- Title
Evolution of pulmonary surfactants for the treatment of neonatal respiratory distress syndrome and paediatric lung diseases.
- Authors
Mazela, Jan; Allen Merritt, T.; Gadzinowski, Janusz; Sinha, Sunil
- Abstract
This review documents the evolution of surfactant therapy, beginning with observations of surfactant deficiency in respiratory distress syndrome, the basis of exogenous surfactant treatment and the development of surfactant-containing novel peptides patterned after SP-B. We critically analyse the molecular interactions of surfactant proteins and phospholipids contributing to surfactant function. Conclusion: Peptide-containing surfactant provides clinical efficacy in the treatment of respiratory distress syndrome and offers promise for treating other lung diseases in infancy.
- Subjects
PULMONARY surfactant; RESPIRATORY therapy for newborn infants; BIOSURFACTANTS; PHOSPHOLIPIDS; LUNG diseases; INFANTS; RESPIRATORY distress syndrome; PULMONARY manifestations of general diseases; SURFACE active agents
- Publication
Acta Paediatrica, 2006, Vol 95, Issue 9, p1036
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1080/08035250600615168